Amino acid dipepetide frequency for Sphingomonas jeddahensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.389AlaAla: 21.389 ± 0.275	1.033AlaCys: 1.033 ± 0.036	7.935AlaAsp: 7.935 ± 0.105	8.012AlaGlu: 8.012 ± 0.122	4.359AlaPhe: 4.359 ± 0.074	12.31AlaGly: 12.31 ± 0.141	2.404AlaHis: 2.404 ± 0.058	6.934AlaIle: 6.934 ± 0.092	4.14AlaLys: 4.14 ± 0.086	14.56AlaLeu: 14.56 ± 0.168	3.947AlaMet: 3.947 ± 0.071	3.196AlaAsn: 3.196 ± 0.065	6.674AlaPro: 6.674 ± 0.105	4.448AlaGln: 4.448 ± 0.071	10.47AlaArg: 10.47 ± 0.152	6.419AlaSer: 6.419 ± 0.082	7.282AlaThr: 7.282 ± 0.081	9.174AlaVal: 9.174 ± 0.122	1.767AlaTrp: 1.767 ± 0.048	2.446AlaTyr: 2.446 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.939CysAla: 0.939 ± 0.032	0.063CysCys: 0.063 ± 0.009	0.525CysAsp: 0.525 ± 0.024	0.322CysGlu: 0.322 ± 0.018	0.245CysPhe: 0.245 ± 0.018	0.806CysGly: 0.806 ± 0.034	0.174CysHis: 0.174 ± 0.013	0.326CysIle: 0.326 ± 0.02	0.137CysLys: 0.137 ± 0.013	0.592CysLeu: 0.592 ± 0.026	0.128CysMet: 0.128 ± 0.01	0.174CysAsn: 0.174 ± 0.015	0.386CysPro: 0.386 ± 0.021	0.17CysGln: 0.17 ± 0.013	0.519CysArg: 0.519 ± 0.026	0.375CysSer: 0.375 ± 0.021	0.354CysThr: 0.354 ± 0.019	0.568CysVal: 0.568 ± 0.025	0.085CysTrp: 0.085 ± 0.01	0.149CysTyr: 0.149 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.904AspAla: 7.904 ± 0.11	0.395AspCys: 0.395 ± 0.024	3.308AspAsp: 3.308 ± 0.07	3.464AspGlu: 3.464 ± 0.067	2.048AspPhe: 2.048 ± 0.044	5.528AspGly: 5.528 ± 0.082	1.346AspHis: 1.346 ± 0.042	2.524AspIle: 2.524 ± 0.059	1.622AspLys: 1.622 ± 0.054	5.822AspLeu: 5.822 ± 0.075	1.283AspMet: 1.283 ± 0.04	1.275AspAsn: 1.275 ± 0.047	3.874AspPro: 3.874 ± 0.071	1.841AspGln: 1.841 ± 0.045	5.175AspArg: 5.175 ± 0.081	2.147AspSer: 2.147 ± 0.052	2.907AspThr: 2.907 ± 0.068	4.377AspVal: 4.377 ± 0.069	1.085AspTrp: 1.085 ± 0.037	1.562AspTyr: 1.562 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	8.026GluAla: 8.026 ± 0.119	0.272GluCys: 0.272 ± 0.018	2.679GluAsp: 2.679 ± 0.062	3.075GluGlu: 3.075 ± 0.072	1.422GluPhe: 1.422 ± 0.049	4.63GluGly: 4.63 ± 0.071	1.122GluHis: 1.122 ± 0.033	2.717GluIle: 2.717 ± 0.063	1.776GluLys: 1.776 ± 0.051	4.88GluLeu: 4.88 ± 0.081	1.296GluMet: 1.296 ± 0.037	1.26GluAsn: 1.26 ± 0.032	2.597GluPro: 2.597 ± 0.053	2.149GluGln: 2.149 ± 0.055	5.316GluArg: 5.316 ± 0.086	2.025GluSer: 2.025 ± 0.048	3.181GluThr: 3.181 ± 0.06	3.825GluVal: 3.825 ± 0.066	0.757GluTrp: 0.757 ± 0.028	0.88GluTyr: 0.88 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.799PheAla: 4.799 ± 0.08	0.276PheCys: 0.276 ± 0.017	2.593PheAsp: 2.593 ± 0.061	1.89PheGlu: 1.89 ± 0.044	1.242PhePhe: 1.242 ± 0.041	3.57PheGly: 3.57 ± 0.08	0.705PheHis: 0.705 ± 0.027	1.282PheIle: 1.282 ± 0.039	0.834PheLys: 0.834 ± 0.03	2.96PheLeu: 2.96 ± 0.06	0.687PheMet: 0.687 ± 0.029	0.966PheAsn: 0.966 ± 0.034	1.452PhePro: 1.452 ± 0.037	0.881PheGln: 0.881 ± 0.029	2.279PheArg: 2.279 ± 0.047	1.716PheSer: 1.716 ± 0.046	1.987PheThr: 1.987 ± 0.043	2.687PheVal: 2.687 ± 0.059	0.485PheTrp: 0.485 ± 0.024	0.797PheTyr: 0.797 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	10.754GlyAla: 10.754 ± 0.127	0.79GlyCys: 0.79 ± 0.032	5.066GlyAsp: 5.066 ± 0.077	5.153GlyGlu: 5.153 ± 0.075	3.492GlyPhe: 3.492 ± 0.065	8.412GlyGly: 8.412 ± 0.133	1.845GlyHis: 1.845 ± 0.046	4.251GlyIle: 4.251 ± 0.078	3.12GlyLys: 3.12 ± 0.064	8.529GlyLeu: 8.529 ± 0.102	2.393GlyMet: 2.393 ± 0.058	2.269GlyAsn: 2.269 ± 0.056	3.647GlyPro: 3.647 ± 0.058	2.893GlyGln: 2.893 ± 0.064	6.774GlyArg: 6.774 ± 0.092	4.627GlySer: 4.627 ± 0.079	5.146GlyThr: 5.146 ± 0.093	6.777GlyVal: 6.777 ± 0.096	1.724GlyTrp: 1.724 ± 0.049	2.402GlyTyr: 2.402 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	2.619HisAla: 2.619 ± 0.053	0.19HisCys: 0.19 ± 0.014	1.298HisAsp: 1.298 ± 0.043	1.051HisGlu: 1.051 ± 0.034	0.73HisPhe: 0.73 ± 0.028	2.016HisGly: 2.016 ± 0.058	0.591HisHis: 0.591 ± 0.03	0.786HisIle: 0.786 ± 0.029	0.406HisLys: 0.406 ± 0.021	1.798HisLeu: 1.798 ± 0.041	0.424HisMet: 0.424 ± 0.021	0.427HisAsn: 0.427 ± 0.024	1.344HisPro: 1.344 ± 0.043	0.572HisGln: 0.572 ± 0.023	1.605HisArg: 1.605 ± 0.052	0.723HisSer: 0.723 ± 0.029	0.722HisThr: 0.722 ± 0.025	1.545HisVal: 1.545 ± 0.047	0.366HisTrp: 0.366 ± 0.02	0.524HisTyr: 0.524 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	8.015IleAla: 8.015 ± 0.106	0.349IleCys: 0.349 ± 0.019	3.956IleAsp: 3.956 ± 0.059	3.358IleGlu: 3.358 ± 0.067	1.28IlePhe: 1.28 ± 0.04	5.179IleGly: 5.179 ± 0.081	0.835IleHis: 0.835 ± 0.029	1.801IleIle: 1.801 ± 0.05	1.129IleLys: 1.129 ± 0.041	3.502IleLeu: 3.502 ± 0.069	0.829IleMet: 0.829 ± 0.029	1.249IleAsn: 1.249 ± 0.047	2.015IlePro: 2.015 ± 0.05	1.042IleGln: 1.042 ± 0.038	3.149IleArg: 3.149 ± 0.062	2.114IleSer: 2.114 ± 0.049	2.666IleThr: 2.666 ± 0.066	4.329IleVal: 4.329 ± 0.066	0.526IleTrp: 0.526 ± 0.024	0.91IleTyr: 0.91 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	3.79LysAla: 3.79 ± 0.082	0.134LysCys: 0.134 ± 0.012	1.4LysAsp: 1.4 ± 0.048	1.192LysGlu: 1.192 ± 0.048	0.724LysPhe: 0.724 ± 0.032	2.392LysGly: 2.392 ± 0.055	0.532LysHis: 0.532 ± 0.027	1.245LysIle: 1.245 ± 0.039	1.078LysLys: 1.078 ± 0.045	3.076LysLeu: 3.076 ± 0.071	0.72LysMet: 0.72 ± 0.03	0.709LysAsn: 0.709 ± 0.03	1.934LysPro: 1.934 ± 0.051	0.949LysGln: 0.949 ± 0.038	2.328LysArg: 2.328 ± 0.054	1.39LysSer: 1.39 ± 0.047	1.541LysThr: 1.541 ± 0.044	2.14LysVal: 2.14 ± 0.056	0.367LysTrp: 0.367 ± 0.024	0.549LysTyr: 0.549 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	14.727LeuAla: 14.727 ± 0.182	0.683LeuCys: 0.683 ± 0.029	6.253LeuAsp: 6.253 ± 0.095	4.472LeuGlu: 4.472 ± 0.076	3.446LeuPhe: 3.446 ± 0.066	8.553LeuGly: 8.553 ± 0.105	1.79LeuHis: 1.79 ± 0.046	4.68LeuIle: 4.68 ± 0.087	2.775LeuLys: 2.775 ± 0.062	9.414LeuLeu: 9.414 ± 0.139	2.06LeuMet: 2.06 ± 0.057	2.343LeuAsn: 2.343 ± 0.05	5.779LeuPro: 5.779 ± 0.076	2.422LeuGln: 2.422 ± 0.055	6.913LeuArg: 6.913 ± 0.099	5.482LeuSer: 5.482 ± 0.079	5.577LeuThr: 5.577 ± 0.075	7.564LeuVal: 7.564 ± 0.121	1.197LeuTrp: 1.197 ± 0.043	1.91LeuTyr: 1.91 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	3.187MetAla: 3.187 ± 0.065	0.145MetCys: 0.145 ± 0.011	0.995MetAsp: 0.995 ± 0.032	1.007MetGlu: 1.007 ± 0.036	0.673MetPhe: 0.673 ± 0.025	1.819MetGly: 1.819 ± 0.047	0.454MetHis: 0.454 ± 0.025	1.333MetIle: 1.333 ± 0.039	0.883MetLys: 0.883 ± 0.034	2.581MetLeu: 2.581 ± 0.059	0.602MetMet: 0.602 ± 0.027	0.675MetAsn: 0.675 ± 0.026	1.476MetPro: 1.476 ± 0.045	0.707MetGln: 0.707 ± 0.028	1.876MetArg: 1.876 ± 0.049	1.293MetSer: 1.293 ± 0.038	1.729MetThr: 1.729 ± 0.042	1.598MetVal: 1.598 ± 0.037	0.224MetTrp: 0.224 ± 0.016	0.286MetTyr: 0.286 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.332AsnAla: 3.332 ± 0.062	0.212AsnCys: 0.212 ± 0.014	1.416AsnAsp: 1.416 ± 0.039	1.148AsnGlu: 1.148 ± 0.041	0.881AsnPhe: 0.881 ± 0.034	2.378AsnGly: 2.378 ± 0.053	0.477AsnHis: 0.477 ± 0.02	1.184AsnIle: 1.184 ± 0.038	0.647AsnLys: 0.647 ± 0.026	2.427AsnLeu: 2.427 ± 0.047	0.548AsnMet: 0.548 ± 0.024	0.724AsnAsn: 0.724 ± 0.036	1.692AsnPro: 1.692 ± 0.043	0.767AsnGln: 0.767 ± 0.03	1.832AsnArg: 1.832 ± 0.047	1.137AsnSer: 1.137 ± 0.043	1.163AsnThr: 1.163 ± 0.045	1.896AsnVal: 1.896 ± 0.051	0.406AsnTrp: 0.406 ± 0.023	0.641AsnTyr: 0.641 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	7.522ProAla: 7.522 ± 0.112	0.298ProCys: 0.298 ± 0.015	3.69ProAsp: 3.69 ± 0.07	3.486ProGlu: 3.486 ± 0.059	1.916ProPhe: 1.916 ± 0.043	4.972ProGly: 4.972 ± 0.084	1.094ProHis: 1.094 ± 0.038	2.539ProIle: 2.539 ± 0.059	1.477ProLys: 1.477 ± 0.044	5.066ProLeu: 5.066 ± 0.066	1.194ProMet: 1.194 ± 0.036	1.36ProAsn: 1.36 ± 0.042	2.818ProPro: 2.818 ± 0.073	1.715ProGln: 1.715 ± 0.048	3.23ProArg: 3.23 ± 0.066	2.645ProSer: 2.645 ± 0.056	2.706ProThr: 2.706 ± 0.056	4.426ProVal: 4.426 ± 0.077	0.672ProTrp: 0.672 ± 0.026	1.055ProTyr: 1.055 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	4.236GlnAla: 4.236 ± 0.074	0.182GlnCys: 0.182 ± 0.014	1.312GlnAsp: 1.312 ± 0.036	1.289GlnGlu: 1.289 ± 0.041	1.047GlnPhe: 1.047 ± 0.037	2.389GlnGly: 2.389 ± 0.06	0.616GlnHis: 0.616 ± 0.026	1.547GlnIle: 1.547 ± 0.04	0.859GlnLys: 0.859 ± 0.03	3.069GlnLeu: 3.069 ± 0.062	0.77GlnMet: 0.77 ± 0.028	0.776GlnAsn: 0.776 ± 0.032	1.922GlnPro: 1.922 ± 0.049	1.212GlnGln: 1.212 ± 0.043	2.771GlnArg: 2.771 ± 0.058	1.574GlnSer: 1.574 ± 0.049	1.587GlnThr: 1.587 ± 0.052	2.288GlnVal: 2.288 ± 0.052	0.42GlnTrp: 0.42 ± 0.024	0.561GlnTyr: 0.561 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	9.735ArgAla: 9.735 ± 0.135	0.498ArgCys: 0.498 ± 0.027	4.65ArgAsp: 4.65 ± 0.072	4.204ArgGlu: 4.204 ± 0.067	3.139ArgPhe: 3.139 ± 0.058	5.647ArgGly: 5.647 ± 0.086	1.751ArgHis: 1.751 ± 0.052	4.128ArgIle: 4.128 ± 0.069	1.783ArgLys: 1.783 ± 0.054	8.442ArgLeu: 8.442 ± 0.134	2.018ArgMet: 2.018 ± 0.044	1.807ArgAsn: 1.807 ± 0.044	3.905ArgPro: 3.905 ± 0.085	2.491ArgGln: 2.491 ± 0.058	6.395ArgArg: 6.395 ± 0.13	3.636ArgSer: 3.636 ± 0.065	3.8ArgThr: 3.8 ± 0.064	5.415ArgVal: 5.415 ± 0.092	1.359ArgTrp: 1.359 ± 0.04	1.912ArgTyr: 1.912 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	6.198SerAla: 6.198 ± 0.092	0.331SerCys: 0.331 ± 0.019	2.832SerAsp: 2.832 ± 0.053	2.292SerGlu: 2.292 ± 0.055	1.921SerPhe: 1.921 ± 0.043	5.085SerGly: 5.085 ± 0.076	0.842SerHis: 0.842 ± 0.032	2.5SerIle: 2.5 ± 0.049	1.277SerLys: 1.277 ± 0.041	4.667SerLeu: 4.667 ± 0.075	1.083SerMet: 1.083 ± 0.035	1.347SerAsn: 1.347 ± 0.044	2.73SerPro: 2.73 ± 0.059	1.359SerGln: 1.359 ± 0.039	3.431SerArg: 3.431 ± 0.065	2.403SerSer: 2.403 ± 0.059	2.616SerThr: 2.616 ± 0.066	3.505SerVal: 3.505 ± 0.056	0.7SerTrp: 0.7 ± 0.029	1.229SerTyr: 1.229 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	6.863ThrAla: 6.863 ± 0.091	0.381ThrCys: 0.381 ± 0.022	2.987ThrAsp: 2.987 ± 0.056	2.344ThrGlu: 2.344 ± 0.056	1.885ThrPhe: 1.885 ± 0.045	5.542ThrGly: 5.542 ± 0.094	0.989ThrHis: 0.989 ± 0.035	3.202ThrIle: 3.202 ± 0.067	1.311ThrLys: 1.311 ± 0.041	5.936ThrLeu: 5.936 ± 0.09	1.205ThrMet: 1.205 ± 0.035	1.303ThrAsn: 1.303 ± 0.044	3.634ThrPro: 3.634 ± 0.062	1.498ThrGln: 1.498 ± 0.045	3.78ThrArg: 3.78 ± 0.075	2.708ThrSer: 2.708 ± 0.061	2.914ThrThr: 2.914 ± 0.076	4.384ThrVal: 4.384 ± 0.079	0.642ThrTrp: 0.642 ± 0.031	1.139ThrTyr: 1.139 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	10.783ValAla: 10.783 ± 0.139	0.484ValCys: 0.484 ± 0.024	4.416ValAsp: 4.416 ± 0.068	4.463ValGlu: 4.463 ± 0.079	2.253ValPhe: 2.253 ± 0.055	5.863ValGly: 5.863 ± 0.082	1.368ValHis: 1.368 ± 0.038	3.835ValIle: 3.835 ± 0.065	1.996ValLys: 1.996 ± 0.053	6.998ValLeu: 6.998 ± 0.104	1.611ValMet: 1.611 ± 0.044	2.009ValAsn: 2.009 ± 0.054	4.302ValPro: 4.302 ± 0.077	1.998ValGln: 1.998 ± 0.047	5.467ValArg: 5.467 ± 0.085	4.048ValSer: 4.048 ± 0.064	4.89ValThr: 4.89 ± 0.075	5.686ValVal: 5.686 ± 0.094	0.814ValTrp: 0.814 ± 0.035	1.28ValTyr: 1.28 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.446TrpAla: 1.446 ± 0.043	0.133TrpCys: 0.133 ± 0.012	0.686TrpAsp: 0.686 ± 0.032	0.565TrpGlu: 0.565 ± 0.026	0.598TrpPhe: 0.598 ± 0.025	0.922TrpGly: 0.922 ± 0.037	0.34TrpHis: 0.34 ± 0.021	0.667TrpIle: 0.667 ± 0.027	0.424TrpLys: 0.424 ± 0.023	1.727TrpLeu: 1.727 ± 0.05	0.362TrpMet: 0.362 ± 0.022	0.435TrpAsn: 0.435 ± 0.024	0.711TrpPro: 0.711 ± 0.031	0.619TrpGln: 0.619 ± 0.027	1.473TrpArg: 1.473 ± 0.044	0.836TrpSer: 0.836 ± 0.029	0.853TrpThr: 0.853 ± 0.032	0.829TrpVal: 0.829 ± 0.034	0.303TrpTrp: 0.303 ± 0.021	0.295TrpTyr: 0.295 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.635TyrAla: 2.635 ± 0.058	0.189TyrCys: 0.189 ± 0.013	1.492TyrAsp: 1.492 ± 0.043	1.097TyrGlu: 1.097 ± 0.036	0.787TyrPhe: 0.787 ± 0.033	2.049TyrGly: 2.049 ± 0.048	0.465TyrHis: 0.465 ± 0.023	0.752TyrIle: 0.752 ± 0.032	0.514TyrLys: 0.514 ± 0.023	1.995TyrLeu: 1.995 ± 0.041	0.384TyrMet: 0.384 ± 0.021	0.602TyrAsn: 0.602 ± 0.029	0.989TyrPro: 0.989 ± 0.032	0.697TyrGln: 0.697 ± 0.029	1.935TyrArg: 1.935 ± 0.045	1.051TyrSer: 1.051 ± 0.037	1.024TyrThr: 1.024 ± 0.037	1.548TyrVal: 1.548 ± 0.04	0.322TyrTrp: 0.322 ± 0.021	0.564TyrTyr: 0.564 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2894 proteins (925443 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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