Amino acid dipepetide frequency for Serratia odorifera DSM 4582

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.079AlaAla: 12.079 ± 0.126
1.162AlaCys: 1.162 ± 0.03
5.487AlaAsp: 5.487 ± 0.056
6.109AlaGlu: 6.109 ± 0.075
3.67AlaPhe: 3.67 ± 0.055
8.271AlaGly: 8.271 ± 0.1
1.874AlaHis: 1.874 ± 0.042
5.983AlaIle: 5.983 ± 0.07
3.762AlaLys: 3.762 ± 0.058
13.107AlaLeu: 13.107 ± 0.114
3.113AlaMet: 3.113 ± 0.046
3.261AlaAsn: 3.261 ± 0.043
3.953AlaPro: 3.953 ± 0.057
5.196AlaGln: 5.196 ± 0.069
5.772AlaArg: 5.772 ± 0.069
5.598AlaSer: 5.598 ± 0.065
5.003AlaThr: 5.003 ± 0.058
7.174AlaVal: 7.174 ± 0.082
1.407AlaTrp: 1.407 ± 0.032
2.417AlaTyr: 2.417 ± 0.044
0.0AlaXaa: 0.0 ± 0.0
Cys
1.045CysAla: 1.045 ± 0.03
0.184CysCys: 0.184 ± 0.01
0.591CysAsp: 0.591 ± 0.021
0.523CysGlu: 0.523 ± 0.02
0.447CysPhe: 0.447 ± 0.018
1.078CysGly: 1.078 ± 0.03
0.338CysHis: 0.338 ± 0.018
0.537CysIle: 0.537 ± 0.021
0.313CysLys: 0.313 ± 0.016
1.055CysLeu: 1.055 ± 0.025
0.248CysMet: 0.248 ± 0.014
0.326CysAsn: 0.326 ± 0.015
0.478CysPro: 0.478 ± 0.023
0.516CysGln: 0.516 ± 0.02
0.681CysArg: 0.681 ± 0.025
0.681CysSer: 0.681 ± 0.021
0.456CysThr: 0.456 ± 0.019
0.716CysVal: 0.716 ± 0.022
0.19CysTrp: 0.19 ± 0.013
0.34CysTyr: 0.34 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
5.565AspAla: 5.565 ± 0.059
0.551AspCys: 0.551 ± 0.02
2.975AspAsp: 2.975 ± 0.048
3.033AspGlu: 3.033 ± 0.053
2.04AspPhe: 2.04 ± 0.043
4.244AspGly: 4.244 ± 0.058
1.025AspHis: 1.025 ± 0.024
3.192AspIle: 3.192 ± 0.045
2.198AspLys: 2.198 ± 0.04
4.712AspLeu: 4.712 ± 0.061
1.312AspMet: 1.312 ± 0.031
2.064AspAsn: 2.064 ± 0.044
2.196AspPro: 2.196 ± 0.039
1.798AspGln: 1.798 ± 0.035
3.163AspArg: 3.163 ± 0.052
2.886AspSer: 2.886 ± 0.048
2.328AspThr: 2.328 ± 0.038
3.564AspVal: 3.564 ± 0.046
0.915AspTrp: 0.915 ± 0.023
1.844AspTyr: 1.844 ± 0.034
0.0AspXaa: 0.0 ± 0.0
Glu
4.862GluAla: 4.862 ± 0.072
0.405GluCys: 0.405 ± 0.017
2.15GluAsp: 2.15 ± 0.045
2.599GluGlu: 2.599 ± 0.05
1.756GluPhe: 1.756 ± 0.035
3.08GluGly: 3.08 ± 0.048
1.321GluHis: 1.321 ± 0.031
2.909GluIle: 2.909 ± 0.044
2.549GluLys: 2.549 ± 0.049
5.648GluLeu: 5.648 ± 0.075
1.599GluMet: 1.599 ± 0.034
1.981GluAsn: 1.981 ± 0.038
2.057GluPro: 2.057 ± 0.046
3.741GluGln: 3.741 ± 0.05
3.788GluArg: 3.788 ± 0.059
2.585GluSer: 2.585 ± 0.046
2.592GluThr: 2.592 ± 0.046
3.535GluVal: 3.535 ± 0.049
0.721GluTrp: 0.721 ± 0.023
1.36GluTyr: 1.36 ± 0.036
0.0GluXaa: 0.0 ± 0.0
Phe
3.755PheAla: 3.755 ± 0.056
0.56PheCys: 0.56 ± 0.021
2.395PheAsp: 2.395 ± 0.042
1.678PheGlu: 1.678 ± 0.035
1.583PhePhe: 1.583 ± 0.036
3.272PheGly: 3.272 ± 0.057
0.81PheHis: 0.81 ± 0.023
2.411PheIle: 2.411 ± 0.043
1.232PheLys: 1.232 ± 0.027
3.229PheLeu: 3.229 ± 0.047
0.962PheMet: 0.962 ± 0.023
1.701PheAsn: 1.701 ± 0.033
1.497PhePro: 1.497 ± 0.031
1.112PheGln: 1.112 ± 0.025
1.82PheArg: 1.82 ± 0.041
3.039PheSer: 3.039 ± 0.044
2.178PheThr: 2.178 ± 0.041
2.487PheVal: 2.487 ± 0.046
0.582PheTrp: 0.582 ± 0.019
1.27PheTyr: 1.27 ± 0.026
0.0PheXaa: 0.0 ± 0.0
Gly
6.766GlyAla: 6.766 ± 0.08
1.005GlyCys: 1.005 ± 0.029
3.81GlyAsp: 3.81 ± 0.05
4.541GlyGlu: 4.541 ± 0.052
3.198GlyPhe: 3.198 ± 0.052
5.819GlyGly: 5.819 ± 0.087
1.661GlyHis: 1.661 ± 0.04
4.898GlyIle: 4.898 ± 0.06
3.947GlyLys: 3.947 ± 0.062
7.798GlyLeu: 7.798 ± 0.093
2.457GlyMet: 2.457 ± 0.041
2.787GlyAsn: 2.787 ± 0.055
2.101GlyPro: 2.101 ± 0.037
3.344GlyGln: 3.344 ± 0.052
4.026GlyArg: 4.026 ± 0.05
4.531GlySer: 4.531 ± 0.067
3.601GlyThr: 3.601 ± 0.059
5.989GlyVal: 5.989 ± 0.067
1.395GlyTrp: 1.395 ± 0.032
2.729GlyTyr: 2.729 ± 0.045
0.0GlyXaa: 0.0 ± 0.0
His
2.137HisAla: 2.137 ± 0.038
0.336HisCys: 0.336 ± 0.014
1.152HisAsp: 1.152 ± 0.03
0.915HisGlu: 0.915 ± 0.022
1.017HisPhe: 1.017 ± 0.032
1.945HisGly: 1.945 ± 0.043
0.766HisHis: 0.766 ± 0.027
1.245HisIle: 1.245 ± 0.03
0.663HisLys: 0.663 ± 0.023
2.23HisLeu: 2.23 ± 0.04
0.539HisMet: 0.539 ± 0.019
0.808HisAsn: 0.808 ± 0.023
1.284HisPro: 1.284 ± 0.03
1.389HisGln: 1.389 ± 0.035
1.349HisArg: 1.349 ± 0.029
1.294HisSer: 1.294 ± 0.03
1.011HisThr: 1.011 ± 0.027
1.153HisVal: 1.153 ± 0.027
0.455HisTrp: 0.455 ± 0.019
0.916HisTyr: 0.916 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
6.625IleAla: 6.625 ± 0.072
0.627IleCys: 0.627 ± 0.022
3.629IleAsp: 3.629 ± 0.051
3.119IleGlu: 3.119 ± 0.046
1.914IlePhe: 1.914 ± 0.036
4.941IleGly: 4.941 ± 0.064
1.084IleHis: 1.084 ± 0.025
3.028IleIle: 3.028 ± 0.054
2.179IleLys: 2.179 ± 0.042
4.555IleLeu: 4.555 ± 0.064
1.22IleMet: 1.22 ± 0.032
2.437IleAsn: 2.437 ± 0.043
2.529IlePro: 2.529 ± 0.044
1.796IleGln: 1.796 ± 0.035
2.852IleArg: 2.852 ± 0.046
3.482IleSer: 3.482 ± 0.053
3.295IleThr: 3.295 ± 0.048
3.776IleVal: 3.776 ± 0.047
0.603IleTrp: 0.603 ± 0.021
1.51IleTyr: 1.51 ± 0.033
0.0IleXaa: 0.0 ± 0.0
Lys
3.725LysAla: 3.725 ± 0.051
0.231LysCys: 0.231 ± 0.01
1.84LysAsp: 1.84 ± 0.041
1.901LysGlu: 1.901 ± 0.038
1.033LysPhe: 1.033 ± 0.03
2.609LysGly: 2.609 ± 0.042
0.792LysHis: 0.792 ± 0.024
2.091LysIle: 2.091 ± 0.046
1.878LysLys: 1.878 ± 0.04
4.0LysLeu: 4.0 ± 0.056
1.16LysMet: 1.16 ± 0.025
1.552LysAsn: 1.552 ± 0.033
2.079LysPro: 2.079 ± 0.043
2.094LysGln: 2.094 ± 0.042
2.471LysArg: 2.471 ± 0.037
2.103LysSer: 2.103 ± 0.042
2.346LysThr: 2.346 ± 0.041
2.753LysVal: 2.753 ± 0.042
0.413LysTrp: 0.413 ± 0.018
0.981LysTyr: 0.981 ± 0.027
0.0LysXaa: 0.0 ± 0.0
Leu
13.108LeuAla: 13.108 ± 0.105
1.262LeuCys: 1.262 ± 0.03
5.601LeuAsp: 5.601 ± 0.071
5.154LeuGlu: 5.154 ± 0.071
4.318LeuPhe: 4.318 ± 0.07
7.86LeuGly: 7.86 ± 0.086
2.402LeuHis: 2.402 ± 0.04
5.686LeuIle: 5.686 ± 0.069
4.125LeuLys: 4.125 ± 0.059
13.171LeuLeu: 13.171 ± 0.145
3.04LeuMet: 3.04 ± 0.047
3.989LeuAsn: 3.989 ± 0.069
6.046LeuPro: 6.046 ± 0.066
4.997LeuGln: 4.997 ± 0.069
6.454LeuArg: 6.454 ± 0.077
7.386LeuSer: 7.386 ± 0.078
6.327LeuThr: 6.327 ± 0.072
7.236LeuVal: 7.236 ± 0.084
1.423LeuTrp: 1.423 ± 0.032
2.633LeuTyr: 2.633 ± 0.039
0.0LeuXaa: 0.0 ± 0.0
Met
3.111MetAla: 3.111 ± 0.049
0.2MetCys: 0.2 ± 0.012
1.071MetAsp: 1.071 ± 0.024
1.111MetGlu: 1.111 ± 0.027
0.904MetPhe: 0.904 ± 0.026
1.806MetGly: 1.806 ± 0.039
0.508MetHis: 0.508 ± 0.02
1.449MetIle: 1.449 ± 0.034
1.262MetLys: 1.262 ± 0.031
3.299MetLeu: 3.299 ± 0.045
0.919MetMet: 0.919 ± 0.025
1.002MetAsn: 1.002 ± 0.027
1.437MetPro: 1.437 ± 0.03
1.294MetGln: 1.294 ± 0.029
1.529MetArg: 1.529 ± 0.028
1.787MetSer: 1.787 ± 0.035
1.674MetThr: 1.674 ± 0.033
1.917MetVal: 1.917 ± 0.041
0.246MetTrp: 0.246 ± 0.013
0.522MetTyr: 0.522 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
3.653AsnAla: 3.653 ± 0.06
0.322AsnCys: 0.322 ± 0.014
1.931AsnAsp: 1.931 ± 0.036
1.609AsnGlu: 1.609 ± 0.036
1.245AsnPhe: 1.245 ± 0.031
3.093AsnGly: 3.093 ± 0.059
0.808AsnHis: 0.808 ± 0.026
2.083AsnIle: 2.083 ± 0.042
1.36AsnLys: 1.36 ± 0.029
3.46AsnLeu: 3.46 ± 0.051
0.849AsnMet: 0.849 ± 0.028
1.449AsnAsn: 1.449 ± 0.035
2.051AsnPro: 2.051 ± 0.037
1.694AsnGln: 1.694 ± 0.042
2.073AsnArg: 2.073 ± 0.04
1.939AsnSer: 1.939 ± 0.052
1.758AsnThr: 1.758 ± 0.035
2.391AsnVal: 2.391 ± 0.046
0.539AsnTrp: 0.539 ± 0.017
1.12AsnTyr: 1.12 ± 0.029
0.0AsnXaa: 0.0 ± 0.0
Pro
5.075ProAla: 5.075 ± 0.074
0.402ProCys: 0.402 ± 0.016
2.563ProAsp: 2.563 ± 0.043
2.901ProGlu: 2.901 ± 0.048
1.814ProPhe: 1.814 ± 0.038
3.372ProGly: 3.372 ± 0.047
1.087ProHis: 1.087 ± 0.032
2.088ProIle: 2.088 ± 0.039
1.398ProLys: 1.398 ± 0.031
5.591ProLeu: 5.591 ± 0.082
1.137ProMet: 1.137 ± 0.024
1.371ProAsn: 1.371 ± 0.032
1.9ProPro: 1.9 ± 0.04
2.771ProGln: 2.771 ± 0.047
2.099ProArg: 2.099 ± 0.043
2.382ProSer: 2.382 ± 0.04
2.297ProThr: 2.297 ± 0.039
3.516ProVal: 3.516 ± 0.055
0.708ProTrp: 0.708 ± 0.02
1.332ProTyr: 1.332 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
5.619GlnAla: 5.619 ± 0.069
0.443GlnCys: 0.443 ± 0.018
2.099GlnAsp: 2.099 ± 0.039
2.101GlnGlu: 2.101 ± 0.038
1.533GlnPhe: 1.533 ± 0.034
3.642GlnGly: 3.642 ± 0.06
1.48GlnHis: 1.48 ± 0.034
2.378GlnIle: 2.378 ± 0.044
1.617GlnLys: 1.617 ± 0.034
5.983GlnLeu: 5.983 ± 0.065
1.263GlnMet: 1.263 ± 0.031
1.349GlnAsn: 1.349 ± 0.032
2.728GlnPro: 2.728 ± 0.055
4.65GlnGln: 4.65 ± 0.086
4.21GlnArg: 4.21 ± 0.066
2.307GlnSer: 2.307 ± 0.043
2.184GlnThr: 2.184 ± 0.042
3.342GlnVal: 3.342 ± 0.046
0.792GlnTrp: 0.792 ± 0.023
1.196GlnTyr: 1.196 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
5.034ArgAla: 5.034 ± 0.063
0.679ArgCys: 0.679 ± 0.024
3.064ArgAsp: 3.064 ± 0.053
3.399ArgGlu: 3.399 ± 0.056
2.623ArgPhe: 2.623 ± 0.046
3.601ArgGly: 3.601 ± 0.052
1.688ArgHis: 1.688 ± 0.035
3.406ArgIle: 3.406 ± 0.049
2.14ArgLys: 2.14 ± 0.039
7.143ArgLeu: 7.143 ± 0.094
1.591ArgMet: 1.591 ± 0.031
1.988ArgAsn: 1.988 ± 0.036
2.386ArgPro: 2.386 ± 0.036
3.876ArgGln: 3.876 ± 0.062
3.918ArgArg: 3.918 ± 0.058
3.067ArgSer: 3.067 ± 0.05
2.354ArgThr: 2.354 ± 0.04
4.007ArgVal: 4.007 ± 0.052
1.078ArgTrp: 1.078 ± 0.032
2.254ArgTyr: 2.254 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
6.041SerAla: 6.041 ± 0.065
0.613SerCys: 0.613 ± 0.024
2.976SerAsp: 2.976 ± 0.042
2.995SerGlu: 2.995 ± 0.046
2.249SerPhe: 2.249 ± 0.039
5.391SerGly: 5.391 ± 0.074
1.399SerHis: 1.399 ± 0.032
2.956SerIle: 2.956 ± 0.05
1.993SerLys: 1.993 ± 0.037
6.646SerLeu: 6.646 ± 0.084
1.446SerMet: 1.446 ± 0.028
1.863SerAsn: 1.863 ± 0.042
2.646SerPro: 2.646 ± 0.041
2.76SerGln: 2.76 ± 0.052
3.328SerArg: 3.328 ± 0.053
3.455SerSer: 3.455 ± 0.058
2.758SerThr: 2.758 ± 0.043
4.152SerVal: 4.152 ± 0.046
0.899SerTrp: 0.899 ± 0.024
1.65SerTyr: 1.65 ± 0.034
0.0SerXaa: 0.0 ± 0.0
Thr
5.129ThrAla: 5.129 ± 0.059
0.441ThrCys: 0.441 ± 0.018
2.439ThrAsp: 2.439 ± 0.041
2.289ThrGlu: 2.289 ± 0.037
1.852ThrPhe: 1.852 ± 0.035
4.13ThrGly: 4.13 ± 0.065
1.115ThrHis: 1.115 ± 0.03
2.568ThrIle: 2.568 ± 0.045
1.329ThrLys: 1.329 ± 0.032
7.563ThrLeu: 7.563 ± 0.083
1.096ThrMet: 1.096 ± 0.028
1.429ThrAsn: 1.429 ± 0.035
3.283ThrPro: 3.283 ± 0.047
2.139ThrGln: 2.139 ± 0.044
2.941ThrArg: 2.941 ± 0.046
2.66ThrSer: 2.66 ± 0.041
2.674ThrThr: 2.674 ± 0.047
3.829ThrVal: 3.829 ± 0.053
0.634ThrTrp: 0.634 ± 0.023
1.19ThrTyr: 1.19 ± 0.029
0.0ThrXaa: 0.0 ± 0.0
Val
7.415ValAla: 7.415 ± 0.079
0.75ValCys: 0.75 ± 0.025
3.72ValAsp: 3.72 ± 0.06
3.749ValGlu: 3.749 ± 0.052
2.575ValPhe: 2.575 ± 0.043
5.022ValGly: 5.022 ± 0.069
1.22ValHis: 1.22 ± 0.03
4.302ValIle: 4.302 ± 0.06
2.883ValLys: 2.883 ± 0.05
7.244ValLeu: 7.244 ± 0.076
2.127ValMet: 2.127 ± 0.042
2.689ValAsn: 2.689 ± 0.05
2.997ValPro: 2.997 ± 0.038
2.522ValGln: 2.522 ± 0.042
3.613ValArg: 3.613 ± 0.05
4.572ValSer: 4.572 ± 0.056
4.06ValThr: 4.06 ± 0.058
5.416ValVal: 5.416 ± 0.062
0.914ValTrp: 0.914 ± 0.024
1.764ValTyr: 1.764 ± 0.036
0.0ValXaa: 0.0 ± 0.0
Trp
1.056TrpAla: 1.056 ± 0.029
0.174TrpCys: 0.174 ± 0.011
0.601TrpAsp: 0.601 ± 0.023
0.52TrpGlu: 0.52 ± 0.019
0.628TrpPhe: 0.628 ± 0.025
0.939TrpGly: 0.939 ± 0.026
0.451TrpHis: 0.451 ± 0.02
0.662TrpIle: 0.662 ± 0.021
0.408TrpLys: 0.408 ± 0.018
2.395TrpLeu: 2.395 ± 0.045
0.403TrpMet: 0.403 ± 0.016
0.455TrpAsn: 0.455 ± 0.019
0.677TrpPro: 0.677 ± 0.023
1.298TrpGln: 1.298 ± 0.03
1.127TrpArg: 1.127 ± 0.03
0.758TrpSer: 0.758 ± 0.021
0.505TrpThr: 0.505 ± 0.017
0.918TrpVal: 0.918 ± 0.025
0.249TrpTrp: 0.249 ± 0.011
0.381TrpTyr: 0.381 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.596TyrAla: 2.596 ± 0.04
0.396TyrCys: 0.396 ± 0.017
1.511TyrAsp: 1.511 ± 0.032
0.996TyrGlu: 0.996 ± 0.026
1.176TyrPhe: 1.176 ± 0.027
2.286TyrGly: 2.286 ± 0.042
0.775TyrHis: 0.775 ± 0.026
1.33TyrIle: 1.33 ± 0.032
0.818TyrLys: 0.818 ± 0.029
3.393TyrLeu: 3.393 ± 0.042
0.565TyrMet: 0.565 ± 0.02
0.927TyrAsn: 0.927 ± 0.029
1.48TyrPro: 1.48 ± 0.029
1.926TyrGln: 1.926 ± 0.038
2.082TyrArg: 2.082 ± 0.037
1.702TyrSer: 1.702 ± 0.034
1.331TyrThr: 1.331 ± 0.03
1.684TyrVal: 1.684 ± 0.039
0.439TyrTrp: 0.439 ± 0.019
0.96TyrTyr: 0.96 ± 0.028
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5121 proteins (1498009 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski