Amino acid dipepetide frequency for Tropicimonas isoalkanivorans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.84AlaAla: 16.84 ± 0.172	1.136AlaCys: 1.136 ± 0.033	7.086AlaAsp: 7.086 ± 0.072	8.644AlaGlu: 8.644 ± 0.088	4.456AlaPhe: 4.456 ± 0.06	10.624AlaGly: 10.624 ± 0.085	2.257AlaHis: 2.257 ± 0.04	5.998AlaIle: 5.998 ± 0.072	3.435AlaLys: 3.435 ± 0.056	13.276AlaLeu: 13.276 ± 0.122	3.708AlaMet: 3.708 ± 0.054	2.677AlaAsn: 2.677 ± 0.042	5.892AlaPro: 5.892 ± 0.077	3.899AlaGln: 3.899 ± 0.06	8.975AlaArg: 8.975 ± 0.096	5.9AlaSer: 5.9 ± 0.066	6.229AlaThr: 6.229 ± 0.067	8.753AlaVal: 8.753 ± 0.074	1.594AlaTrp: 1.594 ± 0.044	2.464AlaTyr: 2.464 ± 0.035	0.0AlaXaa: 0.0 ± 0.0
Cys	1.049CysAla: 1.049 ± 0.027	0.116CysCys: 0.116 ± 0.009	0.587CysAsp: 0.587 ± 0.021	0.475CysGlu: 0.475 ± 0.021	0.322CysPhe: 0.322 ± 0.014	0.966CysGly: 0.966 ± 0.03	0.302CysHis: 0.302 ± 0.019	0.403CysIle: 0.403 ± 0.016	0.21CysLys: 0.21 ± 0.012	0.87CysLeu: 0.87 ± 0.027	0.168CysMet: 0.168 ± 0.011	0.214CysAsn: 0.214 ± 0.012	0.515CysPro: 0.515 ± 0.021	0.234CysGln: 0.234 ± 0.012	0.656CysArg: 0.656 ± 0.022	0.426CysSer: 0.426 ± 0.016	0.44CysThr: 0.44 ± 0.018	0.606CysVal: 0.606 ± 0.022	0.137CysTrp: 0.137 ± 0.01	0.202CysTyr: 0.202 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.475AspAla: 7.475 ± 0.067	0.541AspCys: 0.541 ± 0.02	3.437AspAsp: 3.437 ± 0.068	3.609AspGlu: 3.609 ± 0.059	2.311AspPhe: 2.311 ± 0.041	6.006AspGly: 6.006 ± 0.08	1.288AspHis: 1.288 ± 0.031	2.93AspIle: 2.93 ± 0.046	1.453AspLys: 1.453 ± 0.039	6.613AspLeu: 6.613 ± 0.071	1.552AspMet: 1.552 ± 0.034	1.204AspAsn: 1.204 ± 0.033	3.759AspPro: 3.759 ± 0.05	1.671AspGln: 1.671 ± 0.035	4.734AspArg: 4.734 ± 0.058	2.22AspSer: 2.22 ± 0.046	3.044AspThr: 3.044 ± 0.053	4.61AspVal: 4.61 ± 0.059	1.235AspTrp: 1.235 ± 0.028	1.505AspTyr: 1.505 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	8.603GluAla: 8.603 ± 0.102	0.404GluCys: 0.404 ± 0.019	3.569GluAsp: 3.569 ± 0.055	3.857GluGlu: 3.857 ± 0.062	1.803GluPhe: 1.803 ± 0.034	4.947GluGly: 4.947 ± 0.055	1.211GluHis: 1.211 ± 0.033	3.845GluIle: 3.845 ± 0.057	2.057GluLys: 2.057 ± 0.042	5.098GluLeu: 5.098 ± 0.064	1.863GluMet: 1.863 ± 0.032	1.667GluAsn: 1.667 ± 0.038	2.916GluPro: 2.916 ± 0.054	2.038GluGln: 2.038 ± 0.038	4.928GluArg: 4.928 ± 0.058	2.527GluSer: 2.527 ± 0.043	4.128GluThr: 4.128 ± 0.055	4.464GluVal: 4.464 ± 0.049	0.743GluTrp: 0.743 ± 0.024	1.027GluTyr: 1.027 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.372PheAla: 4.372 ± 0.059	0.397PheCys: 0.397 ± 0.017	2.875PheAsp: 2.875 ± 0.05	2.286PheGlu: 2.286 ± 0.042	1.406PhePhe: 1.406 ± 0.038	3.74PheGly: 3.74 ± 0.057	0.744PheHis: 0.744 ± 0.021	1.576PheIle: 1.576 ± 0.031	0.825PheLys: 0.825 ± 0.024	3.49PheLeu: 3.49 ± 0.059	0.822PheMet: 0.822 ± 0.022	0.968PheAsn: 0.968 ± 0.029	1.585PhePro: 1.585 ± 0.035	0.955PheGln: 0.955 ± 0.024	2.374PheArg: 2.374 ± 0.043	2.067PheSer: 2.067 ± 0.042	1.996PheThr: 1.996 ± 0.037	2.707PheVal: 2.707 ± 0.05	0.582PheTrp: 0.582 ± 0.022	0.897PheTyr: 0.897 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	10.083GlyAla: 10.083 ± 0.094	0.918GlyCys: 0.918 ± 0.025	4.902GlyAsp: 4.902 ± 0.074	4.996GlyGlu: 4.996 ± 0.054	3.551GlyPhe: 3.551 ± 0.049	7.919GlyGly: 7.919 ± 0.192	1.922GlyHis: 1.922 ± 0.038	4.513GlyIle: 4.513 ± 0.061	2.97GlyLys: 2.97 ± 0.049	9.12GlyLeu: 9.12 ± 0.086	2.566GlyMet: 2.566 ± 0.048	2.197GlyAsn: 2.197 ± 0.058	3.832GlyPro: 3.832 ± 0.047	2.874GlyGln: 2.874 ± 0.046	6.264GlyArg: 6.264 ± 0.066	4.422GlySer: 4.422 ± 0.069	5.03GlyThr: 5.03 ± 0.073	6.406GlyVal: 6.406 ± 0.073	1.561GlyTrp: 1.561 ± 0.038	2.218GlyTyr: 2.218 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.293HisAla: 2.293 ± 0.037	0.232HisCys: 0.232 ± 0.014	1.27HisAsp: 1.27 ± 0.033	1.038HisGlu: 1.038 ± 0.028	0.805HisPhe: 0.805 ± 0.024	1.96HisGly: 1.96 ± 0.034	0.558HisHis: 0.558 ± 0.025	0.883HisIle: 0.883 ± 0.025	0.451HisLys: 0.451 ± 0.016	2.105HisLeu: 2.105 ± 0.04	0.539HisMet: 0.539 ± 0.02	0.38HisAsn: 0.38 ± 0.015	1.355HisPro: 1.355 ± 0.029	0.513HisGln: 0.513 ± 0.021	1.464HisArg: 1.464 ± 0.03	0.931HisSer: 0.931 ± 0.025	0.897HisThr: 0.897 ± 0.024	1.543HisVal: 1.543 ± 0.031	0.376HisTrp: 0.376 ± 0.018	0.529HisTyr: 0.529 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.685IleAla: 6.685 ± 0.085	0.564IleCys: 0.564 ± 0.021	3.543IleAsp: 3.543 ± 0.051	3.397IleGlu: 3.397 ± 0.05	1.785IlePhe: 1.785 ± 0.038	4.912IleGly: 4.912 ± 0.06	0.911IleHis: 0.911 ± 0.026	1.932IleIle: 1.932 ± 0.041	1.181IleLys: 1.181 ± 0.031	4.686IleLeu: 4.686 ± 0.068	0.987IleMet: 0.987 ± 0.024	1.238IleAsn: 1.238 ± 0.028	2.314IlePro: 2.314 ± 0.038	1.146IleGln: 1.146 ± 0.026	3.317IleArg: 3.317 ± 0.051	2.838IleSer: 2.838 ± 0.046	2.539IleThr: 2.539 ± 0.047	3.985IleVal: 3.985 ± 0.063	0.691IleTrp: 0.691 ± 0.02	1.145IleTyr: 1.145 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	3.557LysAla: 3.557 ± 0.059	0.168LysCys: 0.168 ± 0.011	1.69LysAsp: 1.69 ± 0.037	1.484LysGlu: 1.484 ± 0.032	0.829LysPhe: 0.829 ± 0.024	2.469LysGly: 2.469 ± 0.048	0.514LysHis: 0.514 ± 0.021	1.471LysIle: 1.471 ± 0.038	1.03LysLys: 1.03 ± 0.032	2.713LysLeu: 2.713 ± 0.045	0.731LysMet: 0.731 ± 0.025	0.712LysAsn: 0.712 ± 0.022	1.637LysPro: 1.637 ± 0.038	0.825LysGln: 0.825 ± 0.025	2.177LysArg: 2.177 ± 0.041	1.612LysSer: 1.612 ± 0.033	1.77LysThr: 1.77 ± 0.036	2.287LysVal: 2.287 ± 0.04	0.342LysTrp: 0.342 ± 0.017	0.58LysTyr: 0.58 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	13.042LeuAla: 13.042 ± 0.113	0.898LeuCys: 0.898 ± 0.026	6.09LeuAsp: 6.09 ± 0.072	5.713LeuGlu: 5.713 ± 0.068	3.454LeuPhe: 3.454 ± 0.055	8.334LeuGly: 8.334 ± 0.085	1.882LeuHis: 1.882 ± 0.039	4.826LeuIle: 4.826 ± 0.065	3.031LeuLys: 3.031 ± 0.046	9.063LeuLeu: 9.063 ± 0.109	2.475LeuMet: 2.475 ± 0.047	2.479LeuAsn: 2.479 ± 0.047	5.494LeuPro: 5.494 ± 0.069	2.612LeuGln: 2.612 ± 0.044	7.058LeuArg: 7.058 ± 0.088	6.446LeuSer: 6.446 ± 0.071	5.925LeuThr: 5.925 ± 0.074	7.224LeuVal: 7.224 ± 0.08	1.244LeuTrp: 1.244 ± 0.033	1.991LeuTyr: 1.991 ± 0.034	0.0LeuXaa: 0.0 ± 0.0
Met	3.363MetAla: 3.363 ± 0.059	0.175MetCys: 0.175 ± 0.011	1.385MetAsp: 1.385 ± 0.033	1.432MetGlu: 1.432 ± 0.035	0.782MetPhe: 0.782 ± 0.023	2.115MetGly: 2.115 ± 0.04	0.453MetHis: 0.453 ± 0.015	1.436MetIle: 1.436 ± 0.033	0.958MetLys: 0.958 ± 0.026	2.472MetLeu: 2.472 ± 0.038	0.714MetMet: 0.714 ± 0.024	0.813MetAsn: 0.813 ± 0.026	1.518MetPro: 1.518 ± 0.035	0.86MetGln: 0.86 ± 0.024	1.828MetArg: 1.828 ± 0.038	1.711MetSer: 1.711 ± 0.035	2.033MetThr: 2.033 ± 0.038	1.894MetVal: 1.894 ± 0.037	0.21MetTrp: 0.21 ± 0.013	0.311MetTyr: 0.311 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.065AsnAla: 3.065 ± 0.05	0.266AsnCys: 0.266 ± 0.012	1.437AsnAsp: 1.437 ± 0.043	1.181AsnGlu: 1.181 ± 0.03	0.899AsnPhe: 0.899 ± 0.024	2.346AsnGly: 2.346 ± 0.053	0.452AsnHis: 0.452 ± 0.018	1.258AsnIle: 1.258 ± 0.031	0.588AsnLys: 0.588 ± 0.022	2.29AsnLeu: 2.29 ± 0.042	0.644AsnMet: 0.644 ± 0.022	0.61AsnAsn: 0.61 ± 0.023	1.777AsnPro: 1.777 ± 0.033	0.648AsnGln: 0.648 ± 0.02	1.715AsnArg: 1.715 ± 0.033	1.111AsnSer: 1.111 ± 0.031	1.212AsnThr: 1.212 ± 0.029	1.878AsnVal: 1.878 ± 0.038	0.431AsnTrp: 0.431 ± 0.018	0.62AsnTyr: 0.62 ± 0.022	0.001AsnXaa: 0.001 ± 0.001
Pro	6.091ProAla: 6.091 ± 0.078	0.384ProCys: 0.384 ± 0.015	4.153ProAsp: 4.153 ± 0.061	4.498ProGlu: 4.498 ± 0.063	2.046ProPhe: 2.046 ± 0.04	4.684ProGly: 4.684 ± 0.067	1.104ProHis: 1.104 ± 0.029	2.242ProIle: 2.242 ± 0.038	1.5ProLys: 1.5 ± 0.034	4.54ProLeu: 4.54 ± 0.056	1.323ProMet: 1.323 ± 0.028	1.252ProAsn: 1.252 ± 0.029	2.632ProPro: 2.632 ± 0.051	1.521ProGln: 1.521 ± 0.034	2.949ProArg: 2.949 ± 0.048	2.682ProSer: 2.682 ± 0.044	2.6ProThr: 2.6 ± 0.045	4.297ProVal: 4.297 ± 0.053	0.683ProTrp: 0.683 ± 0.024	1.192ProTyr: 1.192 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.693GlnAla: 3.693 ± 0.056	0.193GlnCys: 0.193 ± 0.012	1.514GlnAsp: 1.514 ± 0.035	1.626GlnGlu: 1.626 ± 0.035	0.993GlnPhe: 0.993 ± 0.028	2.322GlnGly: 2.322 ± 0.039	0.512GlnHis: 0.512 ± 0.016	1.79GlnIle: 1.79 ± 0.033	0.934GlnLys: 0.934 ± 0.026	2.544GlnLeu: 2.544 ± 0.041	0.958GlnMet: 0.958 ± 0.028	0.777GlnAsn: 0.777 ± 0.024	1.549GlnPro: 1.549 ± 0.033	1.058GlnGln: 1.058 ± 0.033	2.178GlnArg: 2.178 ± 0.04	1.71GlnSer: 1.71 ± 0.041	1.792GlnThr: 1.792 ± 0.036	2.263GlnVal: 2.263 ± 0.039	0.363GlnTrp: 0.363 ± 0.017	0.566GlnTyr: 0.566 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	8.215ArgAla: 8.215 ± 0.093	0.528ArgCys: 0.528 ± 0.02	4.338ArgAsp: 4.338 ± 0.052	4.268ArgGlu: 4.268 ± 0.067	2.744ArgPhe: 2.744 ± 0.051	5.011ArgGly: 5.011 ± 0.063	1.633ArgHis: 1.633 ± 0.032	3.964ArgIle: 3.964 ± 0.057	2.246ArgLys: 2.246 ± 0.041	7.909ArgLeu: 7.909 ± 0.093	2.011ArgMet: 2.011 ± 0.037	1.852ArgAsn: 1.852 ± 0.04	3.686ArgPro: 3.686 ± 0.056	2.431ArgGln: 2.431 ± 0.046	5.795ArgArg: 5.795 ± 0.067	3.625ArgSer: 3.625 ± 0.05	3.502ArgThr: 3.502 ± 0.046	4.859ArgVal: 4.859 ± 0.059	1.017ArgTrp: 1.017 ± 0.031	1.65ArgTyr: 1.65 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	5.982SerAla: 5.982 ± 0.066	0.426SerCys: 0.426 ± 0.018	3.299SerAsp: 3.299 ± 0.054	3.151SerGlu: 3.151 ± 0.042	2.135SerPhe: 2.135 ± 0.038	5.628SerGly: 5.628 ± 0.079	1.085SerHis: 1.085 ± 0.026	2.502SerIle: 2.502 ± 0.046	1.374SerLys: 1.374 ± 0.033	5.08SerLeu: 5.08 ± 0.069	1.333SerMet: 1.333 ± 0.031	1.286SerAsn: 1.286 ± 0.034	2.637SerPro: 2.637 ± 0.045	1.464SerGln: 1.464 ± 0.032	3.612SerArg: 3.612 ± 0.045	2.575SerSer: 2.575 ± 0.051	2.529SerThr: 2.529 ± 0.043	3.923SerVal: 3.923 ± 0.064	0.748SerTrp: 0.748 ± 0.025	1.221SerTyr: 1.221 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	6.438ThrAla: 6.438 ± 0.074	0.507ThrCys: 0.507 ± 0.02	3.335ThrAsp: 3.335 ± 0.055	3.144ThrGlu: 3.144 ± 0.049	2.158ThrPhe: 2.158 ± 0.045	5.444ThrGly: 5.444 ± 0.068	1.079ThrHis: 1.079 ± 0.026	2.652ThrIle: 2.652 ± 0.042	1.359ThrLys: 1.359 ± 0.035	5.871ThrLeu: 5.871 ± 0.065	1.296ThrMet: 1.296 ± 0.029	1.227ThrAsn: 1.227 ± 0.03	3.551ThrPro: 3.551 ± 0.055	1.42ThrGln: 1.42 ± 0.031	3.592ThrArg: 3.592 ± 0.06	2.783ThrSer: 2.783 ± 0.044	2.863ThrThr: 2.863 ± 0.054	4.393ThrVal: 4.393 ± 0.06	0.784ThrTrp: 0.784 ± 0.025	1.286ThrTyr: 1.286 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	9.159ValAla: 9.159 ± 0.09	0.679ValCys: 0.679 ± 0.019	4.334ValAsp: 4.334 ± 0.052	4.819ValGlu: 4.819 ± 0.068	2.842ValPhe: 2.842 ± 0.045	5.667ValGly: 5.667 ± 0.071	1.368ValHis: 1.368 ± 0.031	3.958ValIle: 3.958 ± 0.058	1.995ValLys: 1.995 ± 0.039	7.671ValLeu: 7.671 ± 0.079	1.903ValMet: 1.903 ± 0.039	1.893ValAsn: 1.893 ± 0.037	3.907ValPro: 3.907 ± 0.049	1.966ValGln: 1.966 ± 0.038	4.783ValArg: 4.783 ± 0.07	4.406ValSer: 4.406 ± 0.056	4.75ValThr: 4.75 ± 0.049	5.889ValVal: 5.889 ± 0.075	0.97ValTrp: 0.97 ± 0.028	1.501ValTyr: 1.501 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	1.374TrpAla: 1.374 ± 0.035	0.141TrpCys: 0.141 ± 0.008	0.769TrpAsp: 0.769 ± 0.025	0.75TrpGlu: 0.75 ± 0.023	0.523TrpPhe: 0.523 ± 0.021	1.008TrpGly: 1.008 ± 0.029	0.367TrpHis: 0.367 ± 0.017	0.692TrpIle: 0.692 ± 0.023	0.464TrpLys: 0.464 ± 0.017	1.67TrpLeu: 1.67 ± 0.039	0.389TrpMet: 0.389 ± 0.016	0.426TrpAsn: 0.426 ± 0.015	0.749TrpPro: 0.749 ± 0.025	0.599TrpGln: 0.599 ± 0.025	1.198TrpArg: 1.198 ± 0.031	0.834TrpSer: 0.834 ± 0.024	0.856TrpThr: 0.856 ± 0.028	0.935TrpVal: 0.935 ± 0.026	0.225TrpTrp: 0.225 ± 0.014	0.323TrpTyr: 0.323 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.466TyrAla: 2.466 ± 0.047	0.227TyrCys: 0.227 ± 0.012	1.583TyrAsp: 1.583 ± 0.038	1.328TyrGlu: 1.328 ± 0.037	0.819TyrPhe: 0.819 ± 0.021	2.164TyrGly: 2.164 ± 0.044	0.48TyrHis: 0.48 ± 0.018	0.924TyrIle: 0.924 ± 0.028	0.537TyrLys: 0.537 ± 0.02	2.199TyrLeu: 2.199 ± 0.044	0.479TyrMet: 0.479 ± 0.019	0.557TyrAsn: 0.557 ± 0.02	1.068TyrPro: 1.068 ± 0.031	0.605TyrGln: 0.605 ± 0.02	1.683TyrArg: 1.683 ± 0.034	1.166TyrSer: 1.166 ± 0.027	1.046TyrThr: 1.046 ± 0.024	1.541TyrVal: 1.541 ± 0.034	0.357TyrTrp: 0.357 ± 0.016	0.606TyrTyr: 0.606 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.002

Statistics based on 4790 proteins (1477901 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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