Amino acid dipepetide frequency for Passion fruit chlorotic mottle virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.499AlaAla: 1.499 ± 0.76
0.75AlaCys: 0.75 ± 0.696
3.748AlaAsp: 3.748 ± 1.874
2.999AlaGlu: 2.999 ± 1.972
1.499AlaPhe: 1.499 ± 1.156
2.999AlaGly: 2.999 ± 1.095
1.499AlaHis: 1.499 ± 0.927
2.999AlaIle: 2.999 ± 1.003
2.249AlaLys: 2.249 ± 0.646
2.999AlaLeu: 2.999 ± 1.148
2.999AlaMet: 2.999 ± 0.688
3.748AlaAsn: 3.748 ± 1.459
0.75AlaPro: 0.75 ± 0.635
4.498AlaGln: 4.498 ± 1.747
3.748AlaArg: 3.748 ± 1.26
5.247AlaSer: 5.247 ± 1.899
1.499AlaThr: 1.499 ± 1.242
5.997AlaVal: 5.997 ± 3.202
1.499AlaTrp: 1.499 ± 0.76
0.0AlaTyr: 0.0 ± 0.0
0.0AlaXaa: 0.0 ± 0.0
Cys
2.249CysAla: 2.249 ± 1.598
0.75CysCys: 0.75 ± 1.084
1.499CysAsp: 1.499 ± 0.834
0.75CysGlu: 0.75 ± 0.851
4.498CysPhe: 4.498 ± 1.805
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
2.249CysLys: 2.249 ± 1.239
0.75CysLeu: 0.75 ± 0.635
0.75CysMet: 0.75 ± 0.851
0.75CysAsn: 0.75 ± 0.56
0.0CysPro: 0.0 ± 0.0
1.499CysGln: 1.499 ± 0.682
2.999CysArg: 2.999 ± 1.244
0.75CysSer: 0.75 ± 1.084
0.0CysThr: 0.0 ± 0.0
3.748CysVal: 3.748 ± 1.541
0.75CysTrp: 0.75 ± 0.56
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
2.999AspAla: 2.999 ± 1.782
0.75AspCys: 0.75 ± 0.696
2.249AspAsp: 2.249 ± 0.711
5.997AspGlu: 5.997 ± 1.704
8.996AspPhe: 8.996 ± 2.136
1.499AspGly: 1.499 ± 1.156
3.748AspHis: 3.748 ± 0.515
7.496AspIle: 7.496 ± 2.461
2.999AspLys: 2.999 ± 1.345
3.748AspLeu: 3.748 ± 1.932
4.498AspMet: 4.498 ± 1.638
3.748AspAsn: 3.748 ± 1.26
2.249AspPro: 2.249 ± 0.805
0.0AspGln: 0.0 ± 0.0
3.748AspArg: 3.748 ± 1.762
2.999AspSer: 2.999 ± 1.362
2.999AspThr: 2.999 ± 1.52
4.498AspVal: 4.498 ± 2.52
1.499AspTrp: 1.499 ± 0.973
4.498AspTyr: 4.498 ± 0.814
0.0AspXaa: 0.0 ± 0.0
Glu
4.498GluAla: 4.498 ± 2.31
0.0GluCys: 0.0 ± 0.0
1.499GluAsp: 1.499 ± 0.76
5.247GluGlu: 5.247 ± 2.188
2.999GluPhe: 2.999 ± 1.031
2.999GluGly: 2.999 ± 1.221
1.499GluHis: 1.499 ± 0.76
6.747GluIle: 6.747 ± 3.152
5.247GluLys: 5.247 ± 4.164
2.999GluLeu: 2.999 ± 1.031
0.0GluMet: 0.0 ± 0.0
2.249GluAsn: 2.249 ± 1.226
2.999GluPro: 2.999 ± 0.531
0.0GluGln: 0.0 ± 0.0
2.249GluArg: 2.249 ± 1.214
0.75GluSer: 0.75 ± 0.696
2.999GluThr: 2.999 ± 1.109
1.499GluVal: 1.499 ± 1.27
0.75GluTrp: 0.75 ± 0.851
4.498GluTyr: 4.498 ± 1.574
0.0GluXaa: 0.0 ± 0.0
Phe
4.498PheAla: 4.498 ± 1.569
1.499PheCys: 1.499 ± 1.244
7.496PheAsp: 7.496 ± 2.755
5.997PheGlu: 5.997 ± 0.89
7.496PhePhe: 7.496 ± 1.883
2.249PheGly: 2.249 ± 1.533
2.999PheHis: 2.999 ± 0.941
5.997PheIle: 5.997 ± 1.981
0.0PheLys: 0.0 ± 0.0
5.247PheLeu: 5.247 ± 1.978
0.0PheMet: 0.0 ± 0.0
0.75PheAsn: 0.75 ± 0.635
2.999PhePro: 2.999 ± 0.531
1.499PheGln: 1.499 ± 0.76
2.999PheArg: 2.999 ± 0.531
5.247PheSer: 5.247 ± 1.599
1.499PheThr: 1.499 ± 1.12
2.249PheVal: 2.249 ± 1.346
0.75PheTrp: 0.75 ± 1.084
2.249PheTyr: 2.249 ± 0.646
0.0PheXaa: 0.0 ± 0.0
Gly
0.75GlyAla: 0.75 ± 1.084
1.499GlyCys: 1.499 ± 0.748
5.997GlyAsp: 5.997 ± 0.635
1.499GlyGlu: 1.499 ± 2.168
1.499GlyPhe: 1.499 ± 1.244
5.247GlyGly: 5.247 ± 3.114
0.75GlyHis: 0.75 ± 0.635
2.999GlyIle: 2.999 ± 1.148
4.498GlyLys: 4.498 ± 2.072
2.249GlyLeu: 2.249 ± 1.023
0.75GlyMet: 0.75 ± 0.98
2.249GlyAsn: 2.249 ± 1.424
8.246GlyPro: 8.246 ± 2.37
0.75GlyGln: 0.75 ± 0.621
3.748GlyArg: 3.748 ± 1.84
5.247GlySer: 5.247 ± 2.095
0.75GlyThr: 0.75 ± 0.635
0.0GlyVal: 0.0 ± 0.0
0.75GlyTrp: 0.75 ± 0.851
0.0GlyTyr: 0.0 ± 0.0
0.0GlyXaa: 0.0 ± 0.0
His
1.499HisAla: 1.499 ± 0.76
1.499HisCys: 1.499 ± 1.27
2.999HisAsp: 2.999 ± 0.531
0.75HisGlu: 0.75 ± 0.851
1.499HisPhe: 1.499 ± 0.76
1.499HisGly: 1.499 ± 0.764
2.249HisHis: 2.249 ± 0.646
2.249HisIle: 2.249 ± 0.646
0.0HisLys: 0.0 ± 0.0
0.75HisLeu: 0.75 ± 0.696
0.0HisMet: 0.0 ± 0.0
2.249HisAsn: 2.249 ± 1.166
1.499HisPro: 1.499 ± 0.76
1.499HisGln: 1.499 ± 0.76
2.249HisArg: 2.249 ± 0.929
2.249HisSer: 2.249 ± 1.424
0.75HisThr: 0.75 ± 0.621
3.748HisVal: 3.748 ± 0.515
0.0HisTrp: 0.0 ± 0.0
0.75HisTyr: 0.75 ± 0.696
0.0HisXaa: 0.0 ± 0.0
Ile
1.499IleAla: 1.499 ± 1.242
2.249IleCys: 2.249 ± 1.094
3.748IleAsp: 3.748 ± 0.781
2.249IleGlu: 2.249 ± 0.646
5.997IlePhe: 5.997 ± 2.563
2.999IleGly: 2.999 ± 1.843
2.249IleHis: 2.249 ± 0.646
3.748IleIle: 3.748 ± 1.784
5.997IleLys: 5.997 ± 1.359
5.247IleLeu: 5.247 ± 2.147
2.249IleMet: 2.249 ± 1.256
5.997IleAsn: 5.997 ± 2.22
2.999IlePro: 2.999 ± 0.531
1.499IleGln: 1.499 ± 0.76
6.747IleArg: 6.747 ± 1.115
6.747IleSer: 6.747 ± 1.367
2.999IleThr: 2.999 ± 1.003
2.249IleVal: 2.249 ± 1.256
1.499IleTrp: 1.499 ± 0.76
0.0IleTyr: 0.0 ± 0.0
0.0IleXaa: 0.0 ± 0.0
Lys
4.498LysAla: 4.498 ± 2.193
0.0LysCys: 0.0 ± 0.0
5.997LysAsp: 5.997 ± 1.433
6.747LysGlu: 6.747 ± 1.536
0.75LysPhe: 0.75 ± 0.56
5.247LysGly: 5.247 ± 2.443
0.75LysHis: 0.75 ± 0.635
2.999LysIle: 2.999 ± 1.322
4.498LysLys: 4.498 ± 1.886
2.249LysLeu: 2.249 ± 1.26
1.499LysMet: 1.499 ± 0.764
3.748LysAsn: 3.748 ± 2.404
2.249LysPro: 2.249 ± 1.139
0.0LysGln: 0.0 ± 0.0
2.999LysArg: 2.999 ± 1.695
3.748LysSer: 3.748 ± 0.781
2.999LysThr: 2.999 ± 1.528
3.748LysVal: 3.748 ± 1.784
1.499LysTrp: 1.499 ± 0.973
0.75LysTyr: 0.75 ± 0.56
0.0LysXaa: 0.0 ± 0.0
Leu
2.999LeuAla: 2.999 ± 1.855
4.498LeuCys: 4.498 ± 1.131
2.249LeuAsp: 2.249 ± 0.929
2.999LeuGlu: 2.999 ± 1.362
2.249LeuPhe: 2.249 ± 1.239
1.499LeuGly: 1.499 ± 0.682
2.999LeuHis: 2.999 ± 1.109
1.499LeuIle: 1.499 ± 0.986
3.748LeuLys: 3.748 ± 1.131
5.997LeuLeu: 5.997 ± 1.383
0.75LeuMet: 0.75 ± 0.851
2.999LeuAsn: 2.999 ± 1.031
4.498LeuPro: 4.498 ± 1.329
3.748LeuGln: 3.748 ± 1.26
3.748LeuArg: 3.748 ± 1.438
1.499LeuSer: 1.499 ± 0.682
4.498LeuThr: 4.498 ± 1.22
1.499LeuVal: 1.499 ± 1.242
2.999LeuTrp: 2.999 ± 0.887
1.499LeuTyr: 1.499 ± 0.748
0.0LeuXaa: 0.0 ± 0.0
Met
0.75MetAla: 0.75 ± 0.621
0.0MetCys: 0.0 ± 0.0
4.498MetAsp: 4.498 ± 1.052
2.249MetGlu: 2.249 ± 1.003
0.0MetPhe: 0.0 ± 0.0
1.499MetGly: 1.499 ± 0.682
0.75MetHis: 0.75 ± 0.696
0.75MetIle: 0.75 ± 0.635
3.748MetLys: 3.748 ± 1.365
1.499MetLeu: 1.499 ± 0.986
2.249MetMet: 2.249 ± 1.673
0.0MetAsn: 0.0 ± 0.0
1.499MetPro: 1.499 ± 0.76
1.499MetGln: 1.499 ± 0.764
3.748MetArg: 3.748 ± 0.959
2.999MetSer: 2.999 ± 1.508
0.0MetThr: 0.0 ± 0.0
4.498MetVal: 4.498 ± 1.611
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
1.499AsnAla: 1.499 ± 1.27
1.499AsnCys: 1.499 ± 0.981
4.498AsnAsp: 4.498 ± 0.851
2.249AsnGlu: 2.249 ± 1.905
4.498AsnPhe: 4.498 ± 1.292
3.748AsnGly: 3.748 ± 1.13
0.0AsnHis: 0.0 ± 0.0
5.997AsnIle: 5.997 ± 1.433
2.249AsnLys: 2.249 ± 1.652
3.748AsnLeu: 3.748 ± 1.77
0.75AsnMet: 0.75 ± 0.609
1.499AsnAsn: 1.499 ± 1.27
2.249AsnPro: 2.249 ± 1.139
0.0AsnGln: 0.0 ± 0.0
4.498AsnArg: 4.498 ± 1.859
0.75AsnSer: 0.75 ± 0.635
0.0AsnThr: 0.0 ± 0.0
2.999AsnVal: 2.999 ± 1.339
0.0AsnTrp: 0.0 ± 0.0
1.499AsnTyr: 1.499 ± 1.12
0.0AsnXaa: 0.0 ± 0.0
Pro
5.997ProAla: 5.997 ± 1.062
0.75ProCys: 0.75 ± 0.621
5.247ProAsp: 5.247 ± 2.098
0.75ProGlu: 0.75 ± 0.56
1.499ProPhe: 1.499 ± 0.76
2.999ProGly: 2.999 ± 1.494
2.999ProHis: 2.999 ± 1.52
2.249ProIle: 2.249 ± 0.762
2.249ProLys: 2.249 ± 0.646
2.999ProLeu: 2.999 ± 0.741
2.249ProMet: 2.249 ± 0.805
2.249ProAsn: 2.249 ± 0.646
5.247ProPro: 5.247 ± 2.056
2.999ProGln: 2.999 ± 0.531
2.999ProArg: 2.999 ± 1.003
9.745ProSer: 9.745 ± 2.202
3.748ProThr: 3.748 ± 1.014
0.75ProVal: 0.75 ± 0.621
0.75ProTrp: 0.75 ± 0.635
2.249ProTyr: 2.249 ± 0.646
0.0ProXaa: 0.0 ± 0.0
Gln
0.75GlnAla: 0.75 ± 0.635
2.249GlnCys: 2.249 ± 0.805
0.75GlnAsp: 0.75 ± 0.621
0.0GlnGlu: 0.0 ± 0.0
1.499GlnPhe: 1.499 ± 0.76
0.0GlnGly: 0.0 ± 0.0
0.75GlnHis: 0.75 ± 0.621
2.999GlnIle: 2.999 ± 1.031
0.75GlnLys: 0.75 ± 0.56
0.75GlnLeu: 0.75 ± 0.621
2.249GlnMet: 2.249 ± 0.646
1.499GlnAsn: 1.499 ± 0.76
0.75GlnPro: 0.75 ± 1.084
0.0GlnGln: 0.0 ± 0.0
2.249GlnArg: 2.249 ± 0.805
2.999GlnSer: 2.999 ± 1.459
2.249GlnThr: 2.249 ± 0.805
2.249GlnVal: 2.249 ± 1.26
0.0GlnTrp: 0.0 ± 0.0
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
2.249ArgAla: 2.249 ± 1.346
0.75ArgCys: 0.75 ± 0.635
8.246ArgAsp: 8.246 ± 1.739
1.499ArgGlu: 1.499 ± 0.834
7.496ArgPhe: 7.496 ± 1.503
2.999ArgGly: 2.999 ± 1.574
2.249ArgHis: 2.249 ± 1.729
4.498ArgIle: 4.498 ± 1.653
2.999ArgLys: 2.999 ± 1.612
7.496ArgLeu: 7.496 ± 0.833
3.748ArgMet: 3.748 ± 1.056
1.499ArgAsn: 1.499 ± 0.76
5.247ArgPro: 5.247 ± 1.207
0.0ArgGln: 0.0 ± 0.0
11.244ArgArg: 11.244 ± 3.695
5.997ArgSer: 5.997 ± 1.482
1.499ArgThr: 1.499 ± 0.748
4.498ArgVal: 4.498 ± 1.955
1.499ArgTrp: 1.499 ± 0.76
2.249ArgTyr: 2.249 ± 0.929
0.0ArgXaa: 0.0 ± 0.0
Ser
4.498SerAla: 4.498 ± 1.427
0.75SerCys: 0.75 ± 0.851
2.999SerAsp: 2.999 ± 1.972
2.249SerGlu: 2.249 ± 1.191
3.748SerPhe: 3.748 ± 1.26
4.498SerGly: 4.498 ± 1.886
0.0SerHis: 0.0 ± 0.0
2.249SerIle: 2.249 ± 2.245
5.247SerLys: 5.247 ± 1.044
2.999SerLeu: 2.999 ± 1.325
2.999SerMet: 2.999 ± 1.031
3.748SerAsn: 3.748 ± 1.762
5.997SerPro: 5.997 ± 2.516
2.249SerGln: 2.249 ± 1.26
5.247SerArg: 5.247 ± 1.599
6.747SerSer: 6.747 ± 2.368
9.745SerThr: 9.745 ± 2.388
3.748SerVal: 3.748 ± 1.99
1.499SerTrp: 1.499 ± 1.27
4.498SerTyr: 4.498 ± 1.555
0.0SerXaa: 0.0 ± 0.0
Thr
2.249ThrAla: 2.249 ± 1.864
0.75ThrCys: 0.75 ± 0.56
2.249ThrAsp: 2.249 ± 0.805
2.999ThrGlu: 2.999 ± 1.52
3.748ThrPhe: 3.748 ± 1.438
1.499ThrGly: 1.499 ± 0.76
3.748ThrHis: 3.748 ± 0.959
4.498ThrIle: 4.498 ± 1.251
0.75ThrLys: 0.75 ± 0.621
2.249ThrLeu: 2.249 ± 0.711
0.75ThrMet: 0.75 ± 0.635
2.999ThrAsn: 2.999 ± 0.941
2.999ThrPro: 2.999 ± 1.157
0.75ThrGln: 0.75 ± 0.696
2.249ThrArg: 2.249 ± 1.239
5.247ThrSer: 5.247 ± 1.006
5.247ThrThr: 5.247 ± 1.973
4.498ThrVal: 4.498 ± 1.767
0.0ThrTrp: 0.0 ± 0.0
0.75ThrTyr: 0.75 ± 0.621
0.0ThrXaa: 0.0 ± 0.0
Val
2.249ValAla: 2.249 ± 1.26
2.999ValCys: 2.999 ± 1.003
4.498ValAsp: 4.498 ± 1.074
2.999ValGlu: 2.999 ± 2.54
2.249ValPhe: 2.249 ± 1.652
2.999ValGly: 2.999 ± 1.537
0.0ValHis: 0.0 ± 0.0
5.247ValIle: 5.247 ± 1.853
5.247ValLys: 5.247 ± 1.428
3.748ValLeu: 3.748 ± 1.13
2.249ValMet: 2.249 ± 1.239
0.75ValAsn: 0.75 ± 0.56
5.247ValPro: 5.247 ± 1.282
1.499ValGln: 1.499 ± 0.76
5.247ValArg: 5.247 ± 1.542
3.748ValSer: 3.748 ± 1.946
2.999ValThr: 2.999 ± 2.485
3.748ValVal: 3.748 ± 2.735
0.75ValTrp: 0.75 ± 0.621
1.499ValTyr: 1.499 ± 1.156
0.0ValXaa: 0.0 ± 0.0
Trp
4.498TrpAla: 4.498 ± 1.555
0.0TrpCys: 0.0 ± 0.0
0.75TrpAsp: 0.75 ± 0.696
1.499TrpGlu: 1.499 ± 0.682
0.75TrpPhe: 0.75 ± 0.56
0.75TrpGly: 0.75 ± 0.851
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.75TrpLys: 0.75 ± 0.851
0.75TrpLeu: 0.75 ± 0.621
0.75TrpMet: 0.75 ± 0.851
0.0TrpAsn: 0.0 ± 0.0
1.499TrpPro: 1.499 ± 0.76
0.75TrpGln: 0.75 ± 1.084
2.249TrpArg: 2.249 ± 1.139
0.75TrpSer: 0.75 ± 0.635
0.0TrpThr: 0.0 ± 0.0
0.75TrpVal: 0.75 ± 0.621
0.75TrpTrp: 0.75 ± 0.56
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.499TyrAla: 1.499 ± 0.981
0.75TyrCys: 0.75 ± 0.696
0.0TyrAsp: 0.0 ± 0.0
0.0TyrGlu: 0.0 ± 0.0
0.75TyrPhe: 0.75 ± 0.621
2.249TyrGly: 2.249 ± 1.728
0.75TyrHis: 0.75 ± 0.635
3.748TyrIle: 3.748 ± 2.072
1.499TyrLys: 1.499 ± 0.682
0.0TyrLeu: 0.0 ± 0.0
0.0TyrMet: 0.0 ± 0.0
1.499TyrAsn: 1.499 ± 1.12
1.499TyrPro: 1.499 ± 1.27
0.0TyrGln: 0.0 ± 0.0
3.748TyrArg: 3.748 ± 1.438
2.249TyrSer: 2.249 ± 1.074
3.748TyrThr: 3.748 ± 1.131
2.999TyrVal: 2.999 ± 1.386
0.0TyrTrp: 0.0 ± 0.0
2.249TyrTyr: 2.249 ± 1.405
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (1335 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski