Amino acid dipepetide frequency for Streptomyces boncukensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.297AlaAla: 23.297 ± 0.155	1.196AlaCys: 1.196 ± 0.029	8.724AlaAsp: 8.724 ± 0.065	9.645AlaGlu: 9.645 ± 0.082	3.477AlaPhe: 3.477 ± 0.04	14.151AlaGly: 14.151 ± 0.096	3.125AlaHis: 3.125 ± 0.041	2.907AlaIle: 2.907 ± 0.042	2.45AlaLys: 2.45 ± 0.047	15.734AlaLeu: 15.734 ± 0.1	2.398AlaMet: 2.398 ± 0.032	1.692AlaAsn: 1.692 ± 0.027	7.864AlaPro: 7.864 ± 0.07	3.83AlaGln: 3.83 ± 0.048	11.833AlaArg: 11.833 ± 0.082	5.559AlaSer: 5.559 ± 0.047	6.327AlaThr: 6.327 ± 0.057	12.512AlaVal: 12.512 ± 0.084	1.907AlaTrp: 1.907 ± 0.03	2.737AlaTyr: 2.737 ± 0.035	0.0AlaXaa: 0.0 ± 0.0
Cys	1.282CysAla: 1.282 ± 0.028	0.106CysCys: 0.106 ± 0.007	0.504CysAsp: 0.504 ± 0.014	0.468CysGlu: 0.468 ± 0.014	0.206CysPhe: 0.206 ± 0.01	1.001CysGly: 1.001 ± 0.023	0.188CysHis: 0.188 ± 0.008	0.132CysIle: 0.132 ± 0.007	0.124CysLys: 0.124 ± 0.008	0.742CysLeu: 0.742 ± 0.022	0.131CysMet: 0.131 ± 0.008	0.115CysAsn: 0.115 ± 0.007	0.513CysPro: 0.513 ± 0.016	0.172CysGln: 0.172 ± 0.008	0.69CysArg: 0.69 ± 0.019	0.433CysSer: 0.433 ± 0.014	0.497CysThr: 0.497 ± 0.013	0.702CysVal: 0.702 ± 0.018	0.126CysTrp: 0.126 ± 0.008	0.168CysTyr: 0.168 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	8.119AspAla: 8.119 ± 0.066	0.397AspCys: 0.397 ± 0.015	3.408AspAsp: 3.408 ± 0.048	3.879AspGlu: 3.879 ± 0.049	1.582AspPhe: 1.582 ± 0.029	7.053AspGly: 7.053 ± 0.068	1.333AspHis: 1.333 ± 0.026	1.742AspIle: 1.742 ± 0.026	1.01AspLys: 1.01 ± 0.025	5.742AspLeu: 5.742 ± 0.056	0.773AspMet: 0.773 ± 0.018	0.811AspAsn: 0.811 ± 0.021	4.583AspPro: 4.583 ± 0.049	1.518AspGln: 1.518 ± 0.024	5.022AspArg: 5.022 ± 0.048	2.625AspSer: 2.625 ± 0.036	3.177AspThr: 3.177 ± 0.049	4.4AspVal: 4.4 ± 0.048	1.01AspTrp: 1.01 ± 0.019	1.137AspTyr: 1.137 ± 0.023	0.0AspXaa: 0.0 ± 0.0
Glu	7.796GluAla: 7.796 ± 0.082	0.437GluCys: 0.437 ± 0.013	2.929GluAsp: 2.929 ± 0.04	3.804GluGlu: 3.804 ± 0.052	1.392GluPhe: 1.392 ± 0.024	4.8GluGly: 4.8 ± 0.043	1.642GluHis: 1.642 ± 0.028	1.965GluIle: 1.965 ± 0.031	1.281GluLys: 1.281 ± 0.028	7.351GluLeu: 7.351 ± 0.062	0.941GluMet: 0.941 ± 0.022	0.881GluAsn: 0.881 ± 0.022	3.885GluPro: 3.885 ± 0.047	2.304GluGln: 2.304 ± 0.036	6.606GluArg: 6.606 ± 0.065	2.701GluSer: 2.701 ± 0.034	2.852GluThr: 2.852 ± 0.036	4.42GluVal: 4.42 ± 0.051	0.841GluTrp: 0.841 ± 0.02	1.056GluTyr: 1.056 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	3.743PheAla: 3.743 ± 0.04	0.277PheCys: 0.277 ± 0.011	1.901PheAsp: 1.901 ± 0.029	1.358PheGlu: 1.358 ± 0.028	0.827PhePhe: 0.827 ± 0.021	2.833PheGly: 2.833 ± 0.038	0.627PheHis: 0.627 ± 0.016	0.62PheIle: 0.62 ± 0.019	0.405PheLys: 0.405 ± 0.014	2.463PheLeu: 2.463 ± 0.031	0.349PheMet: 0.349 ± 0.011	0.502PheAsn: 0.502 ± 0.016	1.357PhePro: 1.357 ± 0.025	0.651PheGln: 0.651 ± 0.016	1.851PheArg: 1.851 ± 0.031	1.398PheSer: 1.398 ± 0.026	1.912PheThr: 1.912 ± 0.032	2.053PheVal: 2.053 ± 0.035	0.398PheTrp: 0.398 ± 0.013	0.514PheTyr: 0.514 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	12.615GlyAla: 12.615 ± 0.092	0.869GlyCys: 0.869 ± 0.021	5.414GlyAsp: 5.414 ± 0.055	5.779GlyGlu: 5.779 ± 0.05	2.771GlyPhe: 2.771 ± 0.038	9.846GlyGly: 9.846 ± 0.094	2.394GlyHis: 2.394 ± 0.039	3.138GlyIle: 3.138 ± 0.041	2.276GlyLys: 2.276 ± 0.043	9.593GlyLeu: 9.593 ± 0.076	2.124GlyMet: 2.124 ± 0.033	1.614GlyAsn: 1.614 ± 0.032	5.821GlyPro: 5.821 ± 0.065	2.748GlyGln: 2.748 ± 0.032	8.188GlyArg: 8.188 ± 0.068	5.507GlySer: 5.507 ± 0.055	6.499GlyThr: 6.499 ± 0.061	7.754GlyVal: 7.754 ± 0.068	1.757GlyTrp: 1.757 ± 0.029	2.259GlyTyr: 2.259 ± 0.029	0.0GlyXaa: 0.0 ± 0.0
His	2.881HisAla: 2.881 ± 0.037	0.233HisCys: 0.233 ± 0.01	1.21HisAsp: 1.21 ± 0.023	1.247HisGlu: 1.247 ± 0.024	0.624HisPhe: 0.624 ± 0.014	2.59HisGly: 2.59 ± 0.035	0.68HisHis: 0.68 ± 0.022	0.66HisIle: 0.66 ± 0.016	0.33HisLys: 0.33 ± 0.012	2.385HisLeu: 2.385 ± 0.035	0.325HisMet: 0.325 ± 0.011	0.327HisAsn: 0.327 ± 0.012	1.915HisPro: 1.915 ± 0.031	0.686HisGln: 0.686 ± 0.015	2.321HisArg: 2.321 ± 0.036	1.062HisSer: 1.062 ± 0.017	1.425HisThr: 1.425 ± 0.027	1.598HisVal: 1.598 ± 0.025	0.355HisTrp: 0.355 ± 0.013	0.475HisTyr: 0.475 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.179IleAla: 4.179 ± 0.042	0.258IleCys: 0.258 ± 0.011	1.825IleAsp: 1.825 ± 0.031	1.801IleGlu: 1.801 ± 0.027	0.582IlePhe: 0.582 ± 0.016	3.066IleGly: 3.066 ± 0.039	0.552IleHis: 0.552 ± 0.016	0.67IleIle: 0.67 ± 0.022	0.617IleLys: 0.617 ± 0.018	2.027IleLeu: 2.027 ± 0.03	0.347IleMet: 0.347 ± 0.013	0.596IleAsn: 0.596 ± 0.015	1.67IlePro: 1.67 ± 0.027	0.629IleGln: 0.629 ± 0.017	2.201IleArg: 2.201 ± 0.032	1.472IleSer: 1.472 ± 0.025	1.81IleThr: 1.81 ± 0.025	2.228IleVal: 2.228 ± 0.033	0.309IleTrp: 0.309 ± 0.012	0.474IleTyr: 0.474 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	2.365LysAla: 2.365 ± 0.043	0.102LysCys: 0.102 ± 0.007	1.137LysAsp: 1.137 ± 0.029	1.067LysGlu: 1.067 ± 0.026	0.373LysPhe: 0.373 ± 0.015	1.661LysGly: 1.661 ± 0.035	0.384LysHis: 0.384 ± 0.014	0.665LysIle: 0.665 ± 0.021	0.818LysLys: 0.818 ± 0.031	1.859LysLeu: 1.859 ± 0.032	0.336LysMet: 0.336 ± 0.013	0.424LysAsn: 0.424 ± 0.015	1.212LysPro: 1.212 ± 0.026	0.621LysGln: 0.621 ± 0.019	1.498LysArg: 1.498 ± 0.032	1.072LysSer: 1.072 ± 0.024	1.072LysThr: 1.072 ± 0.027	1.546LysVal: 1.546 ± 0.034	0.223LysTrp: 0.223 ± 0.009	0.361LysTyr: 0.361 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	16.052LeuAla: 16.052 ± 0.102	0.917LeuCys: 0.917 ± 0.023	6.829LeuAsp: 6.829 ± 0.06	5.011LeuGlu: 5.011 ± 0.05	2.588LeuPhe: 2.588 ± 0.04	9.525LeuGly: 9.525 ± 0.067	2.353LeuHis: 2.353 ± 0.031	2.794LeuIle: 2.794 ± 0.036	1.708LeuLys: 1.708 ± 0.032	11.409LeuLeu: 11.409 ± 0.095	1.525LeuMet: 1.525 ± 0.028	1.508LeuAsn: 1.508 ± 0.03	6.611LeuPro: 6.611 ± 0.057	2.037LeuGln: 2.037 ± 0.028	9.671LeuArg: 9.671 ± 0.075	5.341LeuSer: 5.341 ± 0.049	6.799LeuThr: 6.799 ± 0.053	8.548LeuVal: 8.548 ± 0.064	1.318LeuTrp: 1.318 ± 0.026	1.795LeuTyr: 1.795 ± 0.03	0.0LeuXaa: 0.0 ± 0.0
Met	2.312MetAla: 2.312 ± 0.033	0.127MetCys: 0.127 ± 0.007	0.875MetAsp: 0.875 ± 0.02	0.728MetGlu: 0.728 ± 0.018	0.441MetPhe: 0.441 ± 0.017	1.235MetGly: 1.235 ± 0.023	0.324MetHis: 0.324 ± 0.012	0.529MetIle: 0.529 ± 0.016	0.352MetLys: 0.352 ± 0.014	1.666MetLeu: 1.666 ± 0.027	0.283MetMet: 0.283 ± 0.011	0.374MetAsn: 0.374 ± 0.013	1.076MetPro: 1.076 ± 0.021	0.413MetGln: 0.413 ± 0.014	1.446MetArg: 1.446 ± 0.023	1.212MetSer: 1.212 ± 0.022	1.403MetThr: 1.403 ± 0.027	1.237MetVal: 1.237 ± 0.025	0.205MetTrp: 0.205 ± 0.011	0.33MetTyr: 0.33 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.005AsnAla: 2.005 ± 0.035	0.152AsnCys: 0.152 ± 0.008	0.819AsnAsp: 0.819 ± 0.018	0.733AsnGlu: 0.733 ± 0.018	0.424AsnPhe: 0.424 ± 0.012	1.731AsnGly: 1.731 ± 0.033	0.349AsnHis: 0.349 ± 0.013	0.566AsnIle: 0.566 ± 0.017	0.329AsnLys: 0.329 ± 0.013	1.495AsnLeu: 1.495 ± 0.025	0.231AsnMet: 0.231 ± 0.01	0.331AsnAsn: 0.331 ± 0.013	1.207AsnPro: 1.207 ± 0.025	0.449AsnGln: 0.449 ± 0.015	1.215AsnArg: 1.215 ± 0.026	0.789AsnSer: 0.789 ± 0.02	0.916AsnThr: 0.916 ± 0.02	1.15AsnVal: 1.15 ± 0.026	0.247AsnTrp: 0.247 ± 0.01	0.363AsnTyr: 0.363 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	8.868ProAla: 8.868 ± 0.084	0.372ProCys: 0.372 ± 0.014	4.799ProAsp: 4.799 ± 0.047	4.867ProGlu: 4.867 ± 0.049	1.44ProPhe: 1.44 ± 0.023	7.579ProGly: 7.579 ± 0.074	1.525ProHis: 1.525 ± 0.029	1.042ProIle: 1.042 ± 0.02	1.013ProLys: 1.013 ± 0.03	5.623ProLeu: 5.623 ± 0.049	0.985ProMet: 0.985 ± 0.02	0.795ProAsn: 0.795 ± 0.016	3.858ProPro: 3.858 ± 0.054	1.842ProGln: 1.842 ± 0.032	4.504ProArg: 4.504 ± 0.044	3.124ProSer: 3.124 ± 0.039	2.695ProThr: 2.695 ± 0.035	5.353ProVal: 5.353 ± 0.052	0.933ProTrp: 0.933 ± 0.019	1.372ProTyr: 1.372 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.632GlnAla: 3.632 ± 0.043	0.181GlnCys: 0.181 ± 0.009	1.485GlnAsp: 1.485 ± 0.024	1.516GlnGlu: 1.516 ± 0.025	0.65GlnPhe: 0.65 ± 0.018	2.32GlnGly: 2.32 ± 0.035	0.728GlnHis: 0.728 ± 0.018	0.963GlnIle: 0.963 ± 0.021	0.493GlnLys: 0.493 ± 0.015	3.053GlnLeu: 3.053 ± 0.039	0.43GlnMet: 0.43 ± 0.015	0.394GlnAsn: 0.394 ± 0.014	1.738GlnPro: 1.738 ± 0.031	1.262GlnGln: 1.262 ± 0.033	2.693GlnArg: 2.693 ± 0.034	1.213GlnSer: 1.213 ± 0.022	1.217GlnThr: 1.217 ± 0.022	2.181GlnVal: 2.181 ± 0.032	0.435GlnTrp: 0.435 ± 0.015	0.541GlnTyr: 0.541 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	11.552ArgAla: 11.552 ± 0.082	0.698ArgCys: 0.698 ± 0.019	4.699ArgAsp: 4.699 ± 0.049	5.671ArgGlu: 5.671 ± 0.057	2.35ArgPhe: 2.35 ± 0.035	6.761ArgGly: 6.761 ± 0.059	2.286ArgHis: 2.286 ± 0.031	3.059ArgIle: 3.059 ± 0.039	1.687ArgLys: 1.687 ± 0.035	9.464ArgLeu: 9.464 ± 0.079	1.787ArgMet: 1.787 ± 0.025	1.349ArgAsn: 1.349 ± 0.023	5.189ArgPro: 5.189 ± 0.05	2.506ArgGln: 2.506 ± 0.033	8.404ArgArg: 8.404 ± 0.077	4.169ArgSer: 4.169 ± 0.048	5.73ArgThr: 5.73 ± 0.054	6.383ArgVal: 6.383 ± 0.067	1.426ArgTrp: 1.426 ± 0.027	2.008ArgTyr: 2.008 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	6.966SerAla: 6.966 ± 0.058	0.423SerCys: 0.423 ± 0.014	2.507SerAsp: 2.507 ± 0.033	2.465SerGlu: 2.465 ± 0.036	1.45SerPhe: 1.45 ± 0.026	6.346SerGly: 6.346 ± 0.054	0.965SerHis: 0.965 ± 0.022	1.144SerIle: 1.144 ± 0.022	0.888SerLys: 0.888 ± 0.024	4.64SerLeu: 4.64 ± 0.051	0.958SerMet: 0.958 ± 0.023	0.779SerAsn: 0.779 ± 0.018	3.206SerPro: 3.206 ± 0.037	1.188SerGln: 1.188 ± 0.022	3.839SerArg: 3.839 ± 0.04	2.742SerSer: 2.742 ± 0.039	2.693SerThr: 2.693 ± 0.04	4.019SerVal: 4.019 ± 0.046	0.879SerTrp: 0.879 ± 0.019	1.158SerTyr: 1.158 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	8.762ThrAla: 8.762 ± 0.072	0.395ThrCys: 0.395 ± 0.015	3.292ThrAsp: 3.292 ± 0.043	3.206ThrGlu: 3.206 ± 0.043	1.454ThrPhe: 1.454 ± 0.027	6.851ThrGly: 6.851 ± 0.066	1.14ThrHis: 1.14 ± 0.024	1.337ThrIle: 1.337 ± 0.029	0.886ThrLys: 0.886 ± 0.021	5.626ThrLeu: 5.626 ± 0.053	0.87ThrMet: 0.87 ± 0.019	0.813ThrAsn: 0.813 ± 0.019	3.787ThrPro: 3.787 ± 0.045	1.192ThrGln: 1.192 ± 0.024	4.058ThrArg: 4.058 ± 0.04	2.857ThrSer: 2.857 ± 0.036	3.127ThrThr: 3.127 ± 0.043	5.834ThrVal: 5.834 ± 0.056	0.804ThrTrp: 0.804 ± 0.02	1.181ThrTyr: 1.181 ± 0.023	0.0ThrXaa: 0.0 ± 0.0
Val	10.345ValAla: 10.345 ± 0.079	0.813ValCys: 0.813 ± 0.02	4.754ValAsp: 4.754 ± 0.052	4.572ValGlu: 4.572 ± 0.054	2.349ValPhe: 2.349 ± 0.032	6.232ValGly: 6.232 ± 0.062	1.949ValHis: 1.949 ± 0.03	2.458ValIle: 2.458 ± 0.036	1.47ValLys: 1.47 ± 0.03	9.637ValLeu: 9.637 ± 0.074	1.286ValMet: 1.286 ± 0.024	1.533ValAsn: 1.533 ± 0.03	5.243ValPro: 5.243 ± 0.046	1.952ValGln: 1.952 ± 0.028	7.765ValArg: 7.765 ± 0.069	4.207ValSer: 4.207 ± 0.041	5.252ValThr: 5.252 ± 0.049	7.172ValVal: 7.172 ± 0.064	1.11ValTrp: 1.11 ± 0.023	1.452ValTyr: 1.452 ± 0.027	0.0ValXaa: 0.0 ± 0.0
Trp	1.655TrpAla: 1.655 ± 0.026	0.165TrpCys: 0.165 ± 0.008	0.823TrpAsp: 0.823 ± 0.021	0.814TrpGlu: 0.814 ± 0.018	0.479TrpPhe: 0.479 ± 0.014	1.089TrpGly: 1.089 ± 0.021	0.393TrpHis: 0.393 ± 0.011	0.497TrpIle: 0.497 ± 0.016	0.353TrpLys: 0.353 ± 0.015	1.806TrpLeu: 1.806 ± 0.028	0.271TrpMet: 0.271 ± 0.011	0.333TrpAsn: 0.333 ± 0.013	0.798TrpPro: 0.798 ± 0.018	0.577TrpGln: 0.577 ± 0.018	1.455TrpArg: 1.455 ± 0.028	0.927TrpSer: 0.927 ± 0.019	0.96TrpThr: 0.96 ± 0.02	0.932TrpVal: 0.932 ± 0.022	0.328TrpTrp: 0.328 ± 0.012	0.325TrpTyr: 0.325 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.944TyrAla: 2.944 ± 0.036	0.182TyrCys: 0.182 ± 0.008	1.387TyrAsp: 1.387 ± 0.028	1.253TyrGlu: 1.253 ± 0.024	0.579TyrPhe: 0.579 ± 0.017	2.296TyrGly: 2.296 ± 0.041	0.391TyrHis: 0.391 ± 0.013	0.425TyrIle: 0.425 ± 0.012	0.307TyrLys: 0.307 ± 0.012	2.025TyrLeu: 2.025 ± 0.03	0.217TyrMet: 0.217 ± 0.01	0.327TyrAsn: 0.327 ± 0.013	1.056TyrPro: 1.056 ± 0.023	0.546TyrGln: 0.546 ± 0.015	1.917TyrArg: 1.917 ± 0.03	0.845TyrSer: 0.845 ± 0.021	1.112TyrThr: 1.112 ± 0.023	1.53TyrVal: 1.53 ± 0.025	0.368TyrTrp: 0.368 ± 0.012	0.416TyrTyr: 0.416 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7299 proteins (2369374 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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