Amino acid dipepetide frequency for Rochambeau virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.14AlaAla: 1.14 ± 0.316
0.456AlaCys: 0.456 ± 0.478
1.368AlaAsp: 1.368 ± 0.63
2.963AlaGlu: 2.963 ± 0.586
2.279AlaPhe: 2.279 ± 1.1
1.596AlaGly: 1.596 ± 0.457
0.912AlaHis: 0.912 ± 0.38
1.596AlaIle: 1.596 ± 0.67
2.279AlaLys: 2.279 ± 0.426
4.787AlaLeu: 4.787 ± 1.834
1.596AlaMet: 1.596 ± 0.52
0.912AlaAsn: 0.912 ± 0.454
0.912AlaPro: 0.912 ± 0.333
0.912AlaGln: 0.912 ± 0.484
2.279AlaArg: 2.279 ± 0.61
2.052AlaSer: 2.052 ± 0.66
2.279AlaThr: 2.279 ± 0.411
1.824AlaVal: 1.824 ± 0.83
0.684AlaTrp: 0.684 ± 0.817
1.596AlaTyr: 1.596 ± 0.975
0.0AlaXaa: 0.0 ± 0.0
Cys
0.456CysAla: 0.456 ± 0.241
0.228CysCys: 0.228 ± 0.261
0.684CysAsp: 0.684 ± 0.549
0.684CysGlu: 0.684 ± 0.411
1.14CysPhe: 1.14 ± 0.496
0.912CysGly: 0.912 ± 0.486
1.824CysHis: 1.824 ± 0.654
0.684CysIle: 0.684 ± 0.269
1.596CysLys: 1.596 ± 0.879
1.824CysLeu: 1.824 ± 0.625
0.228CysMet: 0.228 ± 0.367
0.684CysAsn: 0.684 ± 0.782
1.14CysPro: 1.14 ± 0.564
0.0CysGln: 0.0 ± 0.0
1.368CysArg: 1.368 ± 0.501
1.596CysSer: 1.596 ± 0.578
0.228CysThr: 0.228 ± 0.28
1.14CysVal: 1.14 ± 0.626
0.228CysTrp: 0.228 ± 0.146
0.912CysTyr: 0.912 ± 0.372
0.0CysXaa: 0.0 ± 0.0
Asp
0.912AspAla: 0.912 ± 0.431
0.912AspCys: 0.912 ± 0.572
6.155AspAsp: 6.155 ± 2.214
5.927AspGlu: 5.927 ± 1.205
2.735AspPhe: 2.735 ± 0.747
2.507AspGly: 2.507 ± 0.639
1.14AspHis: 1.14 ± 0.591
4.559AspIle: 4.559 ± 1.284
5.015AspLys: 5.015 ± 0.886
6.838AspLeu: 6.838 ± 1.532
0.912AspMet: 0.912 ± 0.805
2.279AspAsn: 2.279 ± 0.581
3.191AspPro: 3.191 ± 0.58
2.052AspGln: 2.052 ± 0.588
1.596AspArg: 1.596 ± 0.594
5.699AspSer: 5.699 ± 2.931
1.14AspThr: 1.14 ± 0.533
3.191AspVal: 3.191 ± 1.092
2.052AspTrp: 2.052 ± 0.947
3.191AspTyr: 3.191 ± 1.001
0.0AspXaa: 0.0 ± 0.0
Glu
2.963GluAla: 2.963 ± 0.872
0.456GluCys: 0.456 ± 0.221
3.647GluAsp: 3.647 ± 1.262
11.625GluGlu: 11.625 ± 2.048
3.875GluPhe: 3.875 ± 0.626
4.103GluGly: 4.103 ± 0.698
0.684GluHis: 0.684 ± 0.269
6.61GluIle: 6.61 ± 1.163
8.89GluLys: 8.89 ± 2.089
7.294GluLeu: 7.294 ± 0.897
2.052GluMet: 2.052 ± 0.608
3.875GluAsn: 3.875 ± 1.315
2.052GluPro: 2.052 ± 0.582
0.912GluGln: 0.912 ± 0.483
3.875GluArg: 3.875 ± 0.756
6.382GluSer: 6.382 ± 1.028
5.015GluThr: 5.015 ± 0.806
3.191GluVal: 3.191 ± 1.173
1.824GluTrp: 1.824 ± 0.51
2.279GluTyr: 2.279 ± 1.015
0.0GluXaa: 0.0 ± 0.0
Phe
1.368PheAla: 1.368 ± 1.038
1.14PheCys: 1.14 ± 0.455
1.596PheAsp: 1.596 ± 0.818
4.331PheGlu: 4.331 ± 0.91
2.507PhePhe: 2.507 ± 0.788
2.507PheGly: 2.507 ± 0.785
0.912PheHis: 0.912 ± 0.375
1.368PheIle: 1.368 ± 0.591
3.191PheLys: 3.191 ± 0.685
7.522PheLeu: 7.522 ± 0.859
1.368PheMet: 1.368 ± 0.554
0.912PheAsn: 0.912 ± 0.372
1.824PhePro: 1.824 ± 0.494
0.912PheGln: 0.912 ± 0.372
2.279PheArg: 2.279 ± 1.0
3.191PheSer: 3.191 ± 0.662
1.14PheThr: 1.14 ± 0.336
2.507PheVal: 2.507 ± 0.517
1.368PheTrp: 1.368 ± 0.442
1.14PheTyr: 1.14 ± 0.536
0.0PheXaa: 0.0 ± 0.0
Gly
1.824GlyAla: 1.824 ± 0.55
1.14GlyCys: 1.14 ± 0.771
3.419GlyAsp: 3.419 ± 0.839
5.471GlyGlu: 5.471 ± 1.179
1.368GlyPhe: 1.368 ± 0.54
4.103GlyGly: 4.103 ± 0.93
1.596GlyHis: 1.596 ± 0.892
3.191GlyIle: 3.191 ± 0.661
5.015GlyLys: 5.015 ± 0.762
4.559GlyLeu: 4.559 ± 0.734
2.279GlyMet: 2.279 ± 0.727
2.052GlyAsn: 2.052 ± 0.672
1.368GlyPro: 1.368 ± 0.663
1.824GlyGln: 1.824 ± 0.54
3.875GlyArg: 3.875 ± 0.907
6.838GlySer: 6.838 ± 1.209
3.419GlyThr: 3.419 ± 0.792
3.191GlyVal: 3.191 ± 0.774
1.14GlyTrp: 1.14 ± 0.496
2.963GlyTyr: 2.963 ± 0.711
0.0GlyXaa: 0.0 ± 0.0
His
0.684HisAla: 0.684 ± 0.438
0.684HisCys: 0.684 ± 0.288
1.596HisAsp: 1.596 ± 0.526
1.14HisGlu: 1.14 ± 0.521
1.14HisPhe: 1.14 ± 0.496
1.824HisGly: 1.824 ± 0.46
1.368HisHis: 1.368 ± 0.78
1.368HisIle: 1.368 ± 0.289
0.456HisLys: 0.456 ± 0.221
2.963HisLeu: 2.963 ± 1.518
0.456HisMet: 0.456 ± 0.46
0.228HisAsn: 0.228 ± 0.28
1.14HisPro: 1.14 ± 0.463
0.456HisGln: 0.456 ± 0.291
1.14HisArg: 1.14 ± 0.463
1.368HisSer: 1.368 ± 0.424
0.456HisThr: 0.456 ± 0.291
1.14HisVal: 1.14 ± 0.599
0.684HisTrp: 0.684 ± 0.469
0.912HisTyr: 0.912 ± 0.244
0.0HisXaa: 0.0 ± 0.0
Ile
1.368IleAla: 1.368 ± 0.432
1.368IleCys: 1.368 ± 0.484
3.647IleAsp: 3.647 ± 0.916
4.331IleGlu: 4.331 ± 1.33
2.735IlePhe: 2.735 ± 0.599
3.875IleGly: 3.875 ± 0.725
0.912IleHis: 0.912 ± 0.515
6.61IleIle: 6.61 ± 0.9
6.838IleLys: 6.838 ± 1.451
7.978IleLeu: 7.978 ± 1.018
2.052IleMet: 2.052 ± 0.703
2.507IleAsn: 2.507 ± 0.956
2.735IlePro: 2.735 ± 1.141
2.279IleGln: 2.279 ± 0.714
5.015IleArg: 5.015 ± 1.557
4.331IleSer: 4.331 ± 0.628
2.279IleThr: 2.279 ± 0.48
4.331IleVal: 4.331 ± 0.761
1.14IleTrp: 1.14 ± 0.496
3.647IleTyr: 3.647 ± 0.642
0.0IleXaa: 0.0 ± 0.0
Lys
3.419LysAla: 3.419 ± 0.853
1.596LysCys: 1.596 ± 1.492
4.559LysAsp: 4.559 ± 0.607
8.206LysGlu: 8.206 ± 1.595
2.507LysPhe: 2.507 ± 0.745
5.927LysGly: 5.927 ± 1.203
1.368LysHis: 1.368 ± 0.576
7.978LysIle: 7.978 ± 1.248
6.155LysLys: 6.155 ± 1.662
7.75LysLeu: 7.75 ± 1.096
1.14LysMet: 1.14 ± 0.353
2.507LysAsn: 2.507 ± 0.483
2.735LysPro: 2.735 ± 0.84
0.684LysGln: 0.684 ± 0.437
5.015LysArg: 5.015 ± 0.713
8.206LysSer: 8.206 ± 1.169
5.699LysThr: 5.699 ± 1.646
2.735LysVal: 2.735 ± 0.567
0.912LysTrp: 0.912 ± 0.484
0.684LysTyr: 0.684 ± 0.288
0.0LysXaa: 0.0 ± 0.0
Leu
4.787LeuAla: 4.787 ± 1.244
1.824LeuCys: 1.824 ± 0.482
8.434LeuAsp: 8.434 ± 1.929
8.662LeuGlu: 8.662 ± 1.249
5.927LeuPhe: 5.927 ± 1.08
6.838LeuGly: 6.838 ± 1.419
1.368LeuHis: 1.368 ± 0.422
7.75LeuIle: 7.75 ± 0.809
8.662LeuLys: 8.662 ± 1.475
9.346LeuLeu: 9.346 ± 1.662
1.368LeuMet: 1.368 ± 0.582
5.699LeuAsn: 5.699 ± 1.43
2.963LeuPro: 2.963 ± 0.807
1.596LeuGln: 1.596 ± 1.075
6.382LeuArg: 6.382 ± 2.088
7.522LeuSer: 7.522 ± 1.073
3.875LeuThr: 3.875 ± 0.822
6.155LeuVal: 6.155 ± 1.11
0.456LeuTrp: 0.456 ± 0.353
2.963LeuTyr: 2.963 ± 0.581
0.0LeuXaa: 0.0 ± 0.0
Met
0.912MetAla: 0.912 ± 0.46
0.456MetCys: 0.456 ± 0.241
1.14MetAsp: 1.14 ± 0.503
2.507MetGlu: 2.507 ± 1.224
0.912MetPhe: 0.912 ± 0.339
1.596MetGly: 1.596 ± 0.402
0.0MetHis: 0.0 ± 0.0
2.507MetIle: 2.507 ± 0.722
3.191MetLys: 3.191 ± 0.889
2.507MetLeu: 2.507 ± 0.779
0.456MetMet: 0.456 ± 0.241
1.368MetAsn: 1.368 ± 0.693
0.456MetPro: 0.456 ± 0.376
0.684MetGln: 0.684 ± 0.28
1.14MetArg: 1.14 ± 0.336
1.368MetSer: 1.368 ± 0.712
1.368MetThr: 1.368 ± 0.547
1.368MetVal: 1.368 ± 0.484
0.684MetTrp: 0.684 ± 0.461
0.912MetTyr: 0.912 ± 0.376
0.0MetXaa: 0.0 ± 0.0
Asn
2.507AsnAla: 2.507 ± 0.61
0.912AsnCys: 0.912 ± 0.372
2.507AsnAsp: 2.507 ± 0.747
2.279AsnGlu: 2.279 ± 0.803
1.14AsnPhe: 1.14 ± 0.496
2.052AsnGly: 2.052 ± 0.969
1.368AsnHis: 1.368 ± 0.628
2.507AsnIle: 2.507 ± 0.76
3.875AsnLys: 3.875 ± 1.003
5.243AsnLeu: 5.243 ± 1.256
1.14AsnMet: 1.14 ± 0.342
2.735AsnAsn: 2.735 ± 1.255
2.735AsnPro: 2.735 ± 0.682
1.596AsnGln: 1.596 ± 0.326
2.052AsnArg: 2.052 ± 0.725
2.735AsnSer: 2.735 ± 0.886
2.052AsnThr: 2.052 ± 0.529
1.596AsnVal: 1.596 ± 0.429
2.052AsnTrp: 2.052 ± 0.721
1.368AsnTyr: 1.368 ± 0.742
0.0AsnXaa: 0.0 ± 0.0
Pro
0.912ProAla: 0.912 ± 0.297
0.0ProCys: 0.0 ± 0.0
2.735ProAsp: 2.735 ± 0.995
2.735ProGlu: 2.735 ± 0.78
1.368ProPhe: 1.368 ± 0.689
2.052ProGly: 2.052 ± 0.681
1.14ProHis: 1.14 ± 0.47
2.963ProIle: 2.963 ± 0.596
2.735ProLys: 2.735 ± 0.913
3.875ProLeu: 3.875 ± 1.005
1.368ProMet: 1.368 ± 0.926
2.052ProAsn: 2.052 ± 0.619
2.507ProPro: 2.507 ± 1.313
1.368ProGln: 1.368 ± 0.834
1.824ProArg: 1.824 ± 1.026
3.419ProSer: 3.419 ± 0.64
2.052ProThr: 2.052 ± 1.093
1.368ProVal: 1.368 ± 0.507
0.228ProTrp: 0.228 ± 0.146
2.052ProTyr: 2.052 ± 0.471
0.0ProXaa: 0.0 ± 0.0
Gln
1.368GlnAla: 1.368 ± 0.63
0.456GlnCys: 0.456 ± 0.438
0.684GlnAsp: 0.684 ± 0.269
2.279GlnGlu: 2.279 ± 0.484
0.912GlnPhe: 0.912 ± 0.244
1.596GlnGly: 1.596 ± 0.625
0.228GlnHis: 0.228 ± 0.335
2.052GlnIle: 2.052 ± 0.525
1.368GlnLys: 1.368 ± 0.422
1.368GlnLeu: 1.368 ± 0.633
0.684GlnMet: 0.684 ± 0.269
1.368GlnAsn: 1.368 ± 0.718
0.456GlnPro: 0.456 ± 0.288
0.228GlnGln: 0.228 ± 0.146
1.368GlnArg: 1.368 ± 0.666
2.735GlnSer: 2.735 ± 0.585
1.596GlnThr: 1.596 ± 0.991
1.368GlnVal: 1.368 ± 0.437
0.456GlnTrp: 0.456 ± 0.288
0.456GlnTyr: 0.456 ± 0.241
0.0GlnXaa: 0.0 ± 0.0
Arg
2.507ArgAla: 2.507 ± 0.707
1.14ArgCys: 1.14 ± 0.471
5.243ArgAsp: 5.243 ± 0.938
3.191ArgGlu: 3.191 ± 0.81
2.507ArgPhe: 2.507 ± 0.725
3.419ArgGly: 3.419 ± 1.133
0.912ArgHis: 0.912 ± 0.372
3.419ArgIle: 3.419 ± 0.852
3.875ArgLys: 3.875 ± 0.754
4.787ArgLeu: 4.787 ± 1.037
1.14ArgMet: 1.14 ± 0.697
2.963ArgAsn: 2.963 ± 1.018
2.052ArgPro: 2.052 ± 0.49
1.14ArgGln: 1.14 ± 0.496
5.015ArgArg: 5.015 ± 1.178
6.838ArgSer: 6.838 ± 1.482
2.735ArgThr: 2.735 ± 0.727
2.052ArgVal: 2.052 ± 1.141
1.14ArgTrp: 1.14 ± 0.334
1.368ArgTyr: 1.368 ± 0.465
0.0ArgXaa: 0.0 ± 0.0
Ser
2.963SerAla: 2.963 ± 1.029
1.824SerCys: 1.824 ± 0.65
6.382SerAsp: 6.382 ± 1.632
5.927SerGlu: 5.927 ± 1.107
2.963SerPhe: 2.963 ± 0.725
6.155SerGly: 6.155 ± 1.019
2.507SerHis: 2.507 ± 0.981
6.155SerIle: 6.155 ± 1.534
5.927SerLys: 5.927 ± 1.48
10.03SerLeu: 10.03 ± 1.116
1.824SerMet: 1.824 ± 0.686
3.875SerAsn: 3.875 ± 0.922
3.419SerPro: 3.419 ± 1.08
2.507SerGln: 2.507 ± 0.964
4.103SerArg: 4.103 ± 0.988
8.434SerSer: 8.434 ± 1.27
3.191SerThr: 3.191 ± 0.599
4.103SerVal: 4.103 ± 1.326
2.052SerTrp: 2.052 ± 0.525
2.735SerTyr: 2.735 ± 0.816
0.0SerXaa: 0.0 ± 0.0
Thr
1.596ThrAla: 1.596 ± 1.017
0.912ThrCys: 0.912 ± 0.582
1.824ThrAsp: 1.824 ± 0.601
4.103ThrGlu: 4.103 ± 1.278
1.596ThrPhe: 1.596 ± 0.326
2.507ThrGly: 2.507 ± 0.752
1.14ThrHis: 1.14 ± 0.496
2.279ThrIle: 2.279 ± 0.683
2.052ThrLys: 2.052 ± 0.382
4.331ThrLeu: 4.331 ± 1.26
1.368ThrMet: 1.368 ± 0.44
2.963ThrAsn: 2.963 ± 0.781
2.279ThrPro: 2.279 ± 0.573
1.368ThrGln: 1.368 ± 0.299
3.191ThrArg: 3.191 ± 0.982
5.243ThrSer: 5.243 ± 1.465
2.507ThrThr: 2.507 ± 0.76
3.191ThrVal: 3.191 ± 1.012
1.14ThrTrp: 1.14 ± 0.728
0.684ThrTyr: 0.684 ± 0.313
0.0ThrXaa: 0.0 ± 0.0
Val
1.596ValAla: 1.596 ± 0.677
1.14ValCys: 1.14 ± 0.798
3.647ValAsp: 3.647 ± 0.57
2.735ValGlu: 2.735 ± 0.822
1.368ValPhe: 1.368 ± 0.919
2.963ValGly: 2.963 ± 0.837
0.456ValHis: 0.456 ± 0.353
2.735ValIle: 2.735 ± 1.013
4.559ValLys: 4.559 ± 0.939
4.787ValLeu: 4.787 ± 1.142
2.279ValMet: 2.279 ± 0.79
2.507ValAsn: 2.507 ± 0.59
2.507ValPro: 2.507 ± 0.664
1.368ValGln: 1.368 ± 0.36
3.191ValArg: 3.191 ± 0.447
4.787ValSer: 4.787 ± 1.441
2.735ValThr: 2.735 ± 0.628
2.963ValVal: 2.963 ± 0.966
0.228ValTrp: 0.228 ± 0.406
2.279ValTyr: 2.279 ± 1.239
0.0ValXaa: 0.0 ± 0.0
Trp
0.228TrpAla: 0.228 ± 0.395
0.228TrpCys: 0.228 ± 0.146
1.368TrpAsp: 1.368 ± 0.456
1.596TrpGlu: 1.596 ± 0.504
1.14TrpPhe: 1.14 ± 0.411
1.596TrpGly: 1.596 ± 0.627
0.456TrpHis: 0.456 ± 0.291
1.14TrpIle: 1.14 ± 0.503
2.279TrpLys: 2.279 ± 0.549
1.368TrpLeu: 1.368 ± 0.877
0.456TrpMet: 0.456 ± 0.241
0.912TrpAsn: 0.912 ± 0.372
0.456TrpPro: 0.456 ± 0.221
0.0TrpGln: 0.0 ± 0.0
0.684TrpArg: 0.684 ± 0.312
1.14TrpSer: 1.14 ± 0.675
1.596TrpThr: 1.596 ± 0.468
1.596TrpVal: 1.596 ± 0.868
0.456TrpTrp: 0.456 ± 0.521
0.912TrpTyr: 0.912 ± 0.441
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.912TyrAla: 0.912 ± 0.476
0.684TyrCys: 0.684 ± 0.384
1.368TyrAsp: 1.368 ± 0.534
0.912TyrGlu: 0.912 ± 0.716
2.963TyrPhe: 2.963 ± 0.458
2.735TyrGly: 2.735 ± 0.476
0.912TyrHis: 0.912 ± 0.66
2.507TyrIle: 2.507 ± 1.36
1.824TyrLys: 1.824 ± 0.636
3.419TyrLeu: 3.419 ± 1.017
1.14TyrMet: 1.14 ± 0.713
2.052TyrAsn: 2.052 ± 0.435
1.824TyrPro: 1.824 ± 0.597
1.14TyrGln: 1.14 ± 0.546
2.052TyrArg: 2.052 ± 0.893
3.191TyrSer: 3.191 ± 1.768
0.912TyrThr: 0.912 ± 0.419
1.824TyrVal: 1.824 ± 0.555
0.684TyrTrp: 0.684 ± 0.534
1.14TyrTyr: 1.14 ± 0.472
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 11 proteins (4388 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski