Amino acid dipepetide frequency for Saccharothrix variisporea

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.645AlaAla: 19.645 ± 0.134	1.01AlaCys: 1.01 ± 0.022	8.37AlaAsp: 8.37 ± 0.066	8.545AlaGlu: 8.545 ± 0.077	3.679AlaPhe: 3.679 ± 0.041	12.257AlaGly: 12.257 ± 0.085	2.903AlaHis: 2.903 ± 0.037	3.566AlaIle: 3.566 ± 0.045	2.786AlaLys: 2.786 ± 0.039	14.837AlaLeu: 14.837 ± 0.101	2.24AlaMet: 2.24 ± 0.031	2.256AlaAsn: 2.256 ± 0.028	6.07AlaPro: 6.07 ± 0.064	3.53AlaGln: 3.53 ± 0.036	9.874AlaArg: 9.874 ± 0.079	5.589AlaSer: 5.589 ± 0.044	7.261AlaThr: 7.261 ± 0.057	13.444AlaVal: 13.444 ± 0.084	1.918AlaTrp: 1.918 ± 0.026	2.311AlaTyr: 2.311 ± 0.031	0.0AlaXaa: 0.0 ± 0.0
Cys	1.052CysAla: 1.052 ± 0.02	0.086CysCys: 0.086 ± 0.006	0.453CysAsp: 0.453 ± 0.014	0.356CysGlu: 0.356 ± 0.011	0.205CysPhe: 0.205 ± 0.008	0.883CysGly: 0.883 ± 0.019	0.202CysHis: 0.202 ± 0.01	0.136CysIle: 0.136 ± 0.008	0.123CysLys: 0.123 ± 0.006	0.708CysLeu: 0.708 ± 0.014	0.105CysMet: 0.105 ± 0.005	0.128CysAsn: 0.128 ± 0.007	0.443CysPro: 0.443 ± 0.014	0.17CysGln: 0.17 ± 0.008	0.582CysArg: 0.582 ± 0.016	0.425CysSer: 0.425 ± 0.013	0.5CysThr: 0.5 ± 0.014	0.671CysVal: 0.671 ± 0.018	0.123CysTrp: 0.123 ± 0.007	0.153CysTyr: 0.153 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.463AspAla: 7.463 ± 0.062	0.416AspCys: 0.416 ± 0.015	3.924AspAsp: 3.924 ± 0.046	3.762AspGlu: 3.762 ± 0.044	1.746AspPhe: 1.746 ± 0.027	6.146AspGly: 6.146 ± 0.052	1.691AspHis: 1.691 ± 0.026	1.578AspIle: 1.578 ± 0.025	1.131AspLys: 1.131 ± 0.024	7.159AspLeu: 7.159 ± 0.052	0.707AspMet: 0.707 ± 0.015	1.116AspAsn: 1.116 ± 0.022	4.712AspPro: 4.712 ± 0.047	1.781AspGln: 1.781 ± 0.027	5.39AspArg: 5.39 ± 0.048	2.304AspSer: 2.304 ± 0.031	3.222AspThr: 3.222 ± 0.04	5.896AspVal: 5.896 ± 0.05	0.991AspTrp: 0.991 ± 0.017	1.207AspTyr: 1.207 ± 0.023	0.0AspXaa: 0.0 ± 0.0
Glu	6.644GluAla: 6.644 ± 0.066	0.338GluCys: 0.338 ± 0.011	2.832GluAsp: 2.832 ± 0.033	2.897GluGlu: 2.897 ± 0.044	1.663GluPhe: 1.663 ± 0.027	3.696GluGly: 3.696 ± 0.035	1.69GluHis: 1.69 ± 0.027	1.854GluIle: 1.854 ± 0.027	1.163GluLys: 1.163 ± 0.026	6.792GluLeu: 6.792 ± 0.061	0.728GluMet: 0.728 ± 0.016	0.953GluAsn: 0.953 ± 0.02	3.41GluPro: 3.41 ± 0.042	2.112GluGln: 2.112 ± 0.027	4.993GluArg: 4.993 ± 0.053	2.299GluSer: 2.299 ± 0.031	2.447GluThr: 2.447 ± 0.031	5.67GluVal: 5.67 ± 0.052	0.861GluTrp: 0.861 ± 0.018	1.017GluTyr: 1.017 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	3.975PheAla: 3.975 ± 0.04	0.244PheCys: 0.244 ± 0.009	2.243PheAsp: 2.243 ± 0.032	1.465PheGlu: 1.465 ± 0.025	0.861PhePhe: 0.861 ± 0.017	3.222PheGly: 3.222 ± 0.039	0.641PheHis: 0.641 ± 0.015	0.634PheIle: 0.634 ± 0.017	0.481PheLys: 0.481 ± 0.013	2.691PheLeu: 2.691 ± 0.035	0.323PheMet: 0.323 ± 0.011	0.564PheAsn: 0.564 ± 0.016	1.449PhePro: 1.449 ± 0.026	0.691PheGln: 0.691 ± 0.016	1.996PheArg: 1.996 ± 0.026	1.467PheSer: 1.467 ± 0.023	2.264PheThr: 2.264 ± 0.026	2.543PheVal: 2.543 ± 0.032	0.404PheTrp: 0.404 ± 0.013	0.575PheTyr: 0.575 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	10.057GlyAla: 10.057 ± 0.071	0.785GlyCys: 0.785 ± 0.02	5.222GlyAsp: 5.222 ± 0.053	4.777GlyGlu: 4.777 ± 0.042	3.036GlyPhe: 3.036 ± 0.037	8.555GlyGly: 8.555 ± 0.098	2.159GlyHis: 2.159 ± 0.029	2.973GlyIle: 2.973 ± 0.032	2.326GlyLys: 2.326 ± 0.035	9.329GlyLeu: 9.329 ± 0.065	1.788GlyMet: 1.788 ± 0.024	1.868GlyAsn: 1.868 ± 0.038	4.834GlyPro: 4.834 ± 0.048	2.516GlyGln: 2.516 ± 0.032	7.161GlyArg: 7.161 ± 0.052	4.997GlySer: 4.997 ± 0.051	6.213GlyThr: 6.213 ± 0.062	8.982GlyVal: 8.982 ± 0.076	1.748GlyTrp: 1.748 ± 0.027	2.278GlyTyr: 2.278 ± 0.031	0.0GlyXaa: 0.0 ± 0.0
His	2.724HisAla: 2.724 ± 0.034	0.197HisCys: 0.197 ± 0.008	1.563HisAsp: 1.563 ± 0.022	1.231HisGlu: 1.231 ± 0.022	0.641HisPhe: 0.641 ± 0.015	2.319HisGly: 2.319 ± 0.034	0.767HisHis: 0.767 ± 0.02	0.539HisIle: 0.539 ± 0.013	0.344HisLys: 0.344 ± 0.012	2.488HisLeu: 2.488 ± 0.029	0.267HisMet: 0.267 ± 0.01	0.427HisAsn: 0.427 ± 0.014	1.833HisPro: 1.833 ± 0.031	0.636HisGln: 0.636 ± 0.017	2.261HisArg: 2.261 ± 0.031	0.97HisSer: 0.97 ± 0.02	1.269HisThr: 1.269 ± 0.024	2.146HisVal: 2.146 ± 0.03	0.373HisTrp: 0.373 ± 0.012	0.505HisTyr: 0.505 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.646IleAla: 4.646 ± 0.044	0.214IleCys: 0.214 ± 0.009	1.93IleAsp: 1.93 ± 0.028	1.621IleGlu: 1.621 ± 0.026	0.604IlePhe: 0.604 ± 0.016	3.256IleGly: 3.256 ± 0.038	0.493IleHis: 0.493 ± 0.014	0.709IleIle: 0.709 ± 0.022	0.659IleLys: 0.659 ± 0.016	1.773IleLeu: 1.773 ± 0.029	0.359IleMet: 0.359 ± 0.014	0.605IleAsn: 0.605 ± 0.014	1.568IlePro: 1.568 ± 0.026	0.592IleGln: 0.592 ± 0.016	1.963IleArg: 1.963 ± 0.027	1.582IleSer: 1.582 ± 0.025	2.33IleThr: 2.33 ± 0.033	2.416IleVal: 2.416 ± 0.035	0.325IleTrp: 0.325 ± 0.011	0.463IleTyr: 0.463 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	2.721LysAla: 2.721 ± 0.041	0.125LysCys: 0.125 ± 0.007	1.071LysAsp: 1.071 ± 0.019	0.873LysGlu: 0.873 ± 0.02	0.523LysPhe: 0.523 ± 0.015	1.487LysGly: 1.487 ± 0.026	0.464LysHis: 0.464 ± 0.012	0.747LysIle: 0.747 ± 0.017	0.561LysLys: 0.561 ± 0.018	2.145LysLeu: 2.145 ± 0.031	0.315LysMet: 0.315 ± 0.012	0.406LysAsn: 0.406 ± 0.013	1.411LysPro: 1.411 ± 0.026	0.641LysGln: 0.641 ± 0.018	1.46LysArg: 1.46 ± 0.026	1.086LysSer: 1.086 ± 0.022	1.226LysThr: 1.226 ± 0.024	2.104LysVal: 2.104 ± 0.03	0.334LysTrp: 0.334 ± 0.012	0.43LysTyr: 0.43 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	15.545LeuAla: 15.545 ± 0.089	0.8LeuCys: 0.8 ± 0.016	7.292LeuAsp: 7.292 ± 0.062	4.708LeuGlu: 4.708 ± 0.045	2.687LeuPhe: 2.687 ± 0.035	9.387LeuGly: 9.387 ± 0.077	2.47LeuHis: 2.47 ± 0.034	2.662LeuIle: 2.662 ± 0.041	1.879LeuLys: 1.879 ± 0.03	11.07LeuLeu: 11.07 ± 0.095	1.368LeuMet: 1.368 ± 0.026	1.721LeuAsn: 1.721 ± 0.027	6.468LeuPro: 6.468 ± 0.054	1.908LeuGln: 1.908 ± 0.029	9.016LeuArg: 9.016 ± 0.061	5.427LeuSer: 5.427 ± 0.045	6.517LeuThr: 6.517 ± 0.055	10.998LeuVal: 10.998 ± 0.084	1.388LeuTrp: 1.388 ± 0.029	1.687LeuTyr: 1.687 ± 0.026	0.0LeuXaa: 0.0 ± 0.0
Met	1.996MetAla: 1.996 ± 0.027	0.105MetCys: 0.105 ± 0.006	0.718MetAsp: 0.718 ± 0.016	0.542MetGlu: 0.542 ± 0.014	0.424MetPhe: 0.424 ± 0.014	1.142MetGly: 1.142 ± 0.023	0.293MetHis: 0.293 ± 0.009	0.532MetIle: 0.532 ± 0.014	0.368MetLys: 0.368 ± 0.01	1.472MetLeu: 1.472 ± 0.024	0.216MetMet: 0.216 ± 0.009	0.341MetAsn: 0.341 ± 0.011	0.901MetPro: 0.901 ± 0.019	0.338MetGln: 0.338 ± 0.011	1.334MetArg: 1.334 ± 0.023	1.167MetSer: 1.167 ± 0.023	1.432MetThr: 1.432 ± 0.024	1.295MetVal: 1.295 ± 0.023	0.188MetTrp: 0.188 ± 0.009	0.237MetTyr: 0.237 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.373AsnAla: 2.373 ± 0.031	0.172AsnCys: 0.172 ± 0.008	1.003AsnAsp: 1.003 ± 0.021	0.76AsnGlu: 0.76 ± 0.02	0.51AsnPhe: 0.51 ± 0.016	2.12AsnGly: 2.12 ± 0.041	0.417AsnHis: 0.417 ± 0.012	0.561AsnIle: 0.561 ± 0.014	0.367AsnLys: 0.367 ± 0.013	1.856AsnLeu: 1.856 ± 0.03	0.255AsnMet: 0.255 ± 0.009	0.476AsnAsn: 0.476 ± 0.018	1.596AsnPro: 1.596 ± 0.027	0.58AsnGln: 0.58 ± 0.016	1.41AsnArg: 1.41 ± 0.025	0.887AsnSer: 0.887 ± 0.024	1.219AsnThr: 1.219 ± 0.026	1.481AsnVal: 1.481 ± 0.025	0.311AsnTrp: 0.311 ± 0.012	0.47AsnTyr: 0.47 ± 0.012	0.0AsnXaa: 0.0 ± 0.0
Pro	8.002ProAla: 8.002 ± 0.077	0.334ProCys: 0.334 ± 0.011	4.879ProAsp: 4.879 ± 0.047	4.08ProGlu: 4.08 ± 0.043	1.625ProPhe: 1.625 ± 0.025	6.162ProGly: 6.162 ± 0.06	1.364ProHis: 1.364 ± 0.025	1.42ProIle: 1.42 ± 0.023	1.194ProLys: 1.194 ± 0.022	5.202ProLeu: 5.202 ± 0.05	0.9ProMet: 0.9 ± 0.02	1.18ProAsn: 1.18 ± 0.023	3.842ProPro: 3.842 ± 0.068	1.526ProGln: 1.526 ± 0.024	3.766ProArg: 3.766 ± 0.037	3.008ProSer: 3.008 ± 0.04	3.813ProThr: 3.813 ± 0.042	5.959ProVal: 5.959 ± 0.052	0.966ProTrp: 0.966 ± 0.021	1.065ProTyr: 1.065 ± 0.022	0.0ProXaa: 0.0 ± 0.0
Gln	3.63GlnAla: 3.63 ± 0.043	0.156GlnCys: 0.156 ± 0.007	1.266GlnAsp: 1.266 ± 0.024	1.197GlnGlu: 1.197 ± 0.024	0.726GlnPhe: 0.726 ± 0.016	1.999GlnGly: 1.999 ± 0.027	0.632GlnHis: 0.632 ± 0.015	0.794GlnIle: 0.794 ± 0.018	0.505GlnLys: 0.505 ± 0.016	2.784GlnLeu: 2.784 ± 0.031	0.339GlnMet: 0.339 ± 0.012	0.507GlnAsn: 0.507 ± 0.013	1.816GlnPro: 1.816 ± 0.033	1.107GlnGln: 1.107 ± 0.025	2.455GlnArg: 2.455 ± 0.031	1.165GlnSer: 1.165 ± 0.02	1.278GlnThr: 1.278 ± 0.022	2.772GlnVal: 2.772 ± 0.033	0.516GlnTrp: 0.516 ± 0.014	0.537GlnTyr: 0.537 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	9.79ArgAla: 9.79 ± 0.082	0.586ArgCys: 0.586 ± 0.015	4.553ArgAsp: 4.553 ± 0.048	4.589ArgGlu: 4.589 ± 0.054	2.565ArgPhe: 2.565 ± 0.031	5.809ArgGly: 5.809 ± 0.044	2.069ArgHis: 2.069 ± 0.033	2.735ArgIle: 2.735 ± 0.032	1.723ArgLys: 1.723 ± 0.03	8.797ArgLeu: 8.797 ± 0.063	1.692ArgMet: 1.692 ± 0.027	1.488ArgAsn: 1.488 ± 0.025	4.606ArgPro: 4.606 ± 0.05	2.157ArgGln: 2.157 ± 0.026	7.551ArgArg: 7.551 ± 0.074	3.997ArgSer: 3.997 ± 0.039	5.032ArgThr: 5.032 ± 0.052	7.099ArgVal: 7.099 ± 0.053	1.515ArgTrp: 1.515 ± 0.025	1.847ArgTyr: 1.847 ± 0.027	0.0ArgXaa: 0.0 ± 0.0
Ser	6.44SerAla: 6.44 ± 0.05	0.395SerCys: 0.395 ± 0.013	2.578SerAsp: 2.578 ± 0.034	2.085SerGlu: 2.085 ± 0.034	1.55SerPhe: 1.55 ± 0.024	5.8SerGly: 5.8 ± 0.058	0.92SerHis: 0.92 ± 0.02	1.438SerIle: 1.438 ± 0.027	0.894SerLys: 0.894 ± 0.02	4.665SerLeu: 4.665 ± 0.044	0.898SerMet: 0.898 ± 0.019	0.908SerAsn: 0.908 ± 0.022	3.09SerPro: 3.09 ± 0.039	1.125SerGln: 1.125 ± 0.022	3.591SerArg: 3.591 ± 0.034	2.791SerSer: 2.791 ± 0.04	3.474SerThr: 3.474 ± 0.045	4.496SerVal: 4.496 ± 0.04	0.978SerTrp: 0.978 ± 0.02	1.114SerTyr: 1.114 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	8.854ThrAla: 8.854 ± 0.065	0.492ThrCys: 0.492 ± 0.014	3.609ThrAsp: 3.609 ± 0.038	2.897ThrGlu: 2.897 ± 0.033	1.773ThrPhe: 1.773 ± 0.026	6.58ThrGly: 6.58 ± 0.053	1.235ThrHis: 1.235 ± 0.023	1.859ThrIle: 1.859 ± 0.029	1.17ThrLys: 1.17 ± 0.022	5.591ThrLeu: 5.591 ± 0.043	0.85ThrMet: 0.85 ± 0.02	1.171ThrAsn: 1.171 ± 0.024	4.418ThrPro: 4.418 ± 0.056	1.29ThrGln: 1.29 ± 0.022	4.138ThrArg: 4.138 ± 0.045	3.488ThrSer: 3.488 ± 0.044	5.146ThrThr: 5.146 ± 0.074	6.105ThrVal: 6.105 ± 0.049	1.059ThrTrp: 1.059 ± 0.023	1.283ThrTyr: 1.283 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	12.543ValAla: 12.543 ± 0.082	0.729ValCys: 0.729 ± 0.017	6.569ValAsp: 6.569 ± 0.046	5.968ValGlu: 5.968 ± 0.048	2.726ValPhe: 2.726 ± 0.035	7.81ValGly: 7.81 ± 0.058	2.24ValHis: 2.24 ± 0.031	2.503ValIle: 2.503 ± 0.034	1.816ValLys: 1.816 ± 0.029	11.544ValLeu: 11.544 ± 0.077	1.234ValMet: 1.234 ± 0.023	1.85ValAsn: 1.85 ± 0.028	5.872ValPro: 5.872 ± 0.045	2.227ValGln: 2.227 ± 0.029	7.859ValArg: 7.859 ± 0.058	4.611ValSer: 4.611 ± 0.041	6.032ValThr: 6.032 ± 0.053	11.559ValVal: 11.559 ± 0.086	1.271ValTrp: 1.271 ± 0.023	1.585ValTyr: 1.585 ± 0.027	0.0ValXaa: 0.0 ± 0.0
Trp	1.675TrpAla: 1.675 ± 0.025	0.161TrpCys: 0.161 ± 0.008	0.905TrpAsp: 0.905 ± 0.022	0.681TrpGlu: 0.681 ± 0.017	0.546TrpPhe: 0.546 ± 0.014	1.088TrpGly: 1.088 ± 0.02	0.423TrpHis: 0.423 ± 0.012	0.482TrpIle: 0.482 ± 0.014	0.29TrpLys: 0.29 ± 0.011	1.922TrpLeu: 1.922 ± 0.027	0.267TrpMet: 0.267 ± 0.012	0.431TrpAsn: 0.431 ± 0.014	0.85TrpPro: 0.85 ± 0.019	0.623TrpGln: 0.623 ± 0.016	1.515TrpArg: 1.515 ± 0.025	1.02TrpSer: 1.02 ± 0.02	1.153TrpThr: 1.153 ± 0.023	1.267TrpVal: 1.267 ± 0.021	0.398TrpTrp: 0.398 ± 0.013	0.328TrpTyr: 0.328 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.316TyrAla: 2.316 ± 0.026	0.159TyrCys: 0.159 ± 0.009	1.361TyrAsp: 1.361 ± 0.028	1.027TyrGlu: 1.027 ± 0.02	0.643TyrPhe: 0.643 ± 0.015	1.887TyrGly: 1.887 ± 0.032	0.425TyrHis: 0.425 ± 0.012	0.386TyrIle: 0.386 ± 0.012	0.349TyrLys: 0.349 ± 0.013	2.173TyrLeu: 2.173 ± 0.031	0.193TyrMet: 0.193 ± 0.008	0.428TyrAsn: 0.428 ± 0.014	1.097TyrPro: 1.097 ± 0.019	0.634TyrGln: 0.634 ± 0.017	1.881TyrArg: 1.881 ± 0.03	0.952TyrSer: 0.952 ± 0.021	1.18TyrThr: 1.18 ± 0.025	1.648TyrVal: 1.648 ± 0.028	0.357TyrTrp: 0.357 ± 0.013	0.493TyrTyr: 0.493 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8276 proteins (2813303 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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