Amino acid dipepetide frequency for Corynebacterium urealyticum (strain ATCC 43042 / DSM 7109)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.673AlaAla: 16.673 ± 0.269	0.752AlaCys: 0.752 ± 0.038	6.973AlaAsp: 6.973 ± 0.117	9.227AlaGlu: 9.227 ± 0.155	3.423AlaPhe: 3.423 ± 0.076	11.113AlaGly: 11.113 ± 0.166	2.227AlaHis: 2.227 ± 0.053	5.192AlaIle: 5.192 ± 0.083	4.324AlaLys: 4.324 ± 0.089	11.072AlaLeu: 11.072 ± 0.138	2.762AlaMet: 2.762 ± 0.064	3.031AlaAsn: 3.031 ± 0.066	5.56AlaPro: 5.56 ± 0.162	4.506AlaGln: 4.506 ± 0.104	6.995AlaArg: 6.995 ± 0.122	6.111AlaSer: 6.111 ± 0.111	6.919AlaThr: 6.919 ± 0.109	9.213AlaVal: 9.213 ± 0.155	1.546AlaTrp: 1.546 ± 0.054	2.127AlaTyr: 2.127 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.782CysAla: 0.782 ± 0.035	0.084CysCys: 0.084 ± 0.011	0.325CysAsp: 0.325 ± 0.021	0.373CysGlu: 0.373 ± 0.025	0.212CysPhe: 0.212 ± 0.02	0.74CysGly: 0.74 ± 0.035	0.165CysHis: 0.165 ± 0.015	0.262CysIle: 0.262 ± 0.019	0.165CysLys: 0.165 ± 0.012	0.606CysLeu: 0.606 ± 0.034	0.117CysMet: 0.117 ± 0.012	0.198CysAsn: 0.198 ± 0.016	0.393CysPro: 0.393 ± 0.026	0.184CysGln: 0.184 ± 0.017	0.413CysArg: 0.413 ± 0.028	0.434CysSer: 0.434 ± 0.027	0.384CysThr: 0.384 ± 0.022	0.532CysVal: 0.532 ± 0.029	0.118CysTrp: 0.118 ± 0.015	0.131CysTyr: 0.131 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.02AspAla: 7.02 ± 0.128	0.349AspCys: 0.349 ± 0.023	3.064AspAsp: 3.064 ± 0.089	4.347AspGlu: 4.347 ± 0.094	1.807AspPhe: 1.807 ± 0.054	5.155AspGly: 5.155 ± 0.107	1.254AspHis: 1.254 ± 0.046	2.638AspIle: 2.638 ± 0.065	2.044AspLys: 2.044 ± 0.074	5.236AspLeu: 5.236 ± 0.085	1.239AspMet: 1.239 ± 0.04	1.585AspAsn: 1.585 ± 0.053	3.763AspPro: 3.763 ± 0.088	2.029AspGln: 2.029 ± 0.059	3.754AspArg: 3.754 ± 0.081	3.225AspSer: 3.225 ± 0.075	2.943AspThr: 2.943 ± 0.072	4.792AspVal: 4.792 ± 0.087	0.846AspTrp: 0.846 ± 0.034	1.452AspTyr: 1.452 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	7.363GluAla: 7.363 ± 0.128	0.363GluCys: 0.363 ± 0.024	4.273GluAsp: 4.273 ± 0.104	4.859GluGlu: 4.859 ± 0.118	2.136GluPhe: 2.136 ± 0.055	4.997GluGly: 4.997 ± 0.091	1.735GluHis: 1.735 ± 0.045	3.178GluIle: 3.178 ± 0.072	2.825GluLys: 2.825 ± 0.079	7.345GluLeu: 7.345 ± 0.106	1.32GluMet: 1.32 ± 0.047	2.133GluAsn: 2.133 ± 0.06	3.007GluPro: 3.007 ± 0.081	3.191GluGln: 3.191 ± 0.084	4.381GluArg: 4.381 ± 0.103	3.152GluSer: 3.152 ± 0.078	3.088GluThr: 3.088 ± 0.072	4.977GluVal: 4.977 ± 0.098	0.83GluTrp: 0.83 ± 0.038	1.39GluTyr: 1.39 ± 0.047	0.0GluXaa: 0.0 ± 0.0
Phe	3.595PheAla: 3.595 ± 0.081	0.226PheCys: 0.226 ± 0.021	2.173PheAsp: 2.173 ± 0.053	1.735PheGlu: 1.735 ± 0.05	1.177PhePhe: 1.177 ± 0.047	3.276PheGly: 3.276 ± 0.075	0.7PheHis: 0.7 ± 0.03	1.509PheIle: 1.509 ± 0.053	0.75PheLys: 0.75 ± 0.04	2.944PheLeu: 2.944 ± 0.081	0.571PheMet: 0.571 ± 0.027	0.937PheAsn: 0.937 ± 0.037	1.36PhePro: 1.36 ± 0.047	0.91PheGln: 0.91 ± 0.039	1.821PheArg: 1.821 ± 0.049	1.993PheSer: 1.993 ± 0.062	2.027PheThr: 2.027 ± 0.062	2.282PheVal: 2.282 ± 0.064	0.457PheTrp: 0.457 ± 0.027	0.789PheTyr: 0.789 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	9.88GlyAla: 9.88 ± 0.158	0.658GlyCys: 0.658 ± 0.032	4.57GlyAsp: 4.57 ± 0.09	6.052GlyGlu: 6.052 ± 0.111	3.023GlyPhe: 3.023 ± 0.068	7.446GlyGly: 7.446 ± 0.131	1.938GlyHis: 1.938 ± 0.059	4.307GlyIle: 4.307 ± 0.089	3.443GlyLys: 3.443 ± 0.075	8.277GlyLeu: 8.277 ± 0.136	2.21GlyMet: 2.21 ± 0.049	2.242GlyAsn: 2.242 ± 0.058	3.588GlyPro: 3.588 ± 0.081	3.347GlyGln: 3.347 ± 0.071	5.332GlyArg: 5.332 ± 0.094	5.34GlySer: 5.34 ± 0.103	5.118GlyThr: 5.118 ± 0.084	7.205GlyVal: 7.205 ± 0.108	1.419GlyTrp: 1.419 ± 0.044	2.202GlyTyr: 2.202 ± 0.065	0.0GlyXaa: 0.0 ± 0.0
His	2.22HisAla: 2.22 ± 0.065	0.192HisCys: 0.192 ± 0.016	1.135HisAsp: 1.135 ± 0.043	1.247HisGlu: 1.247 ± 0.048	0.641HisPhe: 0.641 ± 0.033	1.869HisGly: 1.869 ± 0.055	0.56HisHis: 0.56 ± 0.031	1.008HisIle: 1.008 ± 0.036	0.55HisLys: 0.55 ± 0.028	1.891HisLeu: 1.891 ± 0.055	0.441HisMet: 0.441 ± 0.025	0.656HisAsn: 0.656 ± 0.034	1.421HisPro: 1.421 ± 0.046	0.672HisGln: 0.672 ± 0.03	1.691HisArg: 1.691 ± 0.051	1.284HisSer: 1.284 ± 0.04	1.185HisThr: 1.185 ± 0.043	1.558HisVal: 1.558 ± 0.042	0.286HisTrp: 0.286 ± 0.02	0.49HisTyr: 0.49 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.115IleAla: 6.115 ± 0.087	0.364IleCys: 0.364 ± 0.022	3.33IleAsp: 3.33 ± 0.075	2.89IleGlu: 2.89 ± 0.076	1.474IlePhe: 1.474 ± 0.057	4.335IleGly: 4.335 ± 0.088	0.894IleHis: 0.894 ± 0.036	2.276IleIle: 2.276 ± 0.066	1.397IleLys: 1.397 ± 0.049	3.807IleLeu: 3.807 ± 0.083	0.874IleMet: 0.874 ± 0.038	1.509IleAsn: 1.509 ± 0.05	2.511IlePro: 2.511 ± 0.069	1.261IleGln: 1.261 ± 0.039	2.632IleArg: 2.632 ± 0.054	2.694IleSer: 2.694 ± 0.058	3.071IleThr: 3.071 ± 0.067	3.992IleVal: 3.992 ± 0.088	0.481IleTrp: 0.481 ± 0.03	0.96IleTyr: 0.96 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	3.964LysAla: 3.964 ± 0.1	0.135LysCys: 0.135 ± 0.014	2.205LysAsp: 2.205 ± 0.073	2.073LysGlu: 2.073 ± 0.066	0.897LysPhe: 0.897 ± 0.038	2.426LysGly: 2.426 ± 0.07	0.736LysHis: 0.736 ± 0.033	1.784LysIle: 1.784 ± 0.056	2.071LysLys: 2.071 ± 0.082	3.126LysLeu: 3.126 ± 0.074	0.836LysMet: 0.836 ± 0.038	1.323LysAsn: 1.323 ± 0.051	1.929LysPro: 1.929 ± 0.078	1.449LysGln: 1.449 ± 0.055	2.094LysArg: 2.094 ± 0.057	1.773LysSer: 1.773 ± 0.054	2.052LysThr: 2.052 ± 0.067	2.671LysVal: 2.671 ± 0.069	0.363LysTrp: 0.363 ± 0.025	0.705LysTyr: 0.705 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	12.178LeuAla: 12.178 ± 0.159	0.606LeuCys: 0.606 ± 0.029	5.756LeuAsp: 5.756 ± 0.092	5.248LeuGlu: 5.248 ± 0.094	2.748LeuPhe: 2.748 ± 0.077	8.445LeuGly: 8.445 ± 0.134	1.814LeuHis: 1.814 ± 0.057	4.607LeuIle: 4.607 ± 0.085	2.944LeuLys: 2.944 ± 0.067	8.777LeuLeu: 8.777 ± 0.146	2.02LeuMet: 2.02 ± 0.062	2.637LeuAsn: 2.637 ± 0.064	5.29LeuPro: 5.29 ± 0.077	2.855LeuGln: 2.855 ± 0.063	6.301LeuArg: 6.301 ± 0.092	5.824LeuSer: 5.824 ± 0.098	5.402LeuThr: 5.402 ± 0.083	7.563LeuVal: 7.563 ± 0.115	1.207LeuTrp: 1.207 ± 0.041	1.639LeuTyr: 1.639 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	2.648MetAla: 2.648 ± 0.06	0.131MetCys: 0.131 ± 0.015	1.155MetAsp: 1.155 ± 0.041	1.044MetGlu: 1.044 ± 0.042	0.671MetPhe: 0.671 ± 0.031	1.734MetGly: 1.734 ± 0.052	0.369MetHis: 0.369 ± 0.019	1.12MetIle: 1.12 ± 0.042	0.728MetLys: 0.728 ± 0.037	2.214MetLeu: 2.214 ± 0.062	0.498MetMet: 0.498 ± 0.024	0.698MetAsn: 0.698 ± 0.034	1.157MetPro: 1.157 ± 0.042	0.639MetGln: 0.639 ± 0.028	1.358MetArg: 1.358 ± 0.048	1.677MetSer: 1.677 ± 0.053	1.629MetThr: 1.629 ± 0.049	1.683MetVal: 1.683 ± 0.052	0.303MetTrp: 0.303 ± 0.022	0.387MetTyr: 0.387 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.21AsnAla: 3.21 ± 0.064	0.188AsnCys: 0.188 ± 0.016	1.345AsnAsp: 1.345 ± 0.048	1.585AsnGlu: 1.585 ± 0.048	0.923AsnPhe: 0.923 ± 0.04	2.38AsnGly: 2.38 ± 0.067	0.602AsnHis: 0.602 ± 0.028	1.35AsnIle: 1.35 ± 0.047	0.97AsnLys: 0.97 ± 0.039	2.561AsnLeu: 2.561 ± 0.066	0.626AsnMet: 0.626 ± 0.032	0.977AsnAsn: 0.977 ± 0.038	2.268AsnPro: 2.268 ± 0.057	1.145AsnGln: 1.145 ± 0.051	1.854AsnArg: 1.854 ± 0.057	1.76AsnSer: 1.76 ± 0.051	1.805AsnThr: 1.805 ± 0.05	2.037AsnVal: 2.037 ± 0.06	0.45AsnTrp: 0.45 ± 0.028	0.675AsnTyr: 0.675 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	6.575ProAla: 6.575 ± 0.125	0.228ProCys: 0.228 ± 0.02	3.125ProAsp: 3.125 ± 0.076	4.747ProGlu: 4.747 ± 0.087	1.518ProPhe: 1.518 ± 0.051	5.128ProGly: 5.128 ± 0.099	1.122ProHis: 1.122 ± 0.043	2.023ProIle: 2.023 ± 0.057	1.979ProLys: 1.979 ± 0.062	4.157ProLeu: 4.157 ± 0.08	1.055ProMet: 1.055 ± 0.039	1.555ProAsn: 1.555 ± 0.053	1.905ProPro: 1.905 ± 0.057	2.059ProGln: 2.059 ± 0.059	3.209ProArg: 3.209 ± 0.077	2.818ProSer: 2.818 ± 0.075	3.303ProThr: 3.303 ± 0.089	4.211ProVal: 4.211 ± 0.09	0.713ProTrp: 0.713 ± 0.032	1.024ProTyr: 1.024 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	4.181GlnAla: 4.181 ± 0.091	0.179GlnCys: 0.179 ± 0.015	1.899GlnAsp: 1.899 ± 0.053	2.284GlnGlu: 2.284 ± 0.067	1.059GlnPhe: 1.059 ± 0.04	2.696GlnGly: 2.696 ± 0.077	0.846GlnHis: 0.846 ± 0.034	1.701GlnIle: 1.701 ± 0.048	1.125GlnLys: 1.125 ± 0.046	3.901GlnLeu: 3.901 ± 0.092	0.78GlnMet: 0.78 ± 0.033	0.985GlnAsn: 0.985 ± 0.041	2.114GlnPro: 2.114 ± 0.06	1.851GlnGln: 1.851 ± 0.067	3.161GlnArg: 3.161 ± 0.079	1.834GlnSer: 1.834 ± 0.052	1.596GlnThr: 1.596 ± 0.046	2.731GlnVal: 2.731 ± 0.06	0.599GlnTrp: 0.599 ± 0.03	0.656GlnTyr: 0.656 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	6.663ArgAla: 6.663 ± 0.127	0.476ArgCys: 0.476 ± 0.028	3.659ArgAsp: 3.659 ± 0.077	4.53ArgGlu: 4.53 ± 0.084	2.097ArgPhe: 2.097 ± 0.051	5.187ArgGly: 5.187 ± 0.096	1.398ArgHis: 1.398 ± 0.043	3.282ArgIle: 3.282 ± 0.063	2.423ArgLys: 2.423 ± 0.074	5.644ArgLeu: 5.644 ± 0.096	1.622ArgMet: 1.622 ± 0.047	1.965ArgAsn: 1.965 ± 0.056	3.237ArgPro: 3.237 ± 0.062	2.402ArgGln: 2.402 ± 0.062	5.365ArgArg: 5.365 ± 0.124	3.66ArgSer: 3.66 ± 0.069	3.573ArgThr: 3.573 ± 0.07	4.764ArgVal: 4.764 ± 0.086	1.101ArgTrp: 1.101 ± 0.047	1.533ArgTyr: 1.533 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	6.67SerAla: 6.67 ± 0.12	0.359SerCys: 0.359 ± 0.023	3.041SerAsp: 3.041 ± 0.069	3.484SerGlu: 3.484 ± 0.07	1.825SerPhe: 1.825 ± 0.049	5.683SerGly: 5.683 ± 0.096	1.16SerHis: 1.16 ± 0.045	2.503SerIle: 2.503 ± 0.061	1.854SerLys: 1.854 ± 0.059	5.084SerLeu: 5.084 ± 0.082	1.345SerMet: 1.345 ± 0.04	1.575SerAsn: 1.575 ± 0.048	3.121SerPro: 3.121 ± 0.072	2.084SerGln: 2.084 ± 0.048	3.589SerArg: 3.589 ± 0.08	3.949SerSer: 3.949 ± 0.091	3.759SerThr: 3.759 ± 0.079	4.189SerVal: 4.189 ± 0.074	0.878SerTrp: 0.878 ± 0.035	1.281SerTyr: 1.281 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	6.915ThrAla: 6.915 ± 0.112	0.401ThrCys: 0.401 ± 0.025	3.317ThrAsp: 3.317 ± 0.079	3.558ThrGlu: 3.558 ± 0.082	1.831ThrPhe: 1.831 ± 0.051	5.645ThrGly: 5.645 ± 0.083	1.213ThrHis: 1.213 ± 0.047	2.679ThrIle: 2.679 ± 0.065	1.817ThrLys: 1.817 ± 0.067	5.325ThrLeu: 5.325 ± 0.094	1.169ThrMet: 1.169 ± 0.038	1.518ThrAsn: 1.518 ± 0.05	3.845ThrPro: 3.845 ± 0.083	1.922ThrGln: 1.922 ± 0.053	3.246ThrArg: 3.246 ± 0.075	3.337ThrSer: 3.337 ± 0.074	3.784ThrThr: 3.784 ± 0.086	4.925ThrVal: 4.925 ± 0.101	0.83ThrTrp: 0.83 ± 0.037	1.207ThrTyr: 1.207 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	9.493ValAla: 9.493 ± 0.139	0.608ValCys: 0.608 ± 0.028	5.276ValAsp: 5.276 ± 0.091	5.164ValGlu: 5.164 ± 0.096	2.524ValPhe: 2.524 ± 0.069	6.355ValGly: 6.355 ± 0.115	1.558ValHis: 1.558 ± 0.045	3.921ValIle: 3.921 ± 0.079	2.286ValLys: 2.286 ± 0.064	8.091ValLeu: 8.091 ± 0.109	1.657ValMet: 1.657 ± 0.054	2.197ValAsn: 2.197 ± 0.056	4.123ValPro: 4.123 ± 0.083	2.208ValGln: 2.208 ± 0.055	4.661ValArg: 4.661 ± 0.088	4.52ValSer: 4.52 ± 0.093	4.855ValThr: 4.855 ± 0.102	6.814ValVal: 6.814 ± 0.113	0.962ValTrp: 0.962 ± 0.039	1.461ValTyr: 1.461 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	1.412TrpAla: 1.412 ± 0.048	0.151TrpCys: 0.151 ± 0.015	0.713TrpAsp: 0.713 ± 0.029	0.79TrpGlu: 0.79 ± 0.031	0.522TrpPhe: 0.522 ± 0.03	1.032TrpGly: 1.032 ± 0.041	0.312TrpHis: 0.312 ± 0.022	0.696TrpIle: 0.696 ± 0.032	0.396TrpLys: 0.396 ± 0.018	1.689TrpLeu: 1.689 ± 0.054	0.322TrpMet: 0.322 ± 0.02	0.417TrpAsn: 0.417 ± 0.025	0.641TrpPro: 0.641 ± 0.034	0.625TrpGln: 0.625 ± 0.03	1.103TrpArg: 1.103 ± 0.043	0.774TrpSer: 0.774 ± 0.036	0.723TrpThr: 0.723 ± 0.032	1.069TrpVal: 1.069 ± 0.038	0.356TrpTrp: 0.356 ± 0.023	0.292TrpTyr: 0.292 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.187TyrAla: 2.187 ± 0.055	0.168TyrCys: 0.168 ± 0.015	1.209TyrAsp: 1.209 ± 0.041	1.306TyrGlu: 1.306 ± 0.049	0.728TyrPhe: 0.728 ± 0.032	1.952TyrGly: 1.952 ± 0.052	0.393TyrHis: 0.393 ± 0.027	0.831TyrIle: 0.831 ± 0.035	0.522TyrLys: 0.522 ± 0.029	2.114TyrLeu: 2.114 ± 0.059	0.377TyrMet: 0.377 ± 0.026	0.575TyrAsn: 0.575 ± 0.028	1.219TyrPro: 1.219 ± 0.038	0.841TyrGln: 0.841 ± 0.033	1.619TyrArg: 1.619 ± 0.053	1.274TyrSer: 1.274 ± 0.041	1.269TyrThr: 1.269 ± 0.041	1.528TyrVal: 1.528 ± 0.052	0.289TyrTrp: 0.289 ± 0.021	0.535TyrTyr: 0.535 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2011 proteins (702396 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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