Amino acid dipepetide frequency for Lactobacillus phage phi jlb1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.944AlaAla: 6.944 ± 2.876
0.264AlaCys: 0.264 ± 0.139
5.625AlaAsp: 5.625 ± 0.482
4.483AlaGlu: 4.483 ± 0.689
1.846AlaPhe: 1.846 ± 0.491
5.713AlaGly: 5.713 ± 1.056
0.527AlaHis: 0.527 ± 0.226
5.098AlaIle: 5.098 ± 1.064
6.768AlaLys: 6.768 ± 0.85
7.032AlaLeu: 7.032 ± 1.72
2.813AlaMet: 2.813 ± 0.826
4.571AlaAsn: 4.571 ± 0.911
1.494AlaPro: 1.494 ± 0.463
2.725AlaGln: 2.725 ± 0.453
2.373AlaArg: 2.373 ± 0.481
4.131AlaSer: 4.131 ± 0.882
5.01AlaThr: 5.01 ± 0.726
6.416AlaVal: 6.416 ± 2.027
0.967AlaTrp: 0.967 ± 0.259
2.461AlaTyr: 2.461 ± 0.484
0.0AlaXaa: 0.0 ± 0.0
Cys
0.176CysAla: 0.176 ± 0.131
0.088CysCys: 0.088 ± 0.095
0.703CysAsp: 0.703 ± 0.216
0.439CysGlu: 0.439 ± 0.207
0.088CysPhe: 0.088 ± 0.089
0.264CysGly: 0.264 ± 0.181
0.088CysHis: 0.088 ± 0.082
0.439CysIle: 0.439 ± 0.222
0.088CysLys: 0.088 ± 0.086
0.527CysLeu: 0.527 ± 0.227
0.088CysMet: 0.088 ± 0.092
0.264CysAsn: 0.264 ± 0.172
0.264CysPro: 0.264 ± 0.214
0.088CysGln: 0.088 ± 0.086
0.176CysArg: 0.176 ± 0.115
0.439CysSer: 0.439 ± 0.19
0.527CysThr: 0.527 ± 0.223
0.352CysVal: 0.352 ± 0.207
0.0CysTrp: 0.0 ± 0.0
0.264CysTyr: 0.264 ± 0.143
0.0CysXaa: 0.0 ± 0.0
Asp
5.625AspAla: 5.625 ± 0.841
0.264AspCys: 0.264 ± 0.134
5.889AspAsp: 5.889 ± 0.728
4.659AspGlu: 4.659 ± 0.691
2.901AspPhe: 2.901 ± 0.471
4.043AspGly: 4.043 ± 0.504
0.703AspHis: 0.703 ± 0.334
4.131AspIle: 4.131 ± 0.633
7.295AspLys: 7.295 ± 0.84
5.889AspLeu: 5.889 ± 0.708
2.022AspMet: 2.022 ± 0.39
4.131AspAsn: 4.131 ± 0.863
2.373AspPro: 2.373 ± 0.391
2.549AspGln: 2.549 ± 0.471
2.461AspArg: 2.461 ± 0.505
4.043AspSer: 4.043 ± 0.555
3.516AspThr: 3.516 ± 0.553
4.659AspVal: 4.659 ± 0.635
1.494AspTrp: 1.494 ± 0.409
4.483AspTyr: 4.483 ± 0.707
0.0AspXaa: 0.0 ± 0.0
Glu
4.307GluAla: 4.307 ± 0.588
0.527GluCys: 0.527 ± 0.207
4.395GluAsp: 4.395 ± 0.874
4.571GluGlu: 4.571 ± 0.809
2.197GluPhe: 2.197 ± 0.453
3.428GluGly: 3.428 ± 0.672
1.055GluHis: 1.055 ± 0.277
3.78GluIle: 3.78 ± 0.568
5.01GluLys: 5.01 ± 0.876
5.713GluLeu: 5.713 ± 0.616
1.67GluMet: 1.67 ± 0.476
3.867GluAsn: 3.867 ± 0.55
1.758GluPro: 1.758 ± 0.322
2.637GluGln: 2.637 ± 0.443
2.549GluArg: 2.549 ± 0.528
2.725GluSer: 2.725 ± 0.524
2.197GluThr: 2.197 ± 0.456
3.604GluVal: 3.604 ± 0.649
0.791GluTrp: 0.791 ± 0.261
2.901GluTyr: 2.901 ± 0.473
0.0GluXaa: 0.0 ± 0.0
Phe
2.022PheAla: 2.022 ± 0.433
0.176PheCys: 0.176 ± 0.134
3.604PheAsp: 3.604 ± 0.706
3.076PheGlu: 3.076 ± 0.516
1.055PhePhe: 1.055 ± 0.243
2.461PheGly: 2.461 ± 0.474
0.176PheHis: 0.176 ± 0.117
1.231PheIle: 1.231 ± 0.327
3.34PheLys: 3.34 ± 0.65
2.373PheLeu: 2.373 ± 0.393
0.527PheMet: 0.527 ± 0.291
2.022PheAsn: 2.022 ± 0.38
0.879PhePro: 0.879 ± 0.281
1.494PheGln: 1.494 ± 0.387
1.318PheArg: 1.318 ± 0.41
2.461PheSer: 2.461 ± 0.442
2.373PheThr: 2.373 ± 0.409
1.758PheVal: 1.758 ± 0.411
0.176PheTrp: 0.176 ± 0.117
1.494PheTyr: 1.494 ± 0.341
0.0PheXaa: 0.0 ± 0.0
Gly
5.362GlyAla: 5.362 ± 1.69
0.176GlyCys: 0.176 ± 0.134
3.428GlyAsp: 3.428 ± 0.656
2.813GlyGlu: 2.813 ± 0.528
2.901GlyPhe: 2.901 ± 0.528
4.131GlyGly: 4.131 ± 1.054
0.967GlyHis: 0.967 ± 0.33
4.659GlyIle: 4.659 ± 0.797
4.746GlyLys: 4.746 ± 0.692
7.032GlyLeu: 7.032 ± 1.618
1.406GlyMet: 1.406 ± 0.527
3.604GlyAsn: 3.604 ± 0.714
0.967GlyPro: 0.967 ± 0.239
2.461GlyGln: 2.461 ± 0.458
2.901GlyArg: 2.901 ± 0.446
4.219GlySer: 4.219 ± 0.594
4.219GlyThr: 4.219 ± 0.636
4.307GlyVal: 4.307 ± 0.779
0.967GlyTrp: 0.967 ± 0.356
3.34GlyTyr: 3.34 ± 0.585
0.0GlyXaa: 0.0 ± 0.0
His
0.879HisAla: 0.879 ± 0.275
0.0HisCys: 0.0 ± 0.0
0.791HisAsp: 0.791 ± 0.295
0.967HisGlu: 0.967 ± 0.252
0.439HisPhe: 0.439 ± 0.211
0.791HisGly: 0.791 ± 0.248
0.352HisHis: 0.352 ± 0.157
0.703HisIle: 0.703 ± 0.276
1.055HisLys: 1.055 ± 0.313
1.055HisLeu: 1.055 ± 0.25
0.088HisMet: 0.088 ± 0.092
0.703HisAsn: 0.703 ± 0.224
0.527HisPro: 0.527 ± 0.247
0.352HisGln: 0.352 ± 0.178
0.879HisArg: 0.879 ± 0.336
0.879HisSer: 0.879 ± 0.288
0.615HisThr: 0.615 ± 0.279
0.439HisVal: 0.439 ± 0.231
0.352HisTrp: 0.352 ± 0.159
0.791HisTyr: 0.791 ± 0.252
0.0HisXaa: 0.0 ± 0.0
Ile
5.186IleAla: 5.186 ± 1.101
0.176IleCys: 0.176 ± 0.126
6.065IleAsp: 6.065 ± 0.758
3.867IleGlu: 3.867 ± 0.648
2.197IlePhe: 2.197 ± 0.309
2.637IleGly: 2.637 ± 0.54
0.615IleHis: 0.615 ± 0.251
2.813IleIle: 2.813 ± 0.433
5.713IleLys: 5.713 ± 0.669
4.746IleLeu: 4.746 ± 0.545
0.967IleMet: 0.967 ± 0.227
5.01IleAsn: 5.01 ± 0.583
2.725IlePro: 2.725 ± 0.544
1.846IleGln: 1.846 ± 0.382
2.285IleArg: 2.285 ± 0.4
3.252IleSer: 3.252 ± 0.664
3.428IleThr: 3.428 ± 0.504
3.955IleVal: 3.955 ± 0.566
0.791IleTrp: 0.791 ± 0.221
2.285IleTyr: 2.285 ± 0.481
0.0IleXaa: 0.0 ± 0.0
Lys
7.032LysAla: 7.032 ± 0.715
0.264LysCys: 0.264 ± 0.153
5.713LysAsp: 5.713 ± 0.924
5.977LysGlu: 5.977 ± 0.865
2.725LysPhe: 2.725 ± 0.461
3.867LysGly: 3.867 ± 0.519
1.406LysHis: 1.406 ± 0.36
4.571LysIle: 4.571 ± 0.546
8.614LysLys: 8.614 ± 1.222
7.559LysLeu: 7.559 ± 0.628
2.373LysMet: 2.373 ± 0.509
4.307LysAsn: 4.307 ± 0.74
3.252LysPro: 3.252 ± 0.574
3.164LysGln: 3.164 ± 0.576
3.78LysArg: 3.78 ± 0.69
5.801LysSer: 5.801 ± 0.784
5.977LysThr: 5.977 ± 0.752
5.186LysVal: 5.186 ± 0.619
0.879LysTrp: 0.879 ± 0.3
3.076LysTyr: 3.076 ± 0.586
0.0LysXaa: 0.0 ± 0.0
Leu
5.977LeuAla: 5.977 ± 1.25
0.439LeuCys: 0.439 ± 0.213
6.768LeuAsp: 6.768 ± 0.826
4.395LeuGlu: 4.395 ± 0.785
2.373LeuPhe: 2.373 ± 0.397
6.153LeuGly: 6.153 ± 0.859
1.494LeuHis: 1.494 ± 0.457
4.834LeuIle: 4.834 ± 0.767
8.438LeuLys: 8.438 ± 0.806
7.471LeuLeu: 7.471 ± 1.447
1.934LeuMet: 1.934 ± 0.591
5.713LeuAsn: 5.713 ± 0.785
3.252LeuPro: 3.252 ± 0.554
2.549LeuGln: 2.549 ± 0.413
3.955LeuArg: 3.955 ± 0.684
5.537LeuSer: 5.537 ± 0.59
6.065LeuThr: 6.065 ± 0.611
6.153LeuVal: 6.153 ± 1.107
0.527LeuTrp: 0.527 ± 0.225
2.637LeuTyr: 2.637 ± 0.588
0.0LeuXaa: 0.0 ± 0.0
Met
2.461MetAla: 2.461 ± 0.703
0.088MetCys: 0.088 ± 0.083
1.055MetAsp: 1.055 ± 0.324
1.055MetGlu: 1.055 ± 0.289
0.527MetPhe: 0.527 ± 0.21
1.406MetGly: 1.406 ± 0.444
0.088MetHis: 0.088 ± 0.077
1.582MetIle: 1.582 ± 0.444
1.934MetLys: 1.934 ± 0.404
2.637MetLeu: 2.637 ± 0.586
0.879MetMet: 0.879 ± 0.389
0.879MetAsn: 0.879 ± 0.252
0.527MetPro: 0.527 ± 0.245
0.791MetGln: 0.791 ± 0.291
1.143MetArg: 1.143 ± 0.286
1.846MetSer: 1.846 ± 0.392
1.67MetThr: 1.67 ± 0.388
2.637MetVal: 2.637 ± 0.845
0.0MetTrp: 0.0 ± 0.0
1.143MetTyr: 1.143 ± 0.363
0.0MetXaa: 0.0 ± 0.0
Asn
4.571AsnAla: 4.571 ± 0.621
0.615AsnCys: 0.615 ± 0.232
3.867AsnAsp: 3.867 ± 0.636
3.164AsnGlu: 3.164 ± 0.589
2.813AsnPhe: 2.813 ± 0.464
5.713AsnGly: 5.713 ± 0.811
0.703AsnHis: 0.703 ± 0.24
2.637AsnIle: 2.637 ± 0.459
5.625AsnLys: 5.625 ± 0.72
4.043AsnLeu: 4.043 ± 0.932
1.318AsnMet: 1.318 ± 0.256
4.043AsnAsn: 4.043 ± 0.685
1.846AsnPro: 1.846 ± 0.341
1.582AsnGln: 1.582 ± 0.424
1.67AsnArg: 1.67 ± 0.403
3.692AsnSer: 3.692 ± 0.438
4.131AsnThr: 4.131 ± 0.978
3.867AsnVal: 3.867 ± 0.531
1.055AsnTrp: 1.055 ± 0.282
2.988AsnTyr: 2.988 ± 0.609
0.0AsnXaa: 0.0 ± 0.0
Pro
2.988ProAla: 2.988 ± 0.552
0.088ProCys: 0.088 ± 0.095
2.725ProAsp: 2.725 ± 0.491
1.846ProGlu: 1.846 ± 0.534
0.527ProPhe: 0.527 ± 0.183
1.494ProGly: 1.494 ± 0.45
0.352ProHis: 0.352 ± 0.181
2.813ProIle: 2.813 ± 0.477
2.813ProLys: 2.813 ± 0.507
1.318ProLeu: 1.318 ± 0.303
0.615ProMet: 0.615 ± 0.25
1.934ProAsn: 1.934 ± 0.43
0.615ProPro: 0.615 ± 0.259
1.143ProGln: 1.143 ± 0.28
0.967ProArg: 0.967 ± 0.29
2.11ProSer: 2.11 ± 0.394
1.846ProThr: 1.846 ± 0.308
2.022ProVal: 2.022 ± 0.485
0.439ProTrp: 0.439 ± 0.168
1.318ProTyr: 1.318 ± 0.413
0.0ProXaa: 0.0 ± 0.0
Gln
3.076GlnAla: 3.076 ± 0.536
0.176GlnCys: 0.176 ± 0.115
2.373GlnAsp: 2.373 ± 0.434
1.67GlnGlu: 1.67 ± 0.413
1.758GlnPhe: 1.758 ± 0.349
2.197GlnGly: 2.197 ± 0.387
0.176GlnHis: 0.176 ± 0.113
2.813GlnIle: 2.813 ± 0.455
2.988GlnLys: 2.988 ± 0.552
4.307GlnLeu: 4.307 ± 0.713
0.967GlnMet: 0.967 ± 0.26
2.022GlnAsn: 2.022 ± 0.402
1.055GlnPro: 1.055 ± 0.255
2.637GlnGln: 2.637 ± 0.392
1.494GlnArg: 1.494 ± 0.378
2.637GlnSer: 2.637 ± 0.502
2.637GlnThr: 2.637 ± 0.503
2.285GlnVal: 2.285 ± 0.429
0.703GlnTrp: 0.703 ± 0.238
1.318GlnTyr: 1.318 ± 0.351
0.0GlnXaa: 0.0 ± 0.0
Arg
2.725ArgAla: 2.725 ± 0.436
0.527ArgCys: 0.527 ± 0.232
2.725ArgAsp: 2.725 ± 0.483
2.988ArgGlu: 2.988 ± 0.566
1.318ArgPhe: 1.318 ± 0.261
1.846ArgGly: 1.846 ± 0.31
0.703ArgHis: 0.703 ± 0.249
3.076ArgIle: 3.076 ± 0.544
2.813ArgLys: 2.813 ± 0.499
4.043ArgLeu: 4.043 ± 0.619
0.527ArgMet: 0.527 ± 0.216
2.549ArgAsn: 2.549 ± 0.412
1.143ArgPro: 1.143 ± 0.376
1.67ArgGln: 1.67 ± 0.528
2.022ArgArg: 2.022 ± 0.371
2.197ArgSer: 2.197 ± 0.319
2.022ArgThr: 2.022 ± 0.448
2.373ArgVal: 2.373 ± 0.534
0.967ArgTrp: 0.967 ± 0.259
1.934ArgTyr: 1.934 ± 0.422
0.0ArgXaa: 0.0 ± 0.0
Ser
5.186SerAla: 5.186 ± 0.948
0.264SerCys: 0.264 ± 0.165
4.131SerAsp: 4.131 ± 0.554
3.867SerGlu: 3.867 ± 0.724
2.197SerPhe: 2.197 ± 0.464
4.395SerGly: 4.395 ± 0.809
1.231SerHis: 1.231 ± 0.33
3.428SerIle: 3.428 ± 0.46
4.659SerLys: 4.659 ± 0.609
5.274SerLeu: 5.274 ± 0.568
1.934SerMet: 1.934 ± 0.525
3.604SerAsn: 3.604 ± 0.433
2.373SerPro: 2.373 ± 0.528
2.637SerGln: 2.637 ± 0.506
2.197SerArg: 2.197 ± 0.438
4.219SerSer: 4.219 ± 0.509
2.901SerThr: 2.901 ± 0.491
4.483SerVal: 4.483 ± 0.564
0.967SerTrp: 0.967 ± 0.315
2.725SerTyr: 2.725 ± 0.471
0.0SerXaa: 0.0 ± 0.0
Thr
3.955ThrAla: 3.955 ± 0.687
0.439ThrCys: 0.439 ± 0.207
5.01ThrAsp: 5.01 ± 0.872
2.901ThrGlu: 2.901 ± 0.585
2.022ThrPhe: 2.022 ± 0.39
3.78ThrGly: 3.78 ± 0.624
0.615ThrHis: 0.615 ± 0.24
5.01ThrIle: 5.01 ± 0.824
5.186ThrLys: 5.186 ± 0.66
5.625ThrLeu: 5.625 ± 0.697
1.231ThrMet: 1.231 ± 0.348
2.813ThrAsn: 2.813 ± 0.519
1.582ThrPro: 1.582 ± 0.333
2.813ThrGln: 2.813 ± 0.411
2.197ThrArg: 2.197 ± 0.393
4.043ThrSer: 4.043 ± 0.46
4.131ThrThr: 4.131 ± 0.738
4.746ThrVal: 4.746 ± 0.818
0.967ThrTrp: 0.967 ± 0.32
2.988ThrTyr: 2.988 ± 0.581
0.0ThrXaa: 0.0 ± 0.0
Val
5.889ValAla: 5.889 ± 1.469
0.439ValCys: 0.439 ± 0.219
4.571ValAsp: 4.571 ± 0.602
4.043ValGlu: 4.043 ± 0.77
1.758ValPhe: 1.758 ± 0.317
5.713ValGly: 5.713 ± 1.979
0.264ValHis: 0.264 ± 0.144
3.516ValIle: 3.516 ± 0.422
5.186ValLys: 5.186 ± 0.755
4.219ValLeu: 4.219 ± 0.588
1.67ValMet: 1.67 ± 0.398
4.834ValAsn: 4.834 ± 0.666
2.11ValPro: 2.11 ± 0.419
3.34ValGln: 3.34 ± 0.556
2.813ValArg: 2.813 ± 0.488
4.571ValSer: 4.571 ± 0.763
5.274ValThr: 5.274 ± 0.785
4.571ValVal: 4.571 ± 0.819
0.176ValTrp: 0.176 ± 0.11
2.197ValTyr: 2.197 ± 0.628
0.0ValXaa: 0.0 ± 0.0
Trp
0.615TrpAla: 0.615 ± 0.268
0.0TrpCys: 0.0 ± 0.0
0.879TrpAsp: 0.879 ± 0.235
0.439TrpGlu: 0.439 ± 0.189
0.439TrpPhe: 0.439 ± 0.225
1.143TrpGly: 1.143 ± 0.303
0.527TrpHis: 0.527 ± 0.22
0.703TrpIle: 0.703 ± 0.243
0.967TrpLys: 0.967 ± 0.325
1.406TrpLeu: 1.406 ± 0.362
0.0TrpMet: 0.0 ± 0.0
1.231TrpAsn: 1.231 ± 0.443
0.0TrpPro: 0.0 ± 0.0
1.143TrpGln: 1.143 ± 0.257
0.703TrpArg: 0.703 ± 0.2
0.439TrpSer: 0.439 ± 0.206
0.967TrpThr: 0.967 ± 0.384
0.967TrpVal: 0.967 ± 0.304
0.264TrpTrp: 0.264 ± 0.155
0.352TrpTyr: 0.352 ± 0.217
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.285TyrAla: 2.285 ± 0.398
0.352TyrCys: 0.352 ± 0.152
2.813TyrAsp: 2.813 ± 0.632
2.461TyrGlu: 2.461 ± 0.515
1.934TyrPhe: 1.934 ± 0.425
3.428TyrGly: 3.428 ± 0.446
0.615TyrHis: 0.615 ± 0.214
2.725TyrIle: 2.725 ± 0.611
2.285TyrLys: 2.285 ± 0.567
4.395TyrLeu: 4.395 ± 0.636
1.231TyrMet: 1.231 ± 0.304
1.846TyrAsn: 1.846 ± 0.447
1.231TyrPro: 1.231 ± 0.349
1.67TyrGln: 1.67 ± 0.339
2.373TyrArg: 2.373 ± 0.468
3.428TyrSer: 3.428 ± 0.657
2.549TyrThr: 2.549 ± 0.474
2.373TyrVal: 2.373 ± 0.596
0.703TyrTrp: 0.703 ± 0.25
1.055TyrTyr: 1.055 ± 0.32
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 54 proteins (11378 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski