Amino acid dipepetide frequency for Streptococcus satellite phage Javan337

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.0AlaCys: 0.0 ± 0.0
2.711AlaAsp: 2.711 ± 1.274
3.05AlaGlu: 3.05 ± 1.154
3.389AlaPhe: 3.389 ± 0.782
2.372AlaGly: 2.372 ± 1.03
0.678AlaHis: 0.678 ± 0.542
3.389AlaIle: 3.389 ± 1.003
6.777AlaLys: 6.777 ± 1.44
4.744AlaLeu: 4.744 ± 1.459
1.355AlaMet: 1.355 ± 0.579
2.372AlaAsn: 2.372 ± 0.881
0.678AlaPro: 0.678 ± 0.364
0.339AlaGln: 0.339 ± 0.321
2.372AlaArg: 2.372 ± 0.949
4.066AlaSer: 4.066 ± 1.125
4.066AlaThr: 4.066 ± 0.834
2.033AlaVal: 2.033 ± 0.835
1.017AlaTrp: 1.017 ± 0.567
1.355AlaTyr: 1.355 ± 0.813
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.678CysGlu: 0.678 ± 0.473
0.0CysPhe: 0.0 ± 0.0
0.678CysGly: 0.678 ± 0.523
0.339CysHis: 0.339 ± 0.349
0.0CysIle: 0.0 ± 0.0
0.339CysLys: 0.339 ± 0.357
0.339CysLeu: 0.339 ± 0.349
0.339CysMet: 0.339 ± 0.38
0.339CysAsn: 0.339 ± 0.375
0.339CysPro: 0.339 ± 0.349
0.0CysGln: 0.0 ± 0.0
0.339CysArg: 0.339 ± 0.3
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.339CysVal: 0.339 ± 0.286
0.0CysTrp: 0.0 ± 0.0
0.339CysTyr: 0.339 ± 0.286
0.0CysXaa: 0.0 ± 0.0
Asp
0.678AspAla: 0.678 ± 0.462
0.339AspCys: 0.339 ± 0.343
6.1AspAsp: 6.1 ± 1.065
4.744AspGlu: 4.744 ± 1.306
2.711AspPhe: 2.711 ± 1.27
3.05AspGly: 3.05 ± 0.816
0.339AspHis: 0.339 ± 0.286
4.744AspIle: 4.744 ± 1.186
8.133AspLys: 8.133 ± 1.412
9.149AspLeu: 9.149 ± 2.772
0.678AspMet: 0.678 ± 0.434
4.405AspAsn: 4.405 ± 1.067
1.355AspPro: 1.355 ± 0.709
1.694AspGln: 1.694 ± 0.937
4.066AspArg: 4.066 ± 1.345
4.066AspSer: 4.066 ± 1.263
5.422AspThr: 5.422 ± 1.176
2.372AspVal: 2.372 ± 0.645
0.0AspTrp: 0.0 ± 0.0
4.405AspTyr: 4.405 ± 0.89
0.0AspXaa: 0.0 ± 0.0
Glu
4.066GluAla: 4.066 ± 1.144
0.339GluCys: 0.339 ± 0.349
4.744GluAsp: 4.744 ± 1.914
6.438GluGlu: 6.438 ± 1.366
3.389GluPhe: 3.389 ± 0.879
2.711GluGly: 2.711 ± 0.844
2.033GluHis: 2.033 ± 0.648
9.149GluIle: 9.149 ± 1.399
8.472GluLys: 8.472 ± 1.559
9.827GluLeu: 9.827 ± 1.817
2.711GluMet: 2.711 ± 1.047
6.438GluAsn: 6.438 ± 1.281
0.339GluPro: 0.339 ± 0.375
3.05GluGln: 3.05 ± 1.033
2.711GluArg: 2.711 ± 0.929
3.389GluSer: 3.389 ± 0.886
5.083GluThr: 5.083 ± 1.299
5.761GluVal: 5.761 ± 1.837
0.678GluTrp: 0.678 ± 0.399
4.066GluTyr: 4.066 ± 0.865
0.0GluXaa: 0.0 ± 0.0
Phe
1.694PheAla: 1.694 ± 0.681
0.0PheCys: 0.0 ± 0.0
5.422PheAsp: 5.422 ± 0.96
5.083PheGlu: 5.083 ± 0.879
3.05PhePhe: 3.05 ± 1.012
2.033PheGly: 2.033 ± 0.661
0.678PheHis: 0.678 ± 0.437
3.389PheIle: 3.389 ± 0.974
3.05PheLys: 3.05 ± 1.675
4.405PheLeu: 4.405 ± 1.129
1.355PheMet: 1.355 ± 0.746
0.339PheAsn: 0.339 ± 0.271
1.017PhePro: 1.017 ± 0.355
1.017PheGln: 1.017 ± 0.678
1.694PheArg: 1.694 ± 0.787
5.083PheSer: 5.083 ± 1.164
2.033PheThr: 2.033 ± 1.084
3.728PheVal: 3.728 ± 1.177
0.339PheTrp: 0.339 ± 0.286
2.033PheTyr: 2.033 ± 0.664
0.0PheXaa: 0.0 ± 0.0
Gly
2.711GlyAla: 2.711 ± 1.002
0.339GlyCys: 0.339 ± 0.349
3.728GlyAsp: 3.728 ± 1.091
3.389GlyGlu: 3.389 ± 0.873
2.711GlyPhe: 2.711 ± 0.915
2.033GlyGly: 2.033 ± 1.285
0.339GlyHis: 0.339 ± 0.349
2.372GlyIle: 2.372 ± 0.761
5.761GlyLys: 5.761 ± 1.554
4.405GlyLeu: 4.405 ± 1.199
1.017GlyMet: 1.017 ± 0.522
2.372GlyAsn: 2.372 ± 1.041
0.0GlyPro: 0.0 ± 0.0
1.017GlyGln: 1.017 ± 0.451
3.05GlyArg: 3.05 ± 0.964
2.033GlySer: 2.033 ± 1.204
2.372GlyThr: 2.372 ± 0.828
2.033GlyVal: 2.033 ± 0.758
1.355GlyTrp: 1.355 ± 0.728
3.389GlyTyr: 3.389 ± 0.862
0.0GlyXaa: 0.0 ± 0.0
His
2.033HisAla: 2.033 ± 1.06
0.0HisCys: 0.0 ± 0.0
0.678HisAsp: 0.678 ± 0.434
0.339HisGlu: 0.339 ± 0.405
1.355HisPhe: 1.355 ± 0.566
0.0HisGly: 0.0 ± 0.0
0.0HisHis: 0.0 ± 0.0
0.678HisIle: 0.678 ± 0.542
1.694HisLys: 1.694 ± 0.666
1.017HisLeu: 1.017 ± 0.748
0.0HisMet: 0.0 ± 0.0
0.0HisAsn: 0.0 ± 0.0
0.339HisPro: 0.339 ± 0.271
1.694HisGln: 1.694 ± 0.647
0.678HisArg: 0.678 ± 0.473
1.694HisSer: 1.694 ± 0.791
2.372HisThr: 2.372 ± 0.851
0.339HisVal: 0.339 ± 0.343
0.0HisTrp: 0.0 ± 0.0
1.694HisTyr: 1.694 ± 0.589
0.0HisXaa: 0.0 ± 0.0
Ile
3.389IleAla: 3.389 ± 1.277
0.339IleCys: 0.339 ± 0.375
2.711IleAsp: 2.711 ± 1.168
8.472IleGlu: 8.472 ± 2.07
1.355IlePhe: 1.355 ± 0.778
2.711IleGly: 2.711 ± 0.859
0.678IleHis: 0.678 ± 0.542
5.761IleIle: 5.761 ± 1.218
7.116IleLys: 7.116 ± 1.588
7.455IleLeu: 7.455 ± 1.208
1.017IleMet: 1.017 ± 0.462
3.389IleAsn: 3.389 ± 1.071
1.355IlePro: 1.355 ± 0.615
5.083IleGln: 5.083 ± 1.143
3.389IleArg: 3.389 ± 0.734
2.711IleSer: 2.711 ± 1.037
4.405IleThr: 4.405 ± 1.196
4.066IleVal: 4.066 ± 0.924
0.0IleTrp: 0.0 ± 0.0
2.033IleTyr: 2.033 ± 0.78
0.0IleXaa: 0.0 ± 0.0
Lys
6.777LysAla: 6.777 ± 1.547
0.339LysCys: 0.339 ± 0.341
7.794LysAsp: 7.794 ± 1.279
9.827LysGlu: 9.827 ± 1.89
5.083LysPhe: 5.083 ± 1.077
6.438LysGly: 6.438 ± 1.416
2.033LysHis: 2.033 ± 0.818
6.1LysIle: 6.1 ± 1.044
13.555LysLys: 13.555 ± 1.893
8.811LysLeu: 8.811 ± 1.126
3.389LysMet: 3.389 ± 1.194
5.761LysAsn: 5.761 ± 1.565
1.694LysPro: 1.694 ± 0.542
4.066LysGln: 4.066 ± 1.362
6.777LysArg: 6.777 ± 1.55
5.422LysSer: 5.422 ± 1.224
4.405LysThr: 4.405 ± 1.702
6.438LysVal: 6.438 ± 1.414
0.678LysTrp: 0.678 ± 0.454
3.728LysTyr: 3.728 ± 0.718
0.0LysXaa: 0.0 ± 0.0
Leu
5.761LeuAla: 5.761 ± 1.723
0.339LeuCys: 0.339 ± 0.38
8.133LeuAsp: 8.133 ± 1.134
11.183LeuGlu: 11.183 ± 1.849
6.1LeuPhe: 6.1 ± 1.972
6.777LeuGly: 6.777 ± 1.649
2.033LeuHis: 2.033 ± 0.966
5.761LeuIle: 5.761 ± 1.566
10.505LeuLys: 10.505 ± 1.087
8.472LeuLeu: 8.472 ± 1.888
1.017LeuMet: 1.017 ± 0.469
6.1LeuAsn: 6.1 ± 1.437
2.372LeuPro: 2.372 ± 1.008
3.728LeuGln: 3.728 ± 1.325
2.372LeuArg: 2.372 ± 1.129
8.133LeuSer: 8.133 ± 2.174
6.1LeuThr: 6.1 ± 1.709
4.405LeuVal: 4.405 ± 1.631
0.339LeuTrp: 0.339 ± 0.349
2.711LeuTyr: 2.711 ± 0.806
0.0LeuXaa: 0.0 ± 0.0
Met
0.678MetAla: 0.678 ± 0.41
0.0MetCys: 0.0 ± 0.0
2.711MetAsp: 2.711 ± 0.882
2.711MetGlu: 2.711 ± 0.994
0.678MetPhe: 0.678 ± 0.48
1.355MetGly: 1.355 ± 0.907
0.0MetHis: 0.0 ± 0.0
1.017MetIle: 1.017 ± 0.68
1.017MetLys: 1.017 ± 0.451
1.694MetLeu: 1.694 ± 0.624
1.355MetMet: 1.355 ± 0.712
1.694MetAsn: 1.694 ± 0.728
0.0MetPro: 0.0 ± 0.0
0.339MetGln: 0.339 ± 0.286
0.678MetArg: 0.678 ± 0.502
0.678MetSer: 0.678 ± 0.54
1.694MetThr: 1.694 ± 0.573
1.694MetVal: 1.694 ± 0.881
0.0MetTrp: 0.0 ± 0.0
0.678MetTyr: 0.678 ± 0.324
0.0MetXaa: 0.0 ± 0.0
Asn
3.389AsnAla: 3.389 ± 0.665
0.339AsnCys: 0.339 ± 0.403
4.066AsnAsp: 4.066 ± 0.941
4.066AsnGlu: 4.066 ± 1.39
2.372AsnPhe: 2.372 ± 0.88
3.05AsnGly: 3.05 ± 0.831
0.678AsnHis: 0.678 ± 0.511
3.728AsnIle: 3.728 ± 1.027
5.761AsnLys: 5.761 ± 1.449
6.1AsnLeu: 6.1 ± 1.43
0.678AsnMet: 0.678 ± 0.534
3.728AsnAsn: 3.728 ± 0.911
1.355AsnPro: 1.355 ± 0.428
2.372AsnGln: 2.372 ± 1.2
1.694AsnArg: 1.694 ± 0.809
2.033AsnSer: 2.033 ± 0.706
2.033AsnThr: 2.033 ± 0.747
2.711AsnVal: 2.711 ± 1.186
0.678AsnTrp: 0.678 ± 0.373
3.05AsnTyr: 3.05 ± 0.979
0.0AsnXaa: 0.0 ± 0.0
Pro
1.355ProAla: 1.355 ± 0.724
0.0ProCys: 0.0 ± 0.0
1.694ProAsp: 1.694 ± 0.65
0.339ProGlu: 0.339 ± 0.343
1.355ProPhe: 1.355 ± 0.618
0.678ProGly: 0.678 ± 0.48
0.339ProHis: 0.339 ± 0.294
1.694ProIle: 1.694 ± 0.639
3.389ProLys: 3.389 ± 1.189
1.355ProLeu: 1.355 ± 0.509
0.0ProMet: 0.0 ± 0.0
1.017ProAsn: 1.017 ± 0.568
2.372ProPro: 2.372 ± 1.127
0.678ProGln: 0.678 ± 0.449
1.694ProArg: 1.694 ± 0.85
0.339ProSer: 0.339 ± 0.341
1.694ProThr: 1.694 ± 0.701
0.0ProVal: 0.0 ± 0.0
0.0ProTrp: 0.0 ± 0.0
1.355ProTyr: 1.355 ± 0.581
0.0ProXaa: 0.0 ± 0.0
Gln
3.389GlnAla: 3.389 ± 0.888
0.339GlnCys: 0.339 ± 0.357
1.355GlnAsp: 1.355 ± 0.59
3.728GlnGlu: 3.728 ± 0.855
2.033GlnPhe: 2.033 ± 0.724
1.694GlnGly: 1.694 ± 0.828
1.017GlnHis: 1.017 ± 0.455
1.694GlnIle: 1.694 ± 0.661
4.066GlnLys: 4.066 ± 1.01
6.438GlnLeu: 6.438 ± 1.509
0.339GlnMet: 0.339 ± 0.403
2.033GlnAsn: 2.033 ± 0.552
0.339GlnPro: 0.339 ± 0.405
2.033GlnGln: 2.033 ± 0.59
2.033GlnArg: 2.033 ± 0.655
1.694GlnSer: 1.694 ± 0.675
2.372GlnThr: 2.372 ± 0.919
2.372GlnVal: 2.372 ± 1.108
0.678GlnTrp: 0.678 ± 0.419
1.355GlnTyr: 1.355 ± 0.388
0.0GlnXaa: 0.0 ± 0.0
Arg
1.694ArgAla: 1.694 ± 0.906
0.339ArgCys: 0.339 ± 0.286
2.372ArgAsp: 2.372 ± 1.035
3.728ArgGlu: 3.728 ± 1.224
2.033ArgPhe: 2.033 ± 0.683
3.05ArgGly: 3.05 ± 0.969
1.017ArgHis: 1.017 ± 0.637
3.728ArgIle: 3.728 ± 1.311
5.761ArgLys: 5.761 ± 1.552
5.083ArgLeu: 5.083 ± 1.421
1.694ArgMet: 1.694 ± 0.636
1.694ArgAsn: 1.694 ± 0.8
1.017ArgPro: 1.017 ± 0.515
3.389ArgGln: 3.389 ± 0.933
2.711ArgArg: 2.711 ± 1.083
1.694ArgSer: 1.694 ± 0.51
3.389ArgThr: 3.389 ± 0.846
0.678ArgVal: 0.678 ± 0.467
0.0ArgTrp: 0.0 ± 0.0
4.066ArgTyr: 4.066 ± 1.183
0.0ArgXaa: 0.0 ± 0.0
Ser
0.678SerAla: 0.678 ± 0.583
0.678SerCys: 0.678 ± 0.434
4.744SerAsp: 4.744 ± 1.327
3.728SerGlu: 3.728 ± 0.969
3.389SerPhe: 3.389 ± 0.676
2.711SerGly: 2.711 ± 0.892
1.017SerHis: 1.017 ± 0.59
3.05SerIle: 3.05 ± 0.781
6.1SerLys: 6.1 ± 1.52
5.422SerLeu: 5.422 ± 1.057
1.694SerMet: 1.694 ± 0.839
1.355SerAsn: 1.355 ± 0.606
1.694SerPro: 1.694 ± 0.644
4.066SerGln: 4.066 ± 1.168
2.372SerArg: 2.372 ± 0.781
2.711SerSer: 2.711 ± 0.899
4.066SerThr: 4.066 ± 1.063
3.389SerVal: 3.389 ± 1.275
1.017SerTrp: 1.017 ± 0.561
1.355SerTyr: 1.355 ± 0.455
0.0SerXaa: 0.0 ± 0.0
Thr
2.372ThrAla: 2.372 ± 1.162
0.0ThrCys: 0.0 ± 0.0
4.066ThrAsp: 4.066 ± 1.218
3.728ThrGlu: 3.728 ± 0.591
1.694ThrPhe: 1.694 ± 0.676
3.389ThrGly: 3.389 ± 0.794
2.033ThrHis: 2.033 ± 0.62
6.1ThrIle: 6.1 ± 1.173
4.744ThrLys: 4.744 ± 1.411
6.438ThrLeu: 6.438 ± 1.048
0.678ThrMet: 0.678 ± 0.475
3.389ThrAsn: 3.389 ± 0.637
2.372ThrPro: 2.372 ± 0.731
1.694ThrGln: 1.694 ± 0.567
4.066ThrArg: 4.066 ± 1.478
3.05ThrSer: 3.05 ± 1.023
2.711ThrThr: 2.711 ± 0.787
5.422ThrVal: 5.422 ± 1.973
0.0ThrTrp: 0.0 ± 0.0
1.694ThrTyr: 1.694 ± 0.823
0.0ThrXaa: 0.0 ± 0.0
Val
4.405ValAla: 4.405 ± 1.459
0.0ValCys: 0.0 ± 0.0
4.066ValAsp: 4.066 ± 1.696
5.083ValGlu: 5.083 ± 1.194
2.033ValPhe: 2.033 ± 0.688
0.678ValGly: 0.678 ± 0.454
0.678ValHis: 0.678 ± 0.324
2.372ValIle: 2.372 ± 0.724
5.761ValLys: 5.761 ± 1.215
3.389ValLeu: 3.389 ± 0.822
0.339ValMet: 0.339 ± 0.286
3.728ValAsn: 3.728 ± 0.827
1.694ValPro: 1.694 ± 0.61
1.355ValGln: 1.355 ± 0.743
3.389ValArg: 3.389 ± 1.157
3.728ValSer: 3.728 ± 1.264
4.744ValThr: 4.744 ± 1.487
3.05ValVal: 3.05 ± 0.722
0.0ValTrp: 0.0 ± 0.0
3.05ValTyr: 3.05 ± 0.893
0.0ValXaa: 0.0 ± 0.0
Trp
0.339TrpAla: 0.339 ± 0.349
0.339TrpCys: 0.339 ± 0.286
0.0TrpAsp: 0.0 ± 0.0
1.355TrpGlu: 1.355 ± 0.517
0.0TrpPhe: 0.0 ± 0.0
0.339TrpGly: 0.339 ± 0.286
0.0TrpHis: 0.0 ± 0.0
0.678TrpIle: 0.678 ± 0.432
0.678TrpLys: 0.678 ± 0.548
0.678TrpLeu: 0.678 ± 0.433
0.0TrpMet: 0.0 ± 0.0
0.339TrpAsn: 0.339 ± 0.343
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.678TrpArg: 0.678 ± 0.432
0.339TrpSer: 0.339 ± 0.349
0.339TrpThr: 0.339 ± 0.286
0.678TrpVal: 0.678 ± 0.511
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.355TyrAla: 1.355 ± 0.535
0.339TyrCys: 0.339 ± 0.349
1.355TyrAsp: 1.355 ± 0.495
3.728TyrGlu: 3.728 ± 1.017
2.711TyrPhe: 2.711 ± 1.066
0.678TyrGly: 0.678 ± 0.368
0.678TyrHis: 0.678 ± 0.424
2.033TyrIle: 2.033 ± 0.602
6.438TyrLys: 6.438 ± 1.949
7.116TyrLeu: 7.116 ± 1.249
0.678TyrMet: 0.678 ± 0.388
3.728TyrAsn: 3.728 ± 0.871
1.017TyrPro: 1.017 ± 0.437
3.389TyrGln: 3.389 ± 1.229
2.372TyrArg: 2.372 ± 0.895
2.372TyrSer: 2.372 ± 0.726
0.339TyrThr: 0.339 ± 0.375
2.033TyrVal: 2.033 ± 0.652
0.0TyrTrp: 0.0 ± 0.0
2.033TyrTyr: 2.033 ± 0.867
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 18 proteins (2952 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski