Amino acid dipepetide frequency for Thiosulfatimonas sediminis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.163AlaAla: 8.163 ± 0.141
0.871AlaCys: 0.871 ± 0.036
5.043AlaAsp: 5.043 ± 0.099
6.252AlaGlu: 6.252 ± 0.097
3.535AlaPhe: 3.535 ± 0.066
5.772AlaGly: 5.772 ± 0.098
1.944AlaHis: 1.944 ± 0.056
5.708AlaIle: 5.708 ± 0.095
5.368AlaLys: 5.368 ± 0.093
10.757AlaLeu: 10.757 ± 0.15
2.794AlaMet: 2.794 ± 0.076
3.762AlaAsn: 3.762 ± 0.08
3.19AlaPro: 3.19 ± 0.078
5.896AlaGln: 5.896 ± 0.11
3.694AlaArg: 3.694 ± 0.063
5.022AlaSer: 5.022 ± 0.091
4.234AlaThr: 4.234 ± 0.095
5.978AlaVal: 5.978 ± 0.086
1.195AlaTrp: 1.195 ± 0.043
2.638AlaTyr: 2.638 ± 0.058
0.0AlaXaa: 0.0 ± 0.0
Cys
0.721CysAla: 0.721 ± 0.032
0.107CysCys: 0.107 ± 0.011
0.544CysAsp: 0.544 ± 0.026
0.527CysGlu: 0.527 ± 0.026
0.314CysPhe: 0.314 ± 0.022
0.735CysGly: 0.735 ± 0.036
0.282CysHis: 0.282 ± 0.022
0.412CysIle: 0.412 ± 0.023
0.351CysLys: 0.351 ± 0.021
0.869CysLeu: 0.869 ± 0.039
0.167CysMet: 0.167 ± 0.015
0.294CysAsn: 0.294 ± 0.022
0.435CysPro: 0.435 ± 0.024
0.505CysGln: 0.505 ± 0.022
0.402CysArg: 0.402 ± 0.021
0.541CysSer: 0.541 ± 0.025
0.384CysThr: 0.384 ± 0.021
0.519CysVal: 0.519 ± 0.027
0.104CysTrp: 0.104 ± 0.013
0.246CysTyr: 0.246 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
5.043AspAla: 5.043 ± 0.1
0.491AspCys: 0.491 ± 0.023
2.85AspAsp: 2.85 ± 0.094
3.674AspGlu: 3.674 ± 0.077
2.699AspPhe: 2.699 ± 0.066
3.773AspGly: 3.773 ± 0.093
0.953AspHis: 0.953 ± 0.041
3.487AspIle: 3.487 ± 0.064
2.939AspLys: 2.939 ± 0.07
5.829AspLeu: 5.829 ± 0.104
1.385AspMet: 1.385 ± 0.043
2.258AspAsn: 2.258 ± 0.063
1.993AspPro: 1.993 ± 0.054
2.289AspGln: 2.289 ± 0.066
2.103AspArg: 2.103 ± 0.059
3.16AspSer: 3.16 ± 0.076
2.448AspThr: 2.448 ± 0.081
3.608AspVal: 3.608 ± 0.076
0.889AspTrp: 0.889 ± 0.038
2.183AspTyr: 2.183 ± 0.056
0.0AspXaa: 0.0 ± 0.0
Glu
5.253GluAla: 5.253 ± 0.086
0.411GluCys: 0.411 ± 0.022
2.726GluAsp: 2.726 ± 0.065
3.421GluGlu: 3.421 ± 0.086
2.455GluPhe: 2.455 ± 0.051
3.222GluGly: 3.222 ± 0.079
1.451GluHis: 1.451 ± 0.047
4.089GluIle: 4.089 ± 0.07
3.811GluLys: 3.811 ± 0.083
6.55GluLeu: 6.55 ± 0.106
1.855GluMet: 1.855 ± 0.052
2.781GluAsn: 2.781 ± 0.064
2.149GluPro: 2.149 ± 0.067
4.474GluGln: 4.474 ± 0.08
3.313GluArg: 3.313 ± 0.067
3.493GluSer: 3.493 ± 0.085
3.115GluThr: 3.115 ± 0.068
4.399GluVal: 4.399 ± 0.088
0.721GluTrp: 0.721 ± 0.034
1.616GluTyr: 1.616 ± 0.046
0.0GluXaa: 0.0 ± 0.0
Phe
4.155PheAla: 4.155 ± 0.08
0.435PheCys: 0.435 ± 0.025
2.619PheAsp: 2.619 ± 0.057
2.61PheGlu: 2.61 ± 0.06
1.77PhePhe: 1.77 ± 0.058
3.052PheGly: 3.052 ± 0.071
0.795PheHis: 0.795 ± 0.028
2.605PheIle: 2.605 ± 0.067
2.169PheLys: 2.169 ± 0.048
3.463PheLeu: 3.463 ± 0.071
1.067PheMet: 1.067 ± 0.035
1.962PheAsn: 1.962 ± 0.053
1.309PhePro: 1.309 ± 0.047
1.424PheGln: 1.424 ± 0.044
1.453PheArg: 1.453 ± 0.046
3.176PheSer: 3.176 ± 0.068
2.105PheThr: 2.105 ± 0.057
2.665PheVal: 2.665 ± 0.062
0.628PheTrp: 0.628 ± 0.029
1.429PheTyr: 1.429 ± 0.046
0.0PheXaa: 0.0 ± 0.0
Gly
5.27GlyAla: 5.27 ± 0.105
0.796GlyCys: 0.796 ± 0.034
3.528GlyAsp: 3.528 ± 0.072
3.992GlyGlu: 3.992 ± 0.077
3.208GlyPhe: 3.208 ± 0.065
4.407GlyGly: 4.407 ± 0.113
1.45GlyHis: 1.45 ± 0.047
4.248GlyIle: 4.248 ± 0.083
3.889GlyLys: 3.889 ± 0.067
7.123GlyLeu: 7.123 ± 0.112
1.967GlyMet: 1.967 ± 0.051
2.376GlyAsn: 2.376 ± 0.064
1.457GlyPro: 1.457 ± 0.045
3.019GlyGln: 3.019 ± 0.065
3.042GlyArg: 3.042 ± 0.078
3.797GlySer: 3.797 ± 0.089
3.292GlyThr: 3.292 ± 0.1
4.857GlyVal: 4.857 ± 0.089
0.908GlyTrp: 0.908 ± 0.037
2.31GlyTyr: 2.31 ± 0.057
0.0GlyXaa: 0.0 ± 0.0
His
1.908HisAla: 1.908 ± 0.057
0.28HisCys: 0.28 ± 0.022
1.066HisAsp: 1.066 ± 0.037
1.052HisGlu: 1.052 ± 0.038
1.183HisPhe: 1.183 ± 0.042
1.459HisGly: 1.459 ± 0.05
0.682HisHis: 0.682 ± 0.03
1.245HisIle: 1.245 ± 0.04
1.088HisLys: 1.088 ± 0.043
2.613HisLeu: 2.613 ± 0.06
0.463HisMet: 0.463 ± 0.023
0.948HisAsn: 0.948 ± 0.035
1.322HisPro: 1.322 ± 0.044
1.346HisGln: 1.346 ± 0.042
1.072HisArg: 1.072 ± 0.034
1.473HisSer: 1.473 ± 0.044
1.02HisThr: 1.02 ± 0.038
0.96HisVal: 0.96 ± 0.037
0.397HisTrp: 0.397 ± 0.024
0.809HisTyr: 0.809 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
6.406IleAla: 6.406 ± 0.105
0.586IleCys: 0.586 ± 0.024
4.254IleAsp: 4.254 ± 0.078
4.927IleGlu: 4.927 ± 0.092
2.046IlePhe: 2.046 ± 0.054
4.648IleGly: 4.648 ± 0.095
1.285IleHis: 1.285 ± 0.038
3.487IleIle: 3.487 ± 0.082
3.193IleLys: 3.193 ± 0.065
5.412IleLeu: 5.412 ± 0.097
1.374IleMet: 1.374 ± 0.045
2.93IleAsn: 2.93 ± 0.084
2.502IlePro: 2.502 ± 0.06
2.76IleGln: 2.76 ± 0.059
2.881IleArg: 2.881 ± 0.066
4.007IleSer: 4.007 ± 0.077
3.309IleThr: 3.309 ± 0.082
3.713IleVal: 3.713 ± 0.072
0.649IleTrp: 0.649 ± 0.028
1.581IleTyr: 1.581 ± 0.048
0.0IleXaa: 0.0 ± 0.0
Lys
5.016LysAla: 5.016 ± 0.095
0.29LysCys: 0.29 ± 0.026
2.501LysAsp: 2.501 ± 0.053
2.9LysGlu: 2.9 ± 0.071
1.677LysPhe: 1.677 ± 0.051
3.086LysGly: 3.086 ± 0.064
1.16LysHis: 1.16 ± 0.042
3.542LysIle: 3.542 ± 0.069
2.987LysLys: 2.987 ± 0.084
5.076LysLeu: 5.076 ± 0.089
1.584LysMet: 1.584 ± 0.054
2.315LysAsn: 2.315 ± 0.055
2.603LysPro: 2.603 ± 0.07
3.246LysGln: 3.246 ± 0.073
2.79LysArg: 2.79 ± 0.071
3.174LysSer: 3.174 ± 0.068
3.29LysThr: 3.29 ± 0.074
3.69LysVal: 3.69 ± 0.074
0.567LysTrp: 0.567 ± 0.029
1.243LysTyr: 1.243 ± 0.046
0.0LysXaa: 0.0 ± 0.0
Leu
10.186LeuAla: 10.186 ± 0.124
0.822LeuCys: 0.822 ± 0.036
5.838LeuAsp: 5.838 ± 0.086
6.282LeuGlu: 6.282 ± 0.106
4.394LeuPhe: 4.394 ± 0.093
6.831LeuGly: 6.831 ± 0.121
2.3LeuHis: 2.3 ± 0.061
6.372LeuIle: 6.372 ± 0.108
5.797LeuLys: 5.797 ± 0.106
11.399LeuLeu: 11.399 ± 0.177
2.792LeuMet: 2.792 ± 0.067
5.325LeuAsn: 5.325 ± 0.096
5.094LeuPro: 5.094 ± 0.088
6.456LeuGln: 6.456 ± 0.132
4.723LeuArg: 4.723 ± 0.087
7.561LeuSer: 7.561 ± 0.101
5.423LeuThr: 5.423 ± 0.08
6.545LeuVal: 6.545 ± 0.095
1.132LeuTrp: 1.132 ± 0.037
2.79LeuTyr: 2.79 ± 0.059
0.0LeuXaa: 0.0 ± 0.0
Met
2.703MetAla: 2.703 ± 0.062
0.149MetCys: 0.149 ± 0.014
1.421MetAsp: 1.421 ± 0.048
1.228MetGlu: 1.228 ± 0.045
0.798MetPhe: 0.798 ± 0.032
1.742MetGly: 1.742 ± 0.054
0.58MetHis: 0.58 ± 0.029
1.499MetIle: 1.499 ± 0.047
1.36MetLys: 1.36 ± 0.046
2.819MetLeu: 2.819 ± 0.06
0.743MetMet: 0.743 ± 0.033
1.196MetAsn: 1.196 ± 0.038
1.483MetPro: 1.483 ± 0.051
1.796MetGln: 1.796 ± 0.047
1.379MetArg: 1.379 ± 0.042
1.856MetSer: 1.856 ± 0.055
1.547MetThr: 1.547 ± 0.048
1.759MetVal: 1.759 ± 0.049
0.207MetTrp: 0.207 ± 0.018
0.434MetTyr: 0.434 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
3.936AsnAla: 3.936 ± 0.078
0.347AsnCys: 0.347 ± 0.021
2.151AsnAsp: 2.151 ± 0.064
2.329AsnGlu: 2.329 ± 0.061
1.627AsnPhe: 1.627 ± 0.048
3.16AsnGly: 3.16 ± 0.081
0.976AsnHis: 0.976 ± 0.035
2.509AsnIle: 2.509 ± 0.059
1.943AsnLys: 1.943 ± 0.057
4.634AsnLeu: 4.634 ± 0.078
0.964AsnMet: 0.964 ± 0.039
1.867AsnAsn: 1.867 ± 0.066
2.585AsnPro: 2.585 ± 0.058
2.608AsnGln: 2.608 ± 0.06
2.144AsnArg: 2.144 ± 0.055
2.502AsnSer: 2.502 ± 0.065
2.155AsnThr: 2.155 ± 0.066
2.409AsnVal: 2.409 ± 0.069
0.71AsnTrp: 0.71 ± 0.03
1.276AsnTyr: 1.276 ± 0.041
0.0AsnXaa: 0.0 ± 0.0
Pro
3.197ProAla: 3.197 ± 0.083
0.296ProCys: 0.296 ± 0.02
2.193ProAsp: 2.193 ± 0.068
3.178ProGlu: 3.178 ± 0.077
1.711ProPhe: 1.711 ± 0.047
2.275ProGly: 2.275 ± 0.059
0.896ProHis: 0.896 ± 0.032
2.716ProIle: 2.716 ± 0.059
2.28ProLys: 2.28 ± 0.073
4.283ProLeu: 4.283 ± 0.085
1.228ProMet: 1.228 ± 0.038
1.907ProAsn: 1.907 ± 0.047
1.32ProPro: 1.32 ± 0.045
2.432ProGln: 2.432 ± 0.062
1.366ProArg: 1.366 ± 0.044
2.423ProSer: 2.423 ± 0.052
1.993ProThr: 1.993 ± 0.054
3.101ProVal: 3.101 ± 0.08
0.529ProTrp: 0.529 ± 0.029
1.247ProTyr: 1.247 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
6.32GlnAla: 6.32 ± 0.107
0.377GlnCys: 0.377 ± 0.022
2.525GlnAsp: 2.525 ± 0.055
2.917GlnGlu: 2.917 ± 0.06
2.03GlnPhe: 2.03 ± 0.049
3.377GlnGly: 3.377 ± 0.084
1.365GlnHis: 1.365 ± 0.043
3.737GlnIle: 3.737 ± 0.073
3.065GlnLys: 3.065 ± 0.067
6.28GlnLeu: 6.28 ± 0.115
1.513GlnMet: 1.513 ± 0.046
2.548GlnAsn: 2.548 ± 0.058
2.253GlnPro: 2.253 ± 0.058
4.852GlnGln: 4.852 ± 0.133
2.913GlnArg: 2.913 ± 0.08
3.423GlnSer: 3.423 ± 0.08
3.278GlnThr: 3.278 ± 0.069
3.801GlnVal: 3.801 ± 0.08
0.682GlnTrp: 0.682 ± 0.03
1.21GlnTyr: 1.21 ± 0.039
0.0GlnXaa: 0.0 ± 0.0
Arg
3.689ArgAla: 3.689 ± 0.075
0.351ArgCys: 0.351 ± 0.021
2.428ArgAsp: 2.428 ± 0.059
2.797ArgGlu: 2.797 ± 0.065
2.281ArgPhe: 2.281 ± 0.054
2.491ArgGly: 2.491 ± 0.057
1.132ArgHis: 1.132 ± 0.035
3.028ArgIle: 3.028 ± 0.056
2.386ArgLys: 2.386 ± 0.066
5.272ArgLeu: 5.272 ± 0.09
1.266ArgMet: 1.266 ± 0.039
1.901ArgAsn: 1.901 ± 0.057
1.693ArgPro: 1.693 ± 0.049
2.757ArgGln: 2.757 ± 0.071
2.184ArgArg: 2.184 ± 0.068
2.491ArgSer: 2.491 ± 0.065
1.946ArgThr: 1.946 ± 0.049
3.026ArgVal: 3.026 ± 0.07
0.674ArgTrp: 0.674 ± 0.031
1.619ArgTyr: 1.619 ± 0.047
0.0ArgXaa: 0.0 ± 0.0
Ser
5.975SerAla: 5.975 ± 0.1
0.475SerCys: 0.475 ± 0.024
3.447SerAsp: 3.447 ± 0.088
3.875SerGlu: 3.875 ± 0.085
2.43SerPhe: 2.43 ± 0.061
4.714SerGly: 4.714 ± 0.091
1.407SerHis: 1.407 ± 0.038
3.692SerIle: 3.692 ± 0.082
2.975SerLys: 2.975 ± 0.069
6.713SerLeu: 6.713 ± 0.108
1.684SerMet: 1.684 ± 0.052
2.463SerAsn: 2.463 ± 0.059
2.152SerPro: 2.152 ± 0.057
3.132SerGln: 3.132 ± 0.072
2.753SerArg: 2.753 ± 0.066
3.754SerSer: 3.754 ± 0.097
2.991SerThr: 2.991 ± 0.068
4.199SerVal: 4.199 ± 0.096
0.715SerTrp: 0.715 ± 0.03
1.677SerTyr: 1.677 ± 0.056
0.0SerXaa: 0.0 ± 0.0
Thr
4.548ThrAla: 4.548 ± 0.101
0.392ThrCys: 0.392 ± 0.024
2.857ThrAsp: 2.857 ± 0.081
3.035ThrGlu: 3.035 ± 0.063
1.987ThrPhe: 1.987 ± 0.053
3.515ThrGly: 3.515 ± 0.094
1.205ThrHis: 1.205 ± 0.04
2.926ThrIle: 2.926 ± 0.076
2.042ThrLys: 2.042 ± 0.058
6.49ThrLeu: 6.49 ± 0.113
1.104ThrMet: 1.104 ± 0.039
1.842ThrAsn: 1.842 ± 0.066
2.716ThrPro: 2.716 ± 0.064
2.885ThrGln: 2.885 ± 0.065
1.944ThrArg: 1.944 ± 0.047
2.773ThrSer: 2.773 ± 0.068
2.615ThrThr: 2.615 ± 0.082
3.637ThrVal: 3.637 ± 0.111
0.583ThrTrp: 0.583 ± 0.03
1.439ThrTyr: 1.439 ± 0.049
0.0ThrXaa: 0.0 ± 0.0
Val
6.003ValAla: 6.003 ± 0.096
0.579ValCys: 0.579 ± 0.03
3.975ValAsp: 3.975 ± 0.104
4.282ValGlu: 4.282 ± 0.078
2.837ValPhe: 2.837 ± 0.07
4.106ValGly: 4.106 ± 0.074
1.334ValHis: 1.334 ± 0.044
4.548ValIle: 4.548 ± 0.089
3.327ValLys: 3.327 ± 0.07
7.041ValLeu: 7.041 ± 0.114
1.786ValMet: 1.786 ± 0.052
2.766ValAsn: 2.766 ± 0.073
2.504ValPro: 2.504 ± 0.059
3.065ValGln: 3.065 ± 0.07
2.903ValArg: 2.903 ± 0.075
4.087ValSer: 4.087 ± 0.078
3.699ValThr: 3.699 ± 0.115
4.848ValVal: 4.848 ± 0.105
0.734ValTrp: 0.734 ± 0.035
1.801ValTyr: 1.801 ± 0.046
0.0ValXaa: 0.0 ± 0.0
Trp
0.808TrpAla: 0.808 ± 0.028
0.123TrpCys: 0.123 ± 0.012
0.556TrpAsp: 0.556 ± 0.027
0.533TrpGlu: 0.533 ± 0.026
0.588TrpPhe: 0.588 ± 0.026
0.636TrpGly: 0.636 ± 0.03
0.363TrpHis: 0.363 ± 0.021
0.735TrpIle: 0.735 ± 0.032
0.51TrpLys: 0.51 ± 0.025
1.985TrpLeu: 1.985 ± 0.051
0.379TrpMet: 0.379 ± 0.025
0.43TrpAsn: 0.43 ± 0.025
0.473TrpPro: 0.473 ± 0.026
1.287TrpGln: 1.287 ± 0.047
0.705TrpArg: 0.705 ± 0.036
0.63TrpSer: 0.63 ± 0.029
0.443TrpThr: 0.443 ± 0.027
0.908TrpVal: 0.908 ± 0.036
0.17TrpTrp: 0.17 ± 0.016
0.345TrpTyr: 0.345 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.516TyrAla: 2.516 ± 0.062
0.281TyrCys: 0.281 ± 0.019
1.529TyrAsp: 1.529 ± 0.046
1.493TyrGlu: 1.493 ± 0.041
1.322TyrPhe: 1.322 ± 0.045
1.934TyrGly: 1.934 ± 0.053
0.827TyrHis: 0.827 ± 0.038
1.368TyrIle: 1.368 ± 0.039
1.258TyrLys: 1.258 ± 0.041
3.455TyrLeu: 3.455 ± 0.073
0.583TyrMet: 0.583 ± 0.027
0.963TyrAsn: 0.963 ± 0.038
1.338TyrPro: 1.338 ± 0.049
2.238TyrGln: 2.238 ± 0.063
1.65TyrArg: 1.65 ± 0.042
1.879TyrSer: 1.879 ± 0.05
1.247TyrThr: 1.247 ± 0.05
1.6TyrVal: 1.6 ± 0.051
0.411TyrTrp: 0.411 ± 0.024
0.94TyrTyr: 0.94 ± 0.043
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2439 proteins (786091 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski