Amino acid dipepetide frequency for Bifidobacterium bombi DSM 19703

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.615AlaAla: 10.615 ± 0.188	1.156AlaCys: 1.156 ± 0.045	6.363AlaAsp: 6.363 ± 0.114	4.679AlaGlu: 4.679 ± 0.113	3.406AlaPhe: 3.406 ± 0.078	8.504AlaGly: 8.504 ± 0.157	2.166AlaHis: 2.166 ± 0.07	4.807AlaIle: 4.807 ± 0.095	4.501AlaLys: 4.501 ± 0.11	9.762AlaLeu: 9.762 ± 0.166	2.828AlaMet: 2.828 ± 0.073	3.039AlaAsn: 3.039 ± 0.076	3.785AlaPro: 3.785 ± 0.087	4.579AlaGln: 4.579 ± 0.112	6.078AlaArg: 6.078 ± 0.112	6.853AlaSer: 6.853 ± 0.146	4.868AlaThr: 4.868 ± 0.093	7.967AlaVal: 7.967 ± 0.145	1.231AlaTrp: 1.231 ± 0.058	2.39AlaTyr: 2.39 ± 0.07	0.0AlaXaa: 0.0 ± 0.0
Cys	1.123CysAla: 1.123 ± 0.05	0.134CysCys: 0.134 ± 0.017	0.618CysAsp: 0.618 ± 0.035	0.522CysGlu: 0.522 ± 0.03	0.367CysPhe: 0.367 ± 0.028	1.165CysGly: 1.165 ± 0.046	0.237CysHis: 0.237 ± 0.02	0.477CysIle: 0.477 ± 0.03	0.295CysLys: 0.295 ± 0.024	0.827CysLeu: 0.827 ± 0.038	0.251CysMet: 0.251 ± 0.022	0.247CysAsn: 0.247 ± 0.022	0.501CysPro: 0.501 ± 0.036	0.245CysGln: 0.245 ± 0.021	0.572CysArg: 0.572 ± 0.032	0.721CysSer: 0.721 ± 0.043	0.62CysThr: 0.62 ± 0.037	0.85CysVal: 0.85 ± 0.035	0.117CysTrp: 0.117 ± 0.014	0.241CysTyr: 0.241 ± 0.026	0.0CysXaa: 0.0 ± 0.0
Asp	6.78AspAla: 6.78 ± 0.134	0.574AspCys: 0.574 ± 0.035	5.025AspAsp: 5.025 ± 0.115	5.081AspGlu: 5.081 ± 0.124	2.503AspPhe: 2.503 ± 0.077	6.392AspGly: 6.392 ± 0.133	1.24AspHis: 1.24 ± 0.05	3.269AspIle: 3.269 ± 0.086	2.346AspLys: 2.346 ± 0.074	5.236AspLeu: 5.236 ± 0.111	1.851AspMet: 1.851 ± 0.065	1.657AspAsn: 1.657 ± 0.061	3.316AspPro: 3.316 ± 0.091	1.904AspGln: 1.904 ± 0.062	3.525AspArg: 3.525 ± 0.091	4.095AspSer: 4.095 ± 0.096	3.253AspThr: 3.253 ± 0.078	5.485AspVal: 5.485 ± 0.121	0.922AspTrp: 0.922 ± 0.042	1.785AspTyr: 1.785 ± 0.061	0.0AspXaa: 0.0 ± 0.0
Glu	5.762GluAla: 5.762 ± 0.125	0.475GluCys: 0.475 ± 0.029	3.125GluAsp: 3.125 ± 0.094	3.269GluGlu: 3.269 ± 0.103	1.69GluPhe: 1.69 ± 0.061	4.415GluGly: 4.415 ± 0.098	1.629GluHis: 1.629 ± 0.056	2.606GluIle: 2.606 ± 0.072	2.191GluLys: 2.191 ± 0.082	4.889GluLeu: 4.889 ± 0.1	1.351GluMet: 1.351 ± 0.051	1.887GluAsn: 1.887 ± 0.066	2.497GluPro: 2.497 ± 0.075	2.459GluGln: 2.459 ± 0.075	4.273GluArg: 4.273 ± 0.12	3.504GluSer: 3.504 ± 0.095	3.075GluThr: 3.075 ± 0.075	3.921GluVal: 3.921 ± 0.099	0.551GluTrp: 0.551 ± 0.029	1.529GluTyr: 1.529 ± 0.06	0.0GluXaa: 0.0 ± 0.0
Phe	3.531PheAla: 3.531 ± 0.085	0.364PheCys: 0.364 ± 0.027	2.484PheAsp: 2.484 ± 0.072	1.854PheGlu: 1.854 ± 0.068	1.234PhePhe: 1.234 ± 0.051	3.28PheGly: 3.28 ± 0.078	0.764PheHis: 0.764 ± 0.04	1.795PheIle: 1.795 ± 0.06	1.227PheLys: 1.227 ± 0.049	2.828PheLeu: 2.828 ± 0.084	0.852PheMet: 0.852 ± 0.05	1.257PheAsn: 1.257 ± 0.048	1.353PhePro: 1.353 ± 0.047	0.915PheGln: 0.915 ± 0.038	1.594PheArg: 1.594 ± 0.053	2.52PheSer: 2.52 ± 0.072	2.14PheThr: 2.14 ± 0.065	2.781PheVal: 2.781 ± 0.087	0.434PheTrp: 0.434 ± 0.034	0.846PheTyr: 0.846 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	7.525GlyAla: 7.525 ± 0.157	0.84GlyCys: 0.84 ± 0.043	4.88GlyAsp: 4.88 ± 0.097	4.499GlyGlu: 4.499 ± 0.099	3.265GlyPhe: 3.265 ± 0.088	6.641GlyGly: 6.641 ± 0.134	2.007GlyHis: 2.007 ± 0.07	4.568GlyIle: 4.568 ± 0.093	4.248GlyLys: 4.248 ± 0.09	7.582GlyLeu: 7.582 ± 0.125	2.241GlyMet: 2.241 ± 0.07	2.951GlyAsn: 2.951 ± 0.095	2.872GlyPro: 2.872 ± 0.073	2.882GlyGln: 2.882 ± 0.081	5.377GlyArg: 5.377 ± 0.114	6.17GlySer: 6.17 ± 0.122	4.926GlyThr: 4.926 ± 0.11	6.637GlyVal: 6.637 ± 0.118	1.15GlyTrp: 1.15 ± 0.051	2.561GlyTyr: 2.561 ± 0.08	0.0GlyXaa: 0.0 ± 0.0
His	2.101HisAla: 2.101 ± 0.064	0.226HisCys: 0.226 ± 0.023	1.851HisAsp: 1.851 ± 0.057	1.378HisGlu: 1.378 ± 0.058	0.63HisPhe: 0.63 ± 0.034	2.076HisGly: 2.076 ± 0.062	0.57HisHis: 0.57 ± 0.036	1.141HisIle: 1.141 ± 0.056	0.741HisLys: 0.741 ± 0.036	1.644HisLeu: 1.644 ± 0.059	0.622HisMet: 0.622 ± 0.034	0.718HisAsn: 0.718 ± 0.035	1.229HisPro: 1.229 ± 0.049	0.649HisGln: 0.649 ± 0.039	1.548HisArg: 1.548 ± 0.066	1.275HisSer: 1.275 ± 0.045	1.225HisThr: 1.225 ± 0.052	1.918HisVal: 1.918 ± 0.078	0.366HisTrp: 0.366 ± 0.023	0.622HisTyr: 0.622 ± 0.037	0.0HisXaa: 0.0 ± 0.0
Ile	5.49IleAla: 5.49 ± 0.123	0.628IleCys: 0.628 ± 0.04	3.896IleAsp: 3.896 ± 0.097	2.964IleGlu: 2.964 ± 0.09	1.458IlePhe: 1.458 ± 0.06	4.369IleGly: 4.369 ± 0.11	1.131IleHis: 1.131 ± 0.047	2.717IleIle: 2.717 ± 0.1	1.862IleLys: 1.862 ± 0.067	3.778IleLeu: 3.778 ± 0.095	1.158IleMet: 1.158 ± 0.05	1.732IleAsn: 1.732 ± 0.059	2.515IlePro: 2.515 ± 0.076	1.38IleGln: 1.38 ± 0.054	2.92IleArg: 2.92 ± 0.075	3.387IleSer: 3.387 ± 0.087	2.84IleThr: 2.84 ± 0.083	4.457IleVal: 4.457 ± 0.118	0.588IleTrp: 0.588 ± 0.034	1.167IleTyr: 1.167 ± 0.053	0.0IleXaa: 0.0 ± 0.0
Lys	4.71LysAla: 4.71 ± 0.112	0.186LysCys: 0.186 ± 0.018	2.689LysAsp: 2.689 ± 0.085	2.358LysGlu: 2.358 ± 0.077	0.978LysPhe: 0.978 ± 0.044	3.012LysGly: 3.012 ± 0.087	0.854LysHis: 0.854 ± 0.042	1.761LysIle: 1.761 ± 0.058	1.91LysLys: 1.91 ± 0.072	3.242LysLeu: 3.242 ± 0.089	0.991LysMet: 0.991 ± 0.043	1.594LysAsn: 1.594 ± 0.058	2.302LysPro: 2.302 ± 0.079	1.46LysGln: 1.46 ± 0.062	2.557LysArg: 2.557 ± 0.076	2.672LysSer: 2.672 ± 0.074	2.714LysThr: 2.714 ± 0.073	3.225LysVal: 3.225 ± 0.089	0.494LysTrp: 0.494 ± 0.036	1.02LysTyr: 1.02 ± 0.05	0.0LysXaa: 0.0 ± 0.0
Leu	9.0LeuAla: 9.0 ± 0.135	1.014LeuCys: 1.014 ± 0.045	6.109LeuAsp: 6.109 ± 0.133	4.568LeuGlu: 4.568 ± 0.103	3.035LeuPhe: 3.035 ± 0.089	7.192LeuGly: 7.192 ± 0.122	1.956LeuHis: 1.956 ± 0.06	4.447LeuIle: 4.447 ± 0.126	3.699LeuLys: 3.699 ± 0.094	7.846LeuLeu: 7.846 ± 0.163	2.184LeuMet: 2.184 ± 0.06	2.926LeuAsn: 2.926 ± 0.082	4.432LeuPro: 4.432 ± 0.096	2.754LeuGln: 2.754 ± 0.077	5.523LeuArg: 5.523 ± 0.106	6.325LeuSer: 6.325 ± 0.13	5.255LeuThr: 5.255 ± 0.089	6.631LeuVal: 6.631 ± 0.124	0.986LeuTrp: 0.986 ± 0.052	2.051LeuTyr: 2.051 ± 0.069	0.0LeuXaa: 0.0 ± 0.0
Met	2.729MetAla: 2.729 ± 0.074	0.245MetCys: 0.245 ± 0.021	1.629MetAsp: 1.629 ± 0.059	1.202MetGlu: 1.202 ± 0.05	0.924MetPhe: 0.924 ± 0.066	1.854MetGly: 1.854 ± 0.064	0.561MetHis: 0.561 ± 0.032	1.116MetIle: 1.116 ± 0.045	1.167MetLys: 1.167 ± 0.047	2.369MetLeu: 2.369 ± 0.07	0.721MetMet: 0.721 ± 0.038	1.079MetAsn: 1.079 ± 0.042	1.399MetPro: 1.399 ± 0.044	0.961MetGln: 0.961 ± 0.044	1.707MetArg: 1.707 ± 0.056	1.983MetSer: 1.983 ± 0.073	1.852MetThr: 1.852 ± 0.056	1.942MetVal: 1.942 ± 0.061	0.285MetTrp: 0.285 ± 0.02	0.545MetTyr: 0.545 ± 0.032	0.0MetXaa: 0.0 ± 0.0
Asn	3.357AsnAla: 3.357 ± 0.076	0.264AsnCys: 0.264 ± 0.025	2.377AsnAsp: 2.377 ± 0.068	1.872AsnGlu: 1.872 ± 0.066	1.01AsnPhe: 1.01 ± 0.045	3.412AsnGly: 3.412 ± 0.108	0.716AsnHis: 0.716 ± 0.036	1.615AsnIle: 1.615 ± 0.054	1.206AsnLys: 1.206 ± 0.053	2.727AsnLeu: 2.727 ± 0.077	0.871AsnMet: 0.871 ± 0.045	1.133AsnAsn: 1.133 ± 0.06	2.277AsnPro: 2.277 ± 0.074	1.162AsnGln: 1.162 ± 0.046	1.986AsnArg: 1.986 ± 0.062	1.973AsnSer: 1.973 ± 0.077	1.847AsnThr: 1.847 ± 0.071	2.511AsnVal: 2.511 ± 0.078	0.432AsnTrp: 0.432 ± 0.03	0.846AsnTyr: 0.846 ± 0.048	0.0AsnXaa: 0.0 ± 0.0
Pro	4.289ProAla: 4.289 ± 0.094	0.392ProCys: 0.392 ± 0.028	3.389ProAsp: 3.389 ± 0.097	3.075ProGlu: 3.075 ± 0.08	1.546ProPhe: 1.546 ± 0.052	3.647ProGly: 3.647 ± 0.097	1.018ProHis: 1.018 ± 0.048	2.151ProIle: 2.151 ± 0.066	1.883ProLys: 1.883 ± 0.055	3.59ProLeu: 3.59 ± 0.079	1.075ProMet: 1.075 ± 0.049	1.621ProAsn: 1.621 ± 0.058	1.301ProPro: 1.301 ± 0.056	2.042ProGln: 2.042 ± 0.073	2.428ProArg: 2.428 ± 0.065	3.305ProSer: 3.305 ± 0.093	2.58ProThr: 2.58 ± 0.072	4.049ProVal: 4.049 ± 0.081	0.662ProTrp: 0.662 ± 0.033	1.399ProTyr: 1.399 ± 0.058	0.0ProXaa: 0.0 ± 0.0
Gln	4.145GlnAla: 4.145 ± 0.105	0.31GlnCys: 0.31 ± 0.026	1.952GlnAsp: 1.952 ± 0.064	2.017GlnGlu: 2.017 ± 0.063	1.079GlnPhe: 1.079 ± 0.049	2.949GlnGly: 2.949 ± 0.073	0.769GlnHis: 0.769 ± 0.039	1.921GlnIle: 1.921 ± 0.055	1.255GlnLys: 1.255 ± 0.057	3.202GlnLeu: 3.202 ± 0.086	1.047GlnMet: 1.047 ± 0.047	1.183GlnAsn: 1.183 ± 0.056	1.65GlnPro: 1.65 ± 0.066	1.558GlnGln: 1.558 ± 0.069	2.34GlnArg: 2.34 ± 0.074	2.543GlnSer: 2.543 ± 0.073	2.048GlnThr: 2.048 ± 0.063	3.02GlnVal: 3.02 ± 0.085	0.651GlnTrp: 0.651 ± 0.041	0.976GlnTyr: 0.976 ± 0.042	0.0GlnXaa: 0.0 ± 0.0
Arg	5.029ArgAla: 5.029 ± 0.102	0.676ArgCys: 0.676 ± 0.036	3.517ArgAsp: 3.517 ± 0.104	3.602ArgGlu: 3.602 ± 0.09	2.484ArgPhe: 2.484 ± 0.07	4.005ArgGly: 4.005 ± 0.109	1.692ArgHis: 1.692 ± 0.057	3.68ArgIle: 3.68 ± 0.093	2.827ArgLys: 2.827 ± 0.082	5.816ArgLeu: 5.816 ± 0.104	1.977ArgMet: 1.977 ± 0.063	2.189ArgAsn: 2.189 ± 0.067	2.712ArgPro: 2.712 ± 0.08	2.696ArgGln: 2.696 ± 0.076	5.205ArgArg: 5.205 ± 0.14	4.191ArgSer: 4.191 ± 0.105	3.602ArgThr: 3.602 ± 0.08	4.18ArgVal: 4.18 ± 0.102	0.901ArgTrp: 0.901 ± 0.041	1.889ArgTyr: 1.889 ± 0.069	0.0ArgXaa: 0.0 ± 0.0
Ser	6.482SerAla: 6.482 ± 0.148	0.649SerCys: 0.649 ± 0.037	4.503SerAsp: 4.503 ± 0.095	3.246SerGlu: 3.246 ± 0.089	2.187SerPhe: 2.187 ± 0.076	6.596SerGly: 6.596 ± 0.161	1.541SerHis: 1.541 ± 0.059	3.424SerIle: 3.424 ± 0.097	2.737SerLys: 2.737 ± 0.085	6.189SerLeu: 6.189 ± 0.143	1.931SerMet: 1.931 ± 0.06	2.295SerAsn: 2.295 ± 0.086	2.729SerPro: 2.729 ± 0.077	3.02SerGln: 3.02 ± 0.076	4.369SerArg: 4.369 ± 0.096	5.018SerSer: 5.018 ± 0.131	3.868SerThr: 3.868 ± 0.091	5.379SerVal: 5.379 ± 0.126	0.943SerTrp: 0.943 ± 0.045	1.763SerTyr: 1.763 ± 0.071	0.0SerXaa: 0.0 ± 0.0
Thr	5.46ThrAla: 5.46 ± 0.11	0.517ThrCys: 0.517 ± 0.031	3.797ThrAsp: 3.797 ± 0.097	2.522ThrGlu: 2.522 ± 0.072	1.958ThrPhe: 1.958 ± 0.068	5.157ThrGly: 5.157 ± 0.12	1.186ThrHis: 1.186 ± 0.049	3.11ThrIle: 3.11 ± 0.085	2.208ThrLys: 2.208 ± 0.068	5.297ThrLeu: 5.297 ± 0.113	1.389ThrMet: 1.389 ± 0.049	2.013ThrAsn: 2.013 ± 0.075	2.872ThrPro: 2.872 ± 0.076	2.088ThrGln: 2.088 ± 0.068	3.077ThrArg: 3.077 ± 0.094	3.803ThrSer: 3.803 ± 0.095	3.238ThrThr: 3.238 ± 0.092	4.962ThrVal: 4.962 ± 0.118	0.733ThrTrp: 0.733 ± 0.04	1.56ThrTyr: 1.56 ± 0.058	0.0ThrXaa: 0.0 ± 0.0
Val	7.808ValAla: 7.808 ± 0.151	0.997ValCys: 0.997 ± 0.045	5.37ValAsp: 5.37 ± 0.124	4.298ValGlu: 4.298 ± 0.107	2.821ValPhe: 2.821 ± 0.09	5.785ValGly: 5.785 ± 0.12	1.644ValHis: 1.644 ± 0.059	4.122ValIle: 4.122 ± 0.099	3.004ValLys: 3.004 ± 0.078	7.59ValLeu: 7.59 ± 0.148	1.912ValMet: 1.912 ± 0.059	2.629ValAsn: 2.629 ± 0.078	3.959ValPro: 3.959 ± 0.083	2.39ValGln: 2.39 ± 0.078	5.025ValArg: 5.025 ± 0.104	6.017ValSer: 6.017 ± 0.137	4.84ValThr: 4.84 ± 0.126	6.891ValVal: 6.891 ± 0.148	0.922ValTrp: 0.922 ± 0.048	1.778ValTyr: 1.778 ± 0.069	0.0ValXaa: 0.0 ± 0.0
Trp	1.016TrpAla: 1.016 ± 0.052	0.189TrpCys: 0.189 ± 0.022	0.779TrpAsp: 0.779 ± 0.047	0.509TrpGlu: 0.509 ± 0.033	0.522TrpPhe: 0.522 ± 0.032	0.848TrpGly: 0.848 ± 0.043	0.329TrpHis: 0.329 ± 0.025	0.599TrpIle: 0.599 ± 0.033	0.561TrpLys: 0.561 ± 0.036	1.387TrpLeu: 1.387 ± 0.061	0.392TrpMet: 0.392 ± 0.028	0.61TrpAsn: 0.61 ± 0.038	0.553TrpPro: 0.553 ± 0.036	0.563TrpGln: 0.563 ± 0.033	0.968TrpArg: 0.968 ± 0.046	0.884TrpSer: 0.884 ± 0.046	0.71TrpThr: 0.71 ± 0.03	0.907TrpVal: 0.907 ± 0.043	0.253TrpTrp: 0.253 ± 0.027	0.4TrpTyr: 0.4 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.627TyrAla: 2.627 ± 0.073	0.297TyrCys: 0.297 ± 0.024	1.889TyrAsp: 1.889 ± 0.061	1.585TyrGlu: 1.585 ± 0.06	0.953TyrPhe: 0.953 ± 0.046	2.522TyrGly: 2.522 ± 0.069	0.517TyrHis: 0.517 ± 0.03	1.112TyrIle: 1.112 ± 0.047	0.857TyrLys: 0.857 ± 0.038	2.132TyrLeu: 2.132 ± 0.067	0.626TyrMet: 0.626 ± 0.036	0.832TyrAsn: 0.832 ± 0.046	1.188TyrPro: 1.188 ± 0.056	0.909TyrGln: 0.909 ± 0.042	1.793TyrArg: 1.793 ± 0.065	1.629TyrSer: 1.629 ± 0.058	1.449TyrThr: 1.449 ± 0.064	2.092TyrVal: 2.092 ± 0.058	0.36TyrTrp: 0.36 ± 0.029	0.698TyrTyr: 0.698 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1454 proteins (522551 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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