Amino acid dipepetide frequency for Golovinomyces magnicellulatus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.196AlaAla: 6.196 ± 0.058	0.934AlaCys: 0.934 ± 0.017	3.334AlaAsp: 3.334 ± 0.032	4.354AlaGlu: 4.354 ± 0.053	2.672AlaPhe: 2.672 ± 0.037	4.306AlaGly: 4.306 ± 0.043	1.496AlaHis: 1.496 ± 0.022	4.286AlaIle: 4.286 ± 0.032	4.039AlaLys: 4.039 ± 0.036	6.627AlaLeu: 6.627 ± 0.058	1.537AlaMet: 1.537 ± 0.021	2.736AlaAsn: 2.736 ± 0.031	3.216AlaPro: 3.216 ± 0.035	2.856AlaGln: 2.856 ± 0.027	4.015AlaArg: 4.015 ± 0.036	6.057AlaSer: 6.057 ± 0.042	4.21AlaThr: 4.21 ± 0.036	4.19AlaVal: 4.19 ± 0.041	0.854AlaTrp: 0.854 ± 0.016	1.843AlaTyr: 1.843 ± 0.025	0.001AlaXaa: 0.001 ± 0.0
Cys	0.855CysAla: 0.855 ± 0.017	0.239CysCys: 0.239 ± 0.009	0.702CysAsp: 0.702 ± 0.015	0.699CysGlu: 0.699 ± 0.013	0.574CysPhe: 0.574 ± 0.012	0.898CysGly: 0.898 ± 0.018	0.364CysHis: 0.364 ± 0.01	0.825CysIle: 0.825 ± 0.015	0.656CysLys: 0.656 ± 0.015	1.349CysLeu: 1.349 ± 0.021	0.276CysMet: 0.276 ± 0.01	0.537CysAsn: 0.537 ± 0.015	0.594CysPro: 0.594 ± 0.015	0.521CysGln: 0.521 ± 0.013	0.743CysArg: 0.743 ± 0.016	1.101CysSer: 1.101 ± 0.019	0.712CysThr: 0.712 ± 0.015	0.74CysVal: 0.74 ± 0.015	0.178CysTrp: 0.178 ± 0.008	0.364CysTyr: 0.364 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	3.675AspAla: 3.675 ± 0.035	0.689AspCys: 0.689 ± 0.016	3.833AspAsp: 3.833 ± 0.05	4.622AspGlu: 4.622 ± 0.043	2.385AspPhe: 2.385 ± 0.028	3.418AspGly: 3.418 ± 0.033	1.193AspHis: 1.193 ± 0.018	3.608AspIle: 3.608 ± 0.036	2.883AspLys: 2.883 ± 0.03	5.253AspLeu: 5.253 ± 0.038	1.156AspMet: 1.156 ± 0.018	2.245AspAsn: 2.245 ± 0.027	2.785AspPro: 2.785 ± 0.029	2.057AspGln: 2.057 ± 0.024	2.761AspArg: 2.761 ± 0.032	4.567AspSer: 4.567 ± 0.043	2.782AspThr: 2.782 ± 0.032	3.329AspVal: 3.329 ± 0.036	0.753AspTrp: 0.753 ± 0.017	1.637AspTyr: 1.637 ± 0.024	0.0AspXaa: 0.0 ± 0.0
Glu	4.629GluAla: 4.629 ± 0.044	0.673GluCys: 0.673 ± 0.014	4.109GluAsp: 4.109 ± 0.043	5.488GluGlu: 5.488 ± 0.066	2.283GluPhe: 2.283 ± 0.024	3.117GluGly: 3.117 ± 0.035	1.22GluHis: 1.22 ± 0.019	4.45GluIle: 4.45 ± 0.05	4.944GluLys: 4.944 ± 0.054	5.486GluLeu: 5.486 ± 0.051	1.477GluMet: 1.477 ± 0.023	3.656GluAsn: 3.656 ± 0.042	2.283GluPro: 2.283 ± 0.032	2.424GluGln: 2.424 ± 0.033	3.711GluArg: 3.711 ± 0.037	5.045GluSer: 5.045 ± 0.047	3.701GluThr: 3.701 ± 0.034	3.417GluVal: 3.417 ± 0.029	0.819GluTrp: 0.819 ± 0.014	1.797GluTyr: 1.797 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	2.69PheAla: 2.69 ± 0.031	0.621PheCys: 0.621 ± 0.012	2.307PheAsp: 2.307 ± 0.026	2.431PheGlu: 2.431 ± 0.029	1.716PhePhe: 1.716 ± 0.026	2.668PheGly: 2.668 ± 0.035	0.902PheHis: 0.902 ± 0.015	2.249PheIle: 2.249 ± 0.03	1.977PheLys: 1.977 ± 0.025	3.711PheLeu: 3.711 ± 0.041	0.803PheMet: 0.803 ± 0.018	1.787PheAsn: 1.787 ± 0.025	1.874PhePro: 1.874 ± 0.023	1.498PheGln: 1.498 ± 0.02	1.98PheArg: 1.98 ± 0.021	3.566PheSer: 3.566 ± 0.035	2.247PheThr: 2.247 ± 0.025	2.275PheVal: 2.275 ± 0.03	0.575PheTrp: 0.575 ± 0.013	1.17PheTyr: 1.17 ± 0.019	0.001PheXaa: 0.001 ± 0.0
Gly	3.987GlyAla: 3.987 ± 0.04	0.792GlyCys: 0.792 ± 0.016	3.045GlyAsp: 3.045 ± 0.03	3.219GlyGlu: 3.219 ± 0.03	2.559GlyPhe: 2.559 ± 0.03	4.369GlyGly: 4.369 ± 0.053	1.414GlyHis: 1.414 ± 0.024	3.847GlyIle: 3.847 ± 0.035	3.686GlyLys: 3.686 ± 0.035	5.347GlyLeu: 5.347 ± 0.046	1.33GlyMet: 1.33 ± 0.023	2.664GlyAsn: 2.664 ± 0.031	2.461GlyPro: 2.461 ± 0.035	2.185GlyGln: 2.185 ± 0.027	3.396GlyArg: 3.396 ± 0.039	5.021GlySer: 5.021 ± 0.045	3.415GlyThr: 3.415 ± 0.036	3.577GlyVal: 3.577 ± 0.034	0.932GlyTrp: 0.932 ± 0.018	1.886GlyTyr: 1.886 ± 0.029	0.001GlyXaa: 0.001 ± 0.001
His	1.415HisAla: 1.415 ± 0.017	0.328HisCys: 0.328 ± 0.011	1.278HisAsp: 1.278 ± 0.019	1.378HisGlu: 1.378 ± 0.019	0.917HisPhe: 0.917 ± 0.017	1.454HisGly: 1.454 ± 0.024	0.732HisHis: 0.732 ± 0.018	1.399HisIle: 1.399 ± 0.02	1.116HisLys: 1.116 ± 0.019	2.198HisLeu: 2.198 ± 0.026	0.442HisMet: 0.442 ± 0.011	1.026HisAsn: 1.026 ± 0.018	1.417HisPro: 1.417 ± 0.023	1.081HisGln: 1.081 ± 0.019	1.376HisArg: 1.376 ± 0.022	1.916HisSer: 1.916 ± 0.025	1.21HisThr: 1.21 ± 0.021	1.29HisVal: 1.29 ± 0.021	0.278HisTrp: 0.278 ± 0.01	0.68HisTyr: 0.68 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.217IleAla: 4.217 ± 0.038	0.955IleCys: 0.955 ± 0.021	3.565IleAsp: 3.565 ± 0.033	3.883IleGlu: 3.883 ± 0.033	2.647IlePhe: 2.647 ± 0.034	3.523IleGly: 3.523 ± 0.032	1.422IleHis: 1.422 ± 0.021	3.646IleIle: 3.646 ± 0.038	3.549IleLys: 3.549 ± 0.037	5.852IleLeu: 5.852 ± 0.058	1.222IleMet: 1.222 ± 0.018	2.836IleAsn: 2.836 ± 0.027	3.365IlePro: 3.365 ± 0.03	2.407IleGln: 2.407 ± 0.024	3.225IleArg: 3.225 ± 0.031	5.942IleSer: 5.942 ± 0.048	3.44IleThr: 3.44 ± 0.033	3.461IleVal: 3.461 ± 0.032	0.78IleTrp: 0.78 ± 0.018	1.77IleTyr: 1.77 ± 0.024	0.001IleXaa: 0.001 ± 0.0
Lys	4.167LysAla: 4.167 ± 0.044	0.667LysCys: 0.667 ± 0.015	3.458LysAsp: 3.458 ± 0.038	4.205LysGlu: 4.205 ± 0.05	2.152LysPhe: 2.152 ± 0.024	3.009LysGly: 3.009 ± 0.032	1.215LysHis: 1.215 ± 0.018	4.093LysIle: 4.093 ± 0.034	4.939LysLys: 4.939 ± 0.049	5.263LysLeu: 5.263 ± 0.039	1.291LysMet: 1.291 ± 0.018	3.377LysAsn: 3.377 ± 0.035	2.792LysPro: 2.792 ± 0.028	2.145LysGln: 2.145 ± 0.029	3.747LysArg: 3.747 ± 0.036	5.279LysSer: 5.279 ± 0.044	3.569LysThr: 3.569 ± 0.035	3.218LysVal: 3.218 ± 0.028	0.72LysTrp: 0.72 ± 0.014	1.812LysTyr: 1.812 ± 0.024	0.001LysXaa: 0.001 ± 0.001
Leu	6.814LeuAla: 6.814 ± 0.047	1.246LeuCys: 1.246 ± 0.02	5.173LeuAsp: 5.173 ± 0.044	5.967LeuGlu: 5.967 ± 0.039	3.408LeuPhe: 3.408 ± 0.035	5.273LeuGly: 5.273 ± 0.047	2.172LeuHis: 2.172 ± 0.025	5.096LeuIle: 5.096 ± 0.051	5.622LeuLys: 5.622 ± 0.041	8.278LeuLeu: 8.278 ± 0.072	1.815LeuMet: 1.815 ± 0.023	4.199LeuAsn: 4.199 ± 0.041	5.016LeuPro: 5.016 ± 0.038	3.928LeuGln: 3.928 ± 0.036	5.561LeuArg: 5.561 ± 0.044	8.157LeuSer: 8.157 ± 0.05	5.026LeuThr: 5.026 ± 0.043	5.044LeuVal: 5.044 ± 0.045	1.072LeuTrp: 1.072 ± 0.019	2.391LeuTyr: 2.391 ± 0.028	0.002LeuXaa: 0.002 ± 0.001
Met	1.819MetAla: 1.819 ± 0.025	0.244MetCys: 0.244 ± 0.008	1.153MetAsp: 1.153 ± 0.02	1.28MetGlu: 1.28 ± 0.019	0.716MetPhe: 0.716 ± 0.016	1.29MetGly: 1.29 ± 0.019	0.408MetHis: 0.408 ± 0.012	1.22MetIle: 1.22 ± 0.018	1.318MetLys: 1.318 ± 0.021	1.745MetLeu: 1.745 ± 0.024	0.552MetMet: 0.552 ± 0.013	0.985MetAsn: 0.985 ± 0.017	1.05MetPro: 1.05 ± 0.02	0.783MetGln: 0.783 ± 0.015	1.171MetArg: 1.171 ± 0.019	1.885MetSer: 1.885 ± 0.027	1.324MetThr: 1.324 ± 0.02	1.16MetVal: 1.16 ± 0.018	0.21MetTrp: 0.21 ± 0.008	0.508MetTyr: 0.508 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.82AsnAla: 2.82 ± 0.032	0.618AsnCys: 0.618 ± 0.014	2.505AsnAsp: 2.505 ± 0.028	2.947AsnGlu: 2.947 ± 0.034	2.1AsnPhe: 2.1 ± 0.028	2.847AsnGly: 2.847 ± 0.03	1.11AsnHis: 1.11 ± 0.021	3.102AsnIle: 3.102 ± 0.034	2.561AsnLys: 2.561 ± 0.029	4.607AsnLeu: 4.607 ± 0.046	1.005AsnMet: 1.005 ± 0.017	2.348AsnAsn: 2.348 ± 0.039	2.599AsnPro: 2.599 ± 0.029	1.949AsnGln: 1.949 ± 0.026	2.365AsnArg: 2.365 ± 0.024	4.64AsnSer: 4.64 ± 0.047	2.741AsnThr: 2.741 ± 0.033	2.594AsnVal: 2.594 ± 0.028	0.584AsnTrp: 0.584 ± 0.015	1.438AsnTyr: 1.438 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	3.305ProAla: 3.305 ± 0.035	0.522ProCys: 0.522 ± 0.012	2.662ProAsp: 2.662 ± 0.029	3.347ProGlu: 3.347 ± 0.038	1.875ProPhe: 1.875 ± 0.026	2.935ProGly: 2.935 ± 0.038	1.188ProHis: 1.188 ± 0.017	2.943ProIle: 2.943 ± 0.031	2.967ProLys: 2.967 ± 0.031	4.361ProLeu: 4.361 ± 0.037	0.876ProMet: 0.876 ± 0.015	2.39ProAsn: 2.39 ± 0.028	3.544ProPro: 3.544 ± 0.052	2.168ProGln: 2.168 ± 0.032	2.69ProArg: 2.69 ± 0.032	5.144ProSer: 5.144 ± 0.046	3.258ProThr: 3.258 ± 0.033	2.876ProVal: 2.876 ± 0.031	0.557ProTrp: 0.557 ± 0.013	1.346ProTyr: 1.346 ± 0.021	0.001ProXaa: 0.001 ± 0.0
Gln	2.877GlnAla: 2.877 ± 0.034	0.425GlnCys: 0.425 ± 0.011	2.127GlnAsp: 2.127 ± 0.025	2.577GlnGlu: 2.577 ± 0.031	1.331GlnPhe: 1.331 ± 0.019	2.063GlnGly: 2.063 ± 0.029	0.938GlnHis: 0.938 ± 0.018	2.614GlnIle: 2.614 ± 0.026	2.761GlnLys: 2.761 ± 0.029	3.47GlnLeu: 3.47 ± 0.036	0.868GlnMet: 0.868 ± 0.017	2.262GlnAsn: 2.262 ± 0.027	1.968GlnPro: 1.968 ± 0.027	2.193GlnGln: 2.193 ± 0.063	2.477GlnArg: 2.477 ± 0.03	3.424GlnSer: 3.424 ± 0.035	2.313GlnThr: 2.313 ± 0.023	2.163GlnVal: 2.163 ± 0.025	0.478GlnTrp: 0.478 ± 0.012	1.162GlnTyr: 1.162 ± 0.018	0.001GlnXaa: 0.001 ± 0.0
Arg	3.758ArgAla: 3.758 ± 0.038	0.705ArgCys: 0.705 ± 0.014	3.105ArgAsp: 3.105 ± 0.032	3.758ArgGlu: 3.758 ± 0.039	2.095ArgPhe: 2.095 ± 0.025	3.191ArgGly: 3.191 ± 0.032	1.394ArgHis: 1.394 ± 0.021	3.449ArgIle: 3.449 ± 0.034	3.969ArgLys: 3.969 ± 0.04	5.198ArgLeu: 5.198 ± 0.038	1.161ArgMet: 1.161 ± 0.018	2.79ArgAsn: 2.79 ± 0.033	2.734ArgPro: 2.734 ± 0.034	2.429ArgGln: 2.429 ± 0.029	4.307ArgArg: 4.307 ± 0.048	4.732ArgSer: 4.732 ± 0.044	2.963ArgThr: 2.963 ± 0.031	2.94ArgVal: 2.94 ± 0.029	0.744ArgTrp: 0.744 ± 0.014	1.618ArgTyr: 1.618 ± 0.023	0.001ArgXaa: 0.001 ± 0.001
Ser	5.526SerAla: 5.526 ± 0.045	1.099SerCys: 1.099 ± 0.021	4.611SerAsp: 4.611 ± 0.044	5.054SerGlu: 5.054 ± 0.042	3.431SerPhe: 3.431 ± 0.036	5.201SerGly: 5.201 ± 0.043	2.176SerHis: 2.176 ± 0.026	5.482SerIle: 5.482 ± 0.043	5.305SerLys: 5.305 ± 0.048	8.253SerLeu: 8.253 ± 0.055	1.781SerMet: 1.781 ± 0.023	4.546SerAsn: 4.546 ± 0.042	4.992SerPro: 4.992 ± 0.058	3.825SerGln: 3.825 ± 0.043	5.136SerArg: 5.136 ± 0.048	10.072SerSer: 10.072 ± 0.094	5.701SerThr: 5.701 ± 0.05	4.591SerVal: 4.591 ± 0.035	1.056SerTrp: 1.056 ± 0.018	2.319SerTyr: 2.319 ± 0.029	0.001SerXaa: 0.001 ± 0.001
Thr	4.13ThrAla: 4.13 ± 0.039	0.772ThrCys: 0.772 ± 0.016	2.832ThrAsp: 2.832 ± 0.029	3.371ThrGlu: 3.371 ± 0.036	2.197ThrPhe: 2.197 ± 0.025	3.623ThrGly: 3.623 ± 0.037	1.302ThrHis: 1.302 ± 0.021	3.605ThrIle: 3.605 ± 0.033	3.332ThrLys: 3.332 ± 0.033	5.2ThrLeu: 5.2 ± 0.047	1.117ThrMet: 1.117 ± 0.02	2.674ThrAsn: 2.674 ± 0.03	3.506ThrPro: 3.506 ± 0.037	2.19ThrGln: 2.19 ± 0.024	3.001ThrArg: 3.001 ± 0.028	5.696ThrSer: 5.696 ± 0.049	3.802ThrThr: 3.802 ± 0.037	3.367ThrVal: 3.367 ± 0.034	0.677ThrTrp: 0.677 ± 0.013	1.598ThrTyr: 1.598 ± 0.023	0.001ThrXaa: 0.001 ± 0.001
Val	4.163ValAla: 4.163 ± 0.037	0.771ValCys: 0.771 ± 0.016	3.364ValAsp: 3.364 ± 0.03	3.682ValGlu: 3.682 ± 0.036	2.233ValPhe: 2.233 ± 0.027	3.331ValGly: 3.331 ± 0.034	1.211ValHis: 1.211 ± 0.02	3.354ValIle: 3.354 ± 0.036	3.318ValLys: 3.318 ± 0.032	5.098ValLeu: 5.098 ± 0.04	1.224ValMet: 1.224 ± 0.02	2.47ValAsn: 2.47 ± 0.026	2.885ValPro: 2.885 ± 0.027	2.158ValGln: 2.158 ± 0.031	3.022ValArg: 3.022 ± 0.032	4.611ValSer: 4.611 ± 0.04	3.285ValThr: 3.285 ± 0.033	3.511ValVal: 3.511 ± 0.039	0.716ValTrp: 0.716 ± 0.016	1.543ValTyr: 1.543 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	0.869TrpAla: 0.869 ± 0.017	0.19TrpCys: 0.19 ± 0.008	0.78TrpAsp: 0.78 ± 0.017	0.763TrpGlu: 0.763 ± 0.013	0.47TrpPhe: 0.47 ± 0.012	0.751TrpGly: 0.751 ± 0.015	0.298TrpHis: 0.298 ± 0.009	0.796TrpIle: 0.796 ± 0.017	0.822TrpLys: 0.822 ± 0.016	1.155TrpLeu: 1.155 ± 0.021	0.29TrpMet: 0.29 ± 0.009	0.628TrpAsn: 0.628 ± 0.013	0.49TrpPro: 0.49 ± 0.011	0.488TrpGln: 0.488 ± 0.011	0.779TrpArg: 0.779 ± 0.014	0.962TrpSer: 0.962 ± 0.02	0.763TrpThr: 0.763 ± 0.014	0.678TrpVal: 0.678 ± 0.015	0.218TrpTrp: 0.218 ± 0.009	0.376TrpTyr: 0.376 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.844TyrAla: 1.844 ± 0.025	0.435TyrCys: 0.435 ± 0.011	1.688TyrAsp: 1.688 ± 0.025	1.704TyrGlu: 1.704 ± 0.023	1.289TyrPhe: 1.289 ± 0.019	1.864TyrGly: 1.864 ± 0.027	0.775TyrHis: 0.775 ± 0.015	1.642TyrIle: 1.642 ± 0.026	1.356TyrLys: 1.356 ± 0.022	2.81TyrLeu: 2.81 ± 0.034	0.595TyrMet: 0.595 ± 0.012	1.323TyrAsn: 1.323 ± 0.02	1.382TyrPro: 1.382 ± 0.022	1.207TyrGln: 1.207 ± 0.015	1.576TyrArg: 1.576 ± 0.022	2.343TyrSer: 2.343 ± 0.026	1.531TyrThr: 1.531 ± 0.023	1.529TyrVal: 1.529 ± 0.021	0.364TyrTrp: 0.364 ± 0.011	0.924TyrTyr: 0.924 ± 0.017	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.001XaaCys: 0.001 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.001XaaGlu: 0.001 ± 0.001	0.001XaaPhe: 0.001 ± 0.0	0.001XaaGly: 0.001 ± 0.0	0.001XaaHis: 0.001 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.0	0.001XaaMet: 0.001 ± 0.0	0.001XaaAsn: 0.001 ± 0.0	0.001XaaPro: 0.001 ± 0.0	0.001XaaGln: 0.001 ± 0.001	0.001XaaArg: 0.001 ± 0.001	0.001XaaSer: 0.001 ± 0.001	0.001XaaThr: 0.001 ± 0.0	0.001XaaVal: 0.001 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.107XaaXaa: 0.107 ± 0.024

Statistics based on 8170 proteins (3553560 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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