Amino acid dipepetide frequency for Hyalangium minutum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.009AlaAla: 14.009 ± 0.103	1.256AlaCys: 1.256 ± 0.026	4.708AlaAsp: 4.708 ± 0.04	7.605AlaGlu: 7.605 ± 0.074	3.738AlaPhe: 3.738 ± 0.035	9.172AlaGly: 9.172 ± 0.064	2.256AlaHis: 2.256 ± 0.028	3.528AlaIle: 3.528 ± 0.04	3.57AlaLys: 3.57 ± 0.049	13.954AlaLeu: 13.954 ± 0.106	2.344AlaMet: 2.344 ± 0.033	2.384AlaAsn: 2.384 ± 0.046	7.145AlaPro: 7.145 ± 0.069	4.83AlaGln: 4.83 ± 0.041	9.321AlaArg: 9.321 ± 0.088	7.117AlaSer: 7.117 ± 0.065	5.987AlaThr: 5.987 ± 0.078	8.472AlaVal: 8.472 ± 0.055	1.65AlaTrp: 1.65 ± 0.028	2.293AlaTyr: 2.293 ± 0.031	0.0AlaXaa: 0.0 ± 0.0
Cys	1.075CysAla: 1.075 ± 0.019	0.098CysCys: 0.098 ± 0.007	0.51CysAsp: 0.51 ± 0.017	0.554CysGlu: 0.554 ± 0.015	0.32CysPhe: 0.32 ± 0.01	1.015CysGly: 1.015 ± 0.024	0.269CysHis: 0.269 ± 0.011	0.287CysIle: 0.287 ± 0.009	0.247CysLys: 0.247 ± 0.009	0.855CysLeu: 0.855 ± 0.017	0.143CysMet: 0.143 ± 0.006	0.267CysAsn: 0.267 ± 0.011	0.581CysPro: 0.581 ± 0.019	0.36CysGln: 0.36 ± 0.012	0.642CysArg: 0.642 ± 0.015	0.644CysSer: 0.644 ± 0.017	0.582CysThr: 0.582 ± 0.019	0.664CysVal: 0.664 ± 0.015	0.133CysTrp: 0.133 ± 0.007	0.193CysTyr: 0.193 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	5.815AspAla: 5.815 ± 0.049	0.449AspCys: 0.449 ± 0.016	2.262AspAsp: 2.262 ± 0.032	3.117AspGlu: 3.117 ± 0.032	1.987AspPhe: 1.987 ± 0.028	4.757AspGly: 4.757 ± 0.066	0.832AspHis: 0.832 ± 0.018	1.726AspIle: 1.726 ± 0.026	1.449AspLys: 1.449 ± 0.023	4.826AspLeu: 4.826 ± 0.046	0.822AspMet: 0.822 ± 0.016	1.038AspAsn: 1.038 ± 0.026	3.297AspPro: 3.297 ± 0.044	1.358AspGln: 1.358 ± 0.024	3.131AspArg: 3.131 ± 0.039	2.616AspSer: 2.616 ± 0.039	2.691AspThr: 2.691 ± 0.043	3.961AspVal: 3.961 ± 0.041	0.703AspTrp: 0.703 ± 0.018	1.105AspTyr: 1.105 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	8.469GluAla: 8.469 ± 0.086	0.466GluCys: 0.466 ± 0.016	3.047GluAsp: 3.047 ± 0.032	4.651GluGlu: 4.651 ± 0.055	1.736GluPhe: 1.736 ± 0.024	5.398GluGly: 5.398 ± 0.048	1.43GluHis: 1.43 ± 0.024	1.925GluIle: 1.925 ± 0.029	2.509GluLys: 2.509 ± 0.037	7.836GluLeu: 7.836 ± 0.069	1.169GluMet: 1.169 ± 0.02	1.301GluAsn: 1.301 ± 0.019	3.831GluPro: 3.831 ± 0.043	3.019GluGln: 3.019 ± 0.037	6.02GluArg: 6.02 ± 0.064	3.018GluSer: 3.018 ± 0.03	2.858GluThr: 2.858 ± 0.031	5.325GluVal: 5.325 ± 0.047	0.749GluTrp: 0.749 ± 0.014	1.156GluTyr: 1.156 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	3.364PheAla: 3.364 ± 0.034	0.327PheCys: 0.327 ± 0.011	1.914PheAsp: 1.914 ± 0.024	2.252PheGlu: 2.252 ± 0.03	1.441PhePhe: 1.441 ± 0.022	2.881PheGly: 2.881 ± 0.033	0.798PheHis: 0.798 ± 0.016	1.329PheIle: 1.329 ± 0.02	0.986PheLys: 0.986 ± 0.018	3.469PheLeu: 3.469 ± 0.035	0.618PheMet: 0.618 ± 0.014	0.94PheAsn: 0.94 ± 0.022	1.679PhePro: 1.679 ± 0.021	1.29PheGln: 1.29 ± 0.02	2.242PheArg: 2.242 ± 0.027	2.348PheSer: 2.348 ± 0.033	2.319PheThr: 2.319 ± 0.044	2.42PheVal: 2.42 ± 0.027	0.445PheTrp: 0.445 ± 0.011	0.808PheTyr: 0.808 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	8.878GlyAla: 8.878 ± 0.062	1.004GlyCys: 1.004 ± 0.021	3.939GlyAsp: 3.939 ± 0.045	5.15GlyGlu: 5.15 ± 0.047	2.993GlyPhe: 2.993 ± 0.033	7.697GlyGly: 7.697 ± 0.085	1.784GlyHis: 1.784 ± 0.027	3.013GlyIle: 3.013 ± 0.035	3.354GlyLys: 3.354 ± 0.043	8.791GlyLeu: 8.791 ± 0.06	1.972GlyMet: 1.972 ± 0.026	2.257GlyAsn: 2.257 ± 0.045	4.201GlyPro: 4.201 ± 0.044	3.397GlyGln: 3.397 ± 0.038	6.093GlyArg: 6.093 ± 0.054	5.406GlySer: 5.406 ± 0.057	5.935GlyThr: 5.935 ± 0.082	6.406GlyVal: 6.406 ± 0.053	1.301GlyTrp: 1.301 ± 0.023	2.104GlyTyr: 2.104 ± 0.032	0.0GlyXaa: 0.0 ± 0.0
His	2.17HisAla: 2.17 ± 0.029	0.214HisCys: 0.214 ± 0.009	0.865HisAsp: 0.865 ± 0.017	1.271HisGlu: 1.271 ± 0.021	0.829HisPhe: 0.829 ± 0.016	1.892HisGly: 1.892 ± 0.031	0.589HisHis: 0.589 ± 0.016	0.659HisIle: 0.659 ± 0.015	0.465HisLys: 0.465 ± 0.012	2.292HisLeu: 2.292 ± 0.033	0.359HisMet: 0.359 ± 0.011	0.381HisAsn: 0.381 ± 0.01	1.588HisPro: 1.588 ± 0.028	0.692HisGln: 0.692 ± 0.016	1.612HisArg: 1.612 ± 0.023	1.083HisSer: 1.083 ± 0.021	1.057HisThr: 1.057 ± 0.022	1.549HisVal: 1.549 ± 0.027	0.311HisTrp: 0.311 ± 0.01	0.55HisTyr: 0.55 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	3.684IleAla: 3.684 ± 0.04	0.32IleCys: 0.32 ± 0.009	1.863IleAsp: 1.863 ± 0.025	2.166IleGlu: 2.166 ± 0.028	1.128IlePhe: 1.128 ± 0.021	2.541IleGly: 2.541 ± 0.037	0.832IleHis: 0.832 ± 0.014	1.328IleIle: 1.328 ± 0.024	0.895IleLys: 0.895 ± 0.02	2.955IleLeu: 2.955 ± 0.032	0.388IleMet: 0.388 ± 0.011	0.992IleAsn: 0.992 ± 0.019	2.065IlePro: 2.065 ± 0.025	1.299IleGln: 1.299 ± 0.025	2.349IleArg: 2.349 ± 0.032	2.09IleSer: 2.09 ± 0.027	2.036IleThr: 2.036 ± 0.027	2.368IleVal: 2.368 ± 0.028	0.333IleTrp: 0.333 ± 0.01	0.756IleTyr: 0.756 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	4.008LysAla: 4.008 ± 0.057	0.211LysCys: 0.211 ± 0.008	1.956LysAsp: 1.956 ± 0.028	2.147LysGlu: 2.147 ± 0.031	0.757LysPhe: 0.757 ± 0.016	2.77LysGly: 2.77 ± 0.033	0.6LysHis: 0.6 ± 0.016	0.99LysIle: 0.99 ± 0.023	1.576LysLys: 1.576 ± 0.027	3.533LysLeu: 3.533 ± 0.041	0.687LysMet: 0.687 ± 0.017	0.827LysAsn: 0.827 ± 0.019	2.239LysPro: 2.239 ± 0.03	1.169LysGln: 1.169 ± 0.024	2.217LysArg: 2.217 ± 0.03	1.528LysSer: 1.528 ± 0.021	1.672LysThr: 1.672 ± 0.022	2.728LysVal: 2.728 ± 0.036	0.346LysTrp: 0.346 ± 0.011	0.671LysTyr: 0.671 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	13.259LeuAla: 13.259 ± 0.09	0.992LeuCys: 0.992 ± 0.019	5.213LeuAsp: 5.213 ± 0.042	7.519LeuGlu: 7.519 ± 0.072	3.494LeuPhe: 3.494 ± 0.039	9.209LeuGly: 9.209 ± 0.066	2.197LeuHis: 2.197 ± 0.031	3.292LeuIle: 3.292 ± 0.029	3.831LeuLys: 3.831 ± 0.044	11.682LeuLeu: 11.682 ± 0.103	1.982LeuMet: 1.982 ± 0.026	2.37LeuAsn: 2.37 ± 0.029	6.614LeuPro: 6.614 ± 0.059	3.851LeuGln: 3.851 ± 0.039	8.589LeuArg: 8.589 ± 0.08	7.322LeuSer: 7.322 ± 0.058	6.092LeuThr: 6.092 ± 0.051	8.067LeuVal: 8.067 ± 0.055	1.412LeuTrp: 1.412 ± 0.029	2.318LeuTyr: 2.318 ± 0.032	0.0LeuXaa: 0.0 ± 0.0
Met	2.44MetAla: 2.44 ± 0.032	0.127MetCys: 0.127 ± 0.006	1.007MetAsp: 1.007 ± 0.021	1.229MetGlu: 1.229 ± 0.02	0.474MetPhe: 0.474 ± 0.012	1.719MetGly: 1.719 ± 0.026	0.335MetHis: 0.335 ± 0.009	0.518MetIle: 0.518 ± 0.013	0.871MetLys: 0.871 ± 0.016	2.037MetLeu: 2.037 ± 0.028	0.461MetMet: 0.461 ± 0.017	0.559MetAsn: 0.559 ± 0.014	1.226MetPro: 1.226 ± 0.02	0.632MetGln: 0.632 ± 0.014	1.515MetArg: 1.515 ± 0.024	1.36MetSer: 1.36 ± 0.023	1.097MetThr: 1.097 ± 0.02	1.382MetVal: 1.382 ± 0.023	0.175MetTrp: 0.175 ± 0.008	0.292MetTyr: 0.292 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.582AsnAla: 2.582 ± 0.028	0.249AsnCys: 0.249 ± 0.011	1.137AsnAsp: 1.137 ± 0.045	1.165AsnGlu: 1.165 ± 0.022	0.794AsnPhe: 0.794 ± 0.02	2.26AsnGly: 2.26 ± 0.046	0.477AsnHis: 0.477 ± 0.012	0.912AsnIle: 0.912 ± 0.019	0.6AsnLys: 0.6 ± 0.014	2.473AsnLeu: 2.473 ± 0.03	0.382AsnMet: 0.382 ± 0.011	0.734AsnAsn: 0.734 ± 0.021	1.845AsnPro: 1.845 ± 0.03	0.783AsnGln: 0.783 ± 0.016	1.466AsnArg: 1.466 ± 0.022	1.249AsnSer: 1.249 ± 0.027	1.464AsnThr: 1.464 ± 0.029	1.871AsnVal: 1.871 ± 0.033	0.309AsnTrp: 0.309 ± 0.01	0.576AsnTyr: 0.576 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	7.127ProAla: 7.127 ± 0.062	0.426ProCys: 0.426 ± 0.012	3.2ProAsp: 3.2 ± 0.039	5.214ProGlu: 5.214 ± 0.048	1.969ProPhe: 1.969 ± 0.03	5.53ProGly: 5.53 ± 0.051	1.14ProHis: 1.14 ± 0.02	1.709ProIle: 1.709 ± 0.022	1.819ProLys: 1.819 ± 0.026	6.033ProLeu: 6.033 ± 0.052	1.296ProMet: 1.296 ± 0.02	1.353ProAsn: 1.353 ± 0.023	5.01ProPro: 5.01 ± 0.067	2.198ProGln: 2.198 ± 0.03	3.901ProArg: 3.901 ± 0.04	4.244ProSer: 4.244 ± 0.052	3.207ProThr: 3.207 ± 0.038	4.796ProVal: 4.796 ± 0.05	0.817ProTrp: 0.817 ± 0.018	1.158ProTyr: 1.158 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	4.832GlnAla: 4.832 ± 0.048	0.306GlnCys: 0.306 ± 0.011	1.649GlnAsp: 1.649 ± 0.02	2.527GlnGlu: 2.527 ± 0.031	0.986GlnPhe: 0.986 ± 0.018	3.437GlnGly: 3.437 ± 0.04	0.732GlnHis: 0.732 ± 0.014	1.088GlnIle: 1.088 ± 0.021	1.276GlnLys: 1.276 ± 0.027	4.062GlnLeu: 4.062 ± 0.043	0.71GlnMet: 0.71 ± 0.015	0.78GlnAsn: 0.78 ± 0.016	2.315GlnPro: 2.315 ± 0.031	1.75GlnGln: 1.75 ± 0.034	3.135GlnArg: 3.135 ± 0.04	1.909GlnSer: 1.909 ± 0.025	1.664GlnThr: 1.664 ± 0.023	3.346GlnVal: 3.346 ± 0.036	0.517GlnTrp: 0.517 ± 0.014	0.699GlnTyr: 0.699 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	8.277ArgAla: 8.277 ± 0.069	0.684ArgCys: 0.684 ± 0.017	3.374ArgAsp: 3.374 ± 0.033	5.401ArgGlu: 5.401 ± 0.058	3.053ArgPhe: 3.053 ± 0.036	5.33ArgGly: 5.33 ± 0.053	1.558ArgHis: 1.558 ± 0.022	2.985ArgIle: 2.985 ± 0.03	2.455ArgLys: 2.455 ± 0.033	8.51ArgLeu: 8.51 ± 0.074	1.904ArgMet: 1.904 ± 0.026	1.591ArgAsn: 1.591 ± 0.025	3.964ArgPro: 3.964 ± 0.041	2.797ArgGln: 2.797 ± 0.035	5.771ArgArg: 5.771 ± 0.069	4.051ArgSer: 4.051 ± 0.042	3.885ArgThr: 3.885 ± 0.034	5.971ArgVal: 5.971 ± 0.048	1.179ArgTrp: 1.179 ± 0.019	1.984ArgTyr: 1.984 ± 0.028	0.0ArgXaa: 0.0 ± 0.0
Ser	6.82SerAla: 6.82 ± 0.066	0.626SerCys: 0.626 ± 0.017	2.644SerAsp: 2.644 ± 0.037	3.531SerGlu: 3.531 ± 0.037	2.25SerPhe: 2.25 ± 0.03	5.895SerGly: 5.895 ± 0.071	1.176SerHis: 1.176 ± 0.023	1.959SerIle: 1.959 ± 0.03	1.674SerLys: 1.674 ± 0.025	6.483SerLeu: 6.483 ± 0.061	1.229SerMet: 1.229 ± 0.021	1.46SerAsn: 1.46 ± 0.026	4.025SerPro: 4.025 ± 0.042	2.181SerGln: 2.181 ± 0.027	4.216SerArg: 4.216 ± 0.04	4.195SerSer: 4.195 ± 0.054	3.541SerThr: 3.541 ± 0.043	4.421SerVal: 4.421 ± 0.048	0.878SerTrp: 0.878 ± 0.02	1.343SerTyr: 1.343 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	6.272ThrAla: 6.272 ± 0.087	0.624ThrCys: 0.624 ± 0.017	2.519ThrAsp: 2.519 ± 0.039	2.997ThrGlu: 2.997 ± 0.032	2.16ThrPhe: 2.16 ± 0.041	5.21ThrGly: 5.21 ± 0.055	1.153ThrHis: 1.153 ± 0.019	1.576ThrIle: 1.576 ± 0.026	1.268ThrLys: 1.268 ± 0.022	6.661ThrLeu: 6.661 ± 0.056	0.787ThrMet: 0.787 ± 0.017	1.221ThrAsn: 1.221 ± 0.026	4.209ThrPro: 4.209 ± 0.046	2.105ThrGln: 2.105 ± 0.029	3.624ThrArg: 3.624 ± 0.034	3.319ThrSer: 3.319 ± 0.041	2.934ThrThr: 2.934 ± 0.055	4.988ThrVal: 4.988 ± 0.099	0.871ThrTrp: 0.871 ± 0.02	1.417ThrTyr: 1.417 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	8.664ValAla: 8.664 ± 0.073	0.699ValCys: 0.699 ± 0.017	4.24ValAsp: 4.24 ± 0.04	5.219ValGlu: 5.219 ± 0.047	2.434ValPhe: 2.434 ± 0.027	5.981ValGly: 5.981 ± 0.048	1.543ValHis: 1.543 ± 0.024	2.525ValIle: 2.525 ± 0.029	2.655ValLys: 2.655 ± 0.031	8.875ValLeu: 8.875 ± 0.057	1.451ValMet: 1.451 ± 0.023	1.862ValAsn: 1.862 ± 0.036	4.559ValPro: 4.559 ± 0.052	2.687ValGln: 2.687 ± 0.03	5.955ValArg: 5.955 ± 0.057	4.828ValSer: 4.828 ± 0.045	4.766ValThr: 4.766 ± 0.093	6.338ValVal: 6.338 ± 0.055	0.914ValTrp: 0.914 ± 0.023	1.589ValTyr: 1.589 ± 0.027	0.0ValXaa: 0.0 ± 0.0
Trp	1.296TrpAla: 1.296 ± 0.024	0.144TrpCys: 0.144 ± 0.006	0.649TrpAsp: 0.649 ± 0.017	0.776TrpGlu: 0.776 ± 0.017	0.442TrpPhe: 0.442 ± 0.011	1.065TrpGly: 1.065 ± 0.021	0.278TrpHis: 0.278 ± 0.01	0.433TrpIle: 0.433 ± 0.012	0.544TrpLys: 0.544 ± 0.016	1.594TrpLeu: 1.594 ± 0.027	0.37TrpMet: 0.37 ± 0.011	0.443TrpAsn: 0.443 ± 0.012	0.617TrpPro: 0.617 ± 0.015	0.486TrpGln: 0.486 ± 0.014	1.113TrpArg: 1.113 ± 0.023	0.917TrpSer: 0.917 ± 0.024	0.86TrpThr: 0.86 ± 0.018	1.055TrpVal: 1.055 ± 0.02	0.209TrpTrp: 0.209 ± 0.009	0.284TrpTyr: 0.284 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.297TyrAla: 2.297 ± 0.03	0.217TyrCys: 0.217 ± 0.009	1.243TyrAsp: 1.243 ± 0.027	1.425TyrGlu: 1.425 ± 0.026	0.887TyrPhe: 0.887 ± 0.02	1.92TyrGly: 1.92 ± 0.028	0.448TyrHis: 0.448 ± 0.012	0.605TyrIle: 0.605 ± 0.014	0.587TyrLys: 0.587 ± 0.014	2.384TyrLeu: 2.384 ± 0.034	0.381TyrMet: 0.381 ± 0.011	0.567TyrAsn: 0.567 ± 0.016	1.137TyrPro: 1.137 ± 0.022	0.837TyrGln: 0.837 ± 0.017	1.811TyrArg: 1.811 ± 0.029	1.302TyrSer: 1.302 ± 0.025	1.27TyrThr: 1.27 ± 0.03	1.656TyrVal: 1.656 ± 0.025	0.325TyrTrp: 0.325 ± 0.012	0.577TyrTyr: 0.577 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8967 proteins (3319859 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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