Amino acid dipepetide frequency for Geoglobus ahangari

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.582AlaAla: 4.582 ± 0.123
0.835AlaCys: 0.835 ± 0.045
3.458AlaAsp: 3.458 ± 0.087
6.672AlaGlu: 6.672 ± 0.125
3.442AlaPhe: 3.442 ± 0.099
6.419AlaGly: 6.419 ± 0.125
1.085AlaHis: 1.085 ± 0.044
6.274AlaIle: 6.274 ± 0.13
4.41AlaLys: 4.41 ± 0.099
7.419AlaLeu: 7.419 ± 0.147
2.34AlaMet: 2.34 ± 0.07
1.861AlaAsn: 1.861 ± 0.057
1.831AlaPro: 1.831 ± 0.063
1.144AlaGln: 1.144 ± 0.049
4.925AlaArg: 4.925 ± 0.093
3.884AlaSer: 3.884 ± 0.084
2.979AlaThr: 2.979 ± 0.079
7.354AlaVal: 7.354 ± 0.122
0.607AlaTrp: 0.607 ± 0.036
2.686AlaTyr: 2.686 ± 0.077
0.0AlaXaa: 0.0 ± 0.0
Cys
0.587CysAla: 0.587 ± 0.031
0.113CysCys: 0.113 ± 0.017
0.526CysAsp: 0.526 ± 0.032
0.763CysGlu: 0.763 ± 0.04
0.311CysPhe: 0.311 ± 0.021
1.144CysGly: 1.144 ± 0.054
0.442CysHis: 0.442 ± 0.066
0.572CysIle: 0.572 ± 0.037
0.355CysLys: 0.355 ± 0.028
0.633CysLeu: 0.633 ± 0.036
0.246CysMet: 0.246 ± 0.023
0.294CysAsn: 0.294 ± 0.023
0.676CysPro: 0.676 ± 0.042
0.174CysGln: 0.174 ± 0.019
0.761CysArg: 0.761 ± 0.043
0.622CysSer: 0.622 ± 0.036
0.415CysThr: 0.415 ± 0.028
0.713CysVal: 0.713 ± 0.044
0.085CysTrp: 0.085 ± 0.011
0.35CysTyr: 0.35 ± 0.033
0.0CysXaa: 0.0 ± 0.0
Asp
3.518AspAla: 3.518 ± 0.082
0.474AspCys: 0.474 ± 0.034
2.398AspAsp: 2.398 ± 0.075
5.284AspGlu: 5.284 ± 0.106
2.794AspPhe: 2.794 ± 0.068
4.143AspGly: 4.143 ± 0.098
0.818AspHis: 0.818 ± 0.042
3.531AspIle: 3.531 ± 0.078
1.998AspLys: 1.998 ± 0.062
4.597AspLeu: 4.597 ± 0.086
1.263AspMet: 1.263 ± 0.048
1.102AspAsn: 1.102 ± 0.045
2.112AspPro: 2.112 ± 0.074
0.618AspGln: 0.618 ± 0.034
3.421AspArg: 3.421 ± 0.085
2.592AspSer: 2.592 ± 0.068
1.84AspThr: 1.84 ± 0.07
5.987AspVal: 5.987 ± 0.113
0.57AspTrp: 0.57 ± 0.032
2.233AspTyr: 2.233 ± 0.063
0.0AspXaa: 0.0 ± 0.0
Glu
5.182GluAla: 5.182 ± 0.101
0.661GluCys: 0.661 ± 0.04
4.343GluAsp: 4.343 ± 0.096
8.974GluGlu: 8.974 ± 0.17
4.166GluPhe: 4.166 ± 0.111
5.708GluGly: 5.708 ± 0.097
1.318GluHis: 1.318 ± 0.049
7.363GluIle: 7.363 ± 0.148
6.946GluLys: 6.946 ± 0.105
8.378GluLeu: 8.378 ± 0.159
2.725GluMet: 2.725 ± 0.078
3.464GluAsn: 3.464 ± 0.08
2.081GluPro: 2.081 ± 0.065
1.374GluGln: 1.374 ± 0.047
7.276GluArg: 7.276 ± 0.159
4.203GluSer: 4.203 ± 0.101
2.886GluThr: 2.886 ± 0.079
8.64GluVal: 8.64 ± 0.129
0.953GluTrp: 0.953 ± 0.04
2.996GluTyr: 2.996 ± 0.084
0.0GluXaa: 0.0 ± 0.0
Phe
3.453PheAla: 3.453 ± 0.095
0.428PheCys: 0.428 ± 0.027
2.585PheAsp: 2.585 ± 0.065
3.868PheGlu: 3.868 ± 0.087
1.944PhePhe: 1.944 ± 0.079
3.716PheGly: 3.716 ± 0.088
0.709PheHis: 0.709 ± 0.039
2.718PheIle: 2.718 ± 0.084
1.713PheLys: 1.713 ± 0.061
4.116PheLeu: 4.116 ± 0.11
1.079PheMet: 1.079 ± 0.047
1.194PheAsn: 1.194 ± 0.046
1.622PhePro: 1.622 ± 0.052
0.77PheGln: 0.77 ± 0.041
3.036PheArg: 3.036 ± 0.076
3.153PheSer: 3.153 ± 0.099
2.142PheThr: 2.142 ± 0.068
3.751PheVal: 3.751 ± 0.091
0.43PheTrp: 0.43 ± 0.034
1.685PheTyr: 1.685 ± 0.063
0.0PheXaa: 0.0 ± 0.0
Gly
4.595GlyAla: 4.595 ± 0.111
0.876GlyCys: 0.876 ± 0.049
3.908GlyAsp: 3.908 ± 0.088
6.485GlyGlu: 6.485 ± 0.105
3.603GlyPhe: 3.603 ± 0.082
5.106GlyGly: 5.106 ± 0.115
1.242GlyHis: 1.242 ± 0.056
6.215GlyIle: 6.215 ± 0.122
5.612GlyLys: 5.612 ± 0.1
6.306GlyLeu: 6.306 ± 0.126
2.461GlyMet: 2.461 ± 0.079
2.294GlyAsn: 2.294 ± 0.074
1.485GlyPro: 1.485 ± 0.064
1.07GlyGln: 1.07 ± 0.046
4.921GlyArg: 4.921 ± 0.109
3.856GlySer: 3.856 ± 0.093
3.134GlyThr: 3.134 ± 0.102
7.137GlyVal: 7.137 ± 0.135
0.894GlyTrp: 0.894 ± 0.049
3.24GlyTyr: 3.24 ± 0.081
0.0GlyXaa: 0.0 ± 0.0
His
1.414HisAla: 1.414 ± 0.054
0.235HisCys: 0.235 ± 0.023
0.798HisAsp: 0.798 ± 0.038
1.198HisGlu: 1.198 ± 0.041
0.768HisPhe: 0.768 ± 0.042
1.435HisGly: 1.435 ± 0.052
0.4HisHis: 0.4 ± 0.028
1.144HisIle: 1.144 ± 0.049
0.546HisLys: 0.546 ± 0.029
1.498HisLeu: 1.498 ± 0.054
0.404HisMet: 0.404 ± 0.029
0.448HisAsn: 0.448 ± 0.032
1.096HisPro: 1.096 ± 0.047
0.283HisGln: 0.283 ± 0.021
1.018HisArg: 1.018 ± 0.045
0.966HisSer: 0.966 ± 0.05
0.761HisThr: 0.761 ± 0.037
1.392HisVal: 1.392 ± 0.049
0.168HisTrp: 0.168 ± 0.02
0.729HisTyr: 0.729 ± 0.039
0.0HisXaa: 0.0 ± 0.0
Ile
6.872IleAla: 6.872 ± 0.123
0.657IleCys: 0.657 ± 0.036
4.058IleAsp: 4.058 ± 0.096
6.265IleGlu: 6.265 ± 0.117
2.799IlePhe: 2.799 ± 0.075
4.967IleGly: 4.967 ± 0.086
1.294IleHis: 1.294 ± 0.045
4.358IleIle: 4.358 ± 0.101
3.558IleLys: 3.558 ± 0.099
6.761IleLeu: 6.761 ± 0.137
1.516IleMet: 1.516 ± 0.058
2.224IleAsn: 2.224 ± 0.07
3.427IlePro: 3.427 ± 0.08
1.285IleGln: 1.285 ± 0.05
4.086IleArg: 4.086 ± 0.083
4.941IleSer: 4.941 ± 0.104
3.562IleThr: 3.562 ± 0.083
6.102IleVal: 6.102 ± 0.112
0.498IleTrp: 0.498 ± 0.034
2.633IleTyr: 2.633 ± 0.085
0.0IleXaa: 0.0 ± 0.0
Lys
4.825LysAla: 4.825 ± 0.108
0.587LysCys: 0.587 ± 0.044
2.984LysAsp: 2.984 ± 0.086
5.558LysGlu: 5.558 ± 0.119
2.114LysPhe: 2.114 ± 0.063
4.108LysGly: 4.108 ± 0.099
0.955LysHis: 0.955 ± 0.042
4.432LysIle: 4.432 ± 0.1
4.149LysLys: 4.149 ± 0.1
5.26LysLeu: 5.26 ± 0.128
1.524LysMet: 1.524 ± 0.056
1.983LysAsn: 1.983 ± 0.067
2.325LysPro: 2.325 ± 0.076
0.963LysGln: 0.963 ± 0.044
4.073LysArg: 4.073 ± 0.096
3.034LysSer: 3.034 ± 0.075
2.594LysThr: 2.594 ± 0.073
5.091LysVal: 5.091 ± 0.101
0.567LysTrp: 0.567 ± 0.042
2.224LysTyr: 2.224 ± 0.075
0.0LysXaa: 0.0 ± 0.0
Leu
7.881LeuAla: 7.881 ± 0.152
0.67LeuCys: 0.67 ± 0.033
4.553LeuAsp: 4.553 ± 0.099
8.022LeuGlu: 8.022 ± 0.14
3.577LeuPhe: 3.577 ± 0.101
6.519LeuGly: 6.519 ± 0.11
1.387LeuHis: 1.387 ± 0.051
6.389LeuIle: 6.389 ± 0.13
6.495LeuLys: 6.495 ± 0.115
8.729LeuLeu: 8.729 ± 0.192
2.548LeuMet: 2.548 ± 0.073
3.175LeuAsn: 3.175 ± 0.08
3.577LeuPro: 3.577 ± 0.089
1.572LeuGln: 1.572 ± 0.062
6.615LeuArg: 6.615 ± 0.126
6.613LeuSer: 6.613 ± 0.123
4.18LeuThr: 4.18 ± 0.095
6.822LeuVal: 6.822 ± 0.126
0.744LeuTrp: 0.744 ± 0.046
3.044LeuTyr: 3.044 ± 0.095
0.0LeuXaa: 0.0 ± 0.0
Met
2.038MetAla: 2.038 ± 0.071
0.168MetCys: 0.168 ± 0.016
1.463MetAsp: 1.463 ± 0.049
2.177MetGlu: 2.177 ± 0.069
0.952MetPhe: 0.952 ± 0.044
1.996MetGly: 1.996 ± 0.066
0.483MetHis: 0.483 ± 0.026
1.75MetIle: 1.75 ± 0.06
1.875MetLys: 1.875 ± 0.054
2.735MetLeu: 2.735 ± 0.072
0.617MetMet: 0.617 ± 0.034
0.946MetAsn: 0.946 ± 0.042
1.113MetPro: 1.113 ± 0.056
0.478MetGln: 0.478 ± 0.031
2.072MetArg: 2.072 ± 0.066
1.576MetSer: 1.576 ± 0.046
1.007MetThr: 1.007 ± 0.042
2.07MetVal: 2.07 ± 0.066
0.246MetTrp: 0.246 ± 0.023
0.768MetTyr: 0.768 ± 0.033
0.0MetXaa: 0.0 ± 0.0
Asn
2.633AsnAla: 2.633 ± 0.078
0.326AsnCys: 0.326 ± 0.027
1.203AsnAsp: 1.203 ± 0.045
2.042AsnGlu: 2.042 ± 0.061
1.368AsnPhe: 1.368 ± 0.056
2.527AsnGly: 2.527 ± 0.078
0.439AsnHis: 0.439 ± 0.032
2.057AsnIle: 2.057 ± 0.065
1.129AsnLys: 1.129 ± 0.05
3.273AsnLeu: 3.273 ± 0.084
0.679AsnMet: 0.679 ± 0.036
0.816AsnAsn: 0.816 ± 0.056
2.181AsnPro: 2.181 ± 0.062
0.548AsnGln: 0.548 ± 0.035
1.757AsnArg: 1.757 ± 0.055
1.681AsnSer: 1.681 ± 0.057
1.459AsnThr: 1.459 ± 0.059
3.012AsnVal: 3.012 ± 0.08
0.33AsnTrp: 0.33 ± 0.031
1.211AsnTyr: 1.211 ± 0.058
0.0AsnXaa: 0.0 ± 0.0
Pro
2.636ProAla: 2.636 ± 0.077
0.352ProCys: 0.352 ± 0.03
2.401ProAsp: 2.401 ± 0.083
4.267ProGlu: 4.267 ± 0.09
1.813ProPhe: 1.813 ± 0.056
2.542ProGly: 2.542 ± 0.077
0.779ProHis: 0.779 ± 0.038
1.998ProIle: 1.998 ± 0.062
2.168ProLys: 2.168 ± 0.078
3.297ProLeu: 3.297 ± 0.075
0.82ProMet: 0.82 ± 0.038
1.19ProAsn: 1.19 ± 0.052
1.657ProPro: 1.657 ± 0.067
0.733ProGln: 0.733 ± 0.036
1.683ProArg: 1.683 ± 0.061
2.222ProSer: 2.222 ± 0.065
1.718ProThr: 1.718 ± 0.079
3.716ProVal: 3.716 ± 0.094
0.418ProTrp: 0.418 ± 0.026
1.518ProTyr: 1.518 ± 0.057
0.0ProXaa: 0.0 ± 0.0
Gln
1.279GlnAla: 1.279 ± 0.045
0.135GlnCys: 0.135 ± 0.015
0.679GlnAsp: 0.679 ± 0.034
1.294GlnGlu: 1.294 ± 0.049
0.609GlnPhe: 0.609 ± 0.032
0.985GlnGly: 0.985 ± 0.038
0.344GlnHis: 0.344 ± 0.021
1.451GlnIle: 1.451 ± 0.051
1.181GlnLys: 1.181 ± 0.049
1.577GlnLeu: 1.577 ± 0.051
0.511GlnMet: 0.511 ± 0.033
0.694GlnAsn: 0.694 ± 0.037
0.702GlnPro: 0.702 ± 0.035
0.417GlnGln: 0.417 ± 0.031
1.07GlnArg: 1.07 ± 0.049
0.833GlnSer: 0.833 ± 0.044
0.754GlnThr: 0.754 ± 0.041
1.285GlnVal: 1.285 ± 0.054
0.185GlnTrp: 0.185 ± 0.02
0.628GlnTyr: 0.628 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
4.567ArgAla: 4.567 ± 0.095
0.755ArgCys: 0.755 ± 0.047
3.618ArgAsp: 3.618 ± 0.077
6.73ArgGlu: 6.73 ± 0.12
3.001ArgPhe: 3.001 ± 0.085
4.373ArgGly: 4.373 ± 0.083
1.052ArgHis: 1.052 ± 0.046
5.463ArgIle: 5.463 ± 0.109
4.934ArgLys: 4.934 ± 0.109
6.11ArgLeu: 6.11 ± 0.12
1.944ArgMet: 1.944 ± 0.065
2.155ArgAsn: 2.155 ± 0.065
1.912ArgPro: 1.912 ± 0.058
1.113ArgGln: 1.113 ± 0.047
4.962ArgArg: 4.962 ± 0.117
2.89ArgSer: 2.89 ± 0.083
2.062ArgThr: 2.062 ± 0.067
6.269ArgVal: 6.269 ± 0.125
0.648ArgTrp: 0.648 ± 0.035
2.455ArgTyr: 2.455 ± 0.062
0.0ArgXaa: 0.0 ± 0.0
Ser
4.514SerAla: 4.514 ± 0.106
0.581SerCys: 0.581 ± 0.041
2.901SerAsp: 2.901 ± 0.092
4.649SerGlu: 4.649 ± 0.099
2.677SerPhe: 2.677 ± 0.074
5.341SerGly: 5.341 ± 0.118
0.941SerHis: 0.941 ± 0.041
3.762SerIle: 3.762 ± 0.096
3.22SerLys: 3.22 ± 0.078
5.591SerLeu: 5.591 ± 0.123
1.477SerMet: 1.477 ± 0.053
1.527SerAsn: 1.527 ± 0.064
2.54SerPro: 2.54 ± 0.091
1.102SerGln: 1.102 ± 0.049
3.655SerArg: 3.655 ± 0.094
3.653SerSer: 3.653 ± 0.097
2.448SerThr: 2.448 ± 0.081
4.616SerVal: 4.616 ± 0.091
0.531SerTrp: 0.531 ± 0.032
2.227SerTyr: 2.227 ± 0.066
0.0SerXaa: 0.0 ± 0.0
Thr
3.549ThrAla: 3.549 ± 0.089
0.435ThrCys: 0.435 ± 0.032
1.861ThrAsp: 1.861 ± 0.065
2.54ThrGlu: 2.54 ± 0.064
1.888ThrPhe: 1.888 ± 0.06
3.751ThrGly: 3.751 ± 0.089
0.831ThrHis: 0.831 ± 0.041
2.992ThrIle: 2.992 ± 0.082
1.909ThrLys: 1.909 ± 0.067
4.44ThrLeu: 4.44 ± 0.096
0.902ThrMet: 0.902 ± 0.038
1.176ThrAsn: 1.176 ± 0.05
2.655ThrPro: 2.655 ± 0.102
0.754ThrGln: 0.754 ± 0.035
1.975ThrArg: 1.975 ± 0.06
2.716ThrSer: 2.716 ± 0.082
2.075ThrThr: 2.075 ± 0.073
3.481ThrVal: 3.481 ± 0.095
0.354ThrTrp: 0.354 ± 0.027
1.514ThrTyr: 1.514 ± 0.061
0.0ThrXaa: 0.0 ± 0.0
Val
6.552ValAla: 6.552 ± 0.125
0.957ValCys: 0.957 ± 0.052
5.019ValAsp: 5.019 ± 0.114
9.15ValGlu: 9.15 ± 0.174
4.119ValPhe: 4.119 ± 0.104
5.95ValGly: 5.95 ± 0.109
1.331ValHis: 1.331 ± 0.047
6.434ValIle: 6.434 ± 0.105
5.151ValLys: 5.151 ± 0.105
7.757ValLeu: 7.757 ± 0.122
2.322ValMet: 2.322 ± 0.073
2.601ValAsn: 2.601 ± 0.066
2.999ValPro: 2.999 ± 0.07
1.355ValGln: 1.355 ± 0.046
6.276ValArg: 6.276 ± 0.128
5.541ValSer: 5.541 ± 0.105
3.784ValThr: 3.784 ± 0.09
8.976ValVal: 8.976 ± 0.146
0.796ValTrp: 0.796 ± 0.042
3.103ValTyr: 3.103 ± 0.072
0.0ValXaa: 0.0 ± 0.0
Trp
0.555TrpAla: 0.555 ± 0.033
0.1TrpCys: 0.1 ± 0.015
0.518TrpAsp: 0.518 ± 0.027
0.766TrpGlu: 0.766 ± 0.042
0.426TrpPhe: 0.426 ± 0.026
0.65TrpGly: 0.65 ± 0.034
0.161TrpHis: 0.161 ± 0.019
0.718TrpIle: 0.718 ± 0.034
0.657TrpLys: 0.657 ± 0.033
0.983TrpLeu: 0.983 ± 0.045
0.315TrpMet: 0.315 ± 0.023
0.478TrpAsn: 0.478 ± 0.036
0.231TrpPro: 0.231 ± 0.022
0.218TrpGln: 0.218 ± 0.02
0.696TrpArg: 0.696 ± 0.04
0.504TrpSer: 0.504 ± 0.03
0.305TrpThr: 0.305 ± 0.022
0.831TrpVal: 0.831 ± 0.043
0.167TrpTrp: 0.167 ± 0.018
0.37TrpTyr: 0.37 ± 0.028
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.975TyrAla: 2.975 ± 0.078
0.437TyrCys: 0.437 ± 0.033
2.018TyrAsp: 2.018 ± 0.066
2.933TyrGlu: 2.933 ± 0.067
1.738TyrPhe: 1.738 ± 0.058
3.06TyrGly: 3.06 ± 0.083
0.691TyrHis: 0.691 ± 0.032
2.244TyrIle: 2.244 ± 0.068
1.344TyrLys: 1.344 ± 0.061
3.653TyrLeu: 3.653 ± 0.1
0.835TyrMet: 0.835 ± 0.036
1.05TyrAsn: 1.05 ± 0.049
1.707TyrPro: 1.707 ± 0.066
0.644TyrGln: 0.644 ± 0.034
2.735TyrArg: 2.735 ± 0.073
2.472TyrSer: 2.472 ± 0.063
1.69TyrThr: 1.69 ± 0.065
2.929TyrVal: 2.929 ± 0.072
0.459TyrTrp: 0.459 ± 0.031
1.55TyrTyr: 1.55 ± 0.061
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1973 proteins (540133 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski