Amino acid dipepetide frequency for Bizionia argentinensis JUB59

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.212AlaAla: 4.212 ± 0.081
0.575AlaCys: 0.575 ± 0.027
3.378AlaAsp: 3.378 ± 0.06
4.114AlaGlu: 4.114 ± 0.084
3.637AlaPhe: 3.637 ± 0.069
3.981AlaGly: 3.981 ± 0.077
1.231AlaHis: 1.231 ± 0.04
5.771AlaIle: 5.771 ± 0.092
4.825AlaLys: 4.825 ± 0.087
6.579AlaLeu: 6.579 ± 0.097
1.59AlaMet: 1.59 ± 0.047
3.452AlaAsn: 3.452 ± 0.066
1.826AlaPro: 1.826 ± 0.059
2.372AlaGln: 2.372 ± 0.054
2.001AlaArg: 2.001 ± 0.049
4.145AlaSer: 4.145 ± 0.069
3.677AlaThr: 3.677 ± 0.087
4.102AlaVal: 4.102 ± 0.078
0.562AlaTrp: 0.562 ± 0.026
2.506AlaTyr: 2.506 ± 0.059
0.0AlaXaa: 0.0 ± 0.0
Cys
0.451CysAla: 0.451 ± 0.022
0.09CysCys: 0.09 ± 0.009
0.394CysAsp: 0.394 ± 0.022
0.463CysGlu: 0.463 ± 0.025
0.417CysPhe: 0.417 ± 0.027
0.567CysGly: 0.567 ± 0.025
0.184CysHis: 0.184 ± 0.017
0.555CysIle: 0.555 ± 0.029
0.452CysLys: 0.452 ± 0.022
0.632CysLeu: 0.632 ± 0.026
0.148CysMet: 0.148 ± 0.011
0.373CysAsn: 0.373 ± 0.023
0.329CysPro: 0.329 ± 0.022
0.233CysGln: 0.233 ± 0.015
0.195CysArg: 0.195 ± 0.013
0.498CysSer: 0.498 ± 0.026
0.388CysThr: 0.388 ± 0.037
0.426CysVal: 0.426 ± 0.022
0.057CysTrp: 0.057 ± 0.008
0.284CysTyr: 0.284 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
4.02AspAla: 4.02 ± 0.073
0.403AspCys: 0.403 ± 0.024
3.116AspAsp: 3.116 ± 0.066
3.667AspGlu: 3.667 ± 0.067
3.701AspPhe: 3.701 ± 0.065
3.312AspGly: 3.312 ± 0.081
0.922AspHis: 0.922 ± 0.033
4.583AspIle: 4.583 ± 0.077
4.188AspLys: 4.188 ± 0.074
5.399AspLeu: 5.399 ± 0.078
1.307AspMet: 1.307 ± 0.043
3.205AspAsn: 3.205 ± 0.066
1.523AspPro: 1.523 ± 0.055
1.415AspGln: 1.415 ± 0.038
1.796AspArg: 1.796 ± 0.048
3.492AspSer: 3.492 ± 0.066
2.906AspThr: 2.906 ± 0.051
3.899AspVal: 3.899 ± 0.066
0.628AspTrp: 0.628 ± 0.029
3.009AspTyr: 3.009 ± 0.065
0.0AspXaa: 0.0 ± 0.0
Glu
4.716GluAla: 4.716 ± 0.087
0.326GluCys: 0.326 ± 0.022
3.585GluAsp: 3.585 ± 0.071
4.366GluGlu: 4.366 ± 0.079
3.037GluPhe: 3.037 ± 0.062
3.477GluGly: 3.477 ± 0.065
1.17GluHis: 1.17 ± 0.037
5.518GluIle: 5.518 ± 0.074
5.511GluLys: 5.511 ± 0.085
6.148GluLeu: 6.148 ± 0.093
1.527GluMet: 1.527 ± 0.047
4.723GluAsn: 4.723 ± 0.073
1.627GluPro: 1.627 ± 0.042
2.223GluGln: 2.223 ± 0.051
2.551GluArg: 2.551 ± 0.053
3.642GluSer: 3.642 ± 0.057
4.206GluThr: 4.206 ± 0.064
4.004GluVal: 4.004 ± 0.071
0.584GluTrp: 0.584 ± 0.026
2.284GluTyr: 2.284 ± 0.053
0.0GluXaa: 0.0 ± 0.0
Phe
3.026PheAla: 3.026 ± 0.058
0.41PheCys: 0.41 ± 0.02
3.092PheAsp: 3.092 ± 0.064
3.472PheGlu: 3.472 ± 0.054
2.706PhePhe: 2.706 ± 0.071
3.672PheGly: 3.672 ± 0.074
0.926PheHis: 0.926 ± 0.03
4.376PheIle: 4.376 ± 0.089
4.195PheLys: 4.195 ± 0.074
4.715PheLeu: 4.715 ± 0.095
1.136PheMet: 1.136 ± 0.034
3.498PheAsn: 3.498 ± 0.074
1.699PhePro: 1.699 ± 0.048
1.682PheGln: 1.682 ± 0.044
1.555PheArg: 1.555 ± 0.039
4.147PheSer: 4.147 ± 0.076
3.165PheThr: 3.165 ± 0.07
2.994PheVal: 2.994 ± 0.061
0.555PheTrp: 0.555 ± 0.025
2.199PheTyr: 2.199 ± 0.052
0.0PheXaa: 0.0 ± 0.0
Gly
3.965GlyAla: 3.965 ± 0.079
0.572GlyCys: 0.572 ± 0.051
3.34GlyAsp: 3.34 ± 0.067
3.461GlyGlu: 3.461 ± 0.064
3.76GlyPhe: 3.76 ± 0.076
4.192GlyGly: 4.192 ± 0.095
1.153GlyHis: 1.153 ± 0.039
5.073GlyIle: 5.073 ± 0.089
4.597GlyLys: 4.597 ± 0.078
5.616GlyLeu: 5.616 ± 0.089
1.6GlyMet: 1.6 ± 0.046
3.443GlyAsn: 3.443 ± 0.068
1.234GlyPro: 1.234 ± 0.045
1.796GlyGln: 1.796 ± 0.049
1.956GlyArg: 1.956 ± 0.05
3.941GlySer: 3.941 ± 0.077
3.714GlyThr: 3.714 ± 0.102
4.368GlyVal: 4.368 ± 0.072
0.631GlyTrp: 0.631 ± 0.028
2.676GlyTyr: 2.676 ± 0.058
0.0GlyXaa: 0.0 ± 0.0
His
1.084HisAla: 1.084 ± 0.036
0.159HisCys: 0.159 ± 0.013
0.924HisAsp: 0.924 ± 0.035
1.076HisGlu: 1.076 ± 0.035
1.145HisPhe: 1.145 ± 0.038
1.056HisGly: 1.056 ± 0.038
0.479HisHis: 0.479 ± 0.024
1.697HisIle: 1.697 ± 0.045
1.244HisLys: 1.244 ± 0.037
1.764HisLeu: 1.764 ± 0.048
0.351HisMet: 0.351 ± 0.019
1.045HisAsn: 1.045 ± 0.036
0.848HisPro: 0.848 ± 0.027
0.663HisGln: 0.663 ± 0.031
0.623HisArg: 0.623 ± 0.026
1.037HisSer: 1.037 ± 0.038
0.958HisThr: 0.958 ± 0.032
1.053HisVal: 1.053 ± 0.031
0.215HisTrp: 0.215 ± 0.017
0.881HisTyr: 0.881 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
5.743IleAla: 5.743 ± 0.101
0.586IleCys: 0.586 ± 0.024
5.064IleAsp: 5.064 ± 0.072
5.475IleGlu: 5.475 ± 0.083
3.746IlePhe: 3.746 ± 0.06
5.255IleGly: 5.255 ± 0.087
1.449IleHis: 1.449 ± 0.038
6.844IleIle: 6.844 ± 0.096
6.256IleLys: 6.256 ± 0.072
7.434IleLeu: 7.434 ± 0.108
1.647IleMet: 1.647 ± 0.045
4.993IleAsn: 4.993 ± 0.078
3.306IlePro: 3.306 ± 0.068
2.693IleGln: 2.693 ± 0.057
2.491IleArg: 2.491 ± 0.058
6.071IleSer: 6.071 ± 0.086
5.172IleThr: 5.172 ± 0.095
4.859IleVal: 4.859 ± 0.083
0.679IleTrp: 0.679 ± 0.026
2.873IleTyr: 2.873 ± 0.059
0.0IleXaa: 0.0 ± 0.0
Lys
5.091LysAla: 5.091 ± 0.087
0.326LysCys: 0.326 ± 0.02
4.507LysAsp: 4.507 ± 0.072
5.773LysGlu: 5.773 ± 0.094
2.956LysPhe: 2.956 ± 0.061
4.263LysGly: 4.263 ± 0.061
1.544LysHis: 1.544 ± 0.046
6.005LysIle: 6.005 ± 0.1
6.452LysLys: 6.452 ± 0.103
6.819LysLeu: 6.819 ± 0.097
2.102LysMet: 2.102 ± 0.051
5.4LysAsn: 5.4 ± 0.089
2.653LysPro: 2.653 ± 0.063
3.027LysGln: 3.027 ± 0.062
3.091LysArg: 3.091 ± 0.064
4.909LysSer: 4.909 ± 0.085
5.108LysThr: 5.108 ± 0.087
4.329LysVal: 4.329 ± 0.08
0.758LysTrp: 0.758 ± 0.024
2.841LysTyr: 2.841 ± 0.065
0.0LysXaa: 0.0 ± 0.0
Leu
5.968LeuAla: 5.968 ± 0.087
0.626LeuCys: 0.626 ± 0.028
5.204LeuAsp: 5.204 ± 0.073
6.404LeuGlu: 6.404 ± 0.097
4.972LeuPhe: 4.972 ± 0.082
5.638LeuGly: 5.638 ± 0.096
1.594LeuHis: 1.594 ± 0.049
7.616LeuIle: 7.616 ± 0.118
8.166LeuLys: 8.166 ± 0.119
8.685LeuLeu: 8.685 ± 0.141
2.185LeuMet: 2.185 ± 0.051
5.953LeuAsn: 5.953 ± 0.086
3.35LeuPro: 3.35 ± 0.063
3.306LeuGln: 3.306 ± 0.068
2.992LeuArg: 2.992 ± 0.062
6.368LeuSer: 6.368 ± 0.098
5.225LeuThr: 5.225 ± 0.083
5.578LeuVal: 5.578 ± 0.086
0.765LeuTrp: 0.765 ± 0.032
3.187LeuTyr: 3.187 ± 0.064
0.0LeuXaa: 0.0 ± 0.0
Met
1.795MetAla: 1.795 ± 0.042
0.147MetCys: 0.147 ± 0.014
1.313MetAsp: 1.313 ± 0.04
1.393MetGlu: 1.393 ± 0.04
0.979MetPhe: 0.979 ± 0.036
1.337MetGly: 1.337 ± 0.041
0.408MetHis: 0.408 ± 0.024
1.676MetIle: 1.676 ± 0.044
2.244MetLys: 2.244 ± 0.052
2.102MetLeu: 2.102 ± 0.05
0.603MetMet: 0.603 ± 0.03
1.27MetAsn: 1.27 ± 0.04
0.843MetPro: 0.843 ± 0.028
0.871MetGln: 0.871 ± 0.033
0.892MetArg: 0.892 ± 0.031
1.526MetSer: 1.526 ± 0.042
1.287MetThr: 1.287 ± 0.037
1.427MetVal: 1.427 ± 0.044
0.149MetTrp: 0.149 ± 0.014
0.703MetTyr: 0.703 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
3.847AsnAla: 3.847 ± 0.063
0.448AsnCys: 0.448 ± 0.022
3.365AsnAsp: 3.365 ± 0.064
3.653AsnGlu: 3.653 ± 0.059
3.145AsnPhe: 3.145 ± 0.073
3.672AsnGly: 3.672 ± 0.086
1.241AsnHis: 1.241 ± 0.046
5.063AsnIle: 5.063 ± 0.075
4.599AsnLys: 4.599 ± 0.094
5.556AsnLeu: 5.556 ± 0.099
1.444AsnMet: 1.444 ± 0.041
4.078AsnAsn: 4.078 ± 0.087
2.74AsnPro: 2.74 ± 0.061
2.348AsnGln: 2.348 ± 0.056
2.223AsnArg: 2.223 ± 0.051
3.839AsnSer: 3.839 ± 0.068
3.808AsnThr: 3.808 ± 0.072
3.546AsnVal: 3.546 ± 0.056
0.738AsnTrp: 0.738 ± 0.027
2.946AsnTyr: 2.946 ± 0.069
0.0AsnXaa: 0.0 ± 0.0
Pro
1.772ProAla: 1.772 ± 0.051
0.213ProCys: 0.213 ± 0.018
1.942ProAsp: 1.942 ± 0.048
2.92ProGlu: 2.92 ± 0.057
1.948ProPhe: 1.948 ± 0.047
1.737ProGly: 1.737 ± 0.047
0.58ProHis: 0.58 ± 0.025
2.78ProIle: 2.78 ± 0.051
2.546ProLys: 2.546 ± 0.056
2.842ProLeu: 2.842 ± 0.059
0.742ProMet: 0.742 ± 0.026
2.197ProAsn: 2.197 ± 0.048
0.735ProPro: 0.735 ± 0.042
1.049ProGln: 1.049 ± 0.034
0.888ProArg: 0.888 ± 0.033
1.993ProSer: 1.993 ± 0.039
1.913ProThr: 1.913 ± 0.059
2.159ProVal: 2.159 ± 0.053
0.272ProTrp: 0.272 ± 0.018
1.306ProTyr: 1.306 ± 0.039
0.0ProXaa: 0.0 ± 0.0
Gln
2.221GlnAla: 2.221 ± 0.051
0.16GlnCys: 0.16 ± 0.013
1.829GlnAsp: 1.829 ± 0.041
2.335GlnGlu: 2.335 ± 0.057
1.757GlnPhe: 1.757 ± 0.048
1.807GlnGly: 1.807 ± 0.045
0.605GlnHis: 0.605 ± 0.024
2.722GlnIle: 2.722 ± 0.054
2.61GlnLys: 2.61 ± 0.057
3.551GlnLeu: 3.551 ± 0.075
0.812GlnMet: 0.812 ± 0.026
2.202GlnAsn: 2.202 ± 0.05
1.062GlnPro: 1.062 ± 0.036
1.311GlnGln: 1.311 ± 0.041
1.17GlnArg: 1.17 ± 0.041
1.977GlnSer: 1.977 ± 0.042
1.969GlnThr: 1.969 ± 0.048
2.091GlnVal: 2.091 ± 0.049
0.282GlnTrp: 0.282 ± 0.02
1.251GlnTyr: 1.251 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
2.023ArgAla: 2.023 ± 0.049
0.182ArgCys: 0.182 ± 0.013
1.879ArgAsp: 1.879 ± 0.042
2.181ArgGlu: 2.181 ± 0.052
1.854ArgPhe: 1.854 ± 0.047
1.884ArgGly: 1.884 ± 0.046
0.625ArgHis: 0.625 ± 0.025
2.878ArgIle: 2.878 ± 0.053
2.59ArgLys: 2.59 ± 0.052
3.297ArgLeu: 3.297 ± 0.06
0.85ArgMet: 0.85 ± 0.034
2.057ArgAsn: 2.057 ± 0.048
0.952ArgPro: 0.952 ± 0.037
1.122ArgGln: 1.122 ± 0.035
1.279ArgArg: 1.279 ± 0.045
1.891ArgSer: 1.891 ± 0.046
1.731ArgThr: 1.731 ± 0.046
2.111ArgVal: 2.111 ± 0.056
0.345ArgTrp: 0.345 ± 0.017
1.466ArgTyr: 1.466 ± 0.044
0.0ArgXaa: 0.0 ± 0.0
Ser
3.873SerAla: 3.873 ± 0.081
0.616SerCys: 0.616 ± 0.026
3.598SerAsp: 3.598 ± 0.057
4.244SerGlu: 4.244 ± 0.086
3.718SerPhe: 3.718 ± 0.069
4.639SerGly: 4.639 ± 0.087
1.161SerHis: 1.161 ± 0.036
5.409SerIle: 5.409 ± 0.071
5.059SerLys: 5.059 ± 0.091
6.014SerLeu: 6.014 ± 0.083
1.353SerMet: 1.353 ± 0.039
4.032SerAsn: 4.032 ± 0.076
1.95SerPro: 1.95 ± 0.05
2.209SerGln: 2.209 ± 0.048
2.052SerArg: 2.052 ± 0.048
4.161SerSer: 4.161 ± 0.083
3.458SerThr: 3.458 ± 0.074
4.11SerVal: 4.11 ± 0.075
0.642SerTrp: 0.642 ± 0.027
2.791SerTyr: 2.791 ± 0.069
0.0SerXaa: 0.0 ± 0.0
Thr
3.743ThrAla: 3.743 ± 0.087
0.417ThrCys: 0.417 ± 0.028
3.534ThrAsp: 3.534 ± 0.074
3.653ThrGlu: 3.653 ± 0.069
3.063ThrPhe: 3.063 ± 0.05
3.815ThrGly: 3.815 ± 0.103
1.03ThrHis: 1.03 ± 0.038
5.28ThrIle: 5.28 ± 0.085
3.932ThrLys: 3.932 ± 0.054
5.549ThrLeu: 5.549 ± 0.078
1.067ThrMet: 1.067 ± 0.038
3.495ThrAsn: 3.495 ± 0.074
2.216ThrPro: 2.216 ± 0.062
1.809ThrGln: 1.809 ± 0.043
1.658ThrArg: 1.658 ± 0.044
3.728ThrSer: 3.728 ± 0.07
3.435ThrThr: 3.435 ± 0.08
3.888ThrVal: 3.888 ± 0.097
0.549ThrTrp: 0.549 ± 0.029
2.513ThrTyr: 2.513 ± 0.081
0.0ThrXaa: 0.0 ± 0.0
Val
4.092ValAla: 4.092 ± 0.071
0.478ValCys: 0.478 ± 0.025
3.544ValAsp: 3.544 ± 0.063
3.846ValGlu: 3.846 ± 0.062
3.574ValPhe: 3.574 ± 0.076
3.762ValGly: 3.762 ± 0.071
0.991ValHis: 0.991 ± 0.035
5.115ValIle: 5.115 ± 0.076
4.489ValLys: 4.489 ± 0.074
6.212ValLeu: 6.212 ± 0.085
1.383ValMet: 1.383 ± 0.043
3.496ValAsn: 3.496 ± 0.061
2.066ValPro: 2.066 ± 0.051
1.707ValGln: 1.707 ± 0.045
1.929ValArg: 1.929 ± 0.045
4.601ValSer: 4.601 ± 0.074
3.537ValThr: 3.537 ± 0.106
4.08ValVal: 4.08 ± 0.074
0.535ValTrp: 0.535 ± 0.027
2.292ValTyr: 2.292 ± 0.044
0.0ValXaa: 0.0 ± 0.0
Trp
0.547TrpAla: 0.547 ± 0.025
0.094TrpCys: 0.094 ± 0.01
0.558TrpAsp: 0.558 ± 0.024
0.592TrpGlu: 0.592 ± 0.025
0.606TrpPhe: 0.606 ± 0.027
0.517TrpGly: 0.517 ± 0.023
0.224TrpHis: 0.224 ± 0.014
0.703TrpIle: 0.703 ± 0.03
0.71TrpLys: 0.71 ± 0.03
0.991TrpLeu: 0.991 ± 0.035
0.307TrpMet: 0.307 ± 0.019
0.636TrpAsn: 0.636 ± 0.027
0.206TrpPro: 0.206 ± 0.014
0.348TrpGln: 0.348 ± 0.019
0.387TrpArg: 0.387 ± 0.018
0.528TrpSer: 0.528 ± 0.025
0.477TrpThr: 0.477 ± 0.025
0.534TrpVal: 0.534 ± 0.025
0.128TrpTrp: 0.128 ± 0.014
0.404TrpTyr: 0.404 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.346TyrAla: 2.346 ± 0.052
0.308TyrCys: 0.308 ± 0.018
2.323TyrAsp: 2.323 ± 0.054
2.137TyrGlu: 2.137 ± 0.052
2.5TyrPhe: 2.5 ± 0.058
2.506TyrGly: 2.506 ± 0.049
0.786TyrHis: 0.786 ± 0.029
2.972TyrIle: 2.972 ± 0.063
3.288TyrLys: 3.288 ± 0.064
3.877TyrLeu: 3.877 ± 0.074
0.809TyrMet: 0.809 ± 0.03
2.753TyrAsn: 2.753 ± 0.063
1.37TyrPro: 1.37 ± 0.035
1.539TyrGln: 1.539 ± 0.047
1.468TyrArg: 1.468 ± 0.044
2.595TyrSer: 2.595 ± 0.063
2.241TyrThr: 2.241 ± 0.067
2.17TyrVal: 2.17 ± 0.047
0.423TyrTrp: 0.423 ± 0.022
1.806TyrTyr: 1.806 ± 0.048
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2926 proteins (948185 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski