Amino acid dipepetide frequency for Prosthecochloris aestuarii (strain DSM 271 / SK 413)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.279AlaAla: 8.279 ± 0.152	1.036AlaCys: 1.036 ± 0.044	4.585AlaAsp: 4.585 ± 0.149	5.851AlaGlu: 5.851 ± 0.103	3.48AlaPhe: 3.48 ± 0.076	7.031AlaGly: 7.031 ± 0.11	1.523AlaHis: 1.523 ± 0.045	5.482AlaIle: 5.482 ± 0.091	3.413AlaLys: 3.413 ± 0.089	9.575AlaLeu: 9.575 ± 0.155	2.454AlaMet: 2.454 ± 0.054	2.262AlaAsn: 2.262 ± 0.062	2.786AlaPro: 2.786 ± 0.063	2.303AlaGln: 2.303 ± 0.061	4.794AlaArg: 4.794 ± 0.108	5.52AlaSer: 5.52 ± 0.094	3.973AlaThr: 3.973 ± 0.157	6.398AlaVal: 6.398 ± 0.112	0.945AlaTrp: 0.945 ± 0.041	2.217AlaTyr: 2.217 ± 0.059	0.0AlaXaa: 0.0 ± 0.0
Cys	0.819CysAla: 0.819 ± 0.038	0.215CysCys: 0.215 ± 0.021	0.698CysAsp: 0.698 ± 0.032	0.537CysGlu: 0.537 ± 0.031	0.519CysPhe: 0.519 ± 0.03	1.123CysGly: 1.123 ± 0.043	0.298CysHis: 0.298 ± 0.025	0.699CysIle: 0.699 ± 0.034	0.404CysLys: 0.404 ± 0.021	0.942CysLeu: 0.942 ± 0.039	0.277CysMet: 0.277 ± 0.019	0.472CysAsn: 0.472 ± 0.026	0.59CysPro: 0.59 ± 0.034	0.406CysGln: 0.406 ± 0.026	0.849CysArg: 0.849 ± 0.042	0.913CysSer: 0.913 ± 0.037	0.477CysThr: 0.477 ± 0.03	0.721CysVal: 0.721 ± 0.031	0.13CysTrp: 0.13 ± 0.014	0.328CysTyr: 0.328 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	5.107AspAla: 5.107 ± 0.114	0.599AspCys: 0.599 ± 0.027	3.345AspAsp: 3.345 ± 0.143	4.126AspGlu: 4.126 ± 0.084	2.648AspPhe: 2.648 ± 0.061	4.111AspGly: 4.111 ± 0.202	1.265AspHis: 1.265 ± 0.056	4.36AspIle: 4.36 ± 0.082	2.414AspLys: 2.414 ± 0.059	5.295AspLeu: 5.295 ± 0.093	1.465AspMet: 1.465 ± 0.049	2.152AspAsn: 2.152 ± 0.06	2.639AspPro: 2.639 ± 0.096	1.614AspGln: 1.614 ± 0.062	3.576AspArg: 3.576 ± 0.088	3.239AspSer: 3.239 ± 0.101	2.857AspThr: 2.857 ± 0.187	3.789AspVal: 3.789 ± 0.081	0.61AspTrp: 0.61 ± 0.029	1.925AspTyr: 1.925 ± 0.054	0.0AspXaa: 0.0 ± 0.0
Glu	5.647GluAla: 5.647 ± 0.091	0.608GluCys: 0.608 ± 0.034	3.052GluAsp: 3.052 ± 0.11	5.092GluGlu: 5.092 ± 0.105	2.334GluPhe: 2.334 ± 0.049	4.195GluGly: 4.195 ± 0.1	1.647GluHis: 1.647 ± 0.05	4.469GluIle: 4.469 ± 0.089	4.833GluLys: 4.833 ± 0.103	6.782GluLeu: 6.782 ± 0.1	1.68GluMet: 1.68 ± 0.059	2.698GluAsn: 2.698 ± 0.095	2.464GluPro: 2.464 ± 0.065	2.85GluGln: 2.85 ± 0.077	4.183GluArg: 4.183 ± 0.09	3.861GluSer: 3.861 ± 0.068	3.382GluThr: 3.382 ± 0.075	3.968GluVal: 3.968 ± 0.097	0.733GluTrp: 0.733 ± 0.034	1.948GluTyr: 1.948 ± 0.058	0.0GluXaa: 0.0 ± 0.0
Phe	3.208PheAla: 3.208 ± 0.065	0.603PheCys: 0.603 ± 0.031	2.738PheAsp: 2.738 ± 0.069	2.422PheGlu: 2.422 ± 0.055	2.251PhePhe: 2.251 ± 0.074	3.257PheGly: 3.257 ± 0.083	0.91PheHis: 0.91 ± 0.036	2.731PheIle: 2.731 ± 0.068	1.557PheLys: 1.557 ± 0.051	4.211PheLeu: 4.211 ± 0.102	1.08PheMet: 1.08 ± 0.038	1.64PheAsn: 1.64 ± 0.047	1.703PhePro: 1.703 ± 0.054	1.187PheGln: 1.187 ± 0.044	2.564PheArg: 2.564 ± 0.065	3.885PheSer: 3.885 ± 0.081	2.346PheThr: 2.346 ± 0.135	2.679PheVal: 2.679 ± 0.064	0.525PheTrp: 0.525 ± 0.03	1.358PheTyr: 1.358 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	5.609GlyAla: 5.609 ± 0.113	0.971GlyCys: 0.971 ± 0.041	3.877GlyAsp: 3.877 ± 0.125	4.374GlyGlu: 4.374 ± 0.098	3.595GlyPhe: 3.595 ± 0.077	5.565GlyGly: 5.565 ± 0.104	1.58GlyHis: 1.58 ± 0.049	5.528GlyIle: 5.528 ± 0.089	4.202GlyLys: 4.202 ± 0.086	6.976GlyLeu: 6.976 ± 0.141	2.188GlyMet: 2.188 ± 0.058	2.608GlyAsn: 2.608 ± 0.07	2.136GlyPro: 2.136 ± 0.059	2.061GlyGln: 2.061 ± 0.06	4.174GlyArg: 4.174 ± 0.095	5.226GlySer: 5.226 ± 0.12	4.011GlyThr: 4.011 ± 0.127	5.239GlyVal: 5.239 ± 0.101	0.888GlyTrp: 0.888 ± 0.04	2.807GlyTyr: 2.807 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	1.806HisAla: 1.806 ± 0.054	0.302HisCys: 0.302 ± 0.02	1.314HisAsp: 1.314 ± 0.046	1.529HisGlu: 1.529 ± 0.053	0.981HisPhe: 0.981 ± 0.038	1.573HisGly: 1.573 ± 0.05	0.646HisHis: 0.646 ± 0.039	1.446HisIle: 1.446 ± 0.044	0.841HisLys: 0.841 ± 0.038	2.135HisLeu: 2.135 ± 0.06	0.487HisMet: 0.487 ± 0.024	0.837HisAsn: 0.837 ± 0.035	1.269HisPro: 1.269 ± 0.048	0.758HisGln: 0.758 ± 0.034	1.286HisArg: 1.286 ± 0.047	1.305HisSer: 1.305 ± 0.044	1.103HisThr: 1.103 ± 0.043	1.334HisVal: 1.334 ± 0.048	0.253HisTrp: 0.253 ± 0.02	0.837HisTyr: 0.837 ± 0.034	0.0HisXaa: 0.0 ± 0.0
Ile	6.593IleAla: 6.593 ± 0.123	0.77IleCys: 0.77 ± 0.037	4.782IleAsp: 4.782 ± 0.103	4.822IleGlu: 4.822 ± 0.089	2.547IlePhe: 2.547 ± 0.064	5.104IleGly: 5.104 ± 0.105	1.258IleHis: 1.258 ± 0.048	4.283IleIle: 4.283 ± 0.089	2.575IleLys: 2.575 ± 0.072	5.628IleLeu: 5.628 ± 0.104	1.448IleMet: 1.448 ± 0.044	2.368IleAsn: 2.368 ± 0.059	2.916IlePro: 2.916 ± 0.063	1.83IleGln: 1.83 ± 0.058	4.037IleArg: 4.037 ± 0.093	4.624IleSer: 4.624 ± 0.087	3.54IleThr: 3.54 ± 0.09	4.762IleVal: 4.762 ± 0.081	0.56IleTrp: 0.56 ± 0.028	1.801IleTyr: 1.801 ± 0.058	0.0IleXaa: 0.0 ± 0.0
Lys	4.516LysAla: 4.516 ± 0.092	0.329LysCys: 0.329 ± 0.023	2.392LysAsp: 2.392 ± 0.065	3.837LysGlu: 3.837 ± 0.094	1.35LysPhe: 1.35 ± 0.046	3.634LysGly: 3.634 ± 0.083	1.035LysHis: 1.035 ± 0.042	3.309LysIle: 3.309 ± 0.077	3.946LysLys: 3.946 ± 0.098	4.258LysLeu: 4.258 ± 0.097	1.201LysMet: 1.201 ± 0.043	2.306LysAsn: 2.306 ± 0.06	2.298LysPro: 2.298 ± 0.062	1.876LysGln: 1.876 ± 0.062	2.811LysArg: 2.811 ± 0.066	2.989LysSer: 2.989 ± 0.07	3.072LysThr: 3.072 ± 0.079	3.245LysVal: 3.245 ± 0.069	0.448LysTrp: 0.448 ± 0.031	1.353LysTyr: 1.353 ± 0.049	0.0LysXaa: 0.0 ± 0.0
Leu	8.104LeuAla: 8.104 ± 0.111	1.231LeuCys: 1.231 ± 0.048	6.052LeuAsp: 6.052 ± 0.097	6.355LeuGlu: 6.355 ± 0.127	4.683LeuPhe: 4.683 ± 0.1	6.523LeuGly: 6.523 ± 0.108	2.369LeuHis: 2.369 ± 0.06	5.798LeuIle: 5.798 ± 0.111	5.569LeuLys: 5.569 ± 0.095	10.608LeuLeu: 10.608 ± 0.191	2.563LeuMet: 2.563 ± 0.069	3.644LeuAsn: 3.644 ± 0.069	4.496LeuPro: 4.496 ± 0.083	4.112LeuGln: 4.112 ± 0.095	5.388LeuArg: 5.388 ± 0.116	7.369LeuSer: 7.369 ± 0.128	4.861LeuThr: 4.861 ± 0.108	6.529LeuVal: 6.529 ± 0.098	0.929LeuTrp: 0.929 ± 0.039	2.9LeuTyr: 2.9 ± 0.069	0.0LeuXaa: 0.0 ± 0.0
Met	2.152MetAla: 2.152 ± 0.063	0.198MetCys: 0.198 ± 0.016	1.176MetAsp: 1.176 ± 0.039	1.44MetGlu: 1.44 ± 0.044	0.894MetPhe: 0.894 ± 0.038	1.659MetGly: 1.659 ± 0.05	0.656MetHis: 0.656 ± 0.03	1.725MetIle: 1.725 ± 0.051	1.84MetLys: 1.84 ± 0.051	2.952MetLeu: 2.952 ± 0.063	0.825MetMet: 0.825 ± 0.033	1.194MetAsn: 1.194 ± 0.045	1.297MetPro: 1.297 ± 0.04	1.196MetGln: 1.196 ± 0.046	1.394MetArg: 1.394 ± 0.046	1.747MetSer: 1.747 ± 0.053	1.564MetThr: 1.564 ± 0.044	1.848MetVal: 1.848 ± 0.05	0.147MetTrp: 0.147 ± 0.013	0.503MetTyr: 0.503 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	3.128AsnAla: 3.128 ± 0.078	0.416AsnCys: 0.416 ± 0.024	2.163AsnAsp: 2.163 ± 0.081	2.168AsnGlu: 2.168 ± 0.057	1.332AsnPhe: 1.332 ± 0.04	2.765AsnGly: 2.765 ± 0.063	0.731AsnHis: 0.731 ± 0.031	2.827AsnIle: 2.827 ± 0.062	1.52AsnLys: 1.52 ± 0.05	3.409AsnLeu: 3.409 ± 0.075	0.882AsnMet: 0.882 ± 0.036	1.521AsnAsn: 1.521 ± 0.061	2.247AsnPro: 2.247 ± 0.06	1.027AsnGln: 1.027 ± 0.038	2.306AsnArg: 2.306 ± 0.067	1.987AsnSer: 1.987 ± 0.061	2.0AsnThr: 2.0 ± 0.065	2.405AsnVal: 2.405 ± 0.064	0.434AsnTrp: 0.434 ± 0.024	1.107AsnTyr: 1.107 ± 0.042	0.0AsnXaa: 0.0 ± 0.0
Pro	3.43ProAla: 3.43 ± 0.082	0.388ProCys: 0.388 ± 0.022	3.309ProAsp: 3.309 ± 0.092	4.076ProGlu: 4.076 ± 0.079	1.901ProPhe: 1.901 ± 0.054	3.445ProGly: 3.445 ± 0.069	0.893ProHis: 0.893 ± 0.037	1.846ProIle: 1.846 ± 0.046	1.588ProLys: 1.588 ± 0.052	4.346ProLeu: 4.346 ± 0.083	0.908ProMet: 0.908 ± 0.034	1.098ProAsn: 1.098 ± 0.045	1.591ProPro: 1.591 ± 0.061	1.306ProGln: 1.306 ± 0.043	1.575ProArg: 1.575 ± 0.054	2.948ProSer: 2.948 ± 0.064	1.569ProThr: 1.569 ± 0.054	3.904ProVal: 3.904 ± 0.076	0.511ProTrp: 0.511 ± 0.027	1.266ProTyr: 1.266 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	2.953GlnAla: 2.953 ± 0.076	0.362GlnCys: 0.362 ± 0.023	1.69GlnAsp: 1.69 ± 0.044	2.544GlnGlu: 2.544 ± 0.056	1.168GlnPhe: 1.168 ± 0.038	2.057GlnGly: 2.057 ± 0.056	0.905GlnHis: 0.905 ± 0.034	2.009GlnIle: 2.009 ± 0.059	2.188GlnLys: 2.188 ± 0.074	3.273GlnLeu: 3.273 ± 0.083	0.932GlnMet: 0.932 ± 0.039	1.392GlnAsn: 1.392 ± 0.048	1.319GlnPro: 1.319 ± 0.045	1.845GlnGln: 1.845 ± 0.069	2.027GlnArg: 2.027 ± 0.061	2.239GlnSer: 2.239 ± 0.057	1.675GlnThr: 1.675 ± 0.056	2.004GlnVal: 2.004 ± 0.055	0.409GlnTrp: 0.409 ± 0.023	0.977GlnTyr: 0.977 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	3.774ArgAla: 3.774 ± 0.083	0.595ArgCys: 0.595 ± 0.03	3.164ArgAsp: 3.164 ± 0.077	4.199ArgGlu: 4.199 ± 0.092	2.844ArgPhe: 2.844 ± 0.065	3.092ArgGly: 3.092 ± 0.073	1.533ArgHis: 1.533 ± 0.054	4.048ArgIle: 4.048 ± 0.091	3.719ArgLys: 3.719 ± 0.097	5.893ArgLeu: 5.893 ± 0.126	1.62ArgMet: 1.62 ± 0.05	2.315ArgAsn: 2.315 ± 0.062	2.096ArgPro: 2.096 ± 0.054	2.644ArgGln: 2.644 ± 0.069	3.306ArgArg: 3.306 ± 0.1	3.85ArgSer: 3.85 ± 0.086	2.798ArgThr: 2.798 ± 0.07	3.544ArgVal: 3.544 ± 0.086	0.636ArgTrp: 0.636 ± 0.033	2.315ArgTyr: 2.315 ± 0.065	0.0ArgXaa: 0.0 ± 0.0
Ser	5.623SerAla: 5.623 ± 0.104	0.905SerCys: 0.905 ± 0.044	3.679SerAsp: 3.679 ± 0.115	3.643SerGlu: 3.643 ± 0.074	3.061SerPhe: 3.061 ± 0.065	6.214SerGly: 6.214 ± 0.168	1.456SerHis: 1.456 ± 0.053	4.56SerIle: 4.56 ± 0.083	2.731SerLys: 2.731 ± 0.064	6.91SerLeu: 6.91 ± 0.119	1.983SerMet: 1.983 ± 0.055	2.156SerAsn: 2.156 ± 0.057	2.835SerPro: 2.835 ± 0.066	1.916SerGln: 1.916 ± 0.05	4.239SerArg: 4.239 ± 0.095	5.084SerSer: 5.084 ± 0.098	3.136SerThr: 3.136 ± 0.065	4.833SerVal: 4.833 ± 0.114	0.815SerTrp: 0.815 ± 0.037	2.037SerTyr: 2.037 ± 0.086	0.0SerXaa: 0.0 ± 0.0
Thr	4.421ThrAla: 4.421 ± 0.124	0.511ThrCys: 0.511 ± 0.028	2.696ThrAsp: 2.696 ± 0.106	2.827ThrGlu: 2.827 ± 0.073	2.155ThrPhe: 2.155 ± 0.059	4.977ThrGly: 4.977 ± 0.183	0.937ThrHis: 0.937 ± 0.035	3.785ThrIle: 3.785 ± 0.104	1.914ThrLys: 1.914 ± 0.064	5.567ThrLeu: 5.567 ± 0.108	1.384ThrMet: 1.384 ± 0.041	1.576ThrAsn: 1.576 ± 0.062	2.583ThrPro: 2.583 ± 0.062	1.254ThrGln: 1.254 ± 0.038	2.584ThrArg: 2.584 ± 0.061	3.211ThrSer: 3.211 ± 0.074	2.981ThrThr: 2.981 ± 0.111	4.049ThrVal: 4.049 ± 0.259	0.523ThrTrp: 0.523 ± 0.025	1.553ThrTyr: 1.553 ± 0.068	0.0ThrXaa: 0.0 ± 0.0
Val	5.605ValAla: 5.605 ± 0.129	0.857ValCys: 0.857 ± 0.035	3.905ValAsp: 3.905 ± 0.093	4.156ValGlu: 4.156 ± 0.086	3.242ValPhe: 3.242 ± 0.073	4.194ValGly: 4.194 ± 0.092	1.397ValHis: 1.397 ± 0.044	4.897ValIle: 4.897 ± 0.093	3.033ValLys: 3.033 ± 0.079	7.027ValLeu: 7.027 ± 0.099	1.976ValMet: 1.976 ± 0.057	2.516ValAsn: 2.516 ± 0.065	2.837ValPro: 2.837 ± 0.075	2.184ValGln: 2.184 ± 0.079	3.964ValArg: 3.964 ± 0.082	5.089ValSer: 5.089 ± 0.094	4.015ValThr: 4.015 ± 0.135	5.13ValVal: 5.13 ± 0.104	0.702ValTrp: 0.702 ± 0.032	2.019ValTyr: 2.019 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	0.715TrpAla: 0.715 ± 0.035	0.122TrpCys: 0.122 ± 0.014	0.574TrpAsp: 0.574 ± 0.03	0.578TrpGlu: 0.578 ± 0.026	0.527TrpPhe: 0.527 ± 0.024	0.675TrpGly: 0.675 ± 0.032	0.259TrpHis: 0.259 ± 0.02	0.663TrpIle: 0.663 ± 0.032	0.694TrpLys: 0.694 ± 0.03	1.235TrpLeu: 1.235 ± 0.044	0.37TrpMet: 0.37 ± 0.023	0.517TrpAsn: 0.517 ± 0.027	0.358TrpPro: 0.358 ± 0.025	0.548TrpGln: 0.548 ± 0.029	0.587TrpArg: 0.587 ± 0.03	0.639TrpSer: 0.639 ± 0.027	0.496TrpThr: 0.496 ± 0.028	0.643TrpVal: 0.643 ± 0.033	0.162TrpTrp: 0.162 ± 0.016	0.346TrpTyr: 0.346 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.417TyrAla: 2.417 ± 0.065	0.4TyrCys: 0.4 ± 0.024	1.944TyrAsp: 1.944 ± 0.058	1.848TyrGlu: 1.848 ± 0.06	1.346TyrPhe: 1.346 ± 0.045	2.422TyrGly: 2.422 ± 0.062	0.743TyrHis: 0.743 ± 0.033	1.782TyrIle: 1.782 ± 0.048	1.221TyrLys: 1.221 ± 0.044	3.061TyrLeu: 3.061 ± 0.075	0.683TyrMet: 0.683 ± 0.037	1.103TyrAsn: 1.103 ± 0.04	1.437TyrPro: 1.437 ± 0.048	1.051TyrGln: 1.051 ± 0.046	2.344TyrArg: 2.344 ± 0.067	2.092TyrSer: 2.092 ± 0.061	1.632TyrThr: 1.632 ± 0.067	1.722TyrVal: 1.722 ± 0.052	0.349TyrTrp: 0.349 ± 0.021	1.067TyrTyr: 1.067 ± 0.044	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2319 proteins (748019 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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