Amino acid dipepetide frequency for Thioclava dalianensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.374AlaAla: 16.374 ± 0.161	1.165AlaCys: 1.165 ± 0.034	6.584AlaAsp: 6.584 ± 0.085	7.734AlaGlu: 7.734 ± 0.1	4.198AlaPhe: 4.198 ± 0.062	10.425AlaGly: 10.425 ± 0.101	2.483AlaHis: 2.483 ± 0.054	6.138AlaIle: 6.138 ± 0.079	4.186AlaLys: 4.186 ± 0.073	14.826AlaLeu: 14.826 ± 0.172	3.934AlaMet: 3.934 ± 0.056	2.68AlaAsn: 2.68 ± 0.046	6.46AlaPro: 6.46 ± 0.077	5.79AlaGln: 5.79 ± 0.08	9.881AlaArg: 9.881 ± 0.111	5.949AlaSer: 5.949 ± 0.075	5.904AlaThr: 5.904 ± 0.082	7.826AlaVal: 7.826 ± 0.083	1.435AlaTrp: 1.435 ± 0.037	2.452AlaTyr: 2.452 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	1.187CysAla: 1.187 ± 0.036	0.106CysCys: 0.106 ± 0.01	0.633CysAsp: 0.633 ± 0.023	0.487CysGlu: 0.487 ± 0.02	0.303CysPhe: 0.303 ± 0.016	0.871CysGly: 0.871 ± 0.031	0.274CysHis: 0.274 ± 0.015	0.36CysIle: 0.36 ± 0.015	0.208CysLys: 0.208 ± 0.012	0.852CysLeu: 0.852 ± 0.027	0.131CysMet: 0.131 ± 0.01	0.221CysAsn: 0.221 ± 0.013	0.509CysPro: 0.509 ± 0.022	0.245CysGln: 0.245 ± 0.014	0.519CysArg: 0.519 ± 0.022	0.415CysSer: 0.415 ± 0.021	0.428CysThr: 0.428 ± 0.02	0.614CysVal: 0.614 ± 0.023	0.124CysTrp: 0.124 ± 0.009	0.204CysTyr: 0.204 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.122AspAla: 7.122 ± 0.077	0.497AspCys: 0.497 ± 0.022	3.052AspAsp: 3.052 ± 0.064	3.239AspGlu: 3.239 ± 0.061	2.244AspPhe: 2.244 ± 0.047	5.133AspGly: 5.133 ± 0.091	1.314AspHis: 1.314 ± 0.033	2.826AspIle: 2.826 ± 0.048	1.773AspLys: 1.773 ± 0.045	6.579AspLeu: 6.579 ± 0.07	1.524AspMet: 1.524 ± 0.042	1.201AspAsn: 1.201 ± 0.031	3.951AspPro: 3.951 ± 0.067	2.076AspGln: 2.076 ± 0.044	3.966AspArg: 3.966 ± 0.054	2.124AspSer: 2.124 ± 0.048	2.885AspThr: 2.885 ± 0.05	3.782AspVal: 3.782 ± 0.057	1.241AspTrp: 1.241 ± 0.032	1.521AspTyr: 1.521 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	8.437GluAla: 8.437 ± 0.105	0.341GluCys: 0.341 ± 0.015	3.113GluAsp: 3.113 ± 0.051	3.14GluGlu: 3.14 ± 0.071	1.727GluPhe: 1.727 ± 0.039	4.813GluGly: 4.813 ± 0.068	1.094GluHis: 1.094 ± 0.031	3.895GluIle: 3.895 ± 0.063	2.123GluLys: 2.123 ± 0.059	5.235GluLeu: 5.235 ± 0.078	1.922GluMet: 1.922 ± 0.039	1.56GluAsn: 1.56 ± 0.032	2.537GluPro: 2.537 ± 0.049	1.955GluGln: 1.955 ± 0.044	4.406GluArg: 4.406 ± 0.074	2.298GluSer: 2.298 ± 0.041	3.84GluThr: 3.84 ± 0.06	3.896GluVal: 3.896 ± 0.066	0.697GluTrp: 0.697 ± 0.026	0.972GluTyr: 0.972 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.537PheAla: 4.537 ± 0.065	0.38PheCys: 0.38 ± 0.017	2.71PheAsp: 2.71 ± 0.046	2.272PheGlu: 2.272 ± 0.044	1.387PhePhe: 1.387 ± 0.033	3.726PheGly: 3.726 ± 0.07	0.753PheHis: 0.753 ± 0.027	1.565PheIle: 1.565 ± 0.037	0.971PheLys: 0.971 ± 0.032	3.367PheLeu: 3.367 ± 0.059	0.824PheMet: 0.824 ± 0.027	1.028PheAsn: 1.028 ± 0.034	1.493PhePro: 1.493 ± 0.035	0.975PheGln: 0.975 ± 0.03	1.951PheArg: 1.951 ± 0.047	2.179PheSer: 2.179 ± 0.044	2.096PheThr: 2.096 ± 0.045	2.687PheVal: 2.687 ± 0.052	0.615PheTrp: 0.615 ± 0.026	0.901PheTyr: 0.901 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	10.588GlyAla: 10.588 ± 0.119	0.815GlyCys: 0.815 ± 0.024	4.451GlyAsp: 4.451 ± 0.071	4.446GlyGlu: 4.446 ± 0.062	3.62GlyPhe: 3.62 ± 0.055	7.194GlyGly: 7.194 ± 0.1	1.833GlyHis: 1.833 ± 0.039	4.44GlyIle: 4.44 ± 0.073	3.331GlyLys: 3.331 ± 0.067	9.342GlyLeu: 9.342 ± 0.109	2.583GlyMet: 2.583 ± 0.054	2.057GlyAsn: 2.057 ± 0.048	3.868GlyPro: 3.868 ± 0.057	3.179GlyGln: 3.179 ± 0.053	5.644GlyArg: 5.644 ± 0.072	4.292GlySer: 4.292 ± 0.071	4.72GlyThr: 4.72 ± 0.076	6.188GlyVal: 6.188 ± 0.078	1.518GlyTrp: 1.518 ± 0.044	2.286GlyTyr: 2.286 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.399HisAla: 2.399 ± 0.047	0.226HisCys: 0.226 ± 0.013	1.32HisAsp: 1.32 ± 0.039	1.097HisGlu: 1.097 ± 0.032	0.847HisPhe: 0.847 ± 0.028	1.846HisGly: 1.846 ± 0.043	0.564HisHis: 0.564 ± 0.026	0.943HisIle: 0.943 ± 0.027	0.525HisLys: 0.525 ± 0.021	2.082HisLeu: 2.082 ± 0.049	0.526HisMet: 0.526 ± 0.022	0.452HisAsn: 0.452 ± 0.02	1.354HisPro: 1.354 ± 0.034	0.585HisGln: 0.585 ± 0.022	1.327HisArg: 1.327 ± 0.035	0.998HisSer: 0.998 ± 0.032	0.782HisThr: 0.782 ± 0.024	1.456HisVal: 1.456 ± 0.04	0.354HisTrp: 0.354 ± 0.018	0.537HisTyr: 0.537 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	7.486IleAla: 7.486 ± 0.078	0.649IleCys: 0.649 ± 0.026	3.423IleAsp: 3.423 ± 0.054	3.685IleGlu: 3.685 ± 0.052	1.862IlePhe: 1.862 ± 0.043	4.947IleGly: 4.947 ± 0.063	0.919IleHis: 0.919 ± 0.033	2.07IleIle: 2.07 ± 0.05	1.525IleLys: 1.525 ± 0.039	4.698IleLeu: 4.698 ± 0.074	1.033IleMet: 1.033 ± 0.029	1.345IleAsn: 1.345 ± 0.034	2.331IlePro: 2.331 ± 0.045	1.1IleGln: 1.1 ± 0.032	3.197IleArg: 3.197 ± 0.052	3.265IleSer: 3.265 ± 0.055	3.014IleThr: 3.014 ± 0.05	3.79IleVal: 3.79 ± 0.058	0.806IleTrp: 0.806 ± 0.027	1.265IleTyr: 1.265 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	4.104LysAla: 4.104 ± 0.069	0.181LysCys: 0.181 ± 0.012	1.731LysAsp: 1.731 ± 0.043	1.575LysGlu: 1.575 ± 0.041	0.97LysPhe: 0.97 ± 0.032	2.791LysGly: 2.791 ± 0.059	0.611LysHis: 0.611 ± 0.022	1.967LysIle: 1.967 ± 0.044	1.262LysLys: 1.262 ± 0.042	3.222LysLeu: 3.222 ± 0.055	0.973LysMet: 0.973 ± 0.031	0.793LysAsn: 0.793 ± 0.03	1.988LysPro: 1.988 ± 0.046	0.962LysGln: 0.962 ± 0.03	2.333LysArg: 2.333 ± 0.047	1.937LysSer: 1.937 ± 0.037	2.091LysThr: 2.091 ± 0.043	2.405LysVal: 2.405 ± 0.049	0.397LysTrp: 0.397 ± 0.018	0.635LysTyr: 0.635 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	13.222LeuAla: 13.222 ± 0.148	0.996LeuCys: 0.996 ± 0.034	6.01LeuAsp: 6.01 ± 0.065	5.632LeuGlu: 5.632 ± 0.072	3.417LeuPhe: 3.417 ± 0.063	8.918LeuGly: 8.918 ± 0.111	1.91LeuHis: 1.91 ± 0.045	5.611LeuIle: 5.611 ± 0.088	3.26LeuLys: 3.26 ± 0.056	8.817LeuLeu: 8.817 ± 0.136	2.661LeuMet: 2.661 ± 0.052	2.608LeuAsn: 2.608 ± 0.044	5.598LeuPro: 5.598 ± 0.073	2.745LeuGln: 2.745 ± 0.051	7.483LeuArg: 7.483 ± 0.099	7.4LeuSer: 7.4 ± 0.09	5.533LeuThr: 5.533 ± 0.074	6.69LeuVal: 6.69 ± 0.078	1.359LeuTrp: 1.359 ± 0.036	2.009LeuTyr: 2.009 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	3.499MetAla: 3.499 ± 0.054	0.172MetCys: 0.172 ± 0.012	1.219MetAsp: 1.219 ± 0.033	1.356MetGlu: 1.356 ± 0.035	0.817MetPhe: 0.817 ± 0.028	2.355MetGly: 2.355 ± 0.044	0.468MetHis: 0.468 ± 0.017	1.647MetIle: 1.647 ± 0.034	1.117MetLys: 1.117 ± 0.035	2.648MetLeu: 2.648 ± 0.049	0.825MetMet: 0.825 ± 0.03	0.81MetAsn: 0.81 ± 0.028	1.537MetPro: 1.537 ± 0.041	0.997MetGln: 0.997 ± 0.028	2.016MetArg: 2.016 ± 0.046	1.819MetSer: 1.819 ± 0.037	2.015MetThr: 2.015 ± 0.044	1.778MetVal: 1.778 ± 0.043	0.223MetTrp: 0.223 ± 0.015	0.309MetTyr: 0.309 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.138AsnAla: 3.138 ± 0.059	0.223AsnCys: 0.223 ± 0.015	1.408AsnAsp: 1.408 ± 0.042	1.15AsnGlu: 1.15 ± 0.034	0.958AsnPhe: 0.958 ± 0.028	2.295AsnGly: 2.295 ± 0.054	0.474AsnHis: 0.474 ± 0.022	1.284AsnIle: 1.284 ± 0.032	0.671AsnLys: 0.671 ± 0.027	2.499AsnLeu: 2.499 ± 0.045	0.681AsnMet: 0.681 ± 0.022	0.614AsnAsn: 0.614 ± 0.027	1.823AsnPro: 1.823 ± 0.036	0.688AsnGln: 0.688 ± 0.026	1.676AsnArg: 1.676 ± 0.035	1.232AsnSer: 1.232 ± 0.035	1.274AsnThr: 1.274 ± 0.033	1.653AsnVal: 1.653 ± 0.037	0.437AsnTrp: 0.437 ± 0.02	0.618AsnTyr: 0.618 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	6.067ProAla: 6.067 ± 0.071	0.334ProCys: 0.334 ± 0.017	3.951ProAsp: 3.951 ± 0.064	4.515ProGlu: 4.515 ± 0.068	1.944ProPhe: 1.944 ± 0.034	4.629ProGly: 4.629 ± 0.065	1.045ProHis: 1.045 ± 0.03	2.35ProIle: 2.35 ± 0.041	1.845ProLys: 1.845 ± 0.04	4.615ProLeu: 4.615 ± 0.07	1.305ProMet: 1.305 ± 0.034	1.336ProAsn: 1.336 ± 0.031	2.383ProPro: 2.383 ± 0.048	1.897ProGln: 1.897 ± 0.043	2.975ProArg: 2.975 ± 0.052	2.799ProSer: 2.799 ± 0.052	2.32ProThr: 2.32 ± 0.044	4.126ProVal: 4.126 ± 0.052	0.718ProTrp: 0.718 ± 0.025	1.149ProTyr: 1.149 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	4.442GlnAla: 4.442 ± 0.076	0.222GlnCys: 0.222 ± 0.013	1.701GlnAsp: 1.701 ± 0.049	1.614GlnGlu: 1.614 ± 0.04	1.194GlnPhe: 1.194 ± 0.035	2.89GlnGly: 2.89 ± 0.05	0.562GlnHis: 0.562 ± 0.021	2.334GlnIle: 2.334 ± 0.045	1.132GlnLys: 1.132 ± 0.035	3.028GlnLeu: 3.028 ± 0.052	1.195GlnMet: 1.195 ± 0.033	0.906GlnAsn: 0.906 ± 0.033	1.776GlnPro: 1.776 ± 0.043	1.084GlnGln: 1.084 ± 0.035	2.169GlnArg: 2.169 ± 0.049	2.127GlnSer: 2.127 ± 0.039	1.901GlnThr: 1.901 ± 0.035	2.424GlnVal: 2.424 ± 0.042	0.414GlnTrp: 0.414 ± 0.018	0.576GlnTyr: 0.576 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	9.108ArgAla: 9.108 ± 0.116	0.514ArgCys: 0.514 ± 0.021	4.313ArgAsp: 4.313 ± 0.066	4.099ArgGlu: 4.099 ± 0.062	2.698ArgPhe: 2.698 ± 0.052	4.69ArgGly: 4.69 ± 0.071	1.585ArgHis: 1.585 ± 0.04	3.782ArgIle: 3.782 ± 0.05	2.381ArgLys: 2.381 ± 0.046	7.3ArgLeu: 7.3 ± 0.101	1.948ArgMet: 1.948 ± 0.037	1.731ArgAsn: 1.731 ± 0.036	3.326ArgPro: 3.326 ± 0.059	2.232ArgGln: 2.232 ± 0.041	4.869ArgArg: 4.869 ± 0.084	3.362ArgSer: 3.362 ± 0.059	2.839ArgThr: 2.839 ± 0.051	4.598ArgVal: 4.598 ± 0.059	0.951ArgTrp: 0.951 ± 0.026	1.618ArgTyr: 1.618 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	6.371SerAla: 6.371 ± 0.088	0.458SerCys: 0.458 ± 0.021	3.617SerAsp: 3.617 ± 0.056	3.16SerGlu: 3.16 ± 0.055	2.256SerPhe: 2.256 ± 0.045	5.625SerGly: 5.625 ± 0.074	1.058SerHis: 1.058 ± 0.032	2.399SerIle: 2.399 ± 0.049	1.749SerLys: 1.749 ± 0.041	5.281SerLeu: 5.281 ± 0.075	1.341SerMet: 1.341 ± 0.032	1.432SerAsn: 1.432 ± 0.033	2.617SerPro: 2.617 ± 0.051	1.812SerGln: 1.812 ± 0.043	3.256SerArg: 3.256 ± 0.054	2.782SerSer: 2.782 ± 0.059	2.568SerThr: 2.568 ± 0.051	3.899SerVal: 3.899 ± 0.064	0.747SerTrp: 0.747 ± 0.026	1.415SerTyr: 1.415 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	5.953ThrAla: 5.953 ± 0.076	0.462ThrCys: 0.462 ± 0.02	2.888ThrAsp: 2.888 ± 0.046	2.873ThrGlu: 2.873 ± 0.053	1.777ThrPhe: 1.777 ± 0.039	5.211ThrGly: 5.211 ± 0.066	1.118ThrHis: 1.118 ± 0.029	2.694ThrIle: 2.694 ± 0.051	1.553ThrLys: 1.553 ± 0.035	6.098ThrLeu: 6.098 ± 0.073	1.236ThrMet: 1.236 ± 0.033	1.248ThrAsn: 1.248 ± 0.034	3.546ThrPro: 3.546 ± 0.051	1.903ThrGln: 1.903 ± 0.041	3.663ThrArg: 3.663 ± 0.064	2.589ThrSer: 2.589 ± 0.059	2.627ThrThr: 2.627 ± 0.051	3.882ThrVal: 3.882 ± 0.061	0.627ThrTrp: 0.627 ± 0.023	1.172ThrTyr: 1.172 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	8.547ValAla: 8.547 ± 0.091	0.578ValCys: 0.578 ± 0.024	3.625ValAsp: 3.625 ± 0.059	4.013ValGlu: 4.013 ± 0.071	2.734ValPhe: 2.734 ± 0.058	5.017ValGly: 5.017 ± 0.082	1.254ValHis: 1.254 ± 0.031	4.376ValIle: 4.376 ± 0.063	2.188ValLys: 2.188 ± 0.051	7.387ValLeu: 7.387 ± 0.098	2.103ValMet: 2.103 ± 0.044	1.757ValAsn: 1.757 ± 0.042	3.436ValPro: 3.436 ± 0.054	2.136ValGln: 2.136 ± 0.039	3.865ValArg: 3.865 ± 0.063	4.281ValSer: 4.281 ± 0.072	4.52ValThr: 4.52 ± 0.064	5.182ValVal: 5.182 ± 0.079	0.923ValTrp: 0.923 ± 0.03	1.347ValTyr: 1.347 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.368TrpAla: 1.368 ± 0.033	0.134TrpCys: 0.134 ± 0.011	0.744TrpAsp: 0.744 ± 0.024	0.658TrpGlu: 0.658 ± 0.024	0.59TrpPhe: 0.59 ± 0.021	1.062TrpGly: 1.062 ± 0.035	0.384TrpHis: 0.384 ± 0.017	0.771TrpIle: 0.771 ± 0.03	0.503TrpLys: 0.503 ± 0.024	1.706TrpLeu: 1.706 ± 0.042	0.399TrpMet: 0.399 ± 0.019	0.405TrpAsn: 0.405 ± 0.019	0.685TrpPro: 0.685 ± 0.024	0.62TrpGln: 0.62 ± 0.027	1.183TrpArg: 1.183 ± 0.034	0.849TrpSer: 0.849 ± 0.031	0.69TrpThr: 0.69 ± 0.024	0.935TrpVal: 0.935 ± 0.028	0.226TrpTrp: 0.226 ± 0.012	0.267TrpTyr: 0.267 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.478TyrAla: 2.478 ± 0.043	0.239TyrCys: 0.239 ± 0.013	1.556TyrAsp: 1.556 ± 0.037	1.257TyrGlu: 1.257 ± 0.033	0.873TyrPhe: 0.873 ± 0.03	1.958TyrGly: 1.958 ± 0.04	0.519TyrHis: 0.519 ± 0.021	0.962TyrIle: 0.962 ± 0.029	0.626TyrLys: 0.626 ± 0.024	2.297TyrLeu: 2.297 ± 0.042	0.48TyrMet: 0.48 ± 0.021	0.61TyrAsn: 0.61 ± 0.023	1.083TyrPro: 1.083 ± 0.028	0.709TyrGln: 0.709 ± 0.023	1.564TyrArg: 1.564 ± 0.039	1.147TyrSer: 1.147 ± 0.03	1.071TyrThr: 1.071 ± 0.03	1.46TyrVal: 1.46 ± 0.033	0.367TyrTrp: 0.367 ± 0.018	0.554TyrTyr: 0.554 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4007 proteins (1230192 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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