Amino acid dipepetide frequency for Enterobacteria phage HK620 (Bacteriophage HK620)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.673AlaAla: 8.673 ± 1.31
0.708AlaCys: 0.708 ± 0.291
6.991AlaAsp: 6.991 ± 0.827
6.372AlaGlu: 6.372 ± 0.977
3.628AlaPhe: 3.628 ± 0.502
6.726AlaGly: 6.726 ± 1.312
2.124AlaHis: 2.124 ± 0.461
7.788AlaIle: 7.788 ± 0.91
6.637AlaLys: 6.637 ± 0.945
6.549AlaLeu: 6.549 ± 0.877
2.655AlaMet: 2.655 ± 0.497
4.69AlaAsn: 4.69 ± 0.869
2.301AlaPro: 2.301 ± 0.421
4.602AlaGln: 4.602 ± 1.176
4.956AlaArg: 4.956 ± 0.743
5.221AlaSer: 5.221 ± 0.767
6.46AlaThr: 6.46 ± 0.635
4.513AlaVal: 4.513 ± 0.592
1.947AlaTrp: 1.947 ± 0.38
2.478AlaTyr: 2.478 ± 0.514
0.0AlaXaa: 0.0 ± 0.0
Cys
1.327CysAla: 1.327 ± 0.331
0.177CysCys: 0.177 ± 0.124
0.796CysAsp: 0.796 ± 0.219
0.885CysGlu: 0.885 ± 0.3
0.442CysPhe: 0.442 ± 0.19
1.062CysGly: 1.062 ± 0.314
0.531CysHis: 0.531 ± 0.229
0.619CysIle: 0.619 ± 0.241
0.708CysLys: 0.708 ± 0.246
0.796CysLeu: 0.796 ± 0.297
0.265CysMet: 0.265 ± 0.136
0.088CysAsn: 0.088 ± 0.097
0.708CysPro: 0.708 ± 0.246
0.442CysGln: 0.442 ± 0.184
1.062CysArg: 1.062 ± 0.343
0.973CysSer: 0.973 ± 0.295
0.177CysThr: 0.177 ± 0.114
0.619CysVal: 0.619 ± 0.241
0.088CysTrp: 0.088 ± 0.095
0.265CysTyr: 0.265 ± 0.198
0.0CysXaa: 0.0 ± 0.0
Asp
6.372AspAla: 6.372 ± 0.823
0.619AspCys: 0.619 ± 0.216
4.69AspAsp: 4.69 ± 0.724
2.92AspGlu: 2.92 ± 0.556
2.301AspPhe: 2.301 ± 0.343
3.982AspGly: 3.982 ± 0.603
0.796AspHis: 0.796 ± 0.241
4.071AspIle: 4.071 ± 0.583
3.717AspLys: 3.717 ± 0.703
3.717AspLeu: 3.717 ± 0.462
1.947AspMet: 1.947 ± 0.446
2.743AspAsn: 2.743 ± 0.486
2.124AspPro: 2.124 ± 0.54
1.504AspGln: 1.504 ± 0.333
2.832AspArg: 2.832 ± 0.505
3.894AspSer: 3.894 ± 0.592
1.947AspThr: 1.947 ± 0.446
4.159AspVal: 4.159 ± 0.683
0.973AspTrp: 0.973 ± 0.285
3.186AspTyr: 3.186 ± 0.603
0.0AspXaa: 0.0 ± 0.0
Glu
5.841GluAla: 5.841 ± 0.864
0.796GluCys: 0.796 ± 0.223
2.566GluAsp: 2.566 ± 0.395
3.982GluGlu: 3.982 ± 0.662
2.478GluPhe: 2.478 ± 0.556
3.717GluGly: 3.717 ± 0.476
0.885GluHis: 0.885 ± 0.282
4.248GluIle: 4.248 ± 0.492
4.867GluLys: 4.867 ± 0.783
6.46GluLeu: 6.46 ± 0.805
1.77GluMet: 1.77 ± 0.407
3.009GluAsn: 3.009 ± 0.671
1.858GluPro: 1.858 ± 0.416
3.54GluGln: 3.54 ± 0.73
3.717GluArg: 3.717 ± 0.635
4.602GluSer: 4.602 ± 0.644
3.274GluThr: 3.274 ± 0.699
3.451GluVal: 3.451 ± 0.644
0.885GluTrp: 0.885 ± 0.29
2.478GluTyr: 2.478 ± 0.595
0.0GluXaa: 0.0 ± 0.0
Phe
2.566PheAla: 2.566 ± 0.521
0.619PheCys: 0.619 ± 0.262
3.009PheAsp: 3.009 ± 0.491
1.947PheGlu: 1.947 ± 0.43
0.973PhePhe: 0.973 ± 0.333
2.478PheGly: 2.478 ± 0.455
0.531PheHis: 0.531 ± 0.182
2.655PheIle: 2.655 ± 0.63
1.947PheLys: 1.947 ± 0.372
2.389PheLeu: 2.389 ± 0.506
1.327PheMet: 1.327 ± 0.354
1.327PheAsn: 1.327 ± 0.295
1.15PhePro: 1.15 ± 0.287
1.239PheGln: 1.239 ± 0.388
1.593PheArg: 1.593 ± 0.51
2.566PheSer: 2.566 ± 0.498
2.832PheThr: 2.832 ± 0.491
2.035PheVal: 2.035 ± 0.419
0.265PheTrp: 0.265 ± 0.129
1.504PheTyr: 1.504 ± 0.524
0.0PheXaa: 0.0 ± 0.0
Gly
6.903GlyAla: 6.903 ± 1.155
0.708GlyCys: 0.708 ± 0.218
4.159GlyAsp: 4.159 ± 0.714
4.336GlyGlu: 4.336 ± 0.643
2.92GlyPhe: 2.92 ± 0.462
5.31GlyGly: 5.31 ± 1.036
1.15GlyHis: 1.15 ± 0.448
5.133GlyIle: 5.133 ± 0.68
5.133GlyLys: 5.133 ± 0.629
5.133GlyLeu: 5.133 ± 0.757
2.389GlyMet: 2.389 ± 0.518
3.097GlyAsn: 3.097 ± 0.49
0.885GlyPro: 0.885 ± 0.2
3.982GlyGln: 3.982 ± 0.736
4.779GlyArg: 4.779 ± 0.722
4.867GlySer: 4.867 ± 0.74
3.982GlyThr: 3.982 ± 0.53
4.248GlyVal: 4.248 ± 0.818
0.796GlyTrp: 0.796 ± 0.377
2.832GlyTyr: 2.832 ± 0.584
0.0GlyXaa: 0.0 ± 0.0
His
1.504HisAla: 1.504 ± 0.424
0.619HisCys: 0.619 ± 0.237
0.885HisAsp: 0.885 ± 0.318
1.327HisGlu: 1.327 ± 0.331
0.531HisPhe: 0.531 ± 0.221
1.681HisGly: 1.681 ± 0.392
0.177HisHis: 0.177 ± 0.141
1.062HisIle: 1.062 ± 0.274
1.15HisLys: 1.15 ± 0.329
0.973HisLeu: 0.973 ± 0.362
0.531HisMet: 0.531 ± 0.214
0.177HisAsn: 0.177 ± 0.128
0.619HisPro: 0.619 ± 0.211
0.796HisGln: 0.796 ± 0.276
0.708HisArg: 0.708 ± 0.257
1.15HisSer: 1.15 ± 0.396
0.442HisThr: 0.442 ± 0.206
0.796HisVal: 0.796 ± 0.304
0.177HisTrp: 0.177 ± 0.12
0.531HisTyr: 0.531 ± 0.217
0.0HisXaa: 0.0 ± 0.0
Ile
7.345IleAla: 7.345 ± 1.047
1.15IleCys: 1.15 ± 0.298
3.982IleAsp: 3.982 ± 0.441
4.248IleGlu: 4.248 ± 0.472
1.327IlePhe: 1.327 ± 0.535
4.867IleGly: 4.867 ± 0.757
1.327IleHis: 1.327 ± 0.324
3.894IleIle: 3.894 ± 0.739
3.451IleLys: 3.451 ± 0.59
4.779IleLeu: 4.779 ± 0.627
1.062IleMet: 1.062 ± 0.333
3.274IleAsn: 3.274 ± 0.409
2.832IlePro: 2.832 ± 0.439
2.92IleGln: 2.92 ± 0.516
3.982IleArg: 3.982 ± 0.575
3.717IleSer: 3.717 ± 0.558
5.398IleThr: 5.398 ± 0.635
2.655IleVal: 2.655 ± 0.436
0.531IleTrp: 0.531 ± 0.264
2.566IleTyr: 2.566 ± 0.664
0.0IleXaa: 0.0 ± 0.0
Lys
6.549LysAla: 6.549 ± 1.308
0.619LysCys: 0.619 ± 0.268
2.301LysAsp: 2.301 ± 0.381
4.425LysGlu: 4.425 ± 0.719
2.655LysPhe: 2.655 ± 0.476
3.54LysGly: 3.54 ± 0.668
0.885LysHis: 0.885 ± 0.274
4.071LysIle: 4.071 ± 0.661
4.248LysLys: 4.248 ± 0.748
4.867LysLeu: 4.867 ± 0.745
2.212LysMet: 2.212 ± 0.424
3.097LysAsn: 3.097 ± 0.504
3.628LysPro: 3.628 ± 0.649
2.743LysGln: 2.743 ± 0.611
3.54LysArg: 3.54 ± 0.718
3.894LysSer: 3.894 ± 0.553
2.478LysThr: 2.478 ± 0.406
3.274LysVal: 3.274 ± 0.61
0.619LysTrp: 0.619 ± 0.205
2.832LysTyr: 2.832 ± 0.545
0.0LysXaa: 0.0 ± 0.0
Leu
9.204LeuAla: 9.204 ± 0.929
0.619LeuCys: 0.619 ± 0.237
4.071LeuAsp: 4.071 ± 0.67
6.195LeuGlu: 6.195 ± 0.831
2.478LeuPhe: 2.478 ± 0.423
4.159LeuGly: 4.159 ± 0.757
1.15LeuHis: 1.15 ± 0.361
4.425LeuIle: 4.425 ± 0.955
4.602LeuLys: 4.602 ± 0.876
5.752LeuLeu: 5.752 ± 0.935
1.858LeuMet: 1.858 ± 0.415
3.186LeuAsn: 3.186 ± 0.445
3.628LeuPro: 3.628 ± 0.615
2.566LeuGln: 2.566 ± 0.389
5.575LeuArg: 5.575 ± 0.678
6.195LeuSer: 6.195 ± 0.682
4.779LeuThr: 4.779 ± 0.58
4.248LeuVal: 4.248 ± 0.601
0.708LeuTrp: 0.708 ± 0.198
2.389LeuTyr: 2.389 ± 0.57
0.0LeuXaa: 0.0 ± 0.0
Met
3.628MetAla: 3.628 ± 0.574
0.177MetCys: 0.177 ± 0.14
1.15MetAsp: 1.15 ± 0.359
1.504MetGlu: 1.504 ± 0.366
1.239MetPhe: 1.239 ± 0.414
1.504MetGly: 1.504 ± 0.458
0.531MetHis: 0.531 ± 0.228
1.504MetIle: 1.504 ± 0.348
1.77MetLys: 1.77 ± 0.373
2.389MetLeu: 2.389 ± 0.474
0.796MetMet: 0.796 ± 0.269
1.15MetAsn: 1.15 ± 0.36
1.681MetPro: 1.681 ± 0.381
1.947MetGln: 1.947 ± 0.427
1.593MetArg: 1.593 ± 0.311
2.655MetSer: 2.655 ± 0.466
1.858MetThr: 1.858 ± 0.378
1.239MetVal: 1.239 ± 0.36
0.177MetTrp: 0.177 ± 0.127
0.531MetTyr: 0.531 ± 0.231
0.0MetXaa: 0.0 ± 0.0
Asn
4.425AsnAla: 4.425 ± 0.719
0.796AsnCys: 0.796 ± 0.369
2.212AsnAsp: 2.212 ± 0.444
3.451AsnGlu: 3.451 ± 0.581
0.708AsnPhe: 0.708 ± 0.212
4.867AsnGly: 4.867 ± 0.794
0.973AsnHis: 0.973 ± 0.339
3.186AsnIle: 3.186 ± 0.497
2.832AsnLys: 2.832 ± 0.43
3.363AsnLeu: 3.363 ± 0.71
0.708AsnMet: 0.708 ± 0.238
2.389AsnAsn: 2.389 ± 0.618
2.389AsnPro: 2.389 ± 0.627
2.035AsnGln: 2.035 ± 0.359
2.124AsnArg: 2.124 ± 0.456
2.389AsnSer: 2.389 ± 0.473
2.035AsnThr: 2.035 ± 0.433
3.186AsnVal: 3.186 ± 0.754
0.177AsnTrp: 0.177 ± 0.132
1.416AsnTyr: 1.416 ± 0.354
0.0AsnXaa: 0.0 ± 0.0
Pro
3.54ProAla: 3.54 ± 0.601
0.0ProCys: 0.0 ± 0.0
2.301ProAsp: 2.301 ± 0.481
3.717ProGlu: 3.717 ± 0.746
1.858ProPhe: 1.858 ± 0.517
2.743ProGly: 2.743 ± 0.506
0.619ProHis: 0.619 ± 0.284
1.947ProIle: 1.947 ± 0.415
2.566ProLys: 2.566 ± 0.544
2.743ProLeu: 2.743 ± 0.462
1.416ProMet: 1.416 ± 0.405
1.416ProAsn: 1.416 ± 0.397
1.15ProPro: 1.15 ± 0.335
1.239ProGln: 1.239 ± 0.378
1.062ProArg: 1.062 ± 0.292
2.92ProSer: 2.92 ± 0.495
1.681ProThr: 1.681 ± 0.438
3.274ProVal: 3.274 ± 0.514
0.265ProTrp: 0.265 ± 0.175
0.885ProTyr: 0.885 ± 0.236
0.0ProXaa: 0.0 ± 0.0
Gln
4.779GlnAla: 4.779 ± 0.912
0.354GlnCys: 0.354 ± 0.143
1.858GlnAsp: 1.858 ± 0.419
2.301GlnGlu: 2.301 ± 0.58
2.124GlnPhe: 2.124 ± 0.44
2.832GlnGly: 2.832 ± 0.581
0.442GlnHis: 0.442 ± 0.195
2.832GlnIle: 2.832 ± 0.481
2.743GlnLys: 2.743 ± 0.513
4.248GlnLeu: 4.248 ± 0.676
1.504GlnMet: 1.504 ± 0.381
1.858GlnAsn: 1.858 ± 0.444
2.035GlnPro: 2.035 ± 0.43
4.867GlnGln: 4.867 ± 1.2
3.097GlnArg: 3.097 ± 0.525
2.301GlnSer: 2.301 ± 0.512
2.389GlnThr: 2.389 ± 0.475
1.947GlnVal: 1.947 ± 0.439
0.796GlnTrp: 0.796 ± 0.303
1.947GlnTyr: 1.947 ± 0.442
0.0GlnXaa: 0.0 ± 0.0
Arg
4.159ArgAla: 4.159 ± 0.49
0.796ArgCys: 0.796 ± 0.292
2.92ArgAsp: 2.92 ± 0.625
4.248ArgGlu: 4.248 ± 0.702
1.77ArgPhe: 1.77 ± 0.333
3.894ArgGly: 3.894 ± 0.623
1.239ArgHis: 1.239 ± 0.333
3.717ArgIle: 3.717 ± 0.529
4.602ArgLys: 4.602 ± 0.825
3.982ArgLeu: 3.982 ± 0.633
2.566ArgMet: 2.566 ± 0.433
3.363ArgAsn: 3.363 ± 0.522
1.504ArgPro: 1.504 ± 0.414
2.212ArgGln: 2.212 ± 0.384
3.717ArgArg: 3.717 ± 0.672
3.186ArgSer: 3.186 ± 0.603
1.504ArgThr: 1.504 ± 0.406
3.451ArgVal: 3.451 ± 0.651
0.885ArgTrp: 0.885 ± 0.268
2.478ArgTyr: 2.478 ± 0.389
0.0ArgXaa: 0.0 ± 0.0
Ser
4.69SerAla: 4.69 ± 0.767
0.973SerCys: 0.973 ± 0.39
4.425SerAsp: 4.425 ± 0.511
3.54SerGlu: 3.54 ± 0.634
2.389SerPhe: 2.389 ± 0.467
6.814SerGly: 6.814 ± 0.856
0.619SerHis: 0.619 ± 0.201
3.54SerIle: 3.54 ± 0.633
2.743SerLys: 2.743 ± 0.57
6.549SerLeu: 6.549 ± 0.761
2.124SerMet: 2.124 ± 0.564
3.451SerAsn: 3.451 ± 0.614
2.832SerPro: 2.832 ± 0.462
3.54SerGln: 3.54 ± 0.552
3.186SerArg: 3.186 ± 0.626
4.248SerSer: 4.248 ± 0.906
2.301SerThr: 2.301 ± 0.462
5.221SerVal: 5.221 ± 0.706
0.796SerTrp: 0.796 ± 0.239
1.947SerTyr: 1.947 ± 0.557
0.0SerXaa: 0.0 ± 0.0
Thr
4.69ThrAla: 4.69 ± 0.686
0.265ThrCys: 0.265 ± 0.161
3.628ThrAsp: 3.628 ± 0.542
2.743ThrGlu: 2.743 ± 0.49
1.681ThrPhe: 1.681 ± 0.463
4.779ThrGly: 4.779 ± 0.797
0.354ThrHis: 0.354 ± 0.193
3.805ThrIle: 3.805 ± 0.626
3.274ThrLys: 3.274 ± 0.488
3.186ThrLeu: 3.186 ± 0.481
1.239ThrMet: 1.239 ± 0.316
1.858ThrAsn: 1.858 ± 0.357
2.566ThrPro: 2.566 ± 0.446
2.124ThrGln: 2.124 ± 0.364
2.124ThrArg: 2.124 ± 0.372
3.097ThrSer: 3.097 ± 0.537
2.389ThrThr: 2.389 ± 0.434
4.779ThrVal: 4.779 ± 0.771
0.531ThrTrp: 0.531 ± 0.201
2.035ThrTyr: 2.035 ± 0.417
0.0ThrXaa: 0.0 ± 0.0
Val
4.867ValAla: 4.867 ± 0.577
0.973ValCys: 0.973 ± 0.299
2.832ValAsp: 2.832 ± 0.551
3.894ValGlu: 3.894 ± 0.544
1.858ValPhe: 1.858 ± 0.432
4.867ValGly: 4.867 ± 0.673
0.885ValHis: 0.885 ± 0.242
4.513ValIle: 4.513 ± 0.62
3.097ValLys: 3.097 ± 0.445
5.398ValLeu: 5.398 ± 0.595
1.504ValMet: 1.504 ± 0.347
3.097ValAsn: 3.097 ± 0.57
2.124ValPro: 2.124 ± 0.482
2.212ValGln: 2.212 ± 0.341
3.009ValArg: 3.009 ± 0.429
4.867ValSer: 4.867 ± 0.829
3.54ValThr: 3.54 ± 0.705
3.717ValVal: 3.717 ± 0.603
0.708ValTrp: 0.708 ± 0.222
2.124ValTyr: 2.124 ± 0.659
0.0ValXaa: 0.0 ± 0.0
Trp
1.416TrpAla: 1.416 ± 0.374
0.354TrpCys: 0.354 ± 0.175
0.796TrpAsp: 0.796 ± 0.31
0.531TrpGlu: 0.531 ± 0.298
0.531TrpPhe: 0.531 ± 0.295
0.442TrpGly: 0.442 ± 0.183
0.177TrpHis: 0.177 ± 0.129
0.442TrpIle: 0.442 ± 0.249
0.796TrpLys: 0.796 ± 0.237
1.681TrpLeu: 1.681 ± 0.359
0.531TrpMet: 0.531 ± 0.229
0.088TrpAsn: 0.088 ± 0.085
0.354TrpPro: 0.354 ± 0.178
0.442TrpGln: 0.442 ± 0.201
1.062TrpArg: 1.062 ± 0.305
0.796TrpSer: 0.796 ± 0.273
0.177TrpThr: 0.177 ± 0.132
0.796TrpVal: 0.796 ± 0.31
0.265TrpTrp: 0.265 ± 0.157
0.265TrpTyr: 0.265 ± 0.143
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.54TyrAla: 3.54 ± 0.539
0.708TyrCys: 0.708 ± 0.21
2.92TyrAsp: 2.92 ± 0.636
1.947TyrGlu: 1.947 ± 0.448
1.062TyrPhe: 1.062 ± 0.266
2.478TyrGly: 2.478 ± 0.541
0.442TyrHis: 0.442 ± 0.189
1.858TyrIle: 1.858 ± 0.411
1.593TyrLys: 1.593 ± 0.368
2.832TyrLeu: 2.832 ± 0.384
0.531TyrMet: 0.531 ± 0.211
2.301TyrAsn: 2.301 ± 0.587
0.973TyrPro: 0.973 ± 0.276
2.301TyrGln: 2.301 ± 0.455
2.478TyrArg: 2.478 ± 0.466
2.389TyrSer: 2.389 ± 0.574
1.504TyrThr: 1.504 ± 0.351
2.478TyrVal: 2.478 ± 0.482
0.354TyrTrp: 0.354 ± 0.179
0.619TyrTyr: 0.619 ± 0.227
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 58 proteins (11301 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski