Amino acid dipepetide frequency for Hanseniaspora osmophila

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.948AlaAla: 3.948 ± 0.072	0.642AlaCys: 0.642 ± 0.016	2.718AlaAsp: 2.718 ± 0.033	3.227AlaGlu: 3.227 ± 0.046	2.209AlaPhe: 2.209 ± 0.032	2.928AlaGly: 2.928 ± 0.046	1.172AlaHis: 1.172 ± 0.023	3.065AlaIle: 3.065 ± 0.036	4.094AlaLys: 4.094 ± 0.049	5.029AlaLeu: 5.029 ± 0.054	1.224AlaMet: 1.224 ± 0.022	3.526AlaAsn: 3.526 ± 0.046	2.309AlaPro: 2.309 ± 0.046	2.449AlaGln: 2.449 ± 0.039	1.912AlaArg: 1.912 ± 0.025	5.348AlaSer: 5.348 ± 0.071	3.768AlaThr: 3.768 ± 0.055	3.033AlaVal: 3.033 ± 0.037	0.394AlaTrp: 0.394 ± 0.014	1.623AlaTyr: 1.623 ± 0.028	0.159AlaXaa: 0.159 ± 0.008
Cys	0.595CysAla: 0.595 ± 0.016	0.332CysCys: 0.332 ± 0.012	0.666CysAsp: 0.666 ± 0.018	0.647CysGlu: 0.647 ± 0.02	0.707CysPhe: 0.707 ± 0.016	0.817CysGly: 0.817 ± 0.02	0.257CysHis: 0.257 ± 0.011	0.87CysIle: 0.87 ± 0.016	0.878CysLys: 0.878 ± 0.019	1.283CysLeu: 1.283 ± 0.023	0.274CysMet: 0.274 ± 0.011	0.655CysAsn: 0.655 ± 0.017	0.449CysPro: 0.449 ± 0.015	0.377CysGln: 0.377 ± 0.013	0.402CysArg: 0.402 ± 0.011	1.072CysSer: 1.072 ± 0.023	0.637CysThr: 0.637 ± 0.017	0.831CysVal: 0.831 ± 0.019	0.135CysTrp: 0.135 ± 0.008	0.468CysTyr: 0.468 ± 0.014	0.03CysXaa: 0.03 ± 0.004
Asp	2.941AspAla: 2.941 ± 0.04	0.698AspCys: 0.698 ± 0.017	4.438AspAsp: 4.438 ± 0.089	4.82AspGlu: 4.82 ± 0.06	2.992AspPhe: 2.992 ± 0.034	2.758AspGly: 2.758 ± 0.04	1.171AspHis: 1.171 ± 0.025	3.752AspIle: 3.752 ± 0.045	3.555AspLys: 3.555 ± 0.037	5.602AspLeu: 5.602 ± 0.051	1.264AspMet: 1.264 ± 0.023	3.235AspAsn: 3.235 ± 0.043	2.298AspPro: 2.298 ± 0.031	2.124AspGln: 2.124 ± 0.029	1.566AspArg: 1.566 ± 0.029	4.658AspSer: 4.658 ± 0.058	2.947AspThr: 2.947 ± 0.035	3.263AspVal: 3.263 ± 0.039	0.507AspTrp: 0.507 ± 0.014	2.288AspTyr: 2.288 ± 0.033	0.212AspXaa: 0.212 ± 0.01
Glu	3.159GluAla: 3.159 ± 0.043	0.668GluCys: 0.668 ± 0.019	4.108GluAsp: 4.108 ± 0.066	6.096GluGlu: 6.096 ± 0.11	2.678GluPhe: 2.678 ± 0.034	2.312GluGly: 2.312 ± 0.029	1.442GluHis: 1.442 ± 0.03	3.992GluIle: 3.992 ± 0.037	5.688GluLys: 5.688 ± 0.065	6.071GluLeu: 6.071 ± 0.065	1.477GluMet: 1.477 ± 0.028	5.044GluAsn: 5.044 ± 0.049	1.946GluPro: 1.946 ± 0.031	3.234GluGln: 3.234 ± 0.042	2.321GluArg: 2.321 ± 0.032	4.871GluSer: 4.871 ± 0.046	4.004GluThr: 4.004 ± 0.053	3.016GluVal: 3.016 ± 0.035	0.543GluTrp: 0.543 ± 0.016	2.436GluTyr: 2.436 ± 0.032	0.236GluXaa: 0.236 ± 0.012
Phe	2.553PheAla: 2.553 ± 0.035	0.558PheCys: 0.558 ± 0.015	2.923PheAsp: 2.923 ± 0.038	3.069PheGlu: 3.069 ± 0.036	2.246PhePhe: 2.246 ± 0.042	2.579PheGly: 2.579 ± 0.041	1.073PheHis: 1.073 ± 0.024	2.591PheIle: 2.591 ± 0.034	3.259PheLys: 3.259 ± 0.036	4.132PheLeu: 4.132 ± 0.047	0.938PheMet: 0.938 ± 0.019	2.688PheAsn: 2.688 ± 0.037	1.745PhePro: 1.745 ± 0.027	2.204PheGln: 2.204 ± 0.029	1.274PheArg: 1.274 ± 0.026	3.808PheSer: 3.808 ± 0.042	2.431PheThr: 2.431 ± 0.034	2.833PheVal: 2.833 ± 0.04	0.471PheTrp: 0.471 ± 0.016	1.668PheTyr: 1.668 ± 0.03	0.111PheXaa: 0.111 ± 0.006
Gly	2.892GlyAla: 2.892 ± 0.049	0.706GlyCys: 0.706 ± 0.017	2.575GlyAsp: 2.575 ± 0.033	2.719GlyGlu: 2.719 ± 0.038	2.415GlyPhe: 2.415 ± 0.036	3.039GlyGly: 3.039 ± 0.06	1.096GlyHis: 1.096 ± 0.025	2.992GlyIle: 2.992 ± 0.043	3.826GlyLys: 3.826 ± 0.045	4.39GlyLeu: 4.39 ± 0.05	1.027GlyMet: 1.027 ± 0.022	3.238GlyAsn: 3.238 ± 0.04	1.459GlyPro: 1.459 ± 0.028	1.669GlyGln: 1.669 ± 0.031	1.664GlyArg: 1.664 ± 0.031	4.919GlySer: 4.919 ± 0.069	2.959GlyThr: 2.959 ± 0.043	3.014GlyVal: 3.014 ± 0.042	0.468GlyTrp: 0.468 ± 0.016	1.73GlyTyr: 1.73 ± 0.032	0.133GlyXaa: 0.133 ± 0.008
His	1.147HisAla: 1.147 ± 0.024	0.325HisCys: 0.325 ± 0.011	1.199HisAsp: 1.199 ± 0.022	1.358HisGlu: 1.358 ± 0.025	1.029HisPhe: 1.029 ± 0.022	1.223HisGly: 1.223 ± 0.025	0.791HisHis: 0.791 ± 0.023	1.271HisIle: 1.271 ± 0.027	1.481HisLys: 1.481 ± 0.024	2.062HisLeu: 2.062 ± 0.034	0.447HisMet: 0.447 ± 0.014	1.39HisAsn: 1.39 ± 0.028	1.032HisPro: 1.032 ± 0.023	1.019HisGln: 1.019 ± 0.022	0.817HisArg: 0.817 ± 0.021	1.977HisSer: 1.977 ± 0.036	1.229HisThr: 1.229 ± 0.025	1.118HisVal: 1.118 ± 0.018	0.203HisTrp: 0.203 ± 0.009	0.863HisTyr: 0.863 ± 0.02	0.079HisXaa: 0.079 ± 0.006
Ile	3.308IleAla: 3.308 ± 0.036	0.784IleCys: 0.784 ± 0.021	3.82IleAsp: 3.82 ± 0.042	3.663IleGlu: 3.663 ± 0.042	2.723IlePhe: 2.723 ± 0.038	2.793IleGly: 2.793 ± 0.038	1.181IleHis: 1.181 ± 0.025	3.509IleIle: 3.509 ± 0.04	4.391IleLys: 4.391 ± 0.045	5.434IleLeu: 5.434 ± 0.051	1.323IleMet: 1.323 ± 0.023	3.81IleAsn: 3.81 ± 0.044	2.737IlePro: 2.737 ± 0.031	2.288IleGln: 2.288 ± 0.032	1.982IleArg: 1.982 ± 0.026	5.199IleSer: 5.199 ± 0.057	3.453IleThr: 3.453 ± 0.04	3.619IleVal: 3.619 ± 0.041	0.549IleTrp: 0.549 ± 0.015	1.965IleTyr: 1.965 ± 0.032	0.147IleXaa: 0.147 ± 0.009
Lys	3.601LysAla: 3.601 ± 0.044	0.812LysCys: 0.812 ± 0.024	4.302LysAsp: 4.302 ± 0.051	5.264LysGlu: 5.264 ± 0.066	3.26LysPhe: 3.26 ± 0.037	2.732LysGly: 2.732 ± 0.034	1.798LysHis: 1.798 ± 0.028	5.022LysIle: 5.022 ± 0.05	7.463LysLys: 7.463 ± 0.078	7.32LysLeu: 7.32 ± 0.065	1.669LysMet: 1.669 ± 0.029	5.808LysAsn: 5.808 ± 0.052	3.085LysPro: 3.085 ± 0.043	3.489LysGln: 3.489 ± 0.043	3.385LysArg: 3.385 ± 0.046	5.955LysSer: 5.955 ± 0.055	4.957LysThr: 4.957 ± 0.048	3.806LysVal: 3.806 ± 0.045	0.715LysTrp: 0.715 ± 0.018	3.005LysTyr: 3.005 ± 0.036	0.266LysXaa: 0.266 ± 0.01
Leu	4.82LeuAla: 4.82 ± 0.048	1.264LeuCys: 1.264 ± 0.025	5.249LeuAsp: 5.249 ± 0.047	6.029LeuGlu: 6.029 ± 0.048	3.977LeuPhe: 3.977 ± 0.056	4.239LeuGly: 4.239 ± 0.05	2.109LeuHis: 2.109 ± 0.033	5.197LeuIle: 5.197 ± 0.056	7.98LeuLys: 7.98 ± 0.066	8.967LeuLeu: 8.967 ± 0.074	1.93LeuMet: 1.93 ± 0.029	6.15LeuAsn: 6.15 ± 0.053	4.195LeuPro: 4.195 ± 0.047	4.917LeuGln: 4.917 ± 0.046	3.341LeuArg: 3.341 ± 0.035	8.128LeuSer: 8.128 ± 0.062	4.733LeuThr: 4.733 ± 0.044	4.966LeuVal: 4.966 ± 0.053	0.806LeuTrp: 0.806 ± 0.02	3.043LeuTyr: 3.043 ± 0.038	0.238LeuXaa: 0.238 ± 0.012
Met	1.223MetAla: 1.223 ± 0.025	0.297MetCys: 0.297 ± 0.012	1.309MetAsp: 1.309 ± 0.021	1.374MetGlu: 1.374 ± 0.022	0.957MetPhe: 0.957 ± 0.021	1.15MetGly: 1.15 ± 0.025	0.433MetHis: 0.433 ± 0.013	1.259MetIle: 1.259 ± 0.02	1.647MetLys: 1.647 ± 0.025	1.81MetLeu: 1.81 ± 0.025	0.521MetMet: 0.521 ± 0.015	1.527MetAsn: 1.527 ± 0.031	0.759MetPro: 0.759 ± 0.022	0.913MetGln: 0.913 ± 0.021	0.689MetArg: 0.689 ± 0.015	2.145MetSer: 2.145 ± 0.029	1.114MetThr: 1.114 ± 0.02	1.152MetVal: 1.152 ± 0.021	0.16MetTrp: 0.16 ± 0.009	0.643MetTyr: 0.643 ± 0.016	0.059MetXaa: 0.059 ± 0.005
Asn	3.688AsnAla: 3.688 ± 0.043	0.773AsnCys: 0.773 ± 0.017	4.22AsnAsp: 4.22 ± 0.046	4.477AsnGlu: 4.477 ± 0.052	2.874AsnPhe: 2.874 ± 0.034	3.944AsnGly: 3.944 ± 0.052	1.398AsnHis: 1.398 ± 0.027	4.031AsnIle: 4.031 ± 0.047	5.132AsnLys: 5.132 ± 0.053	5.367AsnLeu: 5.367 ± 0.05	1.422AsnMet: 1.422 ± 0.025	6.963AsnAsn: 6.963 ± 0.13	2.468AsnPro: 2.468 ± 0.033	2.327AsnGln: 2.327 ± 0.034	1.937AsnArg: 1.937 ± 0.028	6.356AsnSer: 6.356 ± 0.071	4.598AsnThr: 4.598 ± 0.065	3.663AsnVal: 3.663 ± 0.037	0.532AsnTrp: 0.532 ± 0.017	2.261AsnTyr: 2.261 ± 0.033	0.31AsnXaa: 0.31 ± 0.014
Pro	2.339ProAla: 2.339 ± 0.041	0.342ProCys: 0.342 ± 0.011	1.796ProAsp: 1.796 ± 0.031	2.667ProGlu: 2.667 ± 0.035	1.851ProPhe: 1.851 ± 0.027	1.796ProGly: 1.796 ± 0.03	0.91ProHis: 0.91 ± 0.022	2.386ProIle: 2.386 ± 0.034	2.863ProLys: 2.863 ± 0.035	3.919ProLeu: 3.919 ± 0.042	0.822ProMet: 0.822 ± 0.019	2.442ProAsn: 2.442 ± 0.034	2.079ProPro: 2.079 ± 0.049	2.041ProGln: 2.041 ± 0.04	1.291ProArg: 1.291 ± 0.023	3.947ProSer: 3.947 ± 0.059	2.67ProThr: 2.67 ± 0.043	2.664ProVal: 2.664 ± 0.037	0.344ProTrp: 0.344 ± 0.012	1.358ProTyr: 1.358 ± 0.027	0.139ProXaa: 0.139 ± 0.009
Gln	2.104GlnAla: 2.104 ± 0.033	0.477GlnCys: 0.477 ± 0.015	2.374GlnAsp: 2.374 ± 0.03	3.128GlnGlu: 3.128 ± 0.044	1.699GlnPhe: 1.699 ± 0.028	1.712GlnGly: 1.712 ± 0.029	1.192GlnHis: 1.192 ± 0.028	2.405GlnIle: 2.405 ± 0.032	3.496GlnLys: 3.496 ± 0.041	4.079GlnLeu: 4.079 ± 0.042	0.951GlnMet: 0.951 ± 0.021	3.047GlnAsn: 3.047 ± 0.047	1.799GlnPro: 1.799 ± 0.039	4.379GlnGln: 4.379 ± 0.139	1.75GlnArg: 1.75 ± 0.026	3.362GlnSer: 3.362 ± 0.043	2.469GlnThr: 2.469 ± 0.031	2.15GlnVal: 2.15 ± 0.032	0.388GlnTrp: 0.388 ± 0.014	1.651GlnTyr: 1.651 ± 0.028	0.157GlnXaa: 0.157 ± 0.009
Arg	1.941ArgAla: 1.941 ± 0.028	0.442ArgCys: 0.442 ± 0.012	1.802ArgAsp: 1.802 ± 0.03	2.155ArgGlu: 2.155 ± 0.032	1.595ArgPhe: 1.595 ± 0.029	1.709ArgGly: 1.709 ± 0.033	0.726ArgHis: 0.726 ± 0.018	2.039ArgIle: 2.039 ± 0.029	3.138ArgLys: 3.138 ± 0.039	3.272ArgLeu: 3.272 ± 0.037	0.747ArgMet: 0.747 ± 0.016	2.252ArgAsn: 2.252 ± 0.033	1.261ArgPro: 1.261 ± 0.023	1.367ArgGln: 1.367 ± 0.024	1.793ArgArg: 1.793 ± 0.039	2.976ArgSer: 2.976 ± 0.04	1.833ArgThr: 1.833 ± 0.025	1.963ArgVal: 1.963 ± 0.03	0.326ArgTrp: 0.326 ± 0.013	1.243ArgTyr: 1.243 ± 0.024	0.077ArgXaa: 0.077 ± 0.005
Ser	5.264SerAla: 5.264 ± 0.067	0.975SerCys: 0.975 ± 0.024	4.419SerAsp: 4.419 ± 0.053	4.635SerGlu: 4.635 ± 0.058	4.193SerPhe: 4.193 ± 0.047	4.595SerGly: 4.595 ± 0.065	1.801SerHis: 1.801 ± 0.034	5.116SerIle: 5.116 ± 0.048	6.992SerLys: 6.992 ± 0.064	8.232SerLeu: 8.232 ± 0.06	1.809SerMet: 1.809 ± 0.028	6.587SerAsn: 6.587 ± 0.08	3.598SerPro: 3.598 ± 0.054	3.39SerGln: 3.39 ± 0.049	3.086SerArg: 3.086 ± 0.04	11.915SerSer: 11.915 ± 0.2	6.846SerThr: 6.846 ± 0.129	5.003SerVal: 5.003 ± 0.056	0.68SerTrp: 0.68 ± 0.018	2.568SerTyr: 2.568 ± 0.039	0.328SerXaa: 0.328 ± 0.013
Thr	3.547ThrAla: 3.547 ± 0.046	0.671ThrCys: 0.671 ± 0.02	2.953ThrAsp: 2.953 ± 0.038	3.358ThrGlu: 3.358 ± 0.049	2.63ThrPhe: 2.63 ± 0.037	3.323ThrGly: 3.323 ± 0.052	1.282ThrHis: 1.282 ± 0.022	3.388ThrIle: 3.388 ± 0.038	4.528ThrLys: 4.528 ± 0.045	5.368ThrLeu: 5.368 ± 0.046	1.165ThrMet: 1.165 ± 0.021	4.296ThrAsn: 4.296 ± 0.053	3.205ThrPro: 3.205 ± 0.052	2.356ThrGln: 2.356 ± 0.032	2.033ThrArg: 2.033 ± 0.031	6.251ThrSer: 6.251 ± 0.098	4.918ThrThr: 4.918 ± 0.103	3.488ThrVal: 3.488 ± 0.069	0.476ThrTrp: 0.476 ± 0.016	1.773ThrTyr: 1.773 ± 0.056	0.215ThrXaa: 0.215 ± 0.01
Val	3.389ValAla: 3.389 ± 0.04	0.758ValCys: 0.758 ± 0.018	3.388ValAsp: 3.388 ± 0.044	3.789ValGlu: 3.789 ± 0.044	2.826ValPhe: 2.826 ± 0.041	2.741ValGly: 2.741 ± 0.04	1.129ValHis: 1.129 ± 0.021	3.149ValIle: 3.149 ± 0.042	3.762ValLys: 3.762 ± 0.036	5.543ValLeu: 5.543 ± 0.055	1.103ValMet: 1.103 ± 0.021	3.02ValAsn: 3.02 ± 0.033	2.609ValPro: 2.609 ± 0.037	2.296ValGln: 2.296 ± 0.029	1.778ValArg: 1.778 ± 0.031	5.153ValSer: 5.153 ± 0.053	3.017ValThr: 3.017 ± 0.049	3.574ValVal: 3.574 ± 0.056	0.535ValTrp: 0.535 ± 0.017	2.038ValTyr: 2.038 ± 0.037	0.138ValXaa: 0.138 ± 0.008
Trp	0.437TrpAla: 0.437 ± 0.014	0.229TrpCys: 0.229 ± 0.01	0.554TrpAsp: 0.554 ± 0.016	0.543TrpGlu: 0.543 ± 0.014	0.466TrpPhe: 0.466 ± 0.016	0.468TrpGly: 0.468 ± 0.015	0.164TrpHis: 0.164 ± 0.008	0.511TrpIle: 0.511 ± 0.015	0.759TrpLys: 0.759 ± 0.019	0.782TrpLeu: 0.782 ± 0.017	0.199TrpMet: 0.199 ± 0.009	0.625TrpAsn: 0.625 ± 0.014	0.242TrpPro: 0.242 ± 0.011	0.271TrpGln: 0.271 ± 0.008	0.378TrpArg: 0.378 ± 0.014	0.699TrpSer: 0.699 ± 0.02	0.47TrpThr: 0.47 ± 0.019	0.476TrpVal: 0.476 ± 0.015	0.122TrpTrp: 0.122 ± 0.007	0.339TrpTyr: 0.339 ± 0.013	0.016TrpXaa: 0.016 ± 0.003
Tyr	1.72TyrAla: 1.72 ± 0.026	0.595TyrCys: 0.595 ± 0.015	2.077TyrAsp: 2.077 ± 0.026	2.096TyrGlu: 2.096 ± 0.03	1.689TyrPhe: 1.689 ± 0.029	1.937TyrGly: 1.937 ± 0.035	0.85TyrHis: 0.85 ± 0.022	1.99TyrIle: 1.99 ± 0.029	2.528TyrLys: 2.528 ± 0.036	3.35TyrLeu: 3.35 ± 0.039	0.774TyrMet: 0.774 ± 0.02	2.147TyrAsn: 2.147 ± 0.03	1.277TyrPro: 1.277 ± 0.023	1.497TyrGln: 1.497 ± 0.029	1.18TyrArg: 1.18 ± 0.02	2.948TyrSer: 2.948 ± 0.057	1.98TyrThr: 1.98 ± 0.036	1.96TyrVal: 1.96 ± 0.038	0.375TyrTrp: 0.375 ± 0.017	1.589TyrTyr: 1.589 ± 0.039	0.088TyrXaa: 0.088 ± 0.006
Xaa	0.162XaaAla: 0.162 ± 0.009	0.033XaaCys: 0.033 ± 0.004	0.2XaaAsp: 0.2 ± 0.011	0.227XaaGlu: 0.227 ± 0.011	0.139XaaPhe: 0.139 ± 0.009	0.136XaaGly: 0.136 ± 0.008	0.084XaaHis: 0.084 ± 0.007	0.143XaaIle: 0.143 ± 0.008	0.255XaaLys: 0.255 ± 0.011	0.268XaaLeu: 0.268 ± 0.012	0.052XaaMet: 0.052 ± 0.004	0.287XaaAsn: 0.287 ± 0.013	0.115XaaPro: 0.115 ± 0.007	0.16XaaGln: 0.16 ± 0.009	0.082XaaArg: 0.082 ± 0.006	0.347XaaSer: 0.347 ± 0.015	0.191XaaThr: 0.191 ± 0.009	0.143XaaVal: 0.143 ± 0.007	0.018XaaTrp: 0.018 ± 0.003	0.096XaaTyr: 0.096 ± 0.006	0.104XaaXaa: 0.104 ± 0.009

Statistics based on 4653 proteins (2567851 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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