Amino acid dipepetide frequency for Mycobacterium phage Yecey3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.074AlaAla: 12.074 ± 1.18
0.481AlaCys: 0.481 ± 0.157
5.587AlaAsp: 5.587 ± 0.624
6.908AlaGlu: 6.908 ± 0.908
3.664AlaPhe: 3.664 ± 0.486
9.131AlaGly: 9.131 ± 0.83
1.622AlaHis: 1.622 ± 0.316
4.746AlaIle: 4.746 ± 0.49
5.406AlaLys: 5.406 ± 0.589
9.792AlaLeu: 9.792 ± 0.867
2.763AlaMet: 2.763 ± 0.371
3.664AlaAsn: 3.664 ± 0.675
5.226AlaPro: 5.226 ± 0.896
3.724AlaGln: 3.724 ± 0.495
6.067AlaArg: 6.067 ± 0.566
5.466AlaSer: 5.466 ± 0.656
6.067AlaThr: 6.067 ± 0.789
6.848AlaVal: 6.848 ± 0.654
2.042AlaTrp: 2.042 ± 0.386
2.042AlaTyr: 2.042 ± 0.383
0.0AlaXaa: 0.0 ± 0.0
Cys
0.721CysAla: 0.721 ± 0.196
0.0CysCys: 0.0 ± 0.0
0.481CysAsp: 0.481 ± 0.159
0.661CysGlu: 0.661 ± 0.19
0.42CysPhe: 0.42 ± 0.144
0.661CysGly: 0.661 ± 0.198
0.24CysHis: 0.24 ± 0.135
0.24CysIle: 0.24 ± 0.124
0.18CysLys: 0.18 ± 0.094
0.661CysLeu: 0.661 ± 0.175
0.3CysMet: 0.3 ± 0.167
0.541CysAsn: 0.541 ± 0.163
0.601CysPro: 0.601 ± 0.223
0.18CysGln: 0.18 ± 0.108
0.541CysArg: 0.541 ± 0.178
0.481CysSer: 0.481 ± 0.188
0.721CysThr: 0.721 ± 0.205
0.781CysVal: 0.781 ± 0.201
0.3CysTrp: 0.3 ± 0.159
0.24CysTyr: 0.24 ± 0.116
0.0CysXaa: 0.0 ± 0.0
Asp
6.007AspAla: 6.007 ± 0.779
0.661AspCys: 0.661 ± 0.199
2.823AspAsp: 2.823 ± 0.421
4.926AspGlu: 4.926 ± 0.592
1.982AspPhe: 1.982 ± 0.405
5.887AspGly: 5.887 ± 0.589
1.442AspHis: 1.442 ± 0.309
2.943AspIle: 2.943 ± 0.356
1.922AspLys: 1.922 ± 0.364
5.827AspLeu: 5.827 ± 0.662
1.322AspMet: 1.322 ± 0.308
1.682AspAsn: 1.682 ± 0.313
3.724AspPro: 3.724 ± 0.543
1.922AspGln: 1.922 ± 0.291
2.883AspArg: 2.883 ± 0.446
3.364AspSer: 3.364 ± 0.446
3.364AspThr: 3.364 ± 0.454
4.325AspVal: 4.325 ± 0.601
1.261AspTrp: 1.261 ± 0.267
2.283AspTyr: 2.283 ± 0.409
0.0AspXaa: 0.0 ± 0.0
Glu
8.35GluAla: 8.35 ± 0.867
0.24GluCys: 0.24 ± 0.099
4.565GluAsp: 4.565 ± 0.697
4.385GluGlu: 4.385 ± 0.611
2.583GluPhe: 2.583 ± 0.392
4.505GluGly: 4.505 ± 0.583
1.742GluHis: 1.742 ± 0.344
3.784GluIle: 3.784 ± 0.534
2.583GluLys: 2.583 ± 0.437
6.608GluLeu: 6.608 ± 0.62
1.922GluMet: 1.922 ± 0.355
1.982GluAsn: 1.982 ± 0.369
3.184GluPro: 3.184 ± 0.481
1.982GluGln: 1.982 ± 0.257
4.806GluArg: 4.806 ± 0.64
2.883GluSer: 2.883 ± 0.435
3.124GluThr: 3.124 ± 0.478
4.866GluVal: 4.866 ± 0.573
1.442GluTrp: 1.442 ± 0.262
1.922GluTyr: 1.922 ± 0.272
0.0GluXaa: 0.0 ± 0.0
Phe
3.604PheAla: 3.604 ± 0.504
0.36PheCys: 0.36 ± 0.133
1.982PheAsp: 1.982 ± 0.415
2.643PheGlu: 2.643 ± 0.42
0.42PhePhe: 0.42 ± 0.184
3.424PheGly: 3.424 ± 0.36
0.781PheHis: 0.781 ± 0.225
2.042PheIle: 2.042 ± 0.33
0.961PheLys: 0.961 ± 0.225
1.982PheLeu: 1.982 ± 0.414
0.36PheMet: 0.36 ± 0.141
1.682PheAsn: 1.682 ± 0.36
1.442PhePro: 1.442 ± 0.294
0.721PheGln: 0.721 ± 0.188
2.163PheArg: 2.163 ± 0.336
2.163PheSer: 2.163 ± 0.323
1.802PheThr: 1.802 ± 0.293
2.223PheVal: 2.223 ± 0.407
0.42PheTrp: 0.42 ± 0.19
1.021PheTyr: 1.021 ± 0.218
0.0PheXaa: 0.0 ± 0.0
Gly
6.908GlyAla: 6.908 ± 0.983
0.721GlyCys: 0.721 ± 0.214
5.527GlyAsp: 5.527 ± 0.594
4.986GlyGlu: 4.986 ± 0.629
3.184GlyPhe: 3.184 ± 0.397
9.011GlyGly: 9.011 ± 1.389
2.163GlyHis: 2.163 ± 0.33
4.325GlyIle: 4.325 ± 0.653
3.965GlyLys: 3.965 ± 0.417
6.368GlyLeu: 6.368 ± 0.763
2.223GlyMet: 2.223 ± 0.364
3.424GlyAsn: 3.424 ± 0.515
4.025GlyPro: 4.025 ± 0.477
3.124GlyGln: 3.124 ± 0.482
4.505GlyArg: 4.505 ± 0.405
4.866GlySer: 4.866 ± 0.659
5.106GlyThr: 5.106 ± 0.724
5.466GlyVal: 5.466 ± 0.543
1.261GlyTrp: 1.261 ± 0.214
2.283GlyTyr: 2.283 ± 0.372
0.0GlyXaa: 0.0 ± 0.0
His
1.802HisAla: 1.802 ± 0.396
0.18HisCys: 0.18 ± 0.099
1.201HisAsp: 1.201 ± 0.243
1.021HisGlu: 1.021 ± 0.261
0.541HisPhe: 0.541 ± 0.175
1.802HisGly: 1.802 ± 0.377
0.661HisHis: 0.661 ± 0.21
0.721HisIle: 0.721 ± 0.197
0.841HisLys: 0.841 ± 0.231
1.502HisLeu: 1.502 ± 0.304
0.601HisMet: 0.601 ± 0.186
0.601HisAsn: 0.601 ± 0.184
1.322HisPro: 1.322 ± 0.249
0.841HisGln: 0.841 ± 0.211
1.802HisArg: 1.802 ± 0.346
0.901HisSer: 0.901 ± 0.247
0.961HisThr: 0.961 ± 0.187
1.261HisVal: 1.261 ± 0.241
0.42HisTrp: 0.42 ± 0.178
0.781HisTyr: 0.781 ± 0.282
0.0HisXaa: 0.0 ± 0.0
Ile
5.046IleAla: 5.046 ± 0.513
0.601IleCys: 0.601 ± 0.185
4.025IleAsp: 4.025 ± 0.406
4.085IleGlu: 4.085 ± 0.547
1.261IlePhe: 1.261 ± 0.287
3.304IleGly: 3.304 ± 0.449
0.841IleHis: 0.841 ± 0.21
1.982IleIle: 1.982 ± 0.356
2.343IleLys: 2.343 ± 0.355
3.965IleLeu: 3.965 ± 0.465
0.901IleMet: 0.901 ± 0.215
2.463IleAsn: 2.463 ± 0.409
3.484IlePro: 3.484 ± 0.456
1.322IleGln: 1.322 ± 0.303
3.604IleArg: 3.604 ± 0.445
2.883IleSer: 2.883 ± 0.43
2.763IleThr: 2.763 ± 0.375
3.484IleVal: 3.484 ± 0.433
0.961IleTrp: 0.961 ± 0.234
0.961IleTyr: 0.961 ± 0.236
0.0IleXaa: 0.0 ± 0.0
Lys
5.106LysAla: 5.106 ± 0.461
0.36LysCys: 0.36 ± 0.158
2.042LysAsp: 2.042 ± 0.279
2.223LysGlu: 2.223 ± 0.288
1.261LysPhe: 1.261 ± 0.231
2.703LysGly: 2.703 ± 0.46
0.36LysHis: 0.36 ± 0.153
2.523LysIle: 2.523 ± 0.369
2.763LysLys: 2.763 ± 0.351
4.445LysLeu: 4.445 ± 0.546
1.081LysMet: 1.081 ± 0.225
1.141LysAsn: 1.141 ± 0.269
2.343LysPro: 2.343 ± 0.489
1.442LysGln: 1.442 ± 0.322
3.604LysArg: 3.604 ± 0.556
2.403LysSer: 2.403 ± 0.37
2.223LysThr: 2.223 ± 0.338
3.604LysVal: 3.604 ± 0.569
1.021LysTrp: 1.021 ± 0.258
1.562LysTyr: 1.562 ± 0.351
0.0LysXaa: 0.0 ± 0.0
Leu
10.032LeuAla: 10.032 ± 0.908
1.021LeuCys: 1.021 ± 0.212
4.686LeuAsp: 4.686 ± 0.528
4.986LeuGlu: 4.986 ± 0.614
2.643LeuPhe: 2.643 ± 0.357
6.488LeuGly: 6.488 ± 0.732
1.141LeuHis: 1.141 ± 0.311
4.866LeuIle: 4.866 ± 0.473
3.424LeuLys: 3.424 ± 0.434
5.587LeuLeu: 5.587 ± 0.691
2.223LeuMet: 2.223 ± 0.402
2.403LeuAsn: 2.403 ± 0.384
4.445LeuPro: 4.445 ± 0.522
2.703LeuGln: 2.703 ± 0.363
6.127LeuArg: 6.127 ± 0.64
5.527LeuSer: 5.527 ± 0.549
4.926LeuThr: 4.926 ± 0.428
5.166LeuVal: 5.166 ± 0.442
1.622LeuTrp: 1.622 ± 0.296
1.802LeuTyr: 1.802 ± 0.385
0.0LeuXaa: 0.0 ± 0.0
Met
3.064MetAla: 3.064 ± 0.471
0.06MetCys: 0.06 ± 0.059
0.901MetAsp: 0.901 ± 0.218
1.742MetGlu: 1.742 ± 0.342
0.601MetPhe: 0.601 ± 0.18
1.802MetGly: 1.802 ± 0.35
0.42MetHis: 0.42 ± 0.147
1.442MetIle: 1.442 ± 0.296
1.742MetLys: 1.742 ± 0.335
1.742MetLeu: 1.742 ± 0.33
0.481MetMet: 0.481 ± 0.214
0.781MetAsn: 0.781 ± 0.209
1.442MetPro: 1.442 ± 0.323
0.901MetGln: 0.901 ± 0.239
1.322MetArg: 1.322 ± 0.31
2.042MetSer: 2.042 ± 0.322
2.283MetThr: 2.283 ± 0.365
1.682MetVal: 1.682 ± 0.325
0.36MetTrp: 0.36 ± 0.16
0.541MetTyr: 0.541 ± 0.193
0.0MetXaa: 0.0 ± 0.0
Asn
3.544AsnAla: 3.544 ± 0.378
0.3AsnCys: 0.3 ± 0.132
1.802AsnAsp: 1.802 ± 0.366
2.523AsnGlu: 2.523 ± 0.379
0.901AsnPhe: 0.901 ± 0.271
3.304AsnGly: 3.304 ± 0.467
1.021AsnHis: 1.021 ± 0.248
1.382AsnIle: 1.382 ± 0.266
0.901AsnLys: 0.901 ± 0.258
3.184AsnLeu: 3.184 ± 0.412
0.901AsnMet: 0.901 ± 0.193
0.961AsnAsn: 0.961 ± 0.197
2.703AsnPro: 2.703 ± 0.291
1.081AsnGln: 1.081 ± 0.229
2.102AsnArg: 2.102 ± 0.389
1.802AsnSer: 1.802 ± 0.292
2.102AsnThr: 2.102 ± 0.457
2.583AsnVal: 2.583 ± 0.387
0.661AsnTrp: 0.661 ± 0.189
0.721AsnTyr: 0.721 ± 0.19
0.0AsnXaa: 0.0 ± 0.0
Pro
5.767ProAla: 5.767 ± 0.732
0.36ProCys: 0.36 ± 0.167
3.905ProAsp: 3.905 ± 0.612
4.145ProGlu: 4.145 ± 0.581
1.802ProPhe: 1.802 ± 0.327
4.505ProGly: 4.505 ± 0.516
1.322ProHis: 1.322 ± 0.313
3.064ProIle: 3.064 ± 0.374
1.562ProLys: 1.562 ± 0.364
3.184ProLeu: 3.184 ± 0.407
1.622ProMet: 1.622 ± 0.323
1.862ProAsn: 1.862 ± 0.36
2.163ProPro: 2.163 ± 0.408
1.682ProGln: 1.682 ± 0.282
2.763ProArg: 2.763 ± 0.486
2.943ProSer: 2.943 ± 0.448
4.145ProThr: 4.145 ± 0.433
4.205ProVal: 4.205 ± 0.476
0.661ProTrp: 0.661 ± 0.247
1.502ProTyr: 1.502 ± 0.293
0.0ProXaa: 0.0 ± 0.0
Gln
3.845GlnAla: 3.845 ± 0.502
0.24GlnCys: 0.24 ± 0.105
1.442GlnAsp: 1.442 ± 0.275
1.622GlnGlu: 1.622 ± 0.356
0.961GlnPhe: 0.961 ± 0.192
2.883GlnGly: 2.883 ± 0.494
0.661GlnHis: 0.661 ± 0.183
1.982GlnIle: 1.982 ± 0.279
1.502GlnLys: 1.502 ± 0.375
2.463GlnLeu: 2.463 ± 0.514
1.201GlnMet: 1.201 ± 0.361
1.141GlnAsn: 1.141 ± 0.258
1.742GlnPro: 1.742 ± 0.354
2.102GlnGln: 2.102 ± 0.518
2.643GlnArg: 2.643 ± 0.349
1.862GlnSer: 1.862 ± 0.351
2.403GlnThr: 2.403 ± 0.411
1.982GlnVal: 1.982 ± 0.34
0.781GlnTrp: 0.781 ± 0.203
1.141GlnTyr: 1.141 ± 0.216
0.0GlnXaa: 0.0 ± 0.0
Arg
5.587ArgAla: 5.587 ± 0.654
0.781ArgCys: 0.781 ± 0.218
4.205ArgAsp: 4.205 ± 0.551
5.346ArgGlu: 5.346 ± 0.511
2.883ArgPhe: 2.883 ± 0.509
3.784ArgGly: 3.784 ± 0.494
1.141ArgHis: 1.141 ± 0.272
3.364ArgIle: 3.364 ± 0.541
3.244ArgLys: 3.244 ± 0.425
5.707ArgLeu: 5.707 ± 0.664
1.802ArgMet: 1.802 ± 0.382
2.223ArgAsn: 2.223 ± 0.349
3.064ArgPro: 3.064 ± 0.389
2.583ArgGln: 2.583 ± 0.397
5.286ArgArg: 5.286 ± 0.649
3.124ArgSer: 3.124 ± 0.482
3.484ArgThr: 3.484 ± 0.502
4.686ArgVal: 4.686 ± 0.449
1.322ArgTrp: 1.322 ± 0.231
1.862ArgTyr: 1.862 ± 0.421
0.0ArgXaa: 0.0 ± 0.0
Ser
4.686SerAla: 4.686 ± 0.561
0.721SerCys: 0.721 ± 0.191
3.124SerAsp: 3.124 ± 0.444
3.784SerGlu: 3.784 ± 0.526
1.982SerPhe: 1.982 ± 0.435
5.947SerGly: 5.947 ± 0.811
0.961SerHis: 0.961 ± 0.218
1.862SerIle: 1.862 ± 0.311
2.703SerLys: 2.703 ± 0.406
4.385SerLeu: 4.385 ± 0.576
1.261SerMet: 1.261 ± 0.256
1.562SerAsn: 1.562 ± 0.316
1.982SerPro: 1.982 ± 0.291
1.982SerGln: 1.982 ± 0.349
4.445SerArg: 4.445 ± 0.477
3.064SerSer: 3.064 ± 0.484
2.823SerThr: 2.823 ± 0.475
4.505SerVal: 4.505 ± 0.569
1.382SerTrp: 1.382 ± 0.289
2.102SerTyr: 2.102 ± 0.368
0.0SerXaa: 0.0 ± 0.0
Thr
6.007ThrAla: 6.007 ± 0.585
0.541ThrCys: 0.541 ± 0.173
4.265ThrAsp: 4.265 ± 0.532
2.883ThrGlu: 2.883 ± 0.378
1.562ThrPhe: 1.562 ± 0.273
5.286ThrGly: 5.286 ± 0.626
1.502ThrHis: 1.502 ± 0.311
3.184ThrIle: 3.184 ± 0.5
3.304ThrLys: 3.304 ± 0.537
5.166ThrLeu: 5.166 ± 0.525
1.442ThrMet: 1.442 ± 0.343
1.502ThrAsn: 1.502 ± 0.295
4.445ThrPro: 4.445 ± 0.544
1.982ThrGln: 1.982 ± 0.322
2.943ThrArg: 2.943 ± 0.468
3.124ThrSer: 3.124 ± 0.486
3.304ThrThr: 3.304 ± 0.431
4.866ThrVal: 4.866 ± 0.582
1.021ThrTrp: 1.021 ± 0.276
2.223ThrTyr: 2.223 ± 0.304
0.0ThrXaa: 0.0 ± 0.0
Val
6.728ValAla: 6.728 ± 0.731
0.781ValCys: 0.781 ± 0.184
5.046ValAsp: 5.046 ± 0.517
5.406ValGlu: 5.406 ± 0.646
2.343ValPhe: 2.343 ± 0.502
5.226ValGly: 5.226 ± 0.546
1.021ValHis: 1.021 ± 0.25
3.004ValIle: 3.004 ± 0.402
3.364ValLys: 3.364 ± 0.488
4.986ValLeu: 4.986 ± 0.726
1.742ValMet: 1.742 ± 0.288
3.004ValAsn: 3.004 ± 0.562
3.304ValPro: 3.304 ± 0.44
2.042ValGln: 2.042 ± 0.296
4.746ValArg: 4.746 ± 0.542
4.085ValSer: 4.085 ± 0.483
5.466ValThr: 5.466 ± 0.473
5.166ValVal: 5.166 ± 0.574
1.802ValTrp: 1.802 ± 0.324
1.862ValTyr: 1.862 ± 0.362
0.0ValXaa: 0.0 ± 0.0
Trp
1.682TrpAla: 1.682 ± 0.422
0.18TrpCys: 0.18 ± 0.129
1.021TrpAsp: 1.021 ± 0.254
1.382TrpGlu: 1.382 ± 0.277
0.541TrpPhe: 0.541 ± 0.191
1.562TrpGly: 1.562 ± 0.402
0.36TrpHis: 0.36 ± 0.165
1.562TrpIle: 1.562 ± 0.265
0.781TrpLys: 0.781 ± 0.204
1.261TrpLeu: 1.261 ± 0.239
0.721TrpMet: 0.721 ± 0.21
0.841TrpAsn: 0.841 ± 0.232
0.961TrpPro: 0.961 ± 0.269
1.081TrpGln: 1.081 ± 0.216
1.201TrpArg: 1.201 ± 0.245
1.081TrpSer: 1.081 ± 0.257
1.682TrpThr: 1.682 ± 0.285
1.081TrpVal: 1.081 ± 0.229
0.541TrpTrp: 0.541 ± 0.2
0.36TrpTyr: 0.36 ± 0.146
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.763TyrAla: 2.763 ± 0.421
0.36TyrCys: 0.36 ± 0.155
1.922TyrAsp: 1.922 ± 0.283
1.802TyrGlu: 1.802 ± 0.338
0.661TyrPhe: 0.661 ± 0.198
2.223TyrGly: 2.223 ± 0.37
0.36TyrHis: 0.36 ± 0.142
1.261TyrIle: 1.261 ± 0.279
0.721TyrLys: 0.721 ± 0.254
3.004TyrLeu: 3.004 ± 0.499
0.42TyrMet: 0.42 ± 0.189
1.021TyrAsn: 1.021 ± 0.211
1.562TyrPro: 1.562 ± 0.331
1.201TyrGln: 1.201 ± 0.285
1.982TyrArg: 1.982 ± 0.422
1.201TyrSer: 1.201 ± 0.246
1.802TyrThr: 1.802 ± 0.281
2.343TyrVal: 2.343 ± 0.311
0.601TyrTrp: 0.601 ± 0.189
0.901TyrTyr: 0.901 ± 0.239
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 100 proteins (16648 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski