Amino acid dipepetide frequency for Vitreoscilla filiformis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.474AlaAla: 16.474 ± 0.179	1.532AlaCys: 1.532 ± 0.04	6.542AlaAsp: 6.542 ± 0.071	7.067AlaGlu: 7.067 ± 0.101	3.622AlaPhe: 3.622 ± 0.061	10.079AlaGly: 10.079 ± 0.109	3.226AlaHis: 3.226 ± 0.061	4.25AlaIle: 4.25 ± 0.078	3.629AlaLys: 3.629 ± 0.08	15.706AlaLeu: 15.706 ± 0.174	3.295AlaMet: 3.295 ± 0.071	2.688AlaAsn: 2.688 ± 0.063	6.711AlaPro: 6.711 ± 0.108	7.047AlaGln: 7.047 ± 0.096	8.585AlaArg: 8.585 ± 0.099	6.541AlaSer: 6.541 ± 0.098	6.186AlaThr: 6.186 ± 0.086	8.78AlaVal: 8.78 ± 0.109	2.431AlaTrp: 2.431 ± 0.064	2.314AlaTyr: 2.314 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	1.28CysAla: 1.28 ± 0.039	0.159CysCys: 0.159 ± 0.012	0.582CysAsp: 0.582 ± 0.028	0.569CysGlu: 0.569 ± 0.025	0.335CysPhe: 0.335 ± 0.017	1.078CysGly: 1.078 ± 0.034	0.332CysHis: 0.332 ± 0.018	0.393CysIle: 0.393 ± 0.019	0.248CysLys: 0.248 ± 0.015	0.995CysLeu: 0.995 ± 0.032	0.199CysMet: 0.199 ± 0.014	0.225CysAsn: 0.225 ± 0.014	0.582CysPro: 0.582 ± 0.026	0.419CysGln: 0.419 ± 0.018	0.637CysArg: 0.637 ± 0.026	0.477CysSer: 0.477 ± 0.024	0.582CysThr: 0.582 ± 0.027	0.826CysVal: 0.826 ± 0.03	0.164CysTrp: 0.164 ± 0.011	0.212CysTyr: 0.212 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.21AspAla: 7.21 ± 0.086	0.435AspCys: 0.435 ± 0.02	2.952AspAsp: 2.952 ± 0.077	3.243AspGlu: 3.243 ± 0.063	1.883AspPhe: 1.883 ± 0.042	4.537AspGly: 4.537 ± 0.085	1.159AspHis: 1.159 ± 0.035	2.223AspIle: 2.223 ± 0.05	1.6AspLys: 1.6 ± 0.039	5.136AspLeu: 5.136 ± 0.08	1.192AspMet: 1.192 ± 0.032	1.165AspAsn: 1.165 ± 0.048	2.847AspPro: 2.847 ± 0.054	1.581AspGln: 1.581 ± 0.041	3.011AspArg: 3.011 ± 0.065	2.116AspSer: 2.116 ± 0.056	2.961AspThr: 2.961 ± 0.091	4.612AspVal: 4.612 ± 0.066	1.08AspTrp: 1.08 ± 0.037	1.241AspTyr: 1.241 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	7.286GluAla: 7.286 ± 0.098	0.419GluCys: 0.419 ± 0.023	2.297GluAsp: 2.297 ± 0.047	2.528GluGlu: 2.528 ± 0.063	1.773GluPhe: 1.773 ± 0.046	3.949GluGly: 3.949 ± 0.061	1.486GluHis: 1.486 ± 0.038	2.237GluIle: 2.237 ± 0.05	1.654GluLys: 1.654 ± 0.05	6.064GluLeu: 6.064 ± 0.076	1.099GluMet: 1.099 ± 0.031	1.191GluAsn: 1.191 ± 0.047	2.611GluPro: 2.611 ± 0.051	2.723GluGln: 2.723 ± 0.059	5.117GluArg: 5.117 ± 0.076	2.219GluSer: 2.219 ± 0.048	2.367GluThr: 2.367 ± 0.054	4.289GluVal: 4.289 ± 0.069	0.788GluTrp: 0.788 ± 0.03	0.889GluTyr: 0.889 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	3.642PheAla: 3.642 ± 0.056	0.406PheCys: 0.406 ± 0.02	2.31PheAsp: 2.31 ± 0.047	2.12PheGlu: 2.12 ± 0.048	1.298PhePhe: 1.298 ± 0.04	3.024PheGly: 3.024 ± 0.055	0.733PheHis: 0.733 ± 0.027	1.422PheIle: 1.422 ± 0.039	1.09PheLys: 1.09 ± 0.033	2.787PheLeu: 2.787 ± 0.066	0.731PheMet: 0.731 ± 0.024	1.045PheAsn: 1.045 ± 0.034	1.382PhePro: 1.382 ± 0.038	1.054PheGln: 1.054 ± 0.031	1.747PheArg: 1.747 ± 0.044	2.061PheSer: 2.061 ± 0.048	1.908PheThr: 1.908 ± 0.037	2.48PheVal: 2.48 ± 0.052	0.541PheTrp: 0.541 ± 0.023	0.782PheTyr: 0.782 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	8.85GlyAla: 8.85 ± 0.108	1.005GlyCys: 1.005 ± 0.034	3.895GlyAsp: 3.895 ± 0.09	4.297GlyGlu: 4.297 ± 0.067	2.925GlyPhe: 2.925 ± 0.06	6.655GlyGly: 6.655 ± 0.112	2.284GlyHis: 2.284 ± 0.042	3.109GlyIle: 3.109 ± 0.056	2.767GlyLys: 2.767 ± 0.066	9.443GlyLeu: 9.443 ± 0.095	2.049GlyMet: 2.049 ± 0.047	2.043GlyAsn: 2.043 ± 0.146	3.107GlyPro: 3.107 ± 0.056	3.902GlyGln: 3.902 ± 0.073	5.578GlyArg: 5.578 ± 0.077	4.446GlySer: 4.446 ± 0.084	4.53GlyThr: 4.53 ± 0.129	6.857GlyVal: 6.857 ± 0.085	1.762GlyTrp: 1.762 ± 0.04	2.035GlyTyr: 2.035 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	3.339HisAla: 3.339 ± 0.064	0.342HisCys: 0.342 ± 0.019	1.301HisAsp: 1.301 ± 0.038	1.194HisGlu: 1.194 ± 0.037	0.927HisPhe: 0.927 ± 0.028	2.28HisGly: 2.28 ± 0.047	0.82HisHis: 0.82 ± 0.032	1.042HisIle: 1.042 ± 0.029	0.57HisLys: 0.57 ± 0.027	2.884HisLeu: 2.884 ± 0.053	0.515HisMet: 0.515 ± 0.022	0.579HisAsn: 0.579 ± 0.024	1.834HisPro: 1.834 ± 0.041	1.05HisGln: 1.05 ± 0.038	1.846HisArg: 1.846 ± 0.048	1.098HisSer: 1.098 ± 0.029	1.357HisThr: 1.357 ± 0.036	1.717HisVal: 1.717 ± 0.038	0.552HisTrp: 0.552 ± 0.023	0.654HisTyr: 0.654 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	4.685IleAla: 4.685 ± 0.068	0.362IleCys: 0.362 ± 0.017	2.66IleAsp: 2.66 ± 0.056	2.829IleGlu: 2.829 ± 0.056	1.052IlePhe: 1.052 ± 0.031	3.608IleGly: 3.608 ± 0.071	0.961IleHis: 0.961 ± 0.027	1.4IleIle: 1.4 ± 0.041	1.295IleLys: 1.295 ± 0.04	2.96IleLeu: 2.96 ± 0.064	0.666IleMet: 0.666 ± 0.03	1.264IleAsn: 1.264 ± 0.036	1.82IlePro: 1.82 ± 0.043	1.443IleGln: 1.443 ± 0.033	2.484IleArg: 2.484 ± 0.057	2.021IleSer: 2.021 ± 0.048	2.488IleThr: 2.488 ± 0.057	2.942IleVal: 2.942 ± 0.066	0.439IleTrp: 0.439 ± 0.023	0.837IleTyr: 0.837 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	3.608LysAla: 3.608 ± 0.078	0.17LysCys: 0.17 ± 0.013	1.423LysAsp: 1.423 ± 0.041	1.391LysGlu: 1.391 ± 0.05	0.881LysPhe: 0.881 ± 0.031	2.282LysGly: 2.282 ± 0.052	0.617LysHis: 0.617 ± 0.025	1.336LysIle: 1.336 ± 0.039	1.262LysLys: 1.262 ± 0.042	3.229LysLeu: 3.229 ± 0.064	0.696LysMet: 0.696 ± 0.027	0.83LysAsn: 0.83 ± 0.03	1.718LysPro: 1.718 ± 0.041	1.096LysGln: 1.096 ± 0.034	2.07LysArg: 2.07 ± 0.053	1.568LysSer: 1.568 ± 0.048	1.821LysThr: 1.821 ± 0.046	2.397LysVal: 2.397 ± 0.06	0.317LysTrp: 0.317 ± 0.018	0.577LysTyr: 0.577 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	15.485LeuAla: 15.485 ± 0.156	1.153LeuCys: 1.153 ± 0.03	6.096LeuAsp: 6.096 ± 0.085	5.307LeuGlu: 5.307 ± 0.073	3.217LeuPhe: 3.217 ± 0.062	9.054LeuGly: 9.054 ± 0.122	2.962LeuHis: 2.962 ± 0.064	4.113LeuIle: 4.113 ± 0.071	3.53LeuLys: 3.53 ± 0.062	11.41LeuLeu: 11.41 ± 0.153	2.552LeuMet: 2.552 ± 0.05	2.933LeuAsn: 2.933 ± 0.058	6.658LeuPro: 6.658 ± 0.082	4.02LeuGln: 4.02 ± 0.061	8.615LeuArg: 8.615 ± 0.108	6.402LeuSer: 6.402 ± 0.093	6.157LeuThr: 6.157 ± 0.079	7.718LeuVal: 7.718 ± 0.106	1.714LeuTrp: 1.714 ± 0.046	1.998LeuTyr: 1.998 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	3.025MetAla: 3.025 ± 0.054	0.203MetCys: 0.203 ± 0.013	1.054MetAsp: 1.054 ± 0.037	0.985MetGlu: 0.985 ± 0.033	0.618MetPhe: 0.618 ± 0.024	1.863MetGly: 1.863 ± 0.044	0.601MetHis: 0.601 ± 0.024	0.903MetIle: 0.903 ± 0.031	0.851MetLys: 0.851 ± 0.025	2.567MetLeu: 2.567 ± 0.049	0.631MetMet: 0.631 ± 0.025	0.84MetAsn: 0.84 ± 0.027	1.335MetPro: 1.335 ± 0.032	1.046MetGln: 1.046 ± 0.03	1.628MetArg: 1.628 ± 0.033	1.475MetSer: 1.475 ± 0.036	1.421MetThr: 1.421 ± 0.034	1.726MetVal: 1.726 ± 0.042	0.244MetTrp: 0.244 ± 0.014	0.299MetTyr: 0.299 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.043AsnAla: 3.043 ± 0.064	0.239AsnCys: 0.239 ± 0.016	1.415AsnAsp: 1.415 ± 0.075	1.121AsnGlu: 1.121 ± 0.035	0.86AsnPhe: 0.86 ± 0.03	2.196AsnGly: 2.196 ± 0.062	0.552AsnHis: 0.552 ± 0.02	1.027AsnIle: 1.027 ± 0.035	0.727AsnLys: 0.727 ± 0.027	2.545AsnLeu: 2.545 ± 0.066	0.495AsnMet: 0.495 ± 0.02	0.733AsnAsn: 0.733 ± 0.04	1.769AsnPro: 1.769 ± 0.042	0.915AsnGln: 0.915 ± 0.026	1.64AsnArg: 1.64 ± 0.037	1.16AsnSer: 1.16 ± 0.049	1.43AsnThr: 1.43 ± 0.043	1.866AsnVal: 1.866 ± 0.047	0.419AsnTrp: 0.419 ± 0.021	0.552AsnTyr: 0.552 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	7.335ProAla: 7.335 ± 0.107	0.449ProCys: 0.449 ± 0.023	3.374ProAsp: 3.374 ± 0.07	3.655ProGlu: 3.655 ± 0.06	1.668ProPhe: 1.668 ± 0.04	4.671ProGly: 4.671 ± 0.074	1.349ProHis: 1.349 ± 0.038	1.823ProIle: 1.823 ± 0.039	1.407ProLys: 1.407 ± 0.036	5.572ProLeu: 5.572 ± 0.083	1.441ProMet: 1.441 ± 0.037	1.279ProAsn: 1.279 ± 0.035	3.366ProPro: 3.366 ± 0.092	2.318ProGln: 2.318 ± 0.048	3.081ProArg: 3.081 ± 0.054	3.023ProSer: 3.023 ± 0.061	3.117ProThr: 3.117 ± 0.052	4.556ProVal: 4.556 ± 0.077	0.97ProTrp: 0.97 ± 0.034	1.063ProTyr: 1.063 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	6.975GlnAla: 6.975 ± 0.108	0.33GlnCys: 0.33 ± 0.019	1.778GlnAsp: 1.778 ± 0.044	1.714GlnGlu: 1.714 ± 0.049	1.213GlnPhe: 1.213 ± 0.031	3.517GlnGly: 3.517 ± 0.067	1.268GlnHis: 1.268 ± 0.037	1.66GlnIle: 1.66 ± 0.041	1.001GlnLys: 1.001 ± 0.034	4.496GlnLeu: 4.496 ± 0.073	1.004GlnMet: 1.004 ± 0.033	0.791GlnAsn: 0.791 ± 0.03	2.742GlnPro: 2.742 ± 0.052	2.178GlnGln: 2.178 ± 0.06	4.336GlnArg: 4.336 ± 0.079	1.906GlnSer: 1.906 ± 0.051	2.219GlnThr: 2.219 ± 0.049	3.385GlnVal: 3.385 ± 0.064	0.735GlnTrp: 0.735 ± 0.028	0.675GlnTyr: 0.675 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	7.899ArgAla: 7.899 ± 0.091	0.828ArgCys: 0.828 ± 0.03	3.528ArgAsp: 3.528 ± 0.071	4.186ArgGlu: 4.186 ± 0.067	2.75ArgPhe: 2.75 ± 0.058	4.357ArgGly: 4.357 ± 0.069	2.244ArgHis: 2.244 ± 0.048	2.997ArgIle: 2.997 ± 0.053	1.818ArgLys: 1.818 ± 0.042	8.592ArgLeu: 8.592 ± 0.125	1.809ArgMet: 1.809 ± 0.04	1.666ArgAsn: 1.666 ± 0.043	3.713ArgPro: 3.713 ± 0.067	3.786ArgGln: 3.786 ± 0.063	5.419ArgArg: 5.419 ± 0.08	3.424ArgSer: 3.424 ± 0.051	3.334ArgThr: 3.334 ± 0.05	5.323ArgVal: 5.323 ± 0.082	1.656ArgTrp: 1.656 ± 0.049	1.764ArgTyr: 1.764 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	6.709SerAla: 6.709 ± 0.086	0.454SerCys: 0.454 ± 0.025	2.579SerAsp: 2.579 ± 0.056	2.419SerGlu: 2.419 ± 0.048	1.826SerPhe: 1.826 ± 0.043	4.952SerGly: 4.952 ± 0.092	1.285SerHis: 1.285 ± 0.034	1.917SerIle: 1.917 ± 0.046	1.31SerLys: 1.31 ± 0.042	5.625SerLeu: 5.625 ± 0.081	1.111SerMet: 1.111 ± 0.034	1.21SerAsn: 1.21 ± 0.038	3.061SerPro: 3.061 ± 0.069	1.932SerGln: 1.932 ± 0.038	3.196SerArg: 3.196 ± 0.055	3.002SerSer: 3.002 ± 0.088	3.035SerThr: 3.035 ± 0.089	4.167SerVal: 4.167 ± 0.074	0.814SerTrp: 0.814 ± 0.029	1.142SerTyr: 1.142 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	5.967ThrAla: 5.967 ± 0.093	0.496ThrCys: 0.496 ± 0.024	2.707ThrAsp: 2.707 ± 0.062	2.561ThrGlu: 2.561 ± 0.056	1.717ThrPhe: 1.717 ± 0.041	4.859ThrGly: 4.859 ± 0.128	1.397ThrHis: 1.397 ± 0.036	1.745ThrIle: 1.745 ± 0.043	1.199ThrLys: 1.199 ± 0.041	7.44ThrLeu: 7.44 ± 0.11	0.99ThrMet: 0.99 ± 0.03	1.11ThrAsn: 1.11 ± 0.033	4.035ThrPro: 4.035 ± 0.073	2.27ThrGln: 2.27 ± 0.042	3.46ThrArg: 3.46 ± 0.058	2.649ThrSer: 2.649 ± 0.066	2.875ThrThr: 2.875 ± 0.09	4.27ThrVal: 4.27 ± 0.075	0.916ThrTrp: 0.916 ± 0.029	1.132ThrTyr: 1.132 ± 0.055	0.0ThrXaa: 0.0 ± 0.0
Val	9.45ValAla: 9.45 ± 0.113	0.889ValCys: 0.889 ± 0.031	3.855ValAsp: 3.855 ± 0.074	4.101ValGlu: 4.101 ± 0.067	2.676ValPhe: 2.676 ± 0.052	5.607ValGly: 5.607 ± 0.078	1.619ValHis: 1.619 ± 0.037	3.31ValIle: 3.31 ± 0.064	2.288ValLys: 2.288 ± 0.057	8.937ValLeu: 8.937 ± 0.111	1.993ValMet: 1.993 ± 0.045	2.135ValAsn: 2.135 ± 0.044	4.269ValPro: 4.269 ± 0.066	3.284ValGln: 3.284 ± 0.062	5.421ValArg: 5.421 ± 0.078	4.315ValSer: 4.315 ± 0.065	4.094ValThr: 4.094 ± 0.064	6.313ValVal: 6.313 ± 0.093	1.237ValTrp: 1.237 ± 0.038	1.414ValTyr: 1.414 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.951TrpAla: 1.951 ± 0.05	0.209TrpCys: 0.209 ± 0.013	0.741TrpAsp: 0.741 ± 0.03	0.651TrpGlu: 0.651 ± 0.028	0.575TrpPhe: 0.575 ± 0.022	1.185TrpGly: 1.185 ± 0.04	0.531TrpHis: 0.531 ± 0.022	0.599TrpIle: 0.599 ± 0.021	0.447TrpLys: 0.447 ± 0.023	2.567TrpLeu: 2.567 ± 0.063	0.474TrpMet: 0.474 ± 0.02	0.393TrpAsn: 0.393 ± 0.019	0.992TrpPro: 0.992 ± 0.031	1.012TrpGln: 1.012 ± 0.029	1.62TrpArg: 1.62 ± 0.045	0.791TrpSer: 0.791 ± 0.032	0.663TrpThr: 0.663 ± 0.026	1.432TrpVal: 1.432 ± 0.041	0.423TrpTrp: 0.423 ± 0.029	0.296TrpTyr: 0.296 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.495TyrAla: 2.495 ± 0.053	0.214TyrCys: 0.214 ± 0.014	1.091TyrAsp: 1.091 ± 0.03	1.048TyrGlu: 1.048 ± 0.029	0.749TyrPhe: 0.749 ± 0.023	1.785TyrGly: 1.785 ± 0.046	0.475TyrHis: 0.475 ± 0.02	0.712TyrIle: 0.712 ± 0.027	0.594TyrLys: 0.594 ± 0.025	2.138TyrLeu: 2.138 ± 0.053	0.372TyrMet: 0.372 ± 0.016	0.582TyrAsn: 0.582 ± 0.023	0.968TyrPro: 0.968 ± 0.027	0.848TyrGln: 0.848 ± 0.028	1.602TyrArg: 1.602 ± 0.043	1.046TyrSer: 1.046 ± 0.033	1.253TyrThr: 1.253 ± 0.047	1.553TyrVal: 1.553 ± 0.043	0.352TyrTrp: 0.352 ± 0.017	0.501TyrTyr: 0.501 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3396 proteins (1110830 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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