Amino acid dipepetide frequency for Arthrobacter crystallopoietes BAB-32

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.38AlaAla: 21.38 ± 0.215	0.82AlaCys: 0.82 ± 0.031	7.44AlaAsp: 7.44 ± 0.095	9.003AlaGlu: 9.003 ± 0.094	3.639AlaPhe: 3.639 ± 0.054	13.718AlaGly: 13.718 ± 0.126	2.205AlaHis: 2.205 ± 0.045	4.78AlaIle: 4.78 ± 0.078	3.582AlaLys: 3.582 ± 0.059	12.823AlaLeu: 12.823 ± 0.127	2.876AlaMet: 2.876 ± 0.046	2.82AlaAsn: 2.82 ± 0.05	5.961AlaPro: 5.961 ± 0.098	3.96AlaGln: 3.96 ± 0.052	8.074AlaArg: 8.074 ± 0.1	6.651AlaSer: 6.651 ± 0.07	6.372AlaThr: 6.372 ± 0.083	11.451AlaVal: 11.451 ± 0.119	1.664AlaTrp: 1.664 ± 0.038	2.419AlaTyr: 2.419 ± 0.044	0.001AlaXaa: 0.001 ± 0.001
Cys	0.698CysAla: 0.698 ± 0.023	0.059CysCys: 0.059 ± 0.007	0.35CysAsp: 0.35 ± 0.018	0.349CysGlu: 0.349 ± 0.018	0.219CysPhe: 0.219 ± 0.014	0.755CysGly: 0.755 ± 0.027	0.159CysHis: 0.159 ± 0.013	0.259CysIle: 0.259 ± 0.015	0.116CysLys: 0.116 ± 0.009	0.587CysLeu: 0.587 ± 0.023	0.095CysMet: 0.095 ± 0.008	0.132CysAsn: 0.132 ± 0.011	0.339CysPro: 0.339 ± 0.019	0.162CysGln: 0.162 ± 0.011	0.498CysArg: 0.498 ± 0.022	0.427CysSer: 0.427 ± 0.02	0.436CysThr: 0.436 ± 0.017	0.449CysVal: 0.449 ± 0.021	0.111CysTrp: 0.111 ± 0.01	0.139CysTyr: 0.139 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	6.934AspAla: 6.934 ± 0.085	0.33AspCys: 0.33 ± 0.018	3.01AspAsp: 3.01 ± 0.063	3.901AspGlu: 3.901 ± 0.059	1.92AspPhe: 1.92 ± 0.043	5.735AspGly: 5.735 ± 0.076	1.164AspHis: 1.164 ± 0.031	2.35AspIle: 2.35 ± 0.045	1.398AspLys: 1.398 ± 0.038	5.844AspLeu: 5.844 ± 0.07	0.943AspMet: 0.943 ± 0.028	1.16AspAsn: 1.16 ± 0.037	3.898AspPro: 3.898 ± 0.066	1.749AspGln: 1.749 ± 0.039	3.841AspArg: 3.841 ± 0.055	2.821AspSer: 2.821 ± 0.051	2.63AspThr: 2.63 ± 0.044	4.745AspVal: 4.745 ± 0.072	0.895AspTrp: 0.895 ± 0.03	1.356AspTyr: 1.356 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	8.147GluAla: 8.147 ± 0.101	0.336GluCys: 0.336 ± 0.016	3.546GluAsp: 3.546 ± 0.064	4.073GluGlu: 4.073 ± 0.078	1.859GluPhe: 1.859 ± 0.038	4.429GluGly: 4.429 ± 0.058	1.617GluHis: 1.617 ± 0.04	2.716GluIle: 2.716 ± 0.042	1.69GluLys: 1.69 ± 0.039	7.421GluLeu: 7.421 ± 0.09	1.043GluMet: 1.043 ± 0.03	1.487GluAsn: 1.487 ± 0.037	3.504GluPro: 3.504 ± 0.058	2.794GluGln: 2.794 ± 0.048	4.608GluArg: 4.608 ± 0.065	2.904GluSer: 2.904 ± 0.054	3.207GluThr: 3.207 ± 0.063	4.527GluVal: 4.527 ± 0.07	0.816GluTrp: 0.816 ± 0.026	1.313GluTyr: 1.313 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.972PheAla: 3.972 ± 0.068	0.251PheCys: 0.251 ± 0.016	2.204PheAsp: 2.204 ± 0.038	1.831PheGlu: 1.831 ± 0.041	1.109PhePhe: 1.109 ± 0.039	3.434PheGly: 3.434 ± 0.05	0.644PheHis: 0.644 ± 0.023	1.354PheIle: 1.354 ± 0.044	0.733PheLys: 0.733 ± 0.028	2.894PheLeu: 2.894 ± 0.053	0.565PheMet: 0.565 ± 0.023	0.855PheAsn: 0.855 ± 0.027	1.428PhePro: 1.428 ± 0.038	0.795PheGln: 0.795 ± 0.021	1.871PheArg: 1.871 ± 0.04	1.955PheSer: 1.955 ± 0.041	2.067PheThr: 2.067 ± 0.04	2.394PheVal: 2.394 ± 0.041	0.476PheTrp: 0.476 ± 0.023	0.72PheTyr: 0.72 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	9.939GlyAla: 9.939 ± 0.102	0.67GlyCys: 0.67 ± 0.023	4.211GlyAsp: 4.211 ± 0.07	5.039GlyGlu: 5.039 ± 0.065	3.221GlyPhe: 3.221 ± 0.053	7.875GlyGly: 7.875 ± 0.099	1.988GlyHis: 1.988 ± 0.047	4.63GlyIle: 4.63 ± 0.061	2.912GlyLys: 2.912 ± 0.053	9.493GlyLeu: 9.493 ± 0.099	2.161GlyMet: 2.161 ± 0.044	2.278GlyAsn: 2.278 ± 0.047	4.21GlyPro: 4.21 ± 0.061	3.279GlyGln: 3.279 ± 0.052	6.336GlyArg: 6.336 ± 0.073	5.797GlySer: 5.797 ± 0.064	5.99GlyThr: 5.99 ± 0.078	6.782GlyVal: 6.782 ± 0.083	1.7GlyTrp: 1.7 ± 0.044	2.364GlyTyr: 2.364 ± 0.046	0.001GlyXaa: 0.001 ± 0.001
His	2.331HisAla: 2.331 ± 0.046	0.172HisCys: 0.172 ± 0.013	1.103HisAsp: 1.103 ± 0.033	1.239HisGlu: 1.239 ± 0.03	0.702HisPhe: 0.702 ± 0.026	2.074HisGly: 2.074 ± 0.041	0.609HisHis: 0.609 ± 0.026	0.813HisIle: 0.813 ± 0.028	0.427HisLys: 0.427 ± 0.019	2.04HisLeu: 2.04 ± 0.041	0.358HisMet: 0.358 ± 0.016	0.45HisAsn: 0.45 ± 0.018	1.476HisPro: 1.476 ± 0.033	0.688HisGln: 0.688 ± 0.022	1.629HisArg: 1.629 ± 0.039	1.109HisSer: 1.109 ± 0.028	1.077HisThr: 1.077 ± 0.03	1.556HisVal: 1.556 ± 0.033	0.318HisTrp: 0.318 ± 0.017	0.513HisTyr: 0.513 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	5.688IleAla: 5.688 ± 0.081	0.332IleCys: 0.332 ± 0.017	2.772IleAsp: 2.772 ± 0.05	2.656IleGlu: 2.656 ± 0.061	1.348IlePhe: 1.348 ± 0.037	4.32IleGly: 4.32 ± 0.077	0.823IleHis: 0.823 ± 0.027	1.869IleIle: 1.869 ± 0.045	1.037IleLys: 1.037 ± 0.026	3.669IleLeu: 3.669 ± 0.066	0.778IleMet: 0.778 ± 0.031	1.271IleAsn: 1.271 ± 0.038	2.311IlePro: 2.311 ± 0.047	1.086IleGln: 1.086 ± 0.032	2.678IleArg: 2.678 ± 0.05	2.523IleSer: 2.523 ± 0.039	2.589IleThr: 2.589 ± 0.049	3.616IleVal: 3.616 ± 0.061	0.506IleTrp: 0.506 ± 0.022	0.841IleTyr: 0.841 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	3.46LysAla: 3.46 ± 0.048	0.098LysCys: 0.098 ± 0.009	1.602LysAsp: 1.602 ± 0.043	1.492LysGlu: 1.492 ± 0.037	0.736LysPhe: 0.736 ± 0.026	1.89LysGly: 1.89 ± 0.041	0.563LysHis: 0.563 ± 0.024	1.234LysIle: 1.234 ± 0.033	0.879LysLys: 0.879 ± 0.032	2.622LysLeu: 2.622 ± 0.049	0.572LysMet: 0.572 ± 0.025	0.693LysAsn: 0.693 ± 0.025	1.617LysPro: 1.617 ± 0.039	0.908LysGln: 0.908 ± 0.029	1.74LysArg: 1.74 ± 0.037	1.394LysSer: 1.394 ± 0.033	1.535LysThr: 1.535 ± 0.038	2.334LysVal: 2.334 ± 0.043	0.295LysTrp: 0.295 ± 0.016	0.645LysTyr: 0.645 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	15.271LeuAla: 15.271 ± 0.139	0.632LeuCys: 0.632 ± 0.026	6.301LeuAsp: 6.301 ± 0.079	6.218LeuGlu: 6.218 ± 0.085	2.886LeuPhe: 2.886 ± 0.053	9.125LeuGly: 9.125 ± 0.089	2.067LeuHis: 2.067 ± 0.038	4.1LeuIle: 4.1 ± 0.066	2.686LeuLys: 2.686 ± 0.054	10.931LeuLeu: 10.931 ± 0.123	1.941LeuMet: 1.941 ± 0.044	2.36LeuAsn: 2.36 ± 0.038	5.974LeuPro: 5.974 ± 0.068	3.26LeuGln: 3.26 ± 0.056	6.947LeuArg: 6.947 ± 0.088	5.631LeuSer: 5.631 ± 0.075	5.6LeuThr: 5.6 ± 0.058	8.492LeuVal: 8.492 ± 0.094	1.255LeuTrp: 1.255 ± 0.032	1.744LeuTyr: 1.744 ± 0.043	0.001LeuXaa: 0.001 ± 0.0
Met	2.733MetAla: 2.733 ± 0.049	0.118MetCys: 0.118 ± 0.009	1.064MetAsp: 1.064 ± 0.027	1.046MetGlu: 1.046 ± 0.029	0.58MetPhe: 0.58 ± 0.024	1.588MetGly: 1.588 ± 0.038	0.36MetHis: 0.36 ± 0.018	0.835MetIle: 0.835 ± 0.03	0.594MetLys: 0.594 ± 0.027	2.105MetLeu: 2.105 ± 0.041	0.411MetMet: 0.411 ± 0.019	0.578MetAsn: 0.578 ± 0.021	1.168MetPro: 1.168 ± 0.028	0.624MetGln: 0.624 ± 0.023	1.233MetArg: 1.233 ± 0.03	1.441MetSer: 1.441 ± 0.034	1.548MetThr: 1.548 ± 0.04	1.636MetVal: 1.636 ± 0.04	0.202MetTrp: 0.202 ± 0.013	0.321MetTyr: 0.321 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.74AsnAla: 2.74 ± 0.049	0.179AsnCys: 0.179 ± 0.012	1.371AsnAsp: 1.371 ± 0.037	1.238AsnGlu: 1.238 ± 0.034	0.788AsnPhe: 0.788 ± 0.027	2.245AsnGly: 2.245 ± 0.044	0.516AsnHis: 0.516 ± 0.017	1.095AsnIle: 1.095 ± 0.03	0.624AsnLys: 0.624 ± 0.024	2.348AsnLeu: 2.348 ± 0.051	0.474AsnMet: 0.474 ± 0.019	0.669AsnAsn: 0.669 ± 0.025	1.772AsnPro: 1.772 ± 0.036	0.808AsnGln: 0.808 ± 0.027	1.621AsnArg: 1.621 ± 0.033	1.217AsnSer: 1.217 ± 0.034	1.286AsnThr: 1.286 ± 0.033	1.893AsnVal: 1.893 ± 0.037	0.392AsnTrp: 0.392 ± 0.018	0.564AsnTyr: 0.564 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	8.299ProAla: 8.299 ± 0.106	0.212ProCys: 0.212 ± 0.013	3.818ProAsp: 3.818 ± 0.057	4.71ProGlu: 4.71 ± 0.058	1.623ProPhe: 1.623 ± 0.035	5.512ProGly: 5.512 ± 0.071	1.079ProHis: 1.079 ± 0.033	1.68ProIle: 1.68 ± 0.034	1.356ProLys: 1.356 ± 0.035	4.995ProLeu: 4.995 ± 0.067	1.039ProMet: 1.039 ± 0.032	1.1ProAsn: 1.1 ± 0.03	2.372ProPro: 2.372 ± 0.057	1.864ProGln: 1.864 ± 0.046	2.877ProArg: 2.877 ± 0.051	2.909ProSer: 2.909 ± 0.05	2.566ProThr: 2.566 ± 0.048	4.831ProVal: 4.831 ± 0.06	0.765ProTrp: 0.765 ± 0.024	1.102ProTyr: 1.102 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	4.347GlnAla: 4.347 ± 0.062	0.176GlnCys: 0.176 ± 0.014	1.871GlnAsp: 1.871 ± 0.044	2.002GlnGlu: 2.002 ± 0.04	0.881GlnPhe: 0.881 ± 0.027	2.295GlnGly: 2.295 ± 0.046	0.724GlnHis: 0.724 ± 0.025	1.444GlnIle: 1.444 ± 0.035	0.757GlnLys: 0.757 ± 0.022	4.109GlnLeu: 4.109 ± 0.056	0.605GlnMet: 0.605 ± 0.023	0.756GlnAsn: 0.756 ± 0.027	1.98GlnPro: 1.98 ± 0.045	1.602GlnGln: 1.602 ± 0.042	2.589GlnArg: 2.589 ± 0.049	1.603GlnSer: 1.603 ± 0.035	1.551GlnThr: 1.551 ± 0.035	2.645GlnVal: 2.645 ± 0.049	0.553GlnTrp: 0.553 ± 0.025	0.668GlnTyr: 0.668 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	7.019ArgAla: 7.019 ± 0.077	0.411ArgCys: 0.411 ± 0.018	3.485ArgAsp: 3.485 ± 0.059	4.18ArgGlu: 4.18 ± 0.063	2.274ArgPhe: 2.274 ± 0.043	4.846ArgGly: 4.846 ± 0.065	1.593ArgHis: 1.593 ± 0.038	3.584ArgIle: 3.584 ± 0.063	2.014ArgLys: 2.014 ± 0.045	7.363ArgLeu: 7.363 ± 0.094	1.61ArgMet: 1.61 ± 0.034	1.751ArgAsn: 1.751 ± 0.036	3.729ArgPro: 3.729 ± 0.054	2.633ArgGln: 2.633 ± 0.051	6.064ArgArg: 6.064 ± 0.11	3.921ArgSer: 3.921 ± 0.052	4.151ArgThr: 4.151 ± 0.063	4.524ArgVal: 4.524 ± 0.06	1.056ArgTrp: 1.056 ± 0.027	1.544ArgTyr: 1.544 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	6.998SerAla: 6.998 ± 0.082	0.366SerCys: 0.366 ± 0.019	2.675SerAsp: 2.675 ± 0.05	2.913SerGlu: 2.913 ± 0.052	1.912SerPhe: 1.912 ± 0.043	5.927SerGly: 5.927 ± 0.07	1.051SerHis: 1.051 ± 0.029	2.46SerIle: 2.46 ± 0.045	1.415SerLys: 1.415 ± 0.038	5.518SerLeu: 5.518 ± 0.068	1.363SerMet: 1.363 ± 0.034	1.257SerAsn: 1.257 ± 0.033	3.018SerPro: 3.018 ± 0.053	1.626SerGln: 1.626 ± 0.04	3.752SerArg: 3.752 ± 0.064	3.441SerSer: 3.441 ± 0.054	3.194SerThr: 3.194 ± 0.047	4.384SerVal: 4.384 ± 0.064	0.89SerTrp: 0.89 ± 0.03	1.363SerTyr: 1.363 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	7.783ThrAla: 7.783 ± 0.089	0.324ThrCys: 0.324 ± 0.016	2.98ThrAsp: 2.98 ± 0.054	3.236ThrGlu: 3.236 ± 0.052	1.76ThrPhe: 1.76 ± 0.039	5.903ThrGly: 5.903 ± 0.067	1.078ThrHis: 1.078 ± 0.026	2.392ThrIle: 2.392 ± 0.049	1.299ThrLys: 1.299 ± 0.038	5.217ThrLeu: 5.217 ± 0.068	1.059ThrMet: 1.059 ± 0.032	1.272ThrAsn: 1.272 ± 0.031	3.28ThrPro: 3.28 ± 0.051	1.439ThrGln: 1.439 ± 0.041	3.095ThrArg: 3.095 ± 0.057	3.019ThrSer: 3.019 ± 0.048	3.211ThrThr: 3.211 ± 0.061	5.343ThrVal: 5.343 ± 0.07	0.72ThrTrp: 0.72 ± 0.024	1.205ThrTyr: 1.205 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	10.059ValAla: 10.059 ± 0.095	0.553ValCys: 0.553 ± 0.019	4.806ValAsp: 4.806 ± 0.065	4.995ValGlu: 4.995 ± 0.072	2.731ValPhe: 2.731 ± 0.049	6.162ValGly: 6.162 ± 0.09	1.711ValHis: 1.711 ± 0.039	3.692ValIle: 3.692 ± 0.061	1.905ValLys: 1.905 ± 0.046	9.269ValLeu: 9.269 ± 0.096	1.666ValMet: 1.666 ± 0.039	1.968ValAsn: 1.968 ± 0.039	4.773ValPro: 4.773 ± 0.07	2.512ValGln: 2.512 ± 0.049	5.513ValArg: 5.513 ± 0.066	4.698ValSer: 4.698 ± 0.06	4.57ValThr: 4.57 ± 0.07	7.485ValVal: 7.485 ± 0.091	1.03ValTrp: 1.03 ± 0.031	1.495ValTyr: 1.495 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.476TrpAla: 1.476 ± 0.038	0.111TrpCys: 0.111 ± 0.01	0.716TrpAsp: 0.716 ± 0.026	0.687TrpGlu: 0.687 ± 0.026	0.557TrpPhe: 0.557 ± 0.027	0.966TrpGly: 0.966 ± 0.03	0.365TrpHis: 0.365 ± 0.017	0.697TrpIle: 0.697 ± 0.026	0.414TrpLys: 0.414 ± 0.021	1.858TrpLeu: 1.858 ± 0.042	0.326TrpMet: 0.326 ± 0.018	0.459TrpAsn: 0.459 ± 0.022	0.723TrpPro: 0.723 ± 0.025	0.661TrpGln: 0.661 ± 0.026	1.035TrpArg: 1.035 ± 0.031	0.801TrpSer: 0.801 ± 0.024	0.869TrpThr: 0.869 ± 0.025	0.99TrpVal: 0.99 ± 0.03	0.312TrpTrp: 0.312 ± 0.017	0.291TrpTyr: 0.291 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.365TyrAla: 2.365 ± 0.041	0.187TyrCys: 0.187 ± 0.013	1.3TyrAsp: 1.3 ± 0.03	1.227TyrGlu: 1.227 ± 0.033	0.804TyrPhe: 0.804 ± 0.024	2.076TyrGly: 2.076 ± 0.041	0.367TyrHis: 0.367 ± 0.017	0.729TyrIle: 0.729 ± 0.025	0.468TyrLys: 0.468 ± 0.02	2.316TyrLeu: 2.316 ± 0.043	0.302TyrMet: 0.302 ± 0.017	0.524TyrAsn: 0.524 ± 0.023	1.18TyrPro: 1.18 ± 0.032	0.707TyrGln: 0.707 ± 0.022	1.753TyrArg: 1.753 ± 0.045	1.259TyrSer: 1.259 ± 0.029	1.166TyrThr: 1.166 ± 0.03	1.515TyrVal: 1.515 ± 0.039	0.359TyrTrp: 0.359 ± 0.017	0.504TyrTyr: 0.504 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.001XaaTrp: 0.001 ± 0.001	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4118 proteins (1230685 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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