Amino acid dipepetide frequency for Mycobacterium phage Bxz2 (Mycobacteriophage Bxz2)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.709AlaAla: 10.709 ± 1.087
0.714AlaCys: 0.714 ± 0.203
5.647AlaAsp: 5.647 ± 0.87
7.594AlaGlu: 7.594 ± 0.987
3.7AlaPhe: 3.7 ± 0.605
7.659AlaGly: 7.659 ± 0.924
1.947AlaHis: 1.947 ± 0.373
4.024AlaIle: 4.024 ± 0.525
4.868AlaLys: 4.868 ± 0.632
9.346AlaLeu: 9.346 ± 1.14
2.531AlaMet: 2.531 ± 0.437
3.57AlaAsn: 3.57 ± 0.602
4.349AlaPro: 4.349 ± 0.829
4.803AlaGln: 4.803 ± 0.524
6.75AlaArg: 6.75 ± 0.741
4.738AlaSer: 4.738 ± 0.574
5.712AlaThr: 5.712 ± 0.619
7.075AlaVal: 7.075 ± 0.713
2.077AlaTrp: 2.077 ± 0.392
2.337AlaTyr: 2.337 ± 0.498
0.0AlaXaa: 0.0 ± 0.0
Cys
0.584CysAla: 0.584 ± 0.177
0.0CysCys: 0.0 ± 0.0
0.649CysAsp: 0.649 ± 0.212
0.584CysGlu: 0.584 ± 0.181
0.26CysPhe: 0.26 ± 0.133
1.038CysGly: 1.038 ± 0.299
0.195CysHis: 0.195 ± 0.118
0.26CysIle: 0.26 ± 0.135
0.454CysLys: 0.454 ± 0.16
0.649CysLeu: 0.649 ± 0.224
0.195CysMet: 0.195 ± 0.122
0.519CysAsn: 0.519 ± 0.18
0.454CysPro: 0.454 ± 0.212
0.13CysGln: 0.13 ± 0.087
0.584CysArg: 0.584 ± 0.204
0.325CysSer: 0.325 ± 0.148
0.26CysThr: 0.26 ± 0.135
0.649CysVal: 0.649 ± 0.243
0.065CysTrp: 0.065 ± 0.059
0.26CysTyr: 0.26 ± 0.135
0.0CysXaa: 0.0 ± 0.0
Asp
6.296AspAla: 6.296 ± 0.802
0.844AspCys: 0.844 ± 0.205
4.089AspAsp: 4.089 ± 0.687
3.959AspGlu: 3.959 ± 0.555
2.142AspPhe: 2.142 ± 0.373
5.842AspGly: 5.842 ± 0.688
1.623AspHis: 1.623 ± 0.367
2.466AspIle: 2.466 ± 0.446
2.466AspLys: 2.466 ± 0.585
4.933AspLeu: 4.933 ± 0.53
1.233AspMet: 1.233 ± 0.33
2.012AspAsn: 2.012 ± 0.357
5.647AspPro: 5.647 ± 0.857
1.882AspGln: 1.882 ± 0.367
3.31AspArg: 3.31 ± 0.563
3.115AspSer: 3.115 ± 0.467
3.959AspThr: 3.959 ± 0.73
3.765AspVal: 3.765 ± 0.41
1.168AspTrp: 1.168 ± 0.262
2.856AspTyr: 2.856 ± 0.427
0.0AspXaa: 0.0 ± 0.0
Glu
7.789GluAla: 7.789 ± 0.884
0.389GluCys: 0.389 ± 0.195
4.414GluAsp: 4.414 ± 0.57
5.387GluGlu: 5.387 ± 0.789
2.142GluPhe: 2.142 ± 0.448
4.868GluGly: 4.868 ± 0.583
1.558GluHis: 1.558 ± 0.307
3.505GluIle: 3.505 ± 0.534
2.402GluLys: 2.402 ± 0.367
5.906GluLeu: 5.906 ± 0.634
1.623GluMet: 1.623 ± 0.342
2.077GluAsn: 2.077 ± 0.348
2.921GluPro: 2.921 ± 0.443
2.986GluGln: 2.986 ± 0.358
4.608GluArg: 4.608 ± 0.585
2.921GluSer: 2.921 ± 0.458
3.635GluThr: 3.635 ± 0.498
4.608GluVal: 4.608 ± 0.561
1.493GluTrp: 1.493 ± 0.319
2.142GluTyr: 2.142 ± 0.394
0.0GluXaa: 0.0 ± 0.0
Phe
3.894PheAla: 3.894 ± 0.61
0.26PheCys: 0.26 ± 0.12
2.856PheAsp: 2.856 ± 0.484
2.142PheGlu: 2.142 ± 0.416
0.779PhePhe: 0.779 ± 0.226
3.18PheGly: 3.18 ± 0.529
0.649PheHis: 0.649 ± 0.225
1.493PheIle: 1.493 ± 0.3
1.298PheLys: 1.298 ± 0.303
3.18PheLeu: 3.18 ± 0.513
0.714PheMet: 0.714 ± 0.188
1.233PheAsn: 1.233 ± 0.345
1.623PhePro: 1.623 ± 0.342
1.233PheGln: 1.233 ± 0.313
2.207PheArg: 2.207 ± 0.365
2.077PheSer: 2.077 ± 0.386
2.466PheThr: 2.466 ± 0.447
2.077PheVal: 2.077 ± 0.351
0.584PheTrp: 0.584 ± 0.202
0.714PheTyr: 0.714 ± 0.203
0.0PheXaa: 0.0 ± 0.0
Gly
7.724GlyAla: 7.724 ± 1.086
0.584GlyCys: 0.584 ± 0.225
6.88GlyAsp: 6.88 ± 1.239
4.868GlyGlu: 4.868 ± 0.529
3.375GlyPhe: 3.375 ± 0.581
6.815GlyGly: 6.815 ± 0.895
1.817GlyHis: 1.817 ± 0.342
4.024GlyIle: 4.024 ± 0.535
3.635GlyLys: 3.635 ± 0.498
7.205GlyLeu: 7.205 ± 0.762
2.207GlyMet: 2.207 ± 0.464
3.245GlyAsn: 3.245 ± 0.578
6.166GlyPro: 6.166 ± 2.487
3.051GlyGln: 3.051 ± 0.433
4.349GlyArg: 4.349 ± 0.487
4.219GlySer: 4.219 ± 0.741
5.712GlyThr: 5.712 ± 0.722
5.712GlyVal: 5.712 ± 0.699
2.142GlyTrp: 2.142 ± 0.399
2.661GlyTyr: 2.661 ± 0.505
0.0GlyXaa: 0.0 ± 0.0
His
1.688HisAla: 1.688 ± 0.379
0.389HisCys: 0.389 ± 0.174
1.168HisAsp: 1.168 ± 0.337
1.298HisGlu: 1.298 ± 0.371
0.584HisPhe: 0.584 ± 0.201
2.207HisGly: 2.207 ± 0.447
0.584HisHis: 0.584 ± 0.187
1.493HisIle: 1.493 ± 0.282
0.519HisLys: 0.519 ± 0.202
1.493HisLeu: 1.493 ± 0.373
0.26HisMet: 0.26 ± 0.122
0.714HisAsn: 0.714 ± 0.195
1.363HisPro: 1.363 ± 0.333
0.844HisGln: 0.844 ± 0.222
1.947HisArg: 1.947 ± 0.418
0.779HisSer: 0.779 ± 0.243
1.168HisThr: 1.168 ± 0.287
1.233HisVal: 1.233 ± 0.285
0.325HisTrp: 0.325 ± 0.161
0.714HisTyr: 0.714 ± 0.227
0.0HisXaa: 0.0 ± 0.0
Ile
5.322IleAla: 5.322 ± 0.672
0.389IleCys: 0.389 ± 0.17
3.765IleAsp: 3.765 ± 0.349
3.635IleGlu: 3.635 ± 0.59
1.363IlePhe: 1.363 ± 0.267
3.635IleGly: 3.635 ± 0.53
1.038IleHis: 1.038 ± 0.26
1.558IleIle: 1.558 ± 0.326
1.947IleLys: 1.947 ± 0.31
3.375IleLeu: 3.375 ± 0.397
0.584IleMet: 0.584 ± 0.222
1.298IleAsn: 1.298 ± 0.351
3.7IlePro: 3.7 ± 0.486
1.623IleGln: 1.623 ± 0.276
2.921IleArg: 2.921 ± 0.405
2.596IleSer: 2.596 ± 0.421
2.726IleThr: 2.726 ± 0.42
3.051IleVal: 3.051 ± 0.445
0.974IleTrp: 0.974 ± 0.221
1.233IleTyr: 1.233 ± 0.295
0.0IleXaa: 0.0 ± 0.0
Lys
4.543LysAla: 4.543 ± 0.704
0.13LysCys: 0.13 ± 0.103
2.337LysAsp: 2.337 ± 0.39
2.531LysGlu: 2.531 ± 0.4
1.298LysPhe: 1.298 ± 0.259
4.349LysGly: 4.349 ± 1.07
1.428LysHis: 1.428 ± 0.327
1.947LysIle: 1.947 ± 0.368
2.337LysLys: 2.337 ± 0.425
3.375LysLeu: 3.375 ± 0.502
0.649LysMet: 0.649 ± 0.176
0.779LysAsn: 0.779 ± 0.2
2.207LysPro: 2.207 ± 0.491
2.077LysGln: 2.077 ± 0.329
2.921LysArg: 2.921 ± 0.755
2.402LysSer: 2.402 ± 0.404
2.596LysThr: 2.596 ± 0.357
3.051LysVal: 3.051 ± 0.524
1.038LysTrp: 1.038 ± 0.274
0.779LysTyr: 0.779 ± 0.236
0.0LysXaa: 0.0 ± 0.0
Leu
8.697LeuAla: 8.697 ± 0.933
0.454LeuCys: 0.454 ± 0.157
4.998LeuAsp: 4.998 ± 0.686
5.777LeuGlu: 5.777 ± 0.803
2.531LeuPhe: 2.531 ± 0.364
6.815LeuGly: 6.815 ± 0.689
1.947LeuHis: 1.947 ± 0.455
4.284LeuIle: 4.284 ± 0.403
3.18LeuLys: 3.18 ± 0.448
6.491LeuLeu: 6.491 ± 0.686
2.207LeuMet: 2.207 ± 0.48
2.791LeuAsn: 2.791 ± 0.482
4.024LeuPro: 4.024 ± 0.488
2.207LeuGln: 2.207 ± 0.512
6.685LeuArg: 6.685 ± 0.658
4.154LeuSer: 4.154 ± 0.499
5.257LeuThr: 5.257 ± 0.574
5.517LeuVal: 5.517 ± 0.622
1.233LeuTrp: 1.233 ± 0.271
2.402LeuTyr: 2.402 ± 0.453
0.0LeuXaa: 0.0 ± 0.0
Met
2.791MetAla: 2.791 ± 0.479
0.0MetCys: 0.0 ± 0.0
1.688MetAsp: 1.688 ± 0.366
1.298MetGlu: 1.298 ± 0.308
0.779MetPhe: 0.779 ± 0.2
1.817MetGly: 1.817 ± 0.345
0.195MetHis: 0.195 ± 0.102
1.298MetIle: 1.298 ± 0.302
1.363MetLys: 1.363 ± 0.337
1.882MetLeu: 1.882 ± 0.261
0.584MetMet: 0.584 ± 0.233
0.909MetAsn: 0.909 ± 0.241
1.493MetPro: 1.493 ± 0.386
0.714MetGln: 0.714 ± 0.302
1.882MetArg: 1.882 ± 0.343
1.882MetSer: 1.882 ± 0.338
1.688MetThr: 1.688 ± 0.247
1.363MetVal: 1.363 ± 0.282
0.195MetTrp: 0.195 ± 0.115
0.454MetTyr: 0.454 ± 0.186
0.0MetXaa: 0.0 ± 0.0
Asn
3.894AsnAla: 3.894 ± 0.689
0.325AsnCys: 0.325 ± 0.139
1.752AsnAsp: 1.752 ± 0.333
1.882AsnGlu: 1.882 ± 0.304
1.298AsnPhe: 1.298 ± 0.373
3.245AsnGly: 3.245 ± 0.528
0.714AsnHis: 0.714 ± 0.203
1.493AsnIle: 1.493 ± 0.365
0.909AsnLys: 0.909 ± 0.249
2.531AsnLeu: 2.531 ± 0.485
0.974AsnMet: 0.974 ± 0.253
0.974AsnAsn: 0.974 ± 0.276
2.661AsnPro: 2.661 ± 0.457
0.844AsnGln: 0.844 ± 0.262
1.752AsnArg: 1.752 ± 0.346
2.077AsnSer: 2.077 ± 0.409
1.688AsnThr: 1.688 ± 0.391
2.986AsnVal: 2.986 ± 0.437
0.649AsnTrp: 0.649 ± 0.18
1.038AsnTyr: 1.038 ± 0.191
0.0AsnXaa: 0.0 ± 0.0
Pro
5.842ProAla: 5.842 ± 0.731
0.26ProCys: 0.26 ± 0.148
3.44ProAsp: 3.44 ± 0.511
4.543ProGlu: 4.543 ± 0.589
1.882ProPhe: 1.882 ± 0.379
4.284ProGly: 4.284 ± 0.562
0.909ProHis: 0.909 ± 0.21
2.402ProIle: 2.402 ± 0.358
2.661ProLys: 2.661 ± 0.787
3.894ProLeu: 3.894 ± 0.63
1.688ProMet: 1.688 ± 0.366
2.661ProAsn: 2.661 ± 0.531
2.142ProPro: 2.142 ± 0.428
2.856ProGln: 2.856 ± 0.998
3.051ProArg: 3.051 ± 0.544
2.531ProSer: 2.531 ± 0.381
4.284ProThr: 4.284 ± 0.774
3.44ProVal: 3.44 ± 0.479
0.974ProTrp: 0.974 ± 0.427
1.428ProTyr: 1.428 ± 0.307
0.0ProXaa: 0.0 ± 0.0
Gln
3.765GlnAla: 3.765 ± 0.495
0.13GlnCys: 0.13 ± 0.093
1.752GlnAsp: 1.752 ± 0.306
2.402GlnGlu: 2.402 ± 0.401
2.012GlnPhe: 2.012 ± 0.454
4.414GlnGly: 4.414 ± 1.586
0.649GlnHis: 0.649 ± 0.174
2.207GlnIle: 2.207 ± 0.379
1.363GlnLys: 1.363 ± 0.291
3.57GlnLeu: 3.57 ± 0.498
1.233GlnMet: 1.233 ± 0.45
0.649GlnAsn: 0.649 ± 0.227
2.012GlnPro: 2.012 ± 0.406
1.947GlnGln: 1.947 ± 0.496
3.051GlnArg: 3.051 ± 0.482
1.363GlnSer: 1.363 ± 0.337
2.272GlnThr: 2.272 ± 0.456
2.791GlnVal: 2.791 ± 0.421
0.649GlnTrp: 0.649 ± 0.226
0.714GlnTyr: 0.714 ± 0.231
0.0GlnXaa: 0.0 ± 0.0
Arg
6.101ArgAla: 6.101 ± 0.705
1.168ArgCys: 1.168 ± 0.336
3.7ArgAsp: 3.7 ± 0.538
4.933ArgGlu: 4.933 ± 0.617
2.466ArgPhe: 2.466 ± 0.388
5.063ArgGly: 5.063 ± 0.634
1.038ArgHis: 1.038 ± 0.272
3.44ArgIle: 3.44 ± 0.473
3.57ArgLys: 3.57 ± 0.625
5.063ArgLeu: 5.063 ± 0.564
2.272ArgMet: 2.272 ± 0.408
2.077ArgAsn: 2.077 ± 0.346
2.272ArgPro: 2.272 ± 0.353
2.661ArgGln: 2.661 ± 0.421
5.712ArgArg: 5.712 ± 0.758
3.765ArgSer: 3.765 ± 0.567
3.245ArgThr: 3.245 ± 0.483
5.063ArgVal: 5.063 ± 0.587
1.623ArgTrp: 1.623 ± 0.365
2.402ArgTyr: 2.402 ± 0.38
0.0ArgXaa: 0.0 ± 0.0
Ser
4.284SerAla: 4.284 ± 0.574
0.13SerCys: 0.13 ± 0.091
2.921SerAsp: 2.921 ± 0.415
3.18SerGlu: 3.18 ± 0.476
2.337SerPhe: 2.337 ± 0.411
5.842SerGly: 5.842 ± 0.74
1.038SerHis: 1.038 ± 0.265
2.402SerIle: 2.402 ± 0.35
2.402SerLys: 2.402 ± 0.473
4.673SerLeu: 4.673 ± 0.618
1.623SerMet: 1.623 ± 0.321
1.688SerAsn: 1.688 ± 0.344
2.791SerPro: 2.791 ± 0.436
2.466SerGln: 2.466 ± 0.494
4.154SerArg: 4.154 ± 0.555
1.752SerSer: 1.752 ± 0.295
2.272SerThr: 2.272 ± 0.407
2.726SerVal: 2.726 ± 0.487
1.298SerTrp: 1.298 ± 0.301
1.363SerTyr: 1.363 ± 0.255
0.0SerXaa: 0.0 ± 0.0
Thr
4.738ThrAla: 4.738 ± 0.616
0.454ThrCys: 0.454 ± 0.18
4.154ThrAsp: 4.154 ± 0.636
3.959ThrGlu: 3.959 ± 0.519
2.207ThrPhe: 2.207 ± 0.387
6.555ThrGly: 6.555 ± 1.326
0.974ThrHis: 0.974 ± 0.282
2.077ThrIle: 2.077 ± 0.398
2.402ThrLys: 2.402 ± 0.408
4.414ThrLeu: 4.414 ± 0.569
0.844ThrMet: 0.844 ± 0.221
1.882ThrAsn: 1.882 ± 0.328
3.894ThrPro: 3.894 ± 0.525
2.791ThrGln: 2.791 ± 0.434
3.635ThrArg: 3.635 ± 0.453
2.531ThrSer: 2.531 ± 0.377
3.245ThrThr: 3.245 ± 0.545
4.998ThrVal: 4.998 ± 0.72
1.298ThrTrp: 1.298 ± 0.362
2.207ThrTyr: 2.207 ± 0.4
0.0ThrXaa: 0.0 ± 0.0
Val
6.685ValAla: 6.685 ± 0.74
0.779ValCys: 0.779 ± 0.195
4.089ValAsp: 4.089 ± 0.589
3.829ValGlu: 3.829 ± 0.508
2.402ValPhe: 2.402 ± 0.535
4.868ValGly: 4.868 ± 0.562
1.493ValHis: 1.493 ± 0.36
3.829ValIle: 3.829 ± 0.527
3.7ValLys: 3.7 ± 0.483
5.712ValLeu: 5.712 ± 0.643
1.623ValMet: 1.623 ± 0.282
2.531ValAsn: 2.531 ± 0.423
3.44ValPro: 3.44 ± 0.538
2.142ValGln: 2.142 ± 0.361
4.478ValArg: 4.478 ± 0.533
5.257ValSer: 5.257 ± 0.721
3.959ValThr: 3.959 ± 0.47
4.998ValVal: 4.998 ± 0.612
1.038ValTrp: 1.038 ± 0.301
1.752ValTyr: 1.752 ± 0.373
0.0ValXaa: 0.0 ± 0.0
Trp
1.882TrpAla: 1.882 ± 0.391
0.389TrpCys: 0.389 ± 0.185
1.493TrpAsp: 1.493 ± 0.348
1.103TrpGlu: 1.103 ± 0.24
0.325TrpPhe: 0.325 ± 0.149
1.428TrpGly: 1.428 ± 0.387
0.389TrpHis: 0.389 ± 0.16
1.623TrpIle: 1.623 ± 0.378
0.454TrpLys: 0.454 ± 0.182
1.363TrpLeu: 1.363 ± 0.308
0.649TrpMet: 0.649 ± 0.228
1.038TrpAsn: 1.038 ± 0.297
0.844TrpPro: 0.844 ± 0.254
0.844TrpGln: 0.844 ± 0.238
1.038TrpArg: 1.038 ± 0.259
1.168TrpSer: 1.168 ± 0.306
1.428TrpThr: 1.428 ± 0.326
1.363TrpVal: 1.363 ± 0.268
0.584TrpTrp: 0.584 ± 0.21
0.519TrpTyr: 0.519 ± 0.181
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.921TyrAla: 2.921 ± 0.493
0.325TyrCys: 0.325 ± 0.147
1.817TyrAsp: 1.817 ± 0.37
2.466TyrGlu: 2.466 ± 0.47
0.779TyrPhe: 0.779 ± 0.212
2.466TyrGly: 2.466 ± 0.372
0.584TyrHis: 0.584 ± 0.198
0.974TyrIle: 0.974 ± 0.262
0.844TyrLys: 0.844 ± 0.29
2.596TyrLeu: 2.596 ± 0.355
0.519TyrMet: 0.519 ± 0.183
1.038TyrAsn: 1.038 ± 0.282
1.168TyrPro: 1.168 ± 0.249
0.844TyrGln: 0.844 ± 0.204
2.596TyrArg: 2.596 ± 0.5
1.688TyrSer: 1.688 ± 0.38
1.688TyrThr: 1.688 ± 0.342
2.142TyrVal: 2.142 ± 0.423
0.519TyrTrp: 0.519 ± 0.211
0.974TyrTyr: 0.974 ± 0.31
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 86 proteins (15408 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski