Amino acid dipepetide frequency for Paremcibacter congregatus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.363AlaAla: 10.363 ± 0.128	0.886AlaCys: 0.886 ± 0.028	5.53AlaAsp: 5.53 ± 0.072	6.125AlaGlu: 6.125 ± 0.079	3.647AlaPhe: 3.647 ± 0.058	7.675AlaGly: 7.675 ± 0.106	1.961AlaHis: 1.961 ± 0.042	5.355AlaIle: 5.355 ± 0.073	4.151AlaLys: 4.151 ± 0.074	9.951AlaLeu: 9.951 ± 0.101	2.577AlaMet: 2.577 ± 0.051	2.806AlaAsn: 2.806 ± 0.057	3.829AlaPro: 3.829 ± 0.056	3.632AlaGln: 3.632 ± 0.056	5.352AlaArg: 5.352 ± 0.074	4.989AlaSer: 4.989 ± 0.077	4.922AlaThr: 4.922 ± 0.059	6.307AlaVal: 6.307 ± 0.077	0.982AlaTrp: 0.982 ± 0.035	2.78AlaTyr: 2.78 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.833CysAla: 0.833 ± 0.026	0.12CysCys: 0.12 ± 0.01	0.62CysAsp: 0.62 ± 0.025	0.427CysGlu: 0.427 ± 0.017	0.402CysPhe: 0.402 ± 0.018	0.904CysGly: 0.904 ± 0.033	0.315CysHis: 0.315 ± 0.018	0.451CysIle: 0.451 ± 0.018	0.32CysLys: 0.32 ± 0.017	0.966CysLeu: 0.966 ± 0.029	0.21CysMet: 0.21 ± 0.014	0.273CysAsn: 0.273 ± 0.015	0.489CysPro: 0.489 ± 0.024	0.356CysGln: 0.356 ± 0.019	0.604CysArg: 0.604 ± 0.022	0.521CysSer: 0.521 ± 0.019	0.412CysThr: 0.412 ± 0.017	0.53CysVal: 0.53 ± 0.025	0.114CysTrp: 0.114 ± 0.01	0.268CysTyr: 0.268 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.994AspAla: 4.994 ± 0.074	0.508AspCys: 0.508 ± 0.021	3.344AspAsp: 3.344 ± 0.07	3.435AspGlu: 3.435 ± 0.054	2.841AspPhe: 2.841 ± 0.051	4.904AspGly: 4.904 ± 0.087	1.686AspHis: 1.686 ± 0.041	4.523AspIle: 4.523 ± 0.06	3.019AspLys: 3.019 ± 0.056	6.419AspLeu: 6.419 ± 0.075	1.885AspMet: 1.885 ± 0.043	2.262AspAsn: 2.262 ± 0.043	2.83AspPro: 2.83 ± 0.052	2.634AspGln: 2.634 ± 0.055	3.453AspArg: 3.453 ± 0.062	2.861AspSer: 2.861 ± 0.052	2.915AspThr: 2.915 ± 0.061	4.464AspVal: 4.464 ± 0.071	0.922AspTrp: 0.922 ± 0.026	2.134AspTyr: 2.134 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	5.735GluAla: 5.735 ± 0.083	0.403GluCys: 0.403 ± 0.017	3.728GluAsp: 3.728 ± 0.061	4.042GluGlu: 4.042 ± 0.07	2.058GluPhe: 2.058 ± 0.044	4.211GluGly: 4.211 ± 0.058	1.115GluHis: 1.115 ± 0.035	4.345GluIle: 4.345 ± 0.06	4.065GluLys: 4.065 ± 0.066	5.063GluLeu: 5.063 ± 0.068	1.844GluMet: 1.844 ± 0.038	2.774GluAsn: 2.774 ± 0.047	1.675GluPro: 1.675 ± 0.044	2.424GluGln: 2.424 ± 0.049	3.153GluArg: 3.153 ± 0.058	2.687GluSer: 2.687 ± 0.044	3.501GluThr: 3.501 ± 0.06	4.057GluVal: 4.057 ± 0.062	0.595GluTrp: 0.595 ± 0.022	1.482GluTyr: 1.482 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	3.424PheAla: 3.424 ± 0.047	0.476PheCys: 0.476 ± 0.018	2.91PheAsp: 2.91 ± 0.058	2.232PheGlu: 2.232 ± 0.044	1.76PhePhe: 1.76 ± 0.046	3.367PheGly: 3.367 ± 0.059	0.866PheHis: 0.866 ± 0.027	2.461PheIle: 2.461 ± 0.051	1.68PheLys: 1.68 ± 0.038	3.812PheLeu: 3.812 ± 0.065	1.11PheMet: 1.11 ± 0.029	1.604PheAsn: 1.604 ± 0.041	1.611PhePro: 1.611 ± 0.035	1.281PheGln: 1.281 ± 0.032	1.921PheArg: 1.921 ± 0.04	2.996PheSer: 2.996 ± 0.053	2.607PheThr: 2.607 ± 0.048	2.382PheVal: 2.382 ± 0.038	0.512PheTrp: 0.512 ± 0.021	1.349PheTyr: 1.349 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	7.082GlyAla: 7.082 ± 0.106	0.754GlyCys: 0.754 ± 0.027	4.567GlyAsp: 4.567 ± 0.083	4.349GlyGlu: 4.349 ± 0.054	3.592GlyPhe: 3.592 ± 0.059	6.894GlyGly: 6.894 ± 0.357	1.85GlyHis: 1.85 ± 0.041	4.704GlyIle: 4.704 ± 0.076	3.978GlyLys: 3.978 ± 0.062	7.951GlyLeu: 7.951 ± 0.087	2.186GlyMet: 2.186 ± 0.049	2.635GlyAsn: 2.635 ± 0.069	2.637GlyPro: 2.637 ± 0.053	2.991GlyGln: 2.991 ± 0.054	4.321GlyArg: 4.321 ± 0.074	4.405GlySer: 4.405 ± 0.083	4.314GlyThr: 4.314 ± 0.081	5.653GlyVal: 5.653 ± 0.082	1.05GlyTrp: 1.05 ± 0.028	2.727GlyTyr: 2.727 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	1.799HisAla: 1.799 ± 0.043	0.256HisCys: 0.256 ± 0.014	1.291HisAsp: 1.291 ± 0.035	1.085HisGlu: 1.085 ± 0.028	0.991HisPhe: 0.991 ± 0.029	1.689HisGly: 1.689 ± 0.037	0.685HisHis: 0.685 ± 0.026	1.457HisIle: 1.457 ± 0.039	1.057HisLys: 1.057 ± 0.032	2.308HisLeu: 2.308 ± 0.054	0.665HisMet: 0.665 ± 0.025	0.849HisAsn: 0.849 ± 0.031	1.221HisPro: 1.221 ± 0.037	0.843HisGln: 0.843 ± 0.025	1.113HisArg: 1.113 ± 0.03	1.167HisSer: 1.167 ± 0.033	1.028HisThr: 1.028 ± 0.025	1.414HisVal: 1.414 ± 0.035	0.295HisTrp: 0.295 ± 0.014	0.826HisTyr: 0.826 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.742IleAla: 5.742 ± 0.074	0.732IleCys: 0.732 ± 0.026	3.906IleAsp: 3.906 ± 0.054	3.789IleGlu: 3.789 ± 0.059	2.596IlePhe: 2.596 ± 0.049	4.846IleGly: 4.846 ± 0.075	1.191IleHis: 1.191 ± 0.037	3.822IleIle: 3.822 ± 0.067	2.986IleLys: 2.986 ± 0.06	6.115IleLeu: 6.115 ± 0.084	1.553IleMet: 1.553 ± 0.037	2.433IleAsn: 2.433 ± 0.051	2.771IlePro: 2.771 ± 0.05	1.822IleGln: 1.822 ± 0.036	3.273IleArg: 3.273 ± 0.056	4.526IleSer: 4.526 ± 0.063	4.088IleThr: 4.088 ± 0.063	3.788IleVal: 3.788 ± 0.068	0.673IleTrp: 0.673 ± 0.025	1.779IleTyr: 1.779 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	4.764LysAla: 4.764 ± 0.071	0.314LysCys: 0.314 ± 0.018	3.033LysAsp: 3.033 ± 0.054	2.718LysGlu: 2.718 ± 0.058	1.678LysPhe: 1.678 ± 0.036	3.471LysGly: 3.471 ± 0.062	0.926LysHis: 0.926 ± 0.03	3.473LysIle: 3.473 ± 0.052	3.072LysLys: 3.072 ± 0.059	4.499LysLeu: 4.499 ± 0.072	1.464LysMet: 1.464 ± 0.038	2.244LysAsn: 2.244 ± 0.044	2.079LysPro: 2.079 ± 0.05	1.675LysGln: 1.675 ± 0.038	2.463LysArg: 2.463 ± 0.044	3.006LysSer: 3.006 ± 0.055	3.099LysThr: 3.099 ± 0.052	3.307LysVal: 3.307 ± 0.059	0.602LysTrp: 0.602 ± 0.024	1.49LysTyr: 1.49 ± 0.037	0.0LysXaa: 0.0 ± 0.0
Leu	9.255LeuAla: 9.255 ± 0.108	1.043LeuCys: 1.043 ± 0.026	6.178LeuAsp: 6.178 ± 0.078	5.69LeuGlu: 5.69 ± 0.072	3.785LeuPhe: 3.785 ± 0.063	7.202LeuGly: 7.202 ± 0.077	2.027LeuHis: 2.027 ± 0.042	5.748LeuIle: 5.748 ± 0.085	5.314LeuLys: 5.314 ± 0.071	8.881LeuLeu: 8.881 ± 0.12	2.684LeuMet: 2.684 ± 0.045	3.86LeuAsn: 3.86 ± 0.063	4.741LeuPro: 4.741 ± 0.069	3.286LeuGln: 3.286 ± 0.06	5.027LeuArg: 5.027 ± 0.082	7.226LeuSer: 7.226 ± 0.085	6.049LeuThr: 6.049 ± 0.082	6.152LeuVal: 6.152 ± 0.079	1.063LeuTrp: 1.063 ± 0.033	2.728LeuTyr: 2.728 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	2.988MetAla: 2.988 ± 0.053	0.187MetCys: 0.187 ± 0.013	1.522MetAsp: 1.522 ± 0.037	1.501MetGlu: 1.501 ± 0.036	0.843MetPhe: 0.843 ± 0.029	2.037MetGly: 2.037 ± 0.044	0.441MetHis: 0.441 ± 0.019	1.78MetIle: 1.78 ± 0.04	1.497MetLys: 1.497 ± 0.036	2.318MetLeu: 2.318 ± 0.05	0.918MetMet: 0.918 ± 0.034	1.037MetAsn: 1.037 ± 0.03	1.38MetPro: 1.38 ± 0.032	0.96MetGln: 0.96 ± 0.03	1.408MetArg: 1.408 ± 0.031	1.868MetSer: 1.868 ± 0.042	2.248MetThr: 2.248 ± 0.046	1.943MetVal: 1.943 ± 0.041	0.212MetTrp: 0.212 ± 0.014	0.44MetTyr: 0.44 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.179AsnAla: 3.179 ± 0.061	0.365AsnCys: 0.365 ± 0.018	2.163AsnAsp: 2.163 ± 0.056	1.659AsnGlu: 1.659 ± 0.038	1.638AsnPhe: 1.638 ± 0.039	2.871AsnGly: 2.871 ± 0.065	0.786AsnHis: 0.786 ± 0.025	2.911AsnIle: 2.911 ± 0.052	1.68AsnLys: 1.68 ± 0.041	3.818AsnLeu: 3.818 ± 0.066	1.107AsnMet: 1.107 ± 0.03	1.471AsnAsn: 1.471 ± 0.043	2.07AsnPro: 2.07 ± 0.039	1.306AsnGln: 1.306 ± 0.034	2.05AsnArg: 2.05 ± 0.04	2.155AsnSer: 2.155 ± 0.047	1.873AsnThr: 1.873 ± 0.045	2.428AsnVal: 2.428 ± 0.047	0.499AsnTrp: 0.499 ± 0.025	1.237AsnTyr: 1.237 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	3.991ProAla: 3.991 ± 0.066	0.314ProCys: 0.314 ± 0.015	3.543ProAsp: 3.543 ± 0.057	3.588ProGlu: 3.588 ± 0.054	1.734ProPhe: 1.734 ± 0.037	3.418ProGly: 3.418 ± 0.053	0.944ProHis: 0.944 ± 0.031	2.118ProIle: 2.118 ± 0.041	1.933ProLys: 1.933 ± 0.043	4.394ProLeu: 4.394 ± 0.063	1.043ProMet: 1.043 ± 0.031	1.34ProAsn: 1.34 ± 0.032	1.653ProPro: 1.653 ± 0.046	1.546ProGln: 1.546 ± 0.038	1.929ProArg: 1.929 ± 0.043	2.318ProSer: 2.318 ± 0.039	2.315ProThr: 2.315 ± 0.045	3.522ProVal: 3.522 ± 0.057	0.531ProTrp: 0.531 ± 0.02	1.307ProTyr: 1.307 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	3.924GlnAla: 3.924 ± 0.069	0.24GlnCys: 0.24 ± 0.015	2.39GlnAsp: 2.39 ± 0.043	2.262GlnGlu: 2.262 ± 0.045	1.258GlnPhe: 1.258 ± 0.031	2.66GlnGly: 2.66 ± 0.046	0.746GlnHis: 0.746 ± 0.022	2.307GlnIle: 2.307 ± 0.05	2.29GlnLys: 2.29 ± 0.049	3.0GlnLeu: 3.0 ± 0.063	1.086GlnMet: 1.086 ± 0.03	1.653GlnAsn: 1.653 ± 0.039	1.336GlnPro: 1.336 ± 0.031	1.527GlnGln: 1.527 ± 0.044	1.774GlnArg: 1.774 ± 0.047	2.058GlnSer: 2.058 ± 0.05	2.073GlnThr: 2.073 ± 0.041	2.6GlnVal: 2.6 ± 0.053	0.436GlnTrp: 0.436 ± 0.017	0.941GlnTyr: 0.941 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	4.747ArgAla: 4.747 ± 0.074	0.421ArgCys: 0.421 ± 0.02	3.363ArgAsp: 3.363 ± 0.063	3.229ArgGlu: 3.229 ± 0.056	2.213ArgPhe: 2.213 ± 0.043	3.537ArgGly: 3.537 ± 0.055	1.522ArgHis: 1.522 ± 0.044	3.323ArgIle: 3.323 ± 0.054	2.769ArgLys: 2.769 ± 0.053	5.824ArgLeu: 5.824 ± 0.071	1.453ArgMet: 1.453 ± 0.039	1.955ArgAsn: 1.955 ± 0.046	2.32ArgPro: 2.32 ± 0.043	2.463ArgGln: 2.463 ± 0.052	3.398ArgArg: 3.398 ± 0.055	2.724ArgSer: 2.724 ± 0.049	2.702ArgThr: 2.702 ± 0.043	3.345ArgVal: 3.345 ± 0.056	0.601ArgTrp: 0.601 ± 0.02	1.828ArgTyr: 1.828 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	5.388SerAla: 5.388 ± 0.091	0.57SerCys: 0.57 ± 0.022	3.621SerAsp: 3.621 ± 0.056	3.226SerGlu: 3.226 ± 0.05	2.714SerPhe: 2.714 ± 0.052	5.417SerGly: 5.417 ± 0.102	1.489SerHis: 1.489 ± 0.038	3.346SerIle: 3.346 ± 0.051	2.387SerLys: 2.387 ± 0.046	6.553SerLeu: 6.553 ± 0.081	1.481SerMet: 1.481 ± 0.033	2.0SerAsn: 2.0 ± 0.046	2.889SerPro: 2.889 ± 0.05	2.057SerGln: 2.057 ± 0.042	3.403SerArg: 3.403 ± 0.056	3.638SerSer: 3.638 ± 0.066	2.921SerThr: 2.921 ± 0.061	3.838SerVal: 3.838 ± 0.07	0.739SerTrp: 0.739 ± 0.024	2.148SerTyr: 2.148 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	5.57ThrAla: 5.57 ± 0.069	0.508ThrCys: 0.508 ± 0.021	3.492ThrAsp: 3.492 ± 0.067	3.28ThrGlu: 3.28 ± 0.051	2.211ThrPhe: 2.211 ± 0.05	5.143ThrGly: 5.143 ± 0.075	1.143ThrHis: 1.143 ± 0.031	3.369ThrIle: 3.369 ± 0.056	2.222ThrLys: 2.222 ± 0.036	6.021ThrLeu: 6.021 ± 0.074	1.141ThrMet: 1.141 ± 0.032	1.851ThrAsn: 1.851 ± 0.043	3.215ThrPro: 3.215 ± 0.058	1.807ThrGln: 1.807 ± 0.048	2.817ThrArg: 2.817 ± 0.051	3.502ThrSer: 3.502 ± 0.055	3.332ThrThr: 3.332 ± 0.065	4.155ThrVal: 4.155 ± 0.062	0.593ThrTrp: 0.593 ± 0.027	1.842ThrTyr: 1.842 ± 0.052	0.0ThrXaa: 0.0 ± 0.0
Val	6.54ValAla: 6.54 ± 0.075	0.61ValCys: 0.61 ± 0.024	4.018ValAsp: 4.018 ± 0.054	4.191ValGlu: 4.191 ± 0.067	2.471ValPhe: 2.471 ± 0.051	4.974ValGly: 4.974 ± 0.083	1.237ValHis: 1.237 ± 0.03	4.555ValIle: 4.555 ± 0.063	3.127ValLys: 3.127 ± 0.056	5.831ValLeu: 5.831 ± 0.086	2.046ValMet: 2.046 ± 0.041	2.585ValAsn: 2.585 ± 0.051	2.99ValPro: 2.99 ± 0.05	2.032ValGln: 2.032 ± 0.044	3.623ValArg: 3.623 ± 0.055	4.568ValSer: 4.568 ± 0.07	4.651ValThr: 4.651 ± 0.079	4.862ValVal: 4.862 ± 0.075	0.748ValTrp: 0.748 ± 0.027	1.756ValTyr: 1.756 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	0.96TrpAla: 0.96 ± 0.034	0.118TrpCys: 0.118 ± 0.01	0.734TrpAsp: 0.734 ± 0.023	0.514TrpGlu: 0.514 ± 0.023	0.513TrpPhe: 0.513 ± 0.022	0.849TrpGly: 0.849 ± 0.03	0.293TrpHis: 0.293 ± 0.015	0.617TrpIle: 0.617 ± 0.02	0.527TrpLys: 0.527 ± 0.023	1.226TrpLeu: 1.226 ± 0.038	0.329TrpMet: 0.329 ± 0.017	0.459TrpAsn: 0.459 ± 0.02	0.474TrpPro: 0.474 ± 0.02	0.626TrpGln: 0.626 ± 0.022	0.824TrpArg: 0.824 ± 0.029	0.727TrpSer: 0.727 ± 0.026	0.668TrpThr: 0.668 ± 0.025	0.767TrpVal: 0.767 ± 0.025	0.182TrpTrp: 0.182 ± 0.014	0.351TrpTyr: 0.351 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.543TyrAla: 2.543 ± 0.052	0.312TyrCys: 0.312 ± 0.016	2.08TyrAsp: 2.08 ± 0.044	1.612TyrGlu: 1.612 ± 0.038	1.416TyrPhe: 1.416 ± 0.033	2.571TyrGly: 2.571 ± 0.053	0.813TyrHis: 0.813 ± 0.027	1.765TyrIle: 1.765 ± 0.038	1.303TyrLys: 1.303 ± 0.036	2.988TyrLeu: 2.988 ± 0.054	0.744TyrMet: 0.744 ± 0.028	1.172TyrAsn: 1.172 ± 0.035	1.273TyrPro: 1.273 ± 0.039	1.293TyrGln: 1.293 ± 0.038	1.834TyrArg: 1.834 ± 0.043	1.884TyrSer: 1.884 ± 0.043	1.498TyrThr: 1.498 ± 0.043	1.902TyrVal: 1.902 ± 0.039	0.409TyrTrp: 0.409 ± 0.02	1.064TyrTyr: 1.064 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3533 proteins (1223468 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---