Amino acid dipepetide frequency for Reovirus GCRV104

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.907AlaAla: 8.907 ± 1.1
0.665AlaCys: 0.665 ± 0.406
4.653AlaAsp: 4.653 ± 0.552
3.324AlaGlu: 3.324 ± 0.4
1.994AlaPhe: 1.994 ± 0.586
4.786AlaGly: 4.786 ± 0.476
1.728AlaHis: 1.728 ± 0.503
6.647AlaIle: 6.647 ± 0.941
2.26AlaLys: 2.26 ± 0.575
8.508AlaLeu: 8.508 ± 1.172
3.855AlaMet: 3.855 ± 0.683
5.052AlaAsn: 5.052 ± 0.888
5.717AlaPro: 5.717 ± 0.657
5.052AlaGln: 5.052 ± 1.008
5.451AlaArg: 5.451 ± 0.713
6.248AlaSer: 6.248 ± 0.792
7.179AlaThr: 7.179 ± 0.906
6.115AlaVal: 6.115 ± 0.917
0.931AlaTrp: 0.931 ± 0.417
3.855AlaTyr: 3.855 ± 0.415
0.0AlaXaa: 0.0 ± 0.0
Cys
1.595CysAla: 1.595 ± 0.38
0.266CysCys: 0.266 ± 0.155
0.665CysAsp: 0.665 ± 0.285
0.532CysGlu: 0.532 ± 0.163
0.266CysPhe: 0.266 ± 0.135
0.665CysGly: 0.665 ± 0.414
0.266CysHis: 0.266 ± 0.219
0.532CysIle: 0.532 ± 0.264
0.399CysLys: 0.399 ± 0.166
1.462CysLeu: 1.462 ± 0.38
0.133CysMet: 0.133 ± 0.168
0.266CysAsn: 0.266 ± 0.146
1.064CysPro: 1.064 ± 0.293
0.532CysGln: 0.532 ± 0.199
0.532CysArg: 0.532 ± 0.372
1.064CysSer: 1.064 ± 0.281
0.665CysThr: 0.665 ± 0.401
0.665CysVal: 0.665 ± 0.38
0.0CysTrp: 0.0 ± 0.0
0.399CysTyr: 0.399 ± 0.248
0.0CysXaa: 0.0 ± 0.0
Asp
5.584AspAla: 5.584 ± 0.842
0.399AspCys: 0.399 ± 0.286
3.191AspAsp: 3.191 ± 0.77
2.393AspGlu: 2.393 ± 0.393
1.462AspPhe: 1.462 ± 0.354
3.191AspGly: 3.191 ± 0.594
0.931AspHis: 0.931 ± 0.403
2.925AspIle: 2.925 ± 0.506
1.196AspLys: 1.196 ± 0.386
4.653AspLeu: 4.653 ± 0.618
2.127AspMet: 2.127 ± 0.486
1.462AspAsn: 1.462 ± 0.417
4.254AspPro: 4.254 ± 0.589
2.127AspGln: 2.127 ± 0.742
2.526AspArg: 2.526 ± 0.642
3.855AspSer: 3.855 ± 0.877
4.653AspThr: 4.653 ± 0.675
5.052AspVal: 5.052 ± 0.626
1.064AspTrp: 1.064 ± 0.269
2.127AspTyr: 2.127 ± 0.464
0.0AspXaa: 0.0 ± 0.0
Glu
2.925GluAla: 2.925 ± 0.503
0.399GluCys: 0.399 ± 0.196
1.064GluAsp: 1.064 ± 0.382
2.127GluGlu: 2.127 ± 0.611
1.196GluPhe: 1.196 ± 0.38
2.26GluGly: 2.26 ± 0.411
0.931GluHis: 0.931 ± 0.223
1.861GluIle: 1.861 ± 0.427
0.798GluLys: 0.798 ± 0.255
4.786GluLeu: 4.786 ± 1.11
1.462GluMet: 1.462 ± 0.336
0.399GluAsn: 0.399 ± 0.286
2.659GluPro: 2.659 ± 0.691
2.127GluGln: 2.127 ± 0.403
1.728GluArg: 1.728 ± 0.453
2.925GluSer: 2.925 ± 0.644
1.728GluThr: 1.728 ± 0.424
3.457GluVal: 3.457 ± 0.59
0.532GluTrp: 0.532 ± 0.245
1.861GluTyr: 1.861 ± 0.383
0.0GluXaa: 0.0 ± 0.0
Phe
2.925PheAla: 2.925 ± 0.512
0.133PheCys: 0.133 ± 0.157
1.728PheAsp: 1.728 ± 0.322
1.329PheGlu: 1.329 ± 0.453
0.532PhePhe: 0.532 ± 0.152
1.462PheGly: 1.462 ± 0.286
0.931PheHis: 0.931 ± 0.649
1.595PheIle: 1.595 ± 0.347
0.798PheLys: 0.798 ± 0.443
2.26PheLeu: 2.26 ± 0.854
1.196PheMet: 1.196 ± 0.372
1.861PheAsn: 1.861 ± 0.6
2.393PhePro: 2.393 ± 0.646
1.728PheGln: 1.728 ± 0.563
1.994PheArg: 1.994 ± 0.397
2.526PheSer: 2.526 ± 0.477
3.058PheThr: 3.058 ± 0.581
3.191PheVal: 3.191 ± 0.671
0.266PheTrp: 0.266 ± 0.135
0.798PheTyr: 0.798 ± 0.373
0.0PheXaa: 0.0 ± 0.0
Gly
4.653GlyAla: 4.653 ± 0.666
0.931GlyCys: 0.931 ± 0.311
3.058GlyAsp: 3.058 ± 0.474
1.861GlyGlu: 1.861 ± 0.379
1.861GlyPhe: 1.861 ± 0.355
2.659GlyGly: 2.659 ± 0.469
0.798GlyHis: 0.798 ± 0.43
2.925GlyIle: 2.925 ± 0.52
1.196GlyLys: 1.196 ± 0.317
5.318GlyLeu: 5.318 ± 0.847
2.127GlyMet: 2.127 ± 0.634
1.994GlyAsn: 1.994 ± 0.722
3.457GlyPro: 3.457 ± 0.611
2.792GlyGln: 2.792 ± 0.513
2.925GlyArg: 2.925 ± 0.619
4.653GlySer: 4.653 ± 0.672
3.722GlyThr: 3.722 ± 0.913
4.387GlyVal: 4.387 ± 0.53
0.798GlyTrp: 0.798 ± 0.403
1.595GlyTyr: 1.595 ± 0.623
0.0GlyXaa: 0.0 ± 0.0
His
2.526HisAla: 2.526 ± 1.047
0.0HisCys: 0.0 ± 0.0
1.994HisAsp: 1.994 ± 0.385
0.133HisGlu: 0.133 ± 0.147
0.798HisPhe: 0.798 ± 0.271
2.127HisGly: 2.127 ± 0.622
1.064HisHis: 1.064 ± 0.366
1.064HisIle: 1.064 ± 0.482
0.399HisLys: 0.399 ± 0.16
2.393HisLeu: 2.393 ± 0.66
1.064HisMet: 1.064 ± 0.36
0.798HisAsn: 0.798 ± 0.203
1.728HisPro: 1.728 ± 0.363
0.798HisGln: 0.798 ± 0.231
1.994HisArg: 1.994 ± 1.017
0.665HisSer: 0.665 ± 0.371
1.196HisThr: 1.196 ± 0.641
1.595HisVal: 1.595 ± 0.492
0.532HisTrp: 0.532 ± 0.266
0.665HisTyr: 0.665 ± 0.297
0.0HisXaa: 0.0 ± 0.0
Ile
6.115IleAla: 6.115 ± 0.918
1.595IleCys: 1.595 ± 0.474
3.457IleAsp: 3.457 ± 0.598
1.595IleGlu: 1.595 ± 0.421
1.462IlePhe: 1.462 ± 0.473
2.659IleGly: 2.659 ± 0.466
1.728IleHis: 1.728 ± 0.308
2.792IleIle: 2.792 ± 0.548
1.196IleLys: 1.196 ± 0.589
4.52IleLeu: 4.52 ± 0.504
1.595IleMet: 1.595 ± 0.421
3.324IleAsn: 3.324 ± 0.625
4.121IlePro: 4.121 ± 0.828
1.329IleGln: 1.329 ± 0.41
2.127IleArg: 2.127 ± 0.375
4.919IleSer: 4.919 ± 1.003
4.254IleThr: 4.254 ± 0.864
2.659IleVal: 2.659 ± 0.36
0.399IleTrp: 0.399 ± 0.226
0.665IleTyr: 0.665 ± 0.344
0.0IleXaa: 0.0 ± 0.0
Lys
2.925LysAla: 2.925 ± 0.57
0.399LysCys: 0.399 ± 0.223
1.064LysAsp: 1.064 ± 0.44
0.532LysGlu: 0.532 ± 0.191
1.064LysPhe: 1.064 ± 0.494
1.064LysGly: 1.064 ± 0.455
0.931LysHis: 0.931 ± 0.297
1.994LysIle: 1.994 ± 0.333
0.399LysLys: 0.399 ± 0.18
2.393LysLeu: 2.393 ± 0.519
1.196LysMet: 1.196 ± 0.341
0.399LysAsn: 0.399 ± 0.333
1.462LysPro: 1.462 ± 0.275
1.329LysGln: 1.329 ± 0.317
1.064LysArg: 1.064 ± 0.423
1.861LysSer: 1.861 ± 0.578
1.462LysThr: 1.462 ± 0.385
1.595LysVal: 1.595 ± 0.299
0.266LysTrp: 0.266 ± 0.196
1.196LysTyr: 1.196 ± 0.548
0.0LysXaa: 0.0 ± 0.0
Leu
7.445LeuAla: 7.445 ± 0.715
0.399LeuCys: 0.399 ± 0.224
4.653LeuAsp: 4.653 ± 0.81
3.988LeuGlu: 3.988 ± 0.783
3.589LeuPhe: 3.589 ± 0.684
4.52LeuGly: 4.52 ± 1.061
2.127LeuHis: 2.127 ± 0.737
3.457LeuIle: 3.457 ± 0.606
2.659LeuLys: 2.659 ± 0.755
8.774LeuLeu: 8.774 ± 1.067
3.457LeuMet: 3.457 ± 0.742
3.988LeuAsn: 3.988 ± 0.59
7.046LeuPro: 7.046 ± 0.736
4.52LeuGln: 4.52 ± 0.801
6.248LeuArg: 6.248 ± 1.254
9.04LeuSer: 9.04 ± 1.075
7.844LeuThr: 7.844 ± 0.947
5.717LeuVal: 5.717 ± 0.753
1.329LeuTrp: 1.329 ± 0.306
3.722LeuTyr: 3.722 ± 0.69
0.0LeuXaa: 0.0 ± 0.0
Met
3.457MetAla: 3.457 ± 0.62
0.266MetCys: 0.266 ± 0.175
3.058MetAsp: 3.058 ± 0.421
0.798MetGlu: 0.798 ± 0.331
1.064MetPhe: 1.064 ± 0.278
2.127MetGly: 2.127 ± 0.26
0.665MetHis: 0.665 ± 0.246
1.064MetIle: 1.064 ± 0.28
1.462MetLys: 1.462 ± 0.348
2.792MetLeu: 2.792 ± 0.415
1.196MetMet: 1.196 ± 0.285
1.595MetAsn: 1.595 ± 0.356
2.792MetPro: 2.792 ± 0.643
1.595MetGln: 1.595 ± 0.418
1.728MetArg: 1.728 ± 0.385
2.26MetSer: 2.26 ± 0.548
3.058MetThr: 3.058 ± 0.604
2.26MetVal: 2.26 ± 0.389
0.399MetTrp: 0.399 ± 0.183
1.595MetTyr: 1.595 ± 0.418
0.0MetXaa: 0.0 ± 0.0
Asn
5.052AsnAla: 5.052 ± 0.797
0.665AsnCys: 0.665 ± 0.268
1.861AsnAsp: 1.861 ± 0.485
1.595AsnGlu: 1.595 ± 0.473
1.861AsnPhe: 1.861 ± 0.672
2.792AsnGly: 2.792 ± 0.806
0.532AsnHis: 0.532 ± 0.207
2.659AsnIle: 2.659 ± 0.475
0.931AsnLys: 0.931 ± 0.468
3.058AsnLeu: 3.058 ± 0.619
1.064AsnMet: 1.064 ± 0.291
0.931AsnAsn: 0.931 ± 0.41
4.121AsnPro: 4.121 ± 0.675
1.329AsnGln: 1.329 ± 0.534
1.728AsnArg: 1.728 ± 0.399
2.26AsnSer: 2.26 ± 0.309
2.925AsnThr: 2.925 ± 0.514
4.919AsnVal: 4.919 ± 1.086
0.532AsnTrp: 0.532 ± 0.237
0.798AsnTyr: 0.798 ± 0.301
0.0AsnXaa: 0.0 ± 0.0
Pro
6.381ProAla: 6.381 ± 0.993
1.595ProCys: 1.595 ± 0.353
4.254ProAsp: 4.254 ± 0.51
3.457ProGlu: 3.457 ± 0.503
2.526ProPhe: 2.526 ± 0.525
3.058ProGly: 3.058 ± 0.464
1.329ProHis: 1.329 ± 0.53
4.254ProIle: 4.254 ± 0.715
1.462ProLys: 1.462 ± 0.618
6.381ProLeu: 6.381 ± 0.707
2.26ProMet: 2.26 ± 0.358
4.52ProAsn: 4.52 ± 1.013
5.052ProPro: 5.052 ± 0.828
1.595ProGln: 1.595 ± 0.546
3.722ProArg: 3.722 ± 0.439
5.052ProSer: 5.052 ± 0.773
4.52ProThr: 4.52 ± 0.814
4.919ProVal: 4.919 ± 0.828
0.931ProTrp: 0.931 ± 0.208
1.595ProTyr: 1.595 ± 0.427
0.0ProXaa: 0.0 ± 0.0
Gln
3.589GlnAla: 3.589 ± 0.41
0.665GlnCys: 0.665 ± 0.174
1.462GlnAsp: 1.462 ± 0.299
0.798GlnGlu: 0.798 ± 0.29
2.526GlnPhe: 2.526 ± 0.592
1.861GlnGly: 1.861 ± 0.387
1.196GlnHis: 1.196 ± 0.291
2.393GlnIle: 2.393 ± 0.532
0.665GlnLys: 0.665 ± 0.223
4.919GlnLeu: 4.919 ± 0.753
2.127GlnMet: 2.127 ± 0.453
1.064GlnAsn: 1.064 ± 0.409
3.058GlnPro: 3.058 ± 0.817
1.994GlnGln: 1.994 ± 0.443
2.526GlnArg: 2.526 ± 0.426
2.526GlnSer: 2.526 ± 0.482
3.191GlnThr: 3.191 ± 0.382
4.653GlnVal: 4.653 ± 0.628
0.665GlnTrp: 0.665 ± 0.245
1.861GlnTyr: 1.861 ± 0.593
0.0GlnXaa: 0.0 ± 0.0
Arg
3.457ArgAla: 3.457 ± 0.49
0.399ArgCys: 0.399 ± 0.31
3.457ArgAsp: 3.457 ± 0.556
1.462ArgGlu: 1.462 ± 0.531
2.393ArgPhe: 2.393 ± 0.466
1.595ArgGly: 1.595 ± 0.367
1.595ArgHis: 1.595 ± 0.494
2.393ArgIle: 2.393 ± 0.708
1.595ArgLys: 1.595 ± 0.38
6.248ArgLeu: 6.248 ± 0.739
1.861ArgMet: 1.861 ± 0.555
2.393ArgAsn: 2.393 ± 0.642
2.526ArgPro: 2.526 ± 0.409
3.457ArgGln: 3.457 ± 0.661
3.324ArgArg: 3.324 ± 0.395
3.988ArgSer: 3.988 ± 0.55
3.722ArgThr: 3.722 ± 0.666
5.584ArgVal: 5.584 ± 1.114
1.064ArgTrp: 1.064 ± 0.282
2.925ArgTyr: 2.925 ± 0.622
0.0ArgXaa: 0.0 ± 0.0
Ser
6.913SerAla: 6.913 ± 1.358
0.399SerCys: 0.399 ± 0.25
3.988SerAsp: 3.988 ± 0.86
3.589SerGlu: 3.589 ± 0.651
2.792SerPhe: 2.792 ± 0.608
5.451SerGly: 5.451 ± 0.93
1.728SerHis: 1.728 ± 0.603
3.589SerIle: 3.589 ± 0.562
2.26SerLys: 2.26 ± 0.61
6.514SerLeu: 6.514 ± 0.592
1.994SerMet: 1.994 ± 0.502
3.191SerAsn: 3.191 ± 1.01
3.191SerPro: 3.191 ± 0.561
3.058SerGln: 3.058 ± 0.617
4.786SerArg: 4.786 ± 0.733
4.919SerSer: 4.919 ± 0.901
5.185SerThr: 5.185 ± 1.196
6.913SerVal: 6.913 ± 1.26
0.798SerTrp: 0.798 ± 0.199
1.728SerTyr: 1.728 ± 0.396
0.0SerXaa: 0.0 ± 0.0
Thr
7.312ThrAla: 7.312 ± 0.836
0.665ThrCys: 0.665 ± 0.282
3.058ThrAsp: 3.058 ± 0.496
3.589ThrGlu: 3.589 ± 0.683
2.26ThrPhe: 2.26 ± 0.422
4.919ThrGly: 4.919 ± 0.881
1.861ThrHis: 1.861 ± 0.513
3.324ThrIle: 3.324 ± 0.375
1.462ThrLys: 1.462 ± 0.428
7.179ThrLeu: 7.179 ± 0.709
3.191ThrMet: 3.191 ± 0.479
2.393ThrAsn: 2.393 ± 0.252
4.387ThrPro: 4.387 ± 0.579
3.191ThrGln: 3.191 ± 0.717
4.919ThrArg: 4.919 ± 0.632
6.78ThrSer: 6.78 ± 0.938
5.85ThrThr: 5.85 ± 0.826
5.185ThrVal: 5.185 ± 1.108
0.931ThrTrp: 0.931 ± 0.367
3.191ThrTyr: 3.191 ± 0.682
0.0ThrXaa: 0.0 ± 0.0
Val
5.982ValAla: 5.982 ± 0.881
1.861ValCys: 1.861 ± 0.44
5.185ValAsp: 5.185 ± 0.804
2.127ValGlu: 2.127 ± 0.581
1.064ValPhe: 1.064 ± 0.378
3.988ValGly: 3.988 ± 0.238
1.462ValHis: 1.462 ± 0.503
4.52ValIle: 4.52 ± 0.54
2.26ValLys: 2.26 ± 0.553
8.11ValLeu: 8.11 ± 0.862
1.994ValMet: 1.994 ± 0.516
4.52ValAsn: 4.52 ± 0.71
6.913ValPro: 6.913 ± 0.503
3.058ValGln: 3.058 ± 0.821
3.855ValArg: 3.855 ± 0.729
5.318ValSer: 5.318 ± 0.699
7.179ValThr: 7.179 ± 0.895
5.85ValVal: 5.85 ± 1.036
0.931ValTrp: 0.931 ± 0.41
3.058ValTyr: 3.058 ± 0.851
0.0ValXaa: 0.0 ± 0.0
Trp
1.196TrpAla: 1.196 ± 0.315
0.0TrpCys: 0.0 ± 0.0
0.532TrpAsp: 0.532 ± 0.228
0.266TrpGlu: 0.266 ± 0.205
0.399TrpPhe: 0.399 ± 0.353
0.266TrpGly: 0.266 ± 0.18
0.399TrpHis: 0.399 ± 0.164
0.931TrpIle: 0.931 ± 0.346
0.266TrpLys: 0.266 ± 0.169
1.462TrpLeu: 1.462 ± 0.249
0.399TrpMet: 0.399 ± 0.239
0.532TrpAsn: 0.532 ± 0.458
0.798TrpPro: 0.798 ± 0.327
0.665TrpGln: 0.665 ± 0.353
0.931TrpArg: 0.931 ± 0.377
0.665TrpSer: 0.665 ± 0.26
1.329TrpThr: 1.329 ± 0.356
0.931TrpVal: 0.931 ± 0.279
0.133TrpTrp: 0.133 ± 0.137
0.665TrpTyr: 0.665 ± 0.253
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.121TyrAla: 4.121 ± 0.783
0.266TyrCys: 0.266 ± 0.185
2.792TyrAsp: 2.792 ± 0.398
1.728TyrGlu: 1.728 ± 0.332
1.595TyrPhe: 1.595 ± 0.483
2.26TyrGly: 2.26 ± 0.403
1.329TyrHis: 1.329 ± 0.367
1.595TyrIle: 1.595 ± 0.473
0.931TyrLys: 0.931 ± 0.349
2.792TyrLeu: 2.792 ± 0.973
0.798TyrMet: 0.798 ± 0.316
0.931TyrAsn: 0.931 ± 0.291
2.127TyrPro: 2.127 ± 0.68
1.462TyrGln: 1.462 ± 0.506
1.329TyrArg: 1.329 ± 0.51
1.462TyrSer: 1.462 ± 0.471
2.925TyrThr: 2.925 ± 0.422
3.589TyrVal: 3.589 ± 0.552
0.266TyrTrp: 0.266 ± 0.168
1.329TyrTyr: 1.329 ± 0.404
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 11 proteins (7523 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski