Amino acid dipepetide frequency for Achromobacter phage JWX

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.173AlaAla: 8.173 ± 1.104
0.634AlaCys: 0.634 ± 0.314
5.566AlaAsp: 5.566 ± 0.675
6.764AlaGlu: 6.764 ± 1.02
3.523AlaPhe: 3.523 ± 0.554
7.257AlaGly: 7.257 ± 0.85
1.339AlaHis: 1.339 ± 0.464
5.566AlaIle: 5.566 ± 0.711
4.721AlaLys: 4.721 ± 0.74
9.159AlaLeu: 9.159 ± 0.644
3.1AlaMet: 3.1 ± 0.607
3.523AlaAsn: 3.523 ± 0.539
3.946AlaPro: 3.946 ± 0.628
3.805AlaGln: 3.805 ± 0.603
5.143AlaArg: 5.143 ± 0.759
5.496AlaSer: 5.496 ± 0.709
5.777AlaThr: 5.777 ± 0.672
6.975AlaVal: 6.975 ± 0.621
1.973AlaTrp: 1.973 ± 0.342
2.677AlaTyr: 2.677 ± 0.421
0.0AlaXaa: 0.0 ± 0.0
Cys
1.198CysAla: 1.198 ± 0.338
0.07CysCys: 0.07 ± 0.08
0.564CysAsp: 0.564 ± 0.198
0.352CysGlu: 0.352 ± 0.169
0.352CysPhe: 0.352 ± 0.163
0.423CysGly: 0.423 ± 0.218
0.282CysHis: 0.282 ± 0.14
0.423CysIle: 0.423 ± 0.176
0.282CysLys: 0.282 ± 0.137
0.493CysLeu: 0.493 ± 0.19
0.423CysMet: 0.423 ± 0.171
0.352CysAsn: 0.352 ± 0.192
0.634CysPro: 0.634 ± 0.329
0.0CysGln: 0.0 ± 0.0
0.634CysArg: 0.634 ± 0.238
0.423CysSer: 0.423 ± 0.213
0.07CysThr: 0.07 ± 0.072
0.564CysVal: 0.564 ± 0.173
0.282CysTrp: 0.282 ± 0.131
0.352CysTyr: 0.352 ± 0.189
0.0CysXaa: 0.0 ± 0.0
Asp
6.13AspAla: 6.13 ± 0.658
0.493AspCys: 0.493 ± 0.151
3.875AspAsp: 3.875 ± 0.602
4.509AspGlu: 4.509 ± 0.931
3.03AspPhe: 3.03 ± 0.58
5.073AspGly: 5.073 ± 0.652
0.986AspHis: 0.986 ± 0.355
2.607AspIle: 2.607 ± 0.392
2.677AspLys: 2.677 ± 0.472
4.862AspLeu: 4.862 ± 0.494
1.268AspMet: 1.268 ± 0.255
2.255AspAsn: 2.255 ± 0.425
2.818AspPro: 2.818 ± 0.411
2.184AspGln: 2.184 ± 0.437
2.184AspArg: 2.184 ± 0.501
2.959AspSer: 2.959 ± 0.533
2.396AspThr: 2.396 ± 0.435
3.523AspVal: 3.523 ± 0.499
1.127AspTrp: 1.127 ± 0.303
2.255AspTyr: 2.255 ± 0.323
0.0AspXaa: 0.0 ± 0.0
Glu
7.468GluAla: 7.468 ± 0.891
0.493GluCys: 0.493 ± 0.181
3.452GluAsp: 3.452 ± 0.423
5.355GluGlu: 5.355 ± 0.726
2.114GluPhe: 2.114 ± 0.354
4.227GluGly: 4.227 ± 0.522
1.198GluHis: 1.198 ± 0.33
3.311GluIle: 3.311 ± 0.558
3.875GluLys: 3.875 ± 0.526
7.257GluLeu: 7.257 ± 0.872
1.973GluMet: 1.973 ± 0.355
2.114GluAsn: 2.114 ± 0.311
2.818GluPro: 2.818 ± 0.494
4.087GluGln: 4.087 ± 0.593
3.946GluArg: 3.946 ± 0.564
2.466GluSer: 2.466 ± 0.608
3.1GluThr: 3.1 ± 0.456
4.862GluVal: 4.862 ± 0.616
1.48GluTrp: 1.48 ± 0.388
1.691GluTyr: 1.691 ± 0.322
0.0GluXaa: 0.0 ± 0.0
Phe
3.1PheAla: 3.1 ± 0.492
0.564PheCys: 0.564 ± 0.2
2.466PheAsp: 2.466 ± 0.414
2.889PheGlu: 2.889 ± 0.505
1.057PhePhe: 1.057 ± 0.295
3.523PheGly: 3.523 ± 0.473
0.493PheHis: 0.493 ± 0.311
1.55PheIle: 1.55 ± 0.346
1.902PheLys: 1.902 ± 0.373
2.607PheLeu: 2.607 ± 0.46
1.198PheMet: 1.198 ± 0.257
1.339PheAsn: 1.339 ± 0.291
2.043PhePro: 2.043 ± 0.346
0.845PheGln: 0.845 ± 0.235
2.466PheArg: 2.466 ± 0.471
2.184PheSer: 2.184 ± 0.36
2.043PheThr: 2.043 ± 0.35
2.325PheVal: 2.325 ± 0.608
0.564PheTrp: 0.564 ± 0.18
0.916PheTyr: 0.916 ± 0.31
0.0PheXaa: 0.0 ± 0.0
Gly
6.13GlyAla: 6.13 ± 0.806
0.423GlyCys: 0.423 ± 0.222
3.805GlyAsp: 3.805 ± 0.553
3.946GlyGlu: 3.946 ± 0.481
2.748GlyPhe: 2.748 ± 0.481
6.693GlyGly: 6.693 ± 0.815
1.127GlyHis: 1.127 ± 0.313
3.452GlyIle: 3.452 ± 0.44
4.509GlyLys: 4.509 ± 0.537
5.777GlyLeu: 5.777 ± 0.614
2.536GlyMet: 2.536 ± 0.499
3.805GlyAsn: 3.805 ± 0.571
3.452GlyPro: 3.452 ± 0.492
3.241GlyGln: 3.241 ± 0.4
4.509GlyArg: 4.509 ± 0.682
5.989GlySer: 5.989 ± 0.832
4.509GlyThr: 4.509 ± 0.65
5.848GlyVal: 5.848 ± 0.719
1.902GlyTrp: 1.902 ± 0.41
2.255GlyTyr: 2.255 ± 0.326
0.0GlyXaa: 0.0 ± 0.0
His
1.621HisAla: 1.621 ± 0.385
0.352HisCys: 0.352 ± 0.163
0.564HisAsp: 0.564 ± 0.169
1.127HisGlu: 1.127 ± 0.345
1.057HisPhe: 1.057 ± 0.312
1.198HisGly: 1.198 ± 0.327
0.211HisHis: 0.211 ± 0.153
0.916HisIle: 0.916 ± 0.29
0.564HisLys: 0.564 ± 0.198
1.339HisLeu: 1.339 ± 0.325
0.493HisMet: 0.493 ± 0.224
1.339HisAsn: 1.339 ± 0.301
1.127HisPro: 1.127 ± 0.281
0.282HisGln: 0.282 ± 0.147
1.198HisArg: 1.198 ± 0.398
1.409HisSer: 1.409 ± 0.394
0.564HisThr: 0.564 ± 0.204
1.409HisVal: 1.409 ± 0.262
0.211HisTrp: 0.211 ± 0.127
0.634HisTyr: 0.634 ± 0.193
0.0HisXaa: 0.0 ± 0.0
Ile
5.073IleAla: 5.073 ± 0.752
0.282IleCys: 0.282 ± 0.147
4.087IleAsp: 4.087 ± 0.522
3.1IleGlu: 3.1 ± 0.451
1.198IlePhe: 1.198 ± 0.262
4.087IleGly: 4.087 ± 0.629
0.634IleHis: 0.634 ± 0.217
2.043IleIle: 2.043 ± 0.379
2.818IleLys: 2.818 ± 0.49
3.311IleLeu: 3.311 ± 0.426
1.339IleMet: 1.339 ± 0.3
2.114IleAsn: 2.114 ± 0.293
2.255IlePro: 2.255 ± 0.435
2.043IleGln: 2.043 ± 0.43
3.382IleArg: 3.382 ± 0.639
3.523IleSer: 3.523 ± 0.499
2.818IleThr: 2.818 ± 0.475
3.311IleVal: 3.311 ± 0.435
0.986IleTrp: 0.986 ± 0.333
1.55IleTyr: 1.55 ± 0.331
0.0IleXaa: 0.0 ± 0.0
Lys
5.637LysAla: 5.637 ± 0.807
0.282LysCys: 0.282 ± 0.156
2.255LysAsp: 2.255 ± 0.45
3.382LysGlu: 3.382 ± 0.475
2.255LysPhe: 2.255 ± 0.452
4.157LysGly: 4.157 ± 0.503
1.409LysHis: 1.409 ± 0.32
3.03LysIle: 3.03 ± 0.452
3.171LysLys: 3.171 ± 0.533
4.791LysLeu: 4.791 ± 0.599
1.268LysMet: 1.268 ± 0.289
1.902LysAsn: 1.902 ± 0.323
1.902LysPro: 1.902 ± 0.359
2.677LysGln: 2.677 ± 0.423
3.171LysArg: 3.171 ± 0.393
2.818LysSer: 2.818 ± 0.427
2.466LysThr: 2.466 ± 0.375
4.298LysVal: 4.298 ± 0.509
0.845LysTrp: 0.845 ± 0.29
2.184LysTyr: 2.184 ± 0.497
0.0LysXaa: 0.0 ± 0.0
Leu
8.666LeuAla: 8.666 ± 0.711
0.564LeuCys: 0.564 ± 0.188
5.002LeuAsp: 5.002 ± 0.783
5.918LeuGlu: 5.918 ± 0.72
2.748LeuPhe: 2.748 ± 0.44
5.777LeuGly: 5.777 ± 0.704
1.902LeuHis: 1.902 ± 0.306
3.311LeuIle: 3.311 ± 0.484
4.087LeuLys: 4.087 ± 0.587
6.2LeuLeu: 6.2 ± 0.793
1.761LeuMet: 1.761 ± 0.41
3.805LeuAsn: 3.805 ± 0.653
5.707LeuPro: 5.707 ± 0.702
4.087LeuGln: 4.087 ± 0.479
5.496LeuArg: 5.496 ± 0.592
5.566LeuSer: 5.566 ± 0.554
5.496LeuThr: 5.496 ± 0.648
5.073LeuVal: 5.073 ± 0.539
1.127LeuTrp: 1.127 ± 0.317
1.832LeuTyr: 1.832 ± 0.331
0.0LeuXaa: 0.0 ± 0.0
Met
2.818MetAla: 2.818 ± 0.502
0.352MetCys: 0.352 ± 0.235
1.409MetAsp: 1.409 ± 0.344
2.043MetGlu: 2.043 ± 0.326
1.127MetPhe: 1.127 ± 0.306
1.761MetGly: 1.761 ± 0.32
0.352MetHis: 0.352 ± 0.174
1.409MetIle: 1.409 ± 0.323
2.043MetLys: 2.043 ± 0.375
2.325MetLeu: 2.325 ± 0.396
0.845MetMet: 0.845 ± 0.223
1.409MetAsn: 1.409 ± 0.335
1.409MetPro: 1.409 ± 0.356
1.198MetGln: 1.198 ± 0.305
1.339MetArg: 1.339 ± 0.273
2.043MetSer: 2.043 ± 0.431
1.691MetThr: 1.691 ± 0.342
1.691MetVal: 1.691 ± 0.351
0.141MetTrp: 0.141 ± 0.109
0.423MetTyr: 0.423 ± 0.211
0.0MetXaa: 0.0 ± 0.0
Asn
4.439AsnAla: 4.439 ± 0.527
0.705AsnCys: 0.705 ± 0.223
2.043AsnAsp: 2.043 ± 0.354
2.677AsnGlu: 2.677 ± 0.469
1.127AsnPhe: 1.127 ± 0.276
4.227AsnGly: 4.227 ± 0.588
0.845AsnHis: 0.845 ± 0.205
2.325AsnIle: 2.325 ± 0.364
1.621AsnLys: 1.621 ± 0.322
4.58AsnLeu: 4.58 ± 0.625
1.198AsnMet: 1.198 ± 0.284
1.832AsnAsn: 1.832 ± 0.388
2.607AsnPro: 2.607 ± 0.444
1.48AsnGln: 1.48 ± 0.381
2.184AsnArg: 2.184 ± 0.335
1.902AsnSer: 1.902 ± 0.421
2.114AsnThr: 2.114 ± 0.382
2.255AsnVal: 2.255 ± 0.378
1.057AsnTrp: 1.057 ± 0.335
1.057AsnTyr: 1.057 ± 0.258
0.0AsnXaa: 0.0 ± 0.0
Pro
4.509ProAla: 4.509 ± 0.511
0.211ProCys: 0.211 ± 0.127
3.241ProAsp: 3.241 ± 0.498
3.734ProGlu: 3.734 ± 0.596
1.761ProPhe: 1.761 ± 0.417
4.791ProGly: 4.791 ± 0.65
0.845ProHis: 0.845 ± 0.228
2.114ProIle: 2.114 ± 0.358
3.875ProLys: 3.875 ± 0.576
3.171ProLeu: 3.171 ± 0.504
1.057ProMet: 1.057 ± 0.232
2.396ProAsn: 2.396 ± 0.468
2.466ProPro: 2.466 ± 0.402
1.902ProGln: 1.902 ± 0.425
2.607ProArg: 2.607 ± 0.453
2.818ProSer: 2.818 ± 0.505
2.536ProThr: 2.536 ± 0.378
3.875ProVal: 3.875 ± 0.554
0.423ProTrp: 0.423 ± 0.179
1.127ProTyr: 1.127 ± 0.271
0.0ProXaa: 0.0 ± 0.0
Gln
5.073GlnAla: 5.073 ± 0.666
0.352GlnCys: 0.352 ± 0.16
1.761GlnAsp: 1.761 ± 0.355
2.677GlnGlu: 2.677 ± 0.56
1.621GlnPhe: 1.621 ± 0.344
2.959GlnGly: 2.959 ± 0.453
0.493GlnHis: 0.493 ± 0.177
1.691GlnIle: 1.691 ± 0.359
2.184GlnLys: 2.184 ± 0.414
4.298GlnLeu: 4.298 ± 0.68
1.339GlnMet: 1.339 ± 0.272
1.339GlnAsn: 1.339 ± 0.305
2.043GlnPro: 2.043 ± 0.414
2.184GlnGln: 2.184 ± 0.562
2.466GlnArg: 2.466 ± 0.41
2.043GlnSer: 2.043 ± 0.411
1.621GlnThr: 1.621 ± 0.406
3.311GlnVal: 3.311 ± 0.509
0.916GlnTrp: 0.916 ± 0.265
1.621GlnTyr: 1.621 ± 0.387
0.0GlnXaa: 0.0 ± 0.0
Arg
5.777ArgAla: 5.777 ± 0.632
0.141ArgCys: 0.141 ± 0.11
3.311ArgAsp: 3.311 ± 0.592
3.805ArgGlu: 3.805 ± 0.541
1.761ArgPhe: 1.761 ± 0.459
3.593ArgGly: 3.593 ± 0.472
0.845ArgHis: 0.845 ± 0.242
2.889ArgIle: 2.889 ± 0.484
3.241ArgLys: 3.241 ± 0.501
4.58ArgLeu: 4.58 ± 0.579
2.536ArgMet: 2.536 ± 0.505
2.607ArgAsn: 2.607 ± 0.344
2.818ArgPro: 2.818 ± 0.539
2.043ArgGln: 2.043 ± 0.436
3.593ArgArg: 3.593 ± 0.516
3.241ArgSer: 3.241 ± 0.552
3.171ArgThr: 3.171 ± 0.47
4.862ArgVal: 4.862 ± 0.52
0.986ArgTrp: 0.986 ± 0.294
1.973ArgTyr: 1.973 ± 0.464
0.0ArgXaa: 0.0 ± 0.0
Ser
4.932SerAla: 4.932 ± 0.759
0.493SerCys: 0.493 ± 0.196
3.523SerAsp: 3.523 ± 0.468
3.1SerGlu: 3.1 ± 0.591
2.255SerPhe: 2.255 ± 0.346
4.368SerGly: 4.368 ± 0.687
0.845SerHis: 0.845 ± 0.237
3.593SerIle: 3.593 ± 0.457
2.959SerLys: 2.959 ± 0.522
4.932SerLeu: 4.932 ± 0.568
1.691SerMet: 1.691 ± 0.404
3.171SerAsn: 3.171 ± 0.419
2.748SerPro: 2.748 ± 0.537
2.677SerGln: 2.677 ± 0.464
3.452SerArg: 3.452 ± 0.451
4.58SerSer: 4.58 ± 0.827
3.805SerThr: 3.805 ± 0.695
4.016SerVal: 4.016 ± 0.386
1.268SerTrp: 1.268 ± 0.311
2.325SerTyr: 2.325 ± 0.398
0.0SerXaa: 0.0 ± 0.0
Thr
5.566ThrAla: 5.566 ± 0.806
0.423ThrCys: 0.423 ± 0.183
2.748ThrAsp: 2.748 ± 0.441
3.875ThrGlu: 3.875 ± 0.439
1.973ThrPhe: 1.973 ± 0.416
3.593ThrGly: 3.593 ± 0.495
1.268ThrHis: 1.268 ± 0.343
3.171ThrIle: 3.171 ± 0.374
2.043ThrLys: 2.043 ± 0.478
5.214ThrLeu: 5.214 ± 0.665
0.845ThrMet: 0.845 ± 0.234
2.325ThrAsn: 2.325 ± 0.521
2.748ThrPro: 2.748 ± 0.495
2.607ThrGln: 2.607 ± 0.356
2.607ThrArg: 2.607 ± 0.382
3.311ThrSer: 3.311 ± 0.547
3.311ThrThr: 3.311 ± 0.503
3.593ThrVal: 3.593 ± 0.502
0.986ThrTrp: 0.986 ± 0.238
2.114ThrTyr: 2.114 ± 0.45
0.0ThrXaa: 0.0 ± 0.0
Val
5.002ValAla: 5.002 ± 0.56
0.493ValCys: 0.493 ± 0.255
4.509ValAsp: 4.509 ± 0.437
4.862ValGlu: 4.862 ± 0.82
2.396ValPhe: 2.396 ± 0.471
5.143ValGly: 5.143 ± 0.611
1.761ValHis: 1.761 ± 0.325
4.227ValIle: 4.227 ± 0.615
4.58ValLys: 4.58 ± 0.842
5.707ValLeu: 5.707 ± 0.577
1.409ValMet: 1.409 ± 0.282
2.607ValAsn: 2.607 ± 0.413
3.523ValPro: 3.523 ± 0.651
2.889ValGln: 2.889 ± 0.502
3.875ValArg: 3.875 ± 0.484
4.932ValSer: 4.932 ± 0.712
4.087ValThr: 4.087 ± 0.771
4.58ValVal: 4.58 ± 0.758
1.268ValTrp: 1.268 ± 0.285
2.184ValTyr: 2.184 ± 0.399
0.0ValXaa: 0.0 ± 0.0
Trp
1.198TrpAla: 1.198 ± 0.349
0.352TrpCys: 0.352 ± 0.14
1.198TrpAsp: 1.198 ± 0.309
1.339TrpGlu: 1.339 ± 0.243
0.916TrpPhe: 0.916 ± 0.279
1.55TrpGly: 1.55 ± 0.322
0.282TrpHis: 0.282 ± 0.156
0.775TrpIle: 0.775 ± 0.365
0.775TrpLys: 0.775 ± 0.209
1.339TrpLeu: 1.339 ± 0.355
0.352TrpMet: 0.352 ± 0.161
0.845TrpAsn: 0.845 ± 0.226
1.057TrpPro: 1.057 ± 0.339
0.493TrpGln: 0.493 ± 0.181
1.127TrpArg: 1.127 ± 0.301
1.127TrpSer: 1.127 ± 0.26
1.127TrpThr: 1.127 ± 0.24
1.55TrpVal: 1.55 ± 0.346
0.423TrpTrp: 0.423 ± 0.172
0.775TrpTyr: 0.775 ± 0.198
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.607TyrAla: 2.607 ± 0.452
0.493TyrCys: 0.493 ± 0.197
1.832TyrAsp: 1.832 ± 0.321
1.902TyrGlu: 1.902 ± 0.347
1.057TyrPhe: 1.057 ± 0.279
2.255TyrGly: 2.255 ± 0.432
0.493TyrHis: 0.493 ± 0.223
1.55TyrIle: 1.55 ± 0.365
1.973TyrLys: 1.973 ± 0.398
2.184TyrLeu: 2.184 ± 0.437
1.127TyrMet: 1.127 ± 0.266
1.198TyrAsn: 1.198 ± 0.281
1.339TyrPro: 1.339 ± 0.326
1.268TyrGln: 1.268 ± 0.337
2.396TyrArg: 2.396 ± 0.396
1.902TyrSer: 1.902 ± 0.375
1.621TyrThr: 1.621 ± 0.288
2.114TyrVal: 2.114 ± 0.386
0.634TyrTrp: 0.634 ± 0.26
0.916TyrTyr: 0.916 ± 0.25
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 61 proteins (14194 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski