Amino acid dipepetide frequency for Legionella waltersii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.408AlaAla: 5.408 ± 0.11	1.026AlaCys: 1.026 ± 0.036	3.118AlaAsp: 3.118 ± 0.062	4.062AlaGlu: 4.062 ± 0.074	3.064AlaPhe: 3.064 ± 0.056	4.477AlaGly: 4.477 ± 0.093	1.638AlaHis: 1.638 ± 0.042	5.777AlaIle: 5.777 ± 0.079	4.754AlaLys: 4.754 ± 0.078	8.644AlaLeu: 8.644 ± 0.11	2.008AlaMet: 2.008 ± 0.052	3.411AlaAsn: 3.411 ± 0.059	2.358AlaPro: 2.358 ± 0.055	3.136AlaGln: 3.136 ± 0.059	3.059AlaArg: 3.059 ± 0.061	4.735AlaSer: 4.735 ± 0.071	3.677AlaThr: 3.677 ± 0.062	4.605AlaVal: 4.605 ± 0.075	0.772AlaTrp: 0.772 ± 0.03	2.468AlaTyr: 2.468 ± 0.045	0.003AlaXaa: 0.003 ± 0.002
Cys	0.734CysAla: 0.734 ± 0.03	0.211CysCys: 0.211 ± 0.018	0.578CysAsp: 0.578 ± 0.027	0.605CysGlu: 0.605 ± 0.027	0.621CysPhe: 0.621 ± 0.026	0.907CysGly: 0.907 ± 0.038	0.344CysHis: 0.344 ± 0.018	0.848CysIle: 0.848 ± 0.028	0.644CysLys: 0.644 ± 0.027	1.35CysLeu: 1.35 ± 0.037	0.268CysMet: 0.268 ± 0.015	0.511CysAsn: 0.511 ± 0.024	0.495CysPro: 0.495 ± 0.019	0.453CysGln: 0.453 ± 0.021	0.445CysArg: 0.445 ± 0.02	0.876CysSer: 0.876 ± 0.031	0.544CysThr: 0.544 ± 0.023	0.681CysVal: 0.681 ± 0.025	0.118CysTrp: 0.118 ± 0.01	0.459CysTyr: 0.459 ± 0.023	0.002CysXaa: 0.002 ± 0.001
Asp	3.476AspAla: 3.476 ± 0.068	0.616AspCys: 0.616 ± 0.021	2.396AspAsp: 2.396 ± 0.055	3.474AspGlu: 3.474 ± 0.061	2.375AspPhe: 2.375 ± 0.051	2.649AspGly: 2.649 ± 0.053	1.045AspHis: 1.045 ± 0.031	3.482AspIle: 3.482 ± 0.063	3.567AspLys: 3.567 ± 0.065	5.229AspLeu: 5.229 ± 0.079	1.147AspMet: 1.147 ± 0.032	2.335AspAsn: 2.335 ± 0.048	2.029AspPro: 2.029 ± 0.047	1.905AspGln: 1.905 ± 0.046	1.961AspArg: 1.961 ± 0.04	3.166AspSer: 3.166 ± 0.063	2.315AspThr: 2.315 ± 0.052	3.062AspVal: 3.062 ± 0.057	0.719AspTrp: 0.719 ± 0.025	2.051AspTyr: 2.051 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	4.16GluAla: 4.16 ± 0.061	0.548GluCys: 0.548 ± 0.023	2.587GluAsp: 2.587 ± 0.062	4.153GluGlu: 4.153 ± 0.08	2.624GluPhe: 2.624 ± 0.051	3.071GluGly: 3.071 ± 0.06	1.674GluHis: 1.674 ± 0.041	4.306GluIle: 4.306 ± 0.063	4.461GluLys: 4.461 ± 0.08	7.104GluLeu: 7.104 ± 0.091	1.541GluMet: 1.541 ± 0.041	2.881GluAsn: 2.881 ± 0.053	1.912GluPro: 1.912 ± 0.05	3.483GluGln: 3.483 ± 0.084	2.799GluArg: 2.799 ± 0.052	3.868GluSer: 3.868 ± 0.064	2.904GluThr: 2.904 ± 0.049	3.626GluVal: 3.626 ± 0.064	0.657GluTrp: 0.657 ± 0.026	1.94GluTyr: 1.94 ± 0.045	0.001GluXaa: 0.001 ± 0.001
Phe	3.242PheAla: 3.242 ± 0.058	0.644PheCys: 0.644 ± 0.028	2.361PheAsp: 2.361 ± 0.046	2.319PheGlu: 2.319 ± 0.049	2.23PhePhe: 2.23 ± 0.049	2.698PheGly: 2.698 ± 0.065	0.958PheHis: 0.958 ± 0.031	3.63PheIle: 3.63 ± 0.071	2.728PheLys: 2.728 ± 0.049	4.355PheLeu: 4.355 ± 0.075	1.023PheMet: 1.023 ± 0.034	2.5PheAsn: 2.5 ± 0.051	1.671PhePro: 1.671 ± 0.043	1.492PheGln: 1.492 ± 0.035	1.501PheArg: 1.501 ± 0.041	3.583PheSer: 3.583 ± 0.062	2.323PheThr: 2.323 ± 0.049	2.621PheVal: 2.621 ± 0.05	0.558PheTrp: 0.558 ± 0.023	1.685PheTyr: 1.685 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	4.099GlyAla: 4.099 ± 0.088	0.821GlyCys: 0.821 ± 0.031	2.817GlyAsp: 2.817 ± 0.053	3.096GlyGlu: 3.096 ± 0.062	3.261GlyPhe: 3.261 ± 0.059	3.899GlyGly: 3.899 ± 0.078	1.592GlyHis: 1.592 ± 0.039	4.739GlyIle: 4.739 ± 0.078	3.916GlyLys: 3.916 ± 0.067	6.659GlyLeu: 6.659 ± 0.089	1.669GlyMet: 1.669 ± 0.048	2.635GlyAsn: 2.635 ± 0.057	1.648GlyPro: 1.648 ± 0.048	2.454GlyGln: 2.454 ± 0.05	2.425GlyArg: 2.425 ± 0.058	3.72GlySer: 3.72 ± 0.074	2.96GlyThr: 2.96 ± 0.059	4.318GlyVal: 4.318 ± 0.085	0.79GlyTrp: 0.79 ± 0.026	2.461GlyTyr: 2.461 ± 0.055	0.005GlyXaa: 0.005 ± 0.002
His	1.699HisAla: 1.699 ± 0.035	0.392HisCys: 0.392 ± 0.021	1.164HisAsp: 1.164 ± 0.034	1.437HisGlu: 1.437 ± 0.045	1.313HisPhe: 1.313 ± 0.034	1.515HisGly: 1.515 ± 0.039	0.834HisHis: 0.834 ± 0.031	1.426HisIle: 1.426 ± 0.04	1.21HisLys: 1.21 ± 0.029	2.823HisLeu: 2.823 ± 0.048	0.529HisMet: 0.529 ± 0.021	0.931HisAsn: 0.931 ± 0.03	1.22HisPro: 1.22 ± 0.036	1.354HisGln: 1.354 ± 0.037	1.115HisArg: 1.115 ± 0.036	1.622HisSer: 1.622 ± 0.04	1.143HisThr: 1.143 ± 0.036	1.349HisVal: 1.349 ± 0.039	0.358HisTrp: 0.358 ± 0.02	1.128HisTyr: 1.128 ± 0.034	0.001HisXaa: 0.001 ± 0.001
Ile	6.092IleAla: 6.092 ± 0.076	0.807IleCys: 0.807 ± 0.027	4.29IleAsp: 4.29 ± 0.063	4.915IleGlu: 4.915 ± 0.071	2.458IlePhe: 2.458 ± 0.058	4.572IleGly: 4.572 ± 0.086	1.866IleHis: 1.866 ± 0.044	4.943IleIle: 4.943 ± 0.072	4.861IleLys: 4.861 ± 0.07	6.56IleLeu: 6.56 ± 0.09	1.412IleMet: 1.412 ± 0.035	4.157IleAsn: 4.157 ± 0.066	3.436IlePro: 3.436 ± 0.064	3.198IleGln: 3.198 ± 0.057	2.944IleArg: 2.944 ± 0.05	5.297IleSer: 5.297 ± 0.08	4.021IleThr: 4.021 ± 0.057	4.062IleVal: 4.062 ± 0.065	0.61IleTrp: 0.61 ± 0.03	2.176IleTyr: 2.176 ± 0.051	0.001IleXaa: 0.001 ± 0.001
Lys	4.742LysAla: 4.742 ± 0.088	0.457LysCys: 0.457 ± 0.021	3.241LysAsp: 3.241 ± 0.068	4.862LysGlu: 4.862 ± 0.085	1.729LysPhe: 1.729 ± 0.04	3.524LysGly: 3.524 ± 0.057	1.55LysHis: 1.55 ± 0.043	4.462LysIle: 4.462 ± 0.063	4.751LysLys: 4.751 ± 0.08	6.287LysLeu: 6.287 ± 0.083	1.597LysMet: 1.597 ± 0.045	3.475LysAsn: 3.475 ± 0.063	3.06LysPro: 3.06 ± 0.052	3.602LysGln: 3.602 ± 0.065	3.006LysArg: 3.006 ± 0.06	4.398LysSer: 4.398 ± 0.072	3.753LysThr: 3.753 ± 0.066	3.542LysVal: 3.542 ± 0.064	0.618LysTrp: 0.618 ± 0.025	1.814LysTyr: 1.814 ± 0.044	0.001LysXaa: 0.001 ± 0.001
Leu	8.308LeuAla: 8.308 ± 0.107	1.369LeuCys: 1.369 ± 0.038	5.228LeuAsp: 5.228 ± 0.073	5.905LeuGlu: 5.905 ± 0.091	5.156LeuPhe: 5.156 ± 0.082	6.561LeuGly: 6.561 ± 0.1	2.362LeuHis: 2.362 ± 0.05	7.965LeuIle: 7.965 ± 0.106	7.086LeuLys: 7.086 ± 0.095	11.634LeuLeu: 11.634 ± 0.129	2.748LeuMet: 2.748 ± 0.054	5.808LeuAsn: 5.808 ± 0.08	4.642LeuPro: 4.642 ± 0.069	4.425LeuGln: 4.425 ± 0.072	4.279LeuArg: 4.279 ± 0.07	8.626LeuSer: 8.626 ± 0.111	5.884LeuThr: 5.884 ± 0.079	6.511LeuVal: 6.511 ± 0.076	1.054LeuTrp: 1.054 ± 0.036	3.215LeuTyr: 3.215 ± 0.056	0.001LeuXaa: 0.001 ± 0.001
Met	1.894MetAla: 1.894 ± 0.044	0.197MetCys: 0.197 ± 0.013	1.314MetAsp: 1.314 ± 0.037	1.252MetGlu: 1.252 ± 0.036	0.783MetPhe: 0.783 ± 0.029	1.54MetGly: 1.54 ± 0.04	0.625MetHis: 0.625 ± 0.026	1.684MetIle: 1.684 ± 0.04	1.666MetLys: 1.666 ± 0.035	2.483MetLeu: 2.483 ± 0.057	0.762MetMet: 0.762 ± 0.034	1.445MetAsn: 1.445 ± 0.039	1.162MetPro: 1.162 ± 0.036	1.143MetGln: 1.143 ± 0.03	1.11MetArg: 1.11 ± 0.034	1.726MetSer: 1.726 ± 0.037	1.499MetThr: 1.499 ± 0.038	1.556MetVal: 1.556 ± 0.036	0.164MetTrp: 0.164 ± 0.013	0.607MetTyr: 0.607 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	3.518AsnAla: 3.518 ± 0.061	0.57AsnCys: 0.57 ± 0.026	2.482AsnAsp: 2.482 ± 0.048	3.153AsnGlu: 3.153 ± 0.055	1.814AsnPhe: 1.814 ± 0.036	2.745AsnGly: 2.745 ± 0.056	1.441AsnHis: 1.441 ± 0.039	3.023AsnIle: 3.023 ± 0.055	3.404AsnLys: 3.404 ± 0.054	4.82AsnLeu: 4.82 ± 0.067	1.019AsnMet: 1.019 ± 0.034	2.808AsnAsn: 2.808 ± 0.059	2.861AsnPro: 2.861 ± 0.061	2.894AsnGln: 2.894 ± 0.066	2.17AsnArg: 2.17 ± 0.05	3.661AsnSer: 3.661 ± 0.076	2.803AsnThr: 2.803 ± 0.057	2.406AsnVal: 2.406 ± 0.053	0.631AsnTrp: 0.631 ± 0.024	1.984AsnTyr: 1.984 ± 0.046	0.002AsnXaa: 0.002 ± 0.001
Pro	2.511ProAla: 2.511 ± 0.042	0.392ProCys: 0.392 ± 0.022	2.193ProAsp: 2.193 ± 0.042	3.088ProGlu: 3.088 ± 0.051	1.84ProPhe: 1.84 ± 0.04	2.463ProGly: 2.463 ± 0.064	0.877ProHis: 0.877 ± 0.03	3.11ProIle: 3.11 ± 0.058	2.594ProLys: 2.594 ± 0.052	4.204ProLeu: 4.204 ± 0.062	1.011ProMet: 1.011 ± 0.03	2.06ProAsn: 2.06 ± 0.046	1.422ProPro: 1.422 ± 0.039	1.757ProGln: 1.757 ± 0.053	1.346ProArg: 1.346 ± 0.033	2.844ProSer: 2.844 ± 0.052	2.249ProThr: 2.249 ± 0.049	2.837ProVal: 2.837 ± 0.054	0.485ProTrp: 0.485 ± 0.024	1.412ProTyr: 1.412 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	3.576GlnAla: 3.576 ± 0.07	0.485GlnCys: 0.485 ± 0.022	1.954GlnAsp: 1.954 ± 0.045	2.814GlnGlu: 2.814 ± 0.057	2.202GlnPhe: 2.202 ± 0.044	2.628GlnGly: 2.628 ± 0.062	1.125GlnHis: 1.125 ± 0.038	3.178GlnIle: 3.178 ± 0.051	2.816GlnLys: 2.816 ± 0.056	5.58GlnLeu: 5.58 ± 0.086	1.104GlnMet: 1.104 ± 0.033	2.157GlnAsn: 2.157 ± 0.053	1.51GlnPro: 1.51 ± 0.043	2.62GlnGln: 2.62 ± 0.074	1.955GlnArg: 1.955 ± 0.045	3.15GlnSer: 3.15 ± 0.056	2.34GlnThr: 2.34 ± 0.051	2.788GlnVal: 2.788 ± 0.06	0.58GlnTrp: 0.58 ± 0.025	1.563GlnTyr: 1.563 ± 0.04	0.001GlnXaa: 0.001 ± 0.001
Arg	2.855ArgAla: 2.855 ± 0.056	0.463ArgCys: 0.463 ± 0.024	2.102ArgAsp: 2.102 ± 0.043	2.661ArgGlu: 2.661 ± 0.053	2.105ArgPhe: 2.105 ± 0.047	2.175ArgGly: 2.175 ± 0.044	1.035ArgHis: 1.035 ± 0.033	3.094ArgIle: 3.094 ± 0.057	2.531ArgLys: 2.531 ± 0.051	4.854ArgLeu: 4.854 ± 0.079	1.041ArgMet: 1.041 ± 0.036	1.926ArgAsn: 1.926 ± 0.04	1.419ArgPro: 1.419 ± 0.04	1.81ArgGln: 1.81 ± 0.04	1.78ArgArg: 1.78 ± 0.047	2.446ArgSer: 2.446 ± 0.048	1.999ArgThr: 1.999 ± 0.043	2.683ArgVal: 2.683 ± 0.049	0.525ArgTrp: 0.525 ± 0.022	1.707ArgTyr: 1.707 ± 0.043	0.001ArgXaa: 0.001 ± 0.001
Ser	4.509SerAla: 4.509 ± 0.088	0.825SerCys: 0.825 ± 0.027	3.255SerAsp: 3.255 ± 0.056	4.001SerGlu: 4.001 ± 0.071	3.114SerPhe: 3.114 ± 0.057	4.53SerGly: 4.53 ± 0.081	1.677SerHis: 1.677 ± 0.044	5.374SerIle: 5.374 ± 0.071	4.394SerLys: 4.394 ± 0.069	8.172SerLeu: 8.172 ± 0.106	1.861SerMet: 1.861 ± 0.044	3.377SerAsn: 3.377 ± 0.062	2.902SerPro: 2.902 ± 0.048	3.051SerGln: 3.051 ± 0.057	2.734SerArg: 2.734 ± 0.049	5.244SerSer: 5.244 ± 0.096	3.76SerThr: 3.76 ± 0.068	4.057SerVal: 4.057 ± 0.063	0.806SerTrp: 0.806 ± 0.032	2.376SerTyr: 2.376 ± 0.047	0.007SerXaa: 0.007 ± 0.002
Thr	3.844ThrAla: 3.844 ± 0.077	0.522ThrCys: 0.522 ± 0.025	2.45ThrAsp: 2.45 ± 0.053	2.855ThrGlu: 2.855 ± 0.055	2.012ThrPhe: 2.012 ± 0.047	3.511ThrGly: 3.511 ± 0.069	1.314ThrHis: 1.314 ± 0.034	4.035ThrIle: 4.035 ± 0.067	2.929ThrLys: 2.929 ± 0.054	5.968ThrLeu: 5.968 ± 0.076	1.253ThrMet: 1.253 ± 0.037	2.568ThrAsn: 2.568 ± 0.059	2.771ThrPro: 2.771 ± 0.063	2.466ThrGln: 2.466 ± 0.051	2.035ThrArg: 2.035 ± 0.043	3.455ThrSer: 3.455 ± 0.067	2.981ThrThr: 2.981 ± 0.062	3.397ThrVal: 3.397 ± 0.061	0.529ThrTrp: 0.529 ± 0.022	1.687ThrTyr: 1.687 ± 0.031	0.003ThrXaa: 0.003 ± 0.002
Val	4.544ValAla: 4.544 ± 0.077	0.718ValCys: 0.718 ± 0.03	3.282ValAsp: 3.282 ± 0.058	3.348ValGlu: 3.348 ± 0.065	2.952ValPhe: 2.952 ± 0.062	3.688ValGly: 3.688 ± 0.073	1.361ValHis: 1.361 ± 0.038	4.673ValIle: 4.673 ± 0.07	3.621ValLys: 3.621 ± 0.063	6.58ValLeu: 6.58 ± 0.091	1.597ValMet: 1.597 ± 0.043	3.164ValAsn: 3.164 ± 0.054	2.272ValPro: 2.272 ± 0.052	2.268ValGln: 2.268 ± 0.051	2.374ValArg: 2.374 ± 0.053	4.427ValSer: 4.427 ± 0.075	3.205ValThr: 3.205 ± 0.064	4.221ValVal: 4.221 ± 0.081	0.594ValTrp: 0.594 ± 0.023	1.954ValTyr: 1.954 ± 0.041	0.002ValXaa: 0.002 ± 0.001
Trp	0.672TrpAla: 0.672 ± 0.026	0.145TrpCys: 0.145 ± 0.011	0.529TrpAsp: 0.529 ± 0.024	0.532TrpGlu: 0.532 ± 0.025	0.581TrpPhe: 0.581 ± 0.025	0.689TrpGly: 0.689 ± 0.027	0.335TrpHis: 0.335 ± 0.017	0.837TrpIle: 0.837 ± 0.028	0.577TrpLys: 0.577 ± 0.025	1.391TrpLeu: 1.391 ± 0.038	0.302TrpMet: 0.302 ± 0.016	0.553TrpAsn: 0.553 ± 0.022	0.373TrpPro: 0.373 ± 0.018	0.607TrpGln: 0.607 ± 0.025	0.525TrpArg: 0.525 ± 0.023	0.748TrpSer: 0.748 ± 0.032	0.515TrpThr: 0.515 ± 0.023	0.747TrpVal: 0.747 ± 0.028	0.157TrpTrp: 0.157 ± 0.012	0.417TrpTyr: 0.417 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.313TyrAla: 2.313 ± 0.045	0.482TyrCys: 0.482 ± 0.023	1.657TyrAsp: 1.657 ± 0.046	1.766TyrGlu: 1.766 ± 0.044	1.888TyrPhe: 1.888 ± 0.046	2.141TyrGly: 2.141 ± 0.048	0.909TyrHis: 0.909 ± 0.034	2.092TyrIle: 2.092 ± 0.046	1.957TyrLys: 1.957 ± 0.041	4.069TyrLeu: 4.069 ± 0.062	0.713TyrMet: 0.713 ± 0.029	1.503TyrAsn: 1.503 ± 0.044	1.533TyrPro: 1.533 ± 0.038	2.01TyrGln: 2.01 ± 0.046	1.647TyrArg: 1.647 ± 0.042	2.432TyrSer: 2.432 ± 0.055	1.708TyrThr: 1.708 ± 0.045	1.777TyrVal: 1.777 ± 0.039	0.507TyrTrp: 0.507 ± 0.024	1.454TyrTyr: 1.454 ± 0.045	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.005XaaAla: 0.005 ± 0.003	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.002XaaGlu: 0.002 ± 0.001	0.001XaaPhe: 0.001 ± 0.001	0.001XaaGly: 0.001 ± 0.001	0.001XaaHis: 0.001 ± 0.001	0.0XaaIle: 0.0 ± 0.0	0.004XaaLys: 0.004 ± 0.002	0.003XaaLeu: 0.003 ± 0.002	0.003XaaMet: 0.003 ± 0.002	0.002XaaAsn: 0.002 ± 0.001	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.004XaaArg: 0.004 ± 0.002	0.002XaaSer: 0.002 ± 0.001	0.002XaaThr: 0.002 ± 0.001	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.093XaaXaa: 0.093 ± 0.019

Statistics based on 3346 proteins (1065030 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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