Amino acid dipepetide frequency for Chryseobacterium sp. (strain P1-3)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.61AlaAla: 4.61 ± 0.1	0.547AlaCys: 0.547 ± 0.029	3.497AlaAsp: 3.497 ± 0.065	4.371AlaGlu: 4.371 ± 0.073	3.237AlaPhe: 3.237 ± 0.062	4.774AlaGly: 4.774 ± 0.079	1.087AlaHis: 1.087 ± 0.031	4.697AlaIle: 4.697 ± 0.081	4.526AlaLys: 4.526 ± 0.082	6.02AlaLeu: 6.02 ± 0.095	1.512AlaMet: 1.512 ± 0.043	3.161AlaAsn: 3.161 ± 0.061	1.973AlaPro: 1.973 ± 0.051	2.669AlaGln: 2.669 ± 0.059	2.108AlaArg: 2.108 ± 0.05	3.945AlaSer: 3.945 ± 0.07	3.336AlaThr: 3.336 ± 0.076	4.432AlaVal: 4.432 ± 0.075	0.601AlaTrp: 0.601 ± 0.029	2.472AlaTyr: 2.472 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.43CysAla: 0.43 ± 0.022	0.112CysCys: 0.112 ± 0.012	0.361CysAsp: 0.361 ± 0.019	0.422CysGlu: 0.422 ± 0.023	0.408CysPhe: 0.408 ± 0.021	0.625CysGly: 0.625 ± 0.03	0.188CysHis: 0.188 ± 0.014	0.696CysIle: 0.696 ± 0.027	0.497CysLys: 0.497 ± 0.022	0.679CysLeu: 0.679 ± 0.028	0.2CysMet: 0.2 ± 0.016	0.398CysAsn: 0.398 ± 0.022	0.325CysPro: 0.325 ± 0.021	0.218CysGln: 0.218 ± 0.016	0.245CysArg: 0.245 ± 0.019	0.594CysSer: 0.594 ± 0.029	0.394CysThr: 0.394 ± 0.022	0.436CysVal: 0.436 ± 0.026	0.052CysTrp: 0.052 ± 0.008	0.312CysTyr: 0.312 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.262AspAla: 3.262 ± 0.058	0.34AspCys: 0.34 ± 0.019	2.545AspAsp: 2.545 ± 0.055	3.788AspGlu: 3.788 ± 0.068	3.65AspPhe: 3.65 ± 0.065	3.425AspGly: 3.425 ± 0.076	1.075AspHis: 1.075 ± 0.036	4.295AspIle: 4.295 ± 0.073	4.164AspLys: 4.164 ± 0.076	4.9AspLeu: 4.9 ± 0.079	1.148AspMet: 1.148 ± 0.033	2.829AspAsn: 2.829 ± 0.057	1.951AspPro: 1.951 ± 0.048	1.793AspGln: 1.793 ± 0.049	1.92AspArg: 1.92 ± 0.046	2.883AspSer: 2.883 ± 0.064	2.483AspThr: 2.483 ± 0.053	3.064AspVal: 3.064 ± 0.057	0.751AspTrp: 0.751 ± 0.03	2.75AspTyr: 2.75 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	4.087GluAla: 4.087 ± 0.078	0.351GluCys: 0.351 ± 0.018	3.228GluAsp: 3.228 ± 0.059	4.9GluGlu: 4.9 ± 0.098	2.965GluPhe: 2.965 ± 0.069	3.556GluGly: 3.556 ± 0.067	1.119GluHis: 1.119 ± 0.038	5.71GluIle: 5.71 ± 0.087	6.815GluLys: 6.815 ± 0.103	5.813GluLeu: 5.813 ± 0.093	1.694GluMet: 1.694 ± 0.045	4.972GluAsn: 4.972 ± 0.084	1.478GluPro: 1.478 ± 0.049	2.345GluGln: 2.345 ± 0.058	2.441GluArg: 2.441 ± 0.058	3.183GluSer: 3.183 ± 0.07	3.483GluThr: 3.483 ± 0.061	4.056GluVal: 4.056 ± 0.07	0.679GluTrp: 0.679 ± 0.03	2.621GluTyr: 2.621 ± 0.061	0.0GluXaa: 0.0 ± 0.0
Phe	3.115PheAla: 3.115 ± 0.067	0.465PheCys: 0.465 ± 0.021	2.966PheAsp: 2.966 ± 0.059	3.105PheGlu: 3.105 ± 0.067	2.746PhePhe: 2.746 ± 0.074	3.569PheGly: 3.569 ± 0.071	0.982PheHis: 0.982 ± 0.04	4.043PheIle: 4.043 ± 0.077	3.455PheLys: 3.455 ± 0.064	4.833PheLeu: 4.833 ± 0.08	1.199PheMet: 1.199 ± 0.037	3.141PheAsn: 3.141 ± 0.063	1.921PhePro: 1.921 ± 0.047	1.648PheGln: 1.648 ± 0.049	1.933PheArg: 1.933 ± 0.04	4.146PheSer: 4.146 ± 0.069	3.173PheThr: 3.173 ± 0.058	2.963PheVal: 2.963 ± 0.063	0.608PheTrp: 0.608 ± 0.026	2.305PheTyr: 2.305 ± 0.053	0.0PheXaa: 0.0 ± 0.0
Gly	4.2GlyAla: 4.2 ± 0.079	0.561GlyCys: 0.561 ± 0.022	3.039GlyAsp: 3.039 ± 0.06	3.56GlyGlu: 3.56 ± 0.069	3.661GlyPhe: 3.661 ± 0.07	4.68GlyGly: 4.68 ± 0.092	1.103GlyHis: 1.103 ± 0.037	5.583GlyIle: 5.583 ± 0.086	5.741GlyLys: 5.741 ± 0.091	5.455GlyLeu: 5.455 ± 0.088	1.748GlyMet: 1.748 ± 0.047	4.253GlyAsn: 4.253 ± 0.097	1.278GlyPro: 1.278 ± 0.038	2.039GlyGln: 2.039 ± 0.053	2.251GlyArg: 2.251 ± 0.05	4.155GlySer: 4.155 ± 0.083	4.248GlyThr: 4.248 ± 0.081	4.18GlyVal: 4.18 ± 0.072	0.824GlyTrp: 0.824 ± 0.032	3.116GlyTyr: 3.116 ± 0.063	0.0GlyXaa: 0.0 ± 0.0
His	0.952HisAla: 0.952 ± 0.039	0.199HisCys: 0.199 ± 0.015	0.887HisAsp: 0.887 ± 0.031	1.101HisGlu: 1.101 ± 0.037	1.201HisPhe: 1.201 ± 0.042	1.067HisGly: 1.067 ± 0.039	0.569HisHis: 0.569 ± 0.028	1.456HisIle: 1.456 ± 0.048	1.142HisLys: 1.142 ± 0.032	1.809HisLeu: 1.809 ± 0.047	0.371HisMet: 0.371 ± 0.02	0.91HisAsn: 0.91 ± 0.032	0.891HisPro: 0.891 ± 0.036	0.798HisGln: 0.798 ± 0.034	0.633HisArg: 0.633 ± 0.025	1.188HisSer: 1.188 ± 0.041	0.948HisThr: 0.948 ± 0.031	0.774HisVal: 0.774 ± 0.029	0.239HisTrp: 0.239 ± 0.015	0.897HisTyr: 0.897 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	5.234IleAla: 5.234 ± 0.077	0.67IleCys: 0.67 ± 0.028	4.319IleAsp: 4.319 ± 0.067	4.968IleGlu: 4.968 ± 0.083	3.839IlePhe: 3.839 ± 0.076	4.937IleGly: 4.937 ± 0.09	1.445IleHis: 1.445 ± 0.044	6.295IleIle: 6.295 ± 0.114	5.695IleLys: 5.695 ± 0.086	7.38IleLeu: 7.38 ± 0.104	1.536IleMet: 1.536 ± 0.044	4.686IleAsn: 4.686 ± 0.081	3.495IlePro: 3.495 ± 0.073	2.841IleGln: 2.841 ± 0.068	2.783IleArg: 2.783 ± 0.052	5.946IleSer: 5.946 ± 0.083	4.605IleThr: 4.605 ± 0.072	4.362IleVal: 4.362 ± 0.073	0.68IleTrp: 0.68 ± 0.029	3.044IleTyr: 3.044 ± 0.06	0.0IleXaa: 0.0 ± 0.0
Lys	5.055LysAla: 5.055 ± 0.083	0.37LysCys: 0.37 ± 0.019	4.723LysAsp: 4.723 ± 0.07	6.54LysGlu: 6.54 ± 0.107	3.073LysPhe: 3.073 ± 0.063	4.723LysGly: 4.723 ± 0.075	1.266LysHis: 1.266 ± 0.039	6.873LysIle: 6.873 ± 0.11	7.194LysLys: 7.194 ± 0.112	6.276LysLeu: 6.276 ± 0.085	2.419LysMet: 2.419 ± 0.058	5.869LysAsn: 5.869 ± 0.076	2.526LysPro: 2.526 ± 0.061	2.591LysGln: 2.591 ± 0.06	2.642LysArg: 2.642 ± 0.056	4.491LysSer: 4.491 ± 0.07	4.766LysThr: 4.766 ± 0.07	4.772LysVal: 4.772 ± 0.079	0.747LysTrp: 0.747 ± 0.031	3.103LysTyr: 3.103 ± 0.061	0.0LysXaa: 0.0 ± 0.0
Leu	5.713LeuAla: 5.713 ± 0.09	0.698LeuCys: 0.698 ± 0.03	4.74LeuAsp: 4.74 ± 0.077	5.626LeuGlu: 5.626 ± 0.087	4.732LeuPhe: 4.732 ± 0.098	5.949LeuGly: 5.949 ± 0.084	1.637LeuHis: 1.637 ± 0.052	6.719LeuIle: 6.719 ± 0.091	7.646LeuLys: 7.646 ± 0.091	8.383LeuLeu: 8.383 ± 0.127	2.289LeuMet: 2.289 ± 0.052	5.267LeuAsn: 5.267 ± 0.069	3.778LeuPro: 3.778 ± 0.074	3.343LeuGln: 3.343 ± 0.065	2.959LeuArg: 2.959 ± 0.058	6.75LeuSer: 6.75 ± 0.089	4.935LeuThr: 4.935 ± 0.089	4.777LeuVal: 4.777 ± 0.083	0.835LeuTrp: 0.835 ± 0.033	3.413LeuTyr: 3.413 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	1.611MetAla: 1.611 ± 0.042	0.153MetCys: 0.153 ± 0.013	1.288MetAsp: 1.288 ± 0.044	1.623MetGlu: 1.623 ± 0.052	0.931MetPhe: 0.931 ± 0.034	1.51MetGly: 1.51 ± 0.044	0.365MetHis: 0.365 ± 0.022	1.887MetIle: 1.887 ± 0.048	2.725MetLys: 2.725 ± 0.052	2.115MetLeu: 2.115 ± 0.054	0.749MetMet: 0.749 ± 0.031	1.524MetAsn: 1.524 ± 0.035	0.892MetPro: 0.892 ± 0.035	0.811MetGln: 0.811 ± 0.03	0.867MetArg: 0.867 ± 0.03	1.408MetSer: 1.408 ± 0.041	1.202MetThr: 1.202 ± 0.037	1.398MetVal: 1.398 ± 0.041	0.175MetTrp: 0.175 ± 0.015	0.753MetTyr: 0.753 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	3.826AsnAla: 3.826 ± 0.074	0.431AsnCys: 0.431 ± 0.023	3.011AsnAsp: 3.011 ± 0.056	3.526AsnGlu: 3.526 ± 0.071	3.263AsnPhe: 3.263 ± 0.062	4.31AsnGly: 4.31 ± 0.099	1.107AsnHis: 1.107 ± 0.033	5.135AsnIle: 5.135 ± 0.094	4.342AsnLys: 4.342 ± 0.083	5.261AsnLeu: 5.261 ± 0.084	1.319AsnMet: 1.319 ± 0.042	3.943AsnAsn: 3.943 ± 0.091	2.934AsnPro: 2.934 ± 0.062	2.154AsnGln: 2.154 ± 0.056	2.175AsnArg: 2.175 ± 0.054	3.788AsnSer: 3.788 ± 0.079	3.591AsnThr: 3.591 ± 0.068	3.355AsnVal: 3.355 ± 0.069	0.734AsnTrp: 0.734 ± 0.032	2.872AsnTyr: 2.872 ± 0.057	0.0AsnXaa: 0.0 ± 0.0
Pro	2.579ProAla: 2.579 ± 0.06	0.234ProCys: 0.234 ± 0.017	2.354ProAsp: 2.354 ± 0.055	3.223ProGlu: 3.223 ± 0.064	1.901ProPhe: 1.901 ± 0.044	2.317ProGly: 2.317 ± 0.056	0.617ProHis: 0.617 ± 0.026	2.076ProIle: 2.076 ± 0.047	2.507ProLys: 2.507 ± 0.054	2.945ProLeu: 2.945 ± 0.054	0.769ProMet: 0.769 ± 0.031	1.935ProAsn: 1.935 ± 0.057	0.847ProPro: 0.847 ± 0.039	1.358ProGln: 1.358 ± 0.041	0.914ProArg: 0.914 ± 0.03	2.199ProSer: 2.199 ± 0.053	1.888ProThr: 1.888 ± 0.053	3.1ProVal: 3.1 ± 0.07	0.303ProTrp: 0.303 ± 0.021	1.453ProTyr: 1.453 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	2.059GlnAla: 2.059 ± 0.054	0.192GlnCys: 0.192 ± 0.015	1.753GlnAsp: 1.753 ± 0.04	2.332GlnGlu: 2.332 ± 0.052	1.737GlnPhe: 1.737 ± 0.043	1.874GlnGly: 1.874 ± 0.049	0.662GlnHis: 0.662 ± 0.027	2.645GlnIle: 2.645 ± 0.059	3.478GlnLys: 3.478 ± 0.067	3.396GlnLeu: 3.396 ± 0.069	0.931GlnMet: 0.931 ± 0.033	2.528GlnAsn: 2.528 ± 0.056	1.151GlnPro: 1.151 ± 0.035	1.636GlnGln: 1.636 ± 0.049	1.325GlnArg: 1.325 ± 0.04	2.151GlnSer: 2.151 ± 0.043	1.998GlnThr: 1.998 ± 0.055	1.965GlnVal: 1.965 ± 0.049	0.415GlnTrp: 0.415 ± 0.025	1.718GlnTyr: 1.718 ± 0.049	0.0GlnXaa: 0.0 ± 0.0
Arg	1.909ArgAla: 1.909 ± 0.048	0.201ArgCys: 0.201 ± 0.015	1.632ArgAsp: 1.632 ± 0.047	2.371ArgGlu: 2.371 ± 0.053	1.982ArgPhe: 1.982 ± 0.042	1.765ArgGly: 1.765 ± 0.045	0.602ArgHis: 0.602 ± 0.03	3.01ArgIle: 3.01 ± 0.055	3.228ArgLys: 3.228 ± 0.063	3.298ArgLeu: 3.298 ± 0.063	0.974ArgMet: 0.974 ± 0.034	2.455ArgAsn: 2.455 ± 0.054	1.115ArgPro: 1.115 ± 0.038	1.228ArgGln: 1.228 ± 0.04	1.284ArgArg: 1.284 ± 0.039	1.973ArgSer: 1.973 ± 0.049	1.789ArgThr: 1.789 ± 0.045	1.937ArgVal: 1.937 ± 0.045	0.357ArgTrp: 0.357 ± 0.021	1.524ArgTyr: 1.524 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	3.988SerAla: 3.988 ± 0.077	0.639SerCys: 0.639 ± 0.027	3.404SerAsp: 3.404 ± 0.063	3.927SerGlu: 3.927 ± 0.079	3.669SerPhe: 3.669 ± 0.066	5.044SerGly: 5.044 ± 0.092	1.207SerHis: 1.207 ± 0.036	4.97SerIle: 4.97 ± 0.078	4.613SerLys: 4.613 ± 0.078	6.029SerLeu: 6.029 ± 0.088	1.454SerMet: 1.454 ± 0.038	3.43SerAsn: 3.43 ± 0.073	2.221SerPro: 2.221 ± 0.044	2.411SerGln: 2.411 ± 0.046	2.314SerArg: 2.314 ± 0.055	4.242SerSer: 4.242 ± 0.091	3.368SerThr: 3.368 ± 0.071	4.247SerVal: 4.247 ± 0.077	0.754SerTrp: 0.754 ± 0.03	2.847SerTyr: 2.847 ± 0.061	0.0SerXaa: 0.0 ± 0.0
Thr	4.066ThrAla: 4.066 ± 0.076	0.366ThrCys: 0.366 ± 0.02	3.261ThrAsp: 3.261 ± 0.062	3.502ThrGlu: 3.502 ± 0.058	2.871ThrPhe: 2.871 ± 0.054	4.413ThrGly: 4.413 ± 0.091	0.985ThrHis: 0.985 ± 0.032	4.211ThrIle: 4.211 ± 0.075	3.566ThrLys: 3.566 ± 0.06	5.127ThrLeu: 5.127 ± 0.078	1.057ThrMet: 1.057 ± 0.034	2.871ThrAsn: 2.871 ± 0.077	2.491ThrPro: 2.491 ± 0.061	1.914ThrGln: 1.914 ± 0.046	1.76ThrArg: 1.76 ± 0.042	3.674ThrSer: 3.674 ± 0.078	3.379ThrThr: 3.379 ± 0.095	3.668ThrVal: 3.668 ± 0.072	0.558ThrTrp: 0.558 ± 0.027	2.408ThrTyr: 2.408 ± 0.063	0.0ThrXaa: 0.0 ± 0.0
Val	3.852ValAla: 3.852 ± 0.072	0.561ValCys: 0.561 ± 0.027	3.051ValAsp: 3.051 ± 0.066	3.587ValGlu: 3.587 ± 0.068	3.311ValPhe: 3.311 ± 0.056	3.687ValGly: 3.687 ± 0.076	0.958ValHis: 0.958 ± 0.033	4.599ValIle: 4.599 ± 0.068	4.687ValLys: 4.687 ± 0.074	5.48ValLeu: 5.48 ± 0.091	1.487ValMet: 1.487 ± 0.047	3.514ValAsn: 3.514 ± 0.078	2.324ValPro: 2.324 ± 0.059	1.919ValGln: 1.919 ± 0.048	2.006ValArg: 2.006 ± 0.054	4.451ValSer: 4.451 ± 0.07	3.448ValThr: 3.448 ± 0.069	3.635ValVal: 3.635 ± 0.075	0.655ValTrp: 0.655 ± 0.03	2.608ValTyr: 2.608 ± 0.055	0.0ValXaa: 0.0 ± 0.0
Trp	0.637TrpAla: 0.637 ± 0.031	0.1TrpCys: 0.1 ± 0.01	0.57TrpAsp: 0.57 ± 0.023	0.684TrpGlu: 0.684 ± 0.026	0.556TrpPhe: 0.556 ± 0.025	0.74TrpGly: 0.74 ± 0.03	0.206TrpHis: 0.206 ± 0.015	0.775TrpIle: 0.775 ± 0.032	0.952TrpLys: 0.952 ± 0.034	0.924TrpLeu: 0.924 ± 0.036	0.344TrpMet: 0.344 ± 0.022	0.755TrpAsn: 0.755 ± 0.028	0.2TrpPro: 0.2 ± 0.016	0.438TrpGln: 0.438 ± 0.024	0.389TrpArg: 0.389 ± 0.022	0.633TrpSer: 0.633 ± 0.026	0.583TrpThr: 0.583 ± 0.028	0.576TrpVal: 0.576 ± 0.028	0.161TrpTrp: 0.161 ± 0.014	0.424TrpTyr: 0.424 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.391TyrAla: 2.391 ± 0.05	0.401TyrCys: 0.401 ± 0.023	2.39TyrAsp: 2.39 ± 0.06	2.343TyrGlu: 2.343 ± 0.058	2.581TyrPhe: 2.581 ± 0.057	2.71TyrGly: 2.71 ± 0.055	0.851TyrHis: 0.851 ± 0.03	3.082TyrIle: 3.082 ± 0.056	3.048TyrLys: 3.048 ± 0.06	4.063TyrLeu: 4.063 ± 0.069	0.785TyrMet: 0.785 ± 0.033	2.638TyrAsn: 2.638 ± 0.069	1.729TyrPro: 1.729 ± 0.043	1.789TyrGln: 1.789 ± 0.048	1.689TyrArg: 1.689 ± 0.048	2.978TyrSer: 2.978 ± 0.065	2.53TyrThr: 2.53 ± 0.068	2.12TyrVal: 2.12 ± 0.06	0.519TyrTrp: 0.519 ± 0.026	2.139TyrTyr: 2.139 ± 0.062	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3118 proteins (889964 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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