Amino acid dipepetide frequency for Citricoccus muralis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.639AlaAla: 18.639 ± 0.224
0.748AlaCys: 0.748 ± 0.026
7.527AlaAsp: 7.527 ± 0.093
8.837AlaGlu: 8.837 ± 0.124
3.352AlaPhe: 3.352 ± 0.064
13.888AlaGly: 13.888 ± 0.143
2.347AlaHis: 2.347 ± 0.051
4.45AlaIle: 4.45 ± 0.069
2.433AlaLys: 2.433 ± 0.058
12.527AlaLeu: 12.527 ± 0.153
2.728AlaMet: 2.728 ± 0.051
2.24AlaAsn: 2.24 ± 0.05
6.32AlaPro: 6.32 ± 0.105
4.002AlaGln: 4.002 ± 0.057
7.994AlaArg: 7.994 ± 0.106
6.92AlaSer: 6.92 ± 0.093
7.453AlaThr: 7.453 ± 0.085
11.366AlaVal: 11.366 ± 0.128
1.784AlaTrp: 1.784 ± 0.044
2.072AlaTyr: 2.072 ± 0.041
0.0AlaXaa: 0.0 ± 0.0
Cys
0.68CysAla: 0.68 ± 0.027
0.048CysCys: 0.048 ± 0.008
0.267CysAsp: 0.267 ± 0.015
0.261CysGlu: 0.261 ± 0.015
0.169CysPhe: 0.169 ± 0.012
0.676CysGly: 0.676 ± 0.029
0.137CysHis: 0.137 ± 0.011
0.212CysIle: 0.212 ± 0.014
0.071CysLys: 0.071 ± 0.009
0.554CysLeu: 0.554 ± 0.022
0.104CysMet: 0.104 ± 0.011
0.119CysAsn: 0.119 ± 0.011
0.306CysPro: 0.306 ± 0.019
0.162CysGln: 0.162 ± 0.013
0.379CysArg: 0.379 ± 0.019
0.368CysSer: 0.368 ± 0.018
0.352CysThr: 0.352 ± 0.02
0.451CysVal: 0.451 ± 0.023
0.088CysTrp: 0.088 ± 0.009
0.109CysTyr: 0.109 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
7.328AspAla: 7.328 ± 0.109
0.304AspCys: 0.304 ± 0.017
3.055AspAsp: 3.055 ± 0.069
3.987AspGlu: 3.987 ± 0.069
1.752AspPhe: 1.752 ± 0.046
6.037AspGly: 6.037 ± 0.091
1.58AspHis: 1.58 ± 0.043
2.117AspIle: 2.117 ± 0.041
0.941AspLys: 0.941 ± 0.038
6.585AspLeu: 6.585 ± 0.097
0.921AspMet: 0.921 ± 0.028
0.966AspAsn: 0.966 ± 0.031
4.515AspPro: 4.515 ± 0.069
2.074AspGln: 2.074 ± 0.051
4.56AspArg: 4.56 ± 0.087
3.089AspSer: 3.089 ± 0.057
3.103AspThr: 3.103 ± 0.066
4.664AspVal: 4.664 ± 0.072
0.97AspTrp: 0.97 ± 0.032
1.34AspTyr: 1.34 ± 0.038
0.0AspXaa: 0.0 ± 0.0
Glu
8.04GluAla: 8.04 ± 0.096
0.259GluCys: 0.259 ± 0.018
4.053GluAsp: 4.053 ± 0.066
3.776GluGlu: 3.776 ± 0.057
1.63GluPhe: 1.63 ± 0.042
4.73GluGly: 4.73 ± 0.067
1.663GluHis: 1.663 ± 0.043
2.592GluIle: 2.592 ± 0.054
1.52GluLys: 1.52 ± 0.043
6.259GluLeu: 6.259 ± 0.089
1.155GluMet: 1.155 ± 0.034
1.514GluAsn: 1.514 ± 0.041
3.329GluPro: 3.329 ± 0.056
2.661GluGln: 2.661 ± 0.057
4.63GluArg: 4.63 ± 0.071
3.33GluSer: 3.33 ± 0.061
3.384GluThr: 3.384 ± 0.052
4.737GluVal: 4.737 ± 0.065
0.806GluTrp: 0.806 ± 0.034
1.233GluTyr: 1.233 ± 0.039
0.0GluXaa: 0.0 ± 0.0
Phe
3.49PheAla: 3.49 ± 0.057
0.186PheCys: 0.186 ± 0.013
1.853PheAsp: 1.853 ± 0.043
1.643PheGlu: 1.643 ± 0.038
0.985PhePhe: 0.985 ± 0.039
3.185PheGly: 3.185 ± 0.059
0.65PheHis: 0.65 ± 0.027
1.171PheIle: 1.171 ± 0.042
0.494PheLys: 0.494 ± 0.021
2.795PheLeu: 2.795 ± 0.063
0.541PheMet: 0.541 ± 0.027
0.752PheAsn: 0.752 ± 0.029
1.452PhePro: 1.452 ± 0.037
0.829PheGln: 0.829 ± 0.029
1.756PheArg: 1.756 ± 0.042
1.875PheSer: 1.875 ± 0.04
2.177PheThr: 2.177 ± 0.044
2.267PheVal: 2.267 ± 0.051
0.454PheTrp: 0.454 ± 0.023
0.622PheTyr: 0.622 ± 0.029
0.0PheXaa: 0.0 ± 0.0
Gly
10.568GlyAla: 10.568 ± 0.129
0.606GlyCys: 0.606 ± 0.028
4.587GlyAsp: 4.587 ± 0.07
5.253GlyGlu: 5.253 ± 0.084
3.068GlyPhe: 3.068 ± 0.062
8.202GlyGly: 8.202 ± 0.118
2.324GlyHis: 2.324 ± 0.045
4.254GlyIle: 4.254 ± 0.066
2.136GlyLys: 2.136 ± 0.055
9.791GlyLeu: 9.791 ± 0.104
2.293GlyMet: 2.293 ± 0.055
1.996GlyAsn: 1.996 ± 0.048
4.872GlyPro: 4.872 ± 0.081
3.514GlyGln: 3.514 ± 0.057
6.786GlyArg: 6.786 ± 0.095
5.994GlySer: 5.994 ± 0.072
6.869GlyThr: 6.869 ± 0.092
7.275GlyVal: 7.275 ± 0.097
1.693GlyTrp: 1.693 ± 0.045
2.181GlyTyr: 2.181 ± 0.042
0.0GlyXaa: 0.0 ± 0.0
His
2.419HisAla: 2.419 ± 0.048
0.156HisCys: 0.156 ± 0.012
1.275HisAsp: 1.275 ± 0.041
1.32HisGlu: 1.32 ± 0.035
0.627HisPhe: 0.627 ± 0.022
2.297HisGly: 2.297 ± 0.05
0.742HisHis: 0.742 ± 0.027
0.661HisIle: 0.661 ± 0.028
0.273HisLys: 0.273 ± 0.016
2.399HisLeu: 2.399 ± 0.05
0.324HisMet: 0.324 ± 0.02
0.357HisAsn: 0.357 ± 0.019
1.742HisPro: 1.742 ± 0.043
0.821HisGln: 0.821 ± 0.03
2.057HisArg: 2.057 ± 0.047
1.059HisSer: 1.059 ± 0.027
1.155HisThr: 1.155 ± 0.038
1.63HisVal: 1.63 ± 0.041
0.348HisTrp: 0.348 ± 0.018
0.451HisTyr: 0.451 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
4.932IleAla: 4.932 ± 0.083
0.244IleCys: 0.244 ± 0.013
2.441IleAsp: 2.441 ± 0.056
2.365IleGlu: 2.365 ± 0.052
1.02IlePhe: 1.02 ± 0.033
4.153IleGly: 4.153 ± 0.078
0.788IleHis: 0.788 ± 0.028
1.616IleIle: 1.616 ± 0.046
0.774IleLys: 0.774 ± 0.031
3.589IleLeu: 3.589 ± 0.06
0.748IleMet: 0.748 ± 0.03
0.958IleAsn: 0.958 ± 0.031
2.288IlePro: 2.288 ± 0.048
1.061IleGln: 1.061 ± 0.029
2.458IleArg: 2.458 ± 0.051
2.299IleSer: 2.299 ± 0.042
2.768IleThr: 2.768 ± 0.057
3.284IleVal: 3.284 ± 0.068
0.468IleTrp: 0.468 ± 0.026
0.681IleTyr: 0.681 ± 0.025
0.0IleXaa: 0.0 ± 0.0
Lys
2.54LysAla: 2.54 ± 0.058
0.067LysCys: 0.067 ± 0.008
1.377LysAsp: 1.377 ± 0.035
1.022LysGlu: 1.022 ± 0.036
0.476LysPhe: 0.476 ± 0.024
1.576LysGly: 1.576 ± 0.044
0.404LysHis: 0.404 ± 0.02
0.945LysIle: 0.945 ± 0.034
0.736LysLys: 0.736 ± 0.038
1.795LysLeu: 1.795 ± 0.044
0.442LysMet: 0.442 ± 0.022
0.558LysAsn: 0.558 ± 0.029
1.144LysPro: 1.144 ± 0.045
0.577LysGln: 0.577 ± 0.027
1.35LysArg: 1.35 ± 0.044
1.252LysSer: 1.252 ± 0.044
1.376LysThr: 1.376 ± 0.04
1.772LysVal: 1.772 ± 0.05
0.216LysTrp: 0.216 ± 0.016
0.488LysTyr: 0.488 ± 0.019
0.0LysXaa: 0.0 ± 0.0
Leu
14.163LeuAla: 14.163 ± 0.162
0.563LeuCys: 0.563 ± 0.024
6.725LeuAsp: 6.725 ± 0.095
5.978LeuGlu: 5.978 ± 0.079
2.728LeuPhe: 2.728 ± 0.069
8.929LeuGly: 8.929 ± 0.087
2.065LeuHis: 2.065 ± 0.043
3.684LeuIle: 3.684 ± 0.076
2.073LeuLys: 2.073 ± 0.05
9.841LeuLeu: 9.841 ± 0.119
2.094LeuMet: 2.094 ± 0.051
2.18LeuAsn: 2.18 ± 0.043
5.612LeuPro: 5.612 ± 0.064
2.977LeuGln: 2.977 ± 0.056
6.479LeuArg: 6.479 ± 0.092
5.799LeuSer: 5.799 ± 0.082
6.4LeuThr: 6.4 ± 0.086
9.065LeuVal: 9.065 ± 0.113
1.273LeuTrp: 1.273 ± 0.04
1.651LeuTyr: 1.651 ± 0.038
0.0LeuXaa: 0.0 ± 0.0
Met
2.689MetAla: 2.689 ± 0.056
0.105MetCys: 0.105 ± 0.009
1.246MetAsp: 1.246 ± 0.033
1.018MetGlu: 1.018 ± 0.031
0.55MetPhe: 0.55 ± 0.024
1.659MetGly: 1.659 ± 0.043
0.36MetHis: 0.36 ± 0.021
0.892MetIle: 0.892 ± 0.032
0.489MetLys: 0.489 ± 0.021
1.983MetLeu: 1.983 ± 0.042
0.459MetMet: 0.459 ± 0.024
0.562MetAsn: 0.562 ± 0.022
1.225MetPro: 1.225 ± 0.036
0.551MetGln: 0.551 ± 0.025
1.219MetArg: 1.219 ± 0.034
1.502MetSer: 1.502 ± 0.039
1.809MetThr: 1.809 ± 0.041
1.827MetVal: 1.827 ± 0.047
0.202MetTrp: 0.202 ± 0.012
0.336MetTyr: 0.336 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
2.546AsnAla: 2.546 ± 0.053
0.146AsnCys: 0.146 ± 0.012
1.095AsnAsp: 1.095 ± 0.045
1.147AsnGlu: 1.147 ± 0.037
0.625AsnPhe: 0.625 ± 0.027
2.053AsnGly: 2.053 ± 0.054
0.525AsnHis: 0.525 ± 0.021
0.896AsnIle: 0.896 ± 0.032
0.393AsnLys: 0.393 ± 0.023
2.059AsnLeu: 2.059 ± 0.048
0.417AsnMet: 0.417 ± 0.02
0.522AsnAsn: 0.522 ± 0.026
1.67AsnPro: 1.67 ± 0.044
0.719AsnGln: 0.719 ± 0.03
1.529AsnArg: 1.529 ± 0.039
1.045AsnSer: 1.045 ± 0.03
1.391AsnThr: 1.391 ± 0.038
1.565AsnVal: 1.565 ± 0.035
0.329AsnTrp: 0.329 ± 0.017
0.439AsnTyr: 0.439 ± 0.021
0.0AsnXaa: 0.0 ± 0.0
Pro
7.964ProAla: 7.964 ± 0.097
0.212ProCys: 0.212 ± 0.015
4.271ProAsp: 4.271 ± 0.067
4.837ProGlu: 4.837 ± 0.074
1.678ProPhe: 1.678 ± 0.036
5.797ProGly: 5.797 ± 0.084
1.166ProHis: 1.166 ± 0.033
1.647ProIle: 1.647 ± 0.042
1.017ProLys: 1.017 ± 0.032
4.822ProLeu: 4.822 ± 0.075
1.079ProMet: 1.079 ± 0.033
1.055ProAsn: 1.055 ± 0.03
2.299ProPro: 2.299 ± 0.062
1.82ProGln: 1.82 ± 0.048
3.151ProArg: 3.151 ± 0.056
3.44ProSer: 3.44 ± 0.058
3.338ProThr: 3.338 ± 0.079
5.367ProVal: 5.367 ± 0.078
0.903ProTrp: 0.903 ± 0.031
1.046ProTyr: 1.046 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
4.207GlnAla: 4.207 ± 0.071
0.14GlnCys: 0.14 ± 0.012
2.195GlnAsp: 2.195 ± 0.048
1.874GlnGlu: 1.874 ± 0.04
0.878GlnPhe: 0.878 ± 0.03
2.604GlnGly: 2.604 ± 0.048
0.768GlnHis: 0.768 ± 0.03
1.34GlnIle: 1.34 ± 0.039
0.732GlnLys: 0.732 ± 0.028
3.349GlnLeu: 3.349 ± 0.055
0.718GlnMet: 0.718 ± 0.029
0.749GlnAsn: 0.749 ± 0.028
1.813GlnPro: 1.813 ± 0.043
1.446GlnGln: 1.446 ± 0.04
2.616GlnArg: 2.616 ± 0.051
1.749GlnSer: 1.749 ± 0.043
1.699GlnThr: 1.699 ± 0.04
2.795GlnVal: 2.795 ± 0.056
0.562GlnTrp: 0.562 ± 0.025
0.663GlnTyr: 0.663 ± 0.03
0.0GlnXaa: 0.0 ± 0.0
Arg
7.39ArgAla: 7.39 ± 0.101
0.334ArgCys: 0.334 ± 0.021
3.959ArgAsp: 3.959 ± 0.072
4.068ArgGlu: 4.068 ± 0.062
2.184ArgPhe: 2.184 ± 0.046
5.047ArgGly: 5.047 ± 0.068
1.837ArgHis: 1.837 ± 0.038
3.162ArgIle: 3.162 ± 0.055
1.585ArgLys: 1.585 ± 0.046
7.08ArgLeu: 7.08 ± 0.109
1.666ArgMet: 1.666 ± 0.038
1.528ArgAsn: 1.528 ± 0.04
3.908ArgPro: 3.908 ± 0.077
2.718ArgGln: 2.718 ± 0.059
6.172ArgArg: 6.172 ± 0.098
4.095ArgSer: 4.095 ± 0.073
4.435ArgThr: 4.435 ± 0.069
4.869ArgVal: 4.869 ± 0.066
1.189ArgTrp: 1.189 ± 0.04
1.495ArgTyr: 1.495 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
7.362SerAla: 7.362 ± 0.106
0.296SerCys: 0.296 ± 0.019
2.808SerAsp: 2.808 ± 0.047
3.262SerGlu: 3.262 ± 0.063
1.763SerPhe: 1.763 ± 0.043
6.745SerGly: 6.745 ± 0.099
1.096SerHis: 1.096 ± 0.032
2.101SerIle: 2.101 ± 0.04
1.086SerLys: 1.086 ± 0.037
5.45SerLeu: 5.45 ± 0.079
1.357SerMet: 1.357 ± 0.033
1.129SerAsn: 1.129 ± 0.04
3.437SerPro: 3.437 ± 0.061
1.655SerGln: 1.655 ± 0.043
3.908SerArg: 3.908 ± 0.065
3.821SerSer: 3.821 ± 0.074
4.025SerThr: 4.025 ± 0.072
4.718SerVal: 4.718 ± 0.067
0.866SerTrp: 0.866 ± 0.03
1.143SerTyr: 1.143 ± 0.036
0.0SerXaa: 0.0 ± 0.0
Thr
8.523ThrAla: 8.523 ± 0.101
0.289ThrCys: 0.289 ± 0.016
3.753ThrAsp: 3.753 ± 0.061
3.83ThrGlu: 3.83 ± 0.06
1.776ThrPhe: 1.776 ± 0.041
6.9ThrGly: 6.9 ± 0.083
1.241ThrHis: 1.241 ± 0.038
2.327ThrIle: 2.327 ± 0.055
1.045ThrLys: 1.045 ± 0.033
5.836ThrLeu: 5.836 ± 0.067
1.182ThrMet: 1.182 ± 0.034
1.15ThrAsn: 1.15 ± 0.035
4.073ThrPro: 4.073 ± 0.076
1.624ThrGln: 1.624 ± 0.045
3.504ThrArg: 3.504 ± 0.057
3.626ThrSer: 3.626 ± 0.065
4.304ThrThr: 4.304 ± 0.074
6.437ThrVal: 6.437 ± 0.087
0.853ThrTrp: 0.853 ± 0.033
1.236ThrTyr: 1.236 ± 0.041
0.0ThrXaa: 0.0 ± 0.0
Val
10.364ValAla: 10.364 ± 0.118
0.543ValCys: 0.543 ± 0.025
5.4ValAsp: 5.4 ± 0.08
4.954ValGlu: 4.954 ± 0.062
2.702ValPhe: 2.702 ± 0.058
6.701ValGly: 6.701 ± 0.085
1.796ValHis: 1.796 ± 0.047
3.563ValIle: 3.563 ± 0.068
1.649ValLys: 1.649 ± 0.046
9.574ValLeu: 9.574 ± 0.126
1.786ValMet: 1.786 ± 0.046
1.937ValAsn: 1.937 ± 0.051
5.137ValPro: 5.137 ± 0.069
2.519ValGln: 2.519 ± 0.05
5.458ValArg: 5.458 ± 0.071
4.681ValSer: 4.681 ± 0.066
5.389ValThr: 5.389 ± 0.081
8.261ValVal: 8.261 ± 0.104
1.011ValTrp: 1.011 ± 0.036
1.451ValTyr: 1.451 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
1.559TrpAla: 1.559 ± 0.048
0.112TrpCys: 0.112 ± 0.011
0.867TrpAsp: 0.867 ± 0.031
0.708TrpGlu: 0.708 ± 0.026
0.569TrpPhe: 0.569 ± 0.025
1.075TrpGly: 1.075 ± 0.034
0.294TrpHis: 0.294 ± 0.017
0.709TrpIle: 0.709 ± 0.025
0.346TrpLys: 0.346 ± 0.02
1.778TrpLeu: 1.778 ± 0.052
0.385TrpMet: 0.385 ± 0.018
0.412TrpAsn: 0.412 ± 0.021
0.737TrpPro: 0.737 ± 0.031
0.53TrpGln: 0.53 ± 0.024
1.05TrpArg: 1.05 ± 0.035
0.915TrpSer: 0.915 ± 0.032
0.926TrpThr: 0.926 ± 0.035
1.094TrpVal: 1.094 ± 0.036
0.364TrpTrp: 0.364 ± 0.022
0.278TrpTyr: 0.278 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.224TyrAla: 2.224 ± 0.047
0.155TyrCys: 0.155 ± 0.012
1.133TyrAsp: 1.133 ± 0.034
1.159TyrGlu: 1.159 ± 0.035
0.644TyrPhe: 0.644 ± 0.023
2.006TyrGly: 2.006 ± 0.045
0.329TyrHis: 0.329 ± 0.019
0.597TyrIle: 0.597 ± 0.026
0.322TyrLys: 0.322 ± 0.022
2.212TyrLeu: 2.212 ± 0.047
0.284TyrMet: 0.284 ± 0.015
0.428TyrAsn: 0.428 ± 0.022
1.032TyrPro: 1.032 ± 0.028
0.636TyrGln: 0.636 ± 0.025
1.667TyrArg: 1.667 ± 0.04
1.17TyrSer: 1.17 ± 0.037
1.155TyrThr: 1.155 ± 0.037
1.432TyrVal: 1.432 ± 0.034
0.331TyrTrp: 0.331 ± 0.018
0.429TyrTyr: 0.429 ± 0.022
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3030 proteins (1053604 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski