Amino acid dipepetide frequency for Antrodiella citrinella

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.079AlaAla: 9.079 ± 0.062	0.98AlaCys: 0.98 ± 0.015	4.64AlaAsp: 4.64 ± 0.036	5.211AlaGlu: 5.211 ± 0.043	3.366AlaPhe: 3.366 ± 0.037	5.394AlaGly: 5.394 ± 0.038	2.104AlaHis: 2.104 ± 0.022	4.144AlaIle: 4.144 ± 0.033	4.177AlaLys: 4.177 ± 0.037	8.234AlaLeu: 8.234 ± 0.05	1.997AlaMet: 1.997 ± 0.023	2.81AlaAsn: 2.81 ± 0.026	5.377AlaPro: 5.377 ± 0.055	3.511AlaGln: 3.511 ± 0.032	5.076AlaArg: 5.076 ± 0.037	7.619AlaSer: 7.619 ± 0.047	5.425AlaThr: 5.425 ± 0.033	5.705AlaVal: 5.705 ± 0.045	1.116AlaTrp: 1.116 ± 0.016	2.282AlaTyr: 2.282 ± 0.025	0.044AlaXaa: 0.044 ± 0.003
Cys	0.89CysAla: 0.89 ± 0.015	0.184CysCys: 0.184 ± 0.008	0.611CysAsp: 0.611 ± 0.012	0.528CysGlu: 0.528 ± 0.011	0.455CysPhe: 0.455 ± 0.011	0.783CysGly: 0.783 ± 0.015	0.276CysHis: 0.276 ± 0.008	0.602CysIle: 0.602 ± 0.013	0.505CysLys: 0.505 ± 0.011	1.089CysLeu: 1.089 ± 0.017	0.258CysMet: 0.258 ± 0.007	0.36CysAsn: 0.36 ± 0.009	0.612CysPro: 0.612 ± 0.013	0.372CysGln: 0.372 ± 0.009	0.634CysArg: 0.634 ± 0.011	0.762CysSer: 0.762 ± 0.016	0.654CysThr: 0.654 ± 0.012	0.748CysVal: 0.748 ± 0.012	0.173CysTrp: 0.173 ± 0.006	0.297CysTyr: 0.297 ± 0.008	0.006CysXaa: 0.006 ± 0.001
Asp	5.39AspAla: 5.39 ± 0.033	0.542AspCys: 0.542 ± 0.013	5.001AspAsp: 5.001 ± 0.044	4.918AspGlu: 4.918 ± 0.043	2.221AspPhe: 2.221 ± 0.022	4.065AspGly: 4.065 ± 0.031	1.336AspHis: 1.336 ± 0.013	3.282AspIle: 3.282 ± 0.033	2.319AspLys: 2.319 ± 0.023	5.194AspLeu: 5.194 ± 0.034	1.37AspMet: 1.37 ± 0.018	1.855AspAsn: 1.855 ± 0.022	3.605AspPro: 3.605 ± 0.032	1.689AspGln: 1.689 ± 0.019	2.904AspArg: 2.904 ± 0.03	4.174AspSer: 4.174 ± 0.034	3.229AspThr: 3.229 ± 0.028	4.618AspVal: 4.618 ± 0.033	0.887AspTrp: 0.887 ± 0.015	1.511AspTyr: 1.511 ± 0.018	0.039AspXaa: 0.039 ± 0.004
Glu	5.209GluAla: 5.209 ± 0.041	0.548GluCys: 0.548 ± 0.011	4.832GluAsp: 4.832 ± 0.049	5.781GluGlu: 5.781 ± 0.061	1.953GluPhe: 1.953 ± 0.02	3.686GluGly: 3.686 ± 0.03	1.556GluHis: 1.556 ± 0.022	2.818GluIle: 2.818 ± 0.028	3.27GluLys: 3.27 ± 0.04	5.386GluLeu: 5.386 ± 0.038	1.444GluMet: 1.444 ± 0.017	1.889GluAsn: 1.889 ± 0.021	2.704GluPro: 2.704 ± 0.03	2.279GluGln: 2.279 ± 0.025	3.956GluArg: 3.956 ± 0.039	4.004GluSer: 4.004 ± 0.037	3.153GluThr: 3.153 ± 0.022	3.967GluVal: 3.967 ± 0.03	0.896GluTrp: 0.896 ± 0.014	1.613GluTyr: 1.613 ± 0.021	0.035GluXaa: 0.035 ± 0.003
Phe	3.219PheAla: 3.219 ± 0.029	0.482PheCys: 0.482 ± 0.01	2.331PheAsp: 2.331 ± 0.025	1.988PheGlu: 1.988 ± 0.019	1.548PhePhe: 1.548 ± 0.021	2.739PheGly: 2.739 ± 0.033	0.922PheHis: 0.922 ± 0.015	1.849PheIle: 1.849 ± 0.02	1.608PheLys: 1.608 ± 0.017	3.385PheLeu: 3.385 ± 0.03	0.828PheMet: 0.828 ± 0.012	1.363PheAsn: 1.363 ± 0.019	2.013PhePro: 2.013 ± 0.02	1.221PheGln: 1.221 ± 0.018	1.911PheArg: 1.911 ± 0.021	3.046PheSer: 3.046 ± 0.026	2.302PheThr: 2.302 ± 0.025	2.631PheVal: 2.631 ± 0.025	0.564PheTrp: 0.564 ± 0.013	1.051PheTyr: 1.051 ± 0.015	0.025PheXaa: 0.025 ± 0.003
Gly	4.946GlyAla: 4.946 ± 0.045	0.716GlyCys: 0.716 ± 0.016	3.536GlyAsp: 3.536 ± 0.033	3.427GlyGlu: 3.427 ± 0.029	2.512GlyPhe: 2.512 ± 0.023	5.261GlyGly: 5.261 ± 0.054	1.624GlyHis: 1.624 ± 0.019	3.087GlyIle: 3.087 ± 0.029	3.326GlyLys: 3.326 ± 0.029	5.483GlyLeu: 5.483 ± 0.04	1.501GlyMet: 1.501 ± 0.023	2.247GlyAsn: 2.247 ± 0.026	3.359GlyPro: 3.359 ± 0.032	2.252GlyGln: 2.252 ± 0.027	3.782GlyArg: 3.782 ± 0.029	5.324GlySer: 5.324 ± 0.043	3.822GlyThr: 3.822 ± 0.032	4.306GlyVal: 4.306 ± 0.036	1.038GlyTrp: 1.038 ± 0.013	1.806GlyTyr: 1.806 ± 0.022	0.034GlyXaa: 0.034 ± 0.003
His	2.193HisAla: 2.193 ± 0.021	0.299HisCys: 0.299 ± 0.007	1.422HisAsp: 1.422 ± 0.019	1.321HisGlu: 1.321 ± 0.017	0.988HisPhe: 0.988 ± 0.016	1.566HisGly: 1.566 ± 0.021	0.841HisHis: 0.841 ± 0.016	1.422HisIle: 1.422 ± 0.019	0.941HisLys: 0.941 ± 0.015	2.471HisLeu: 2.471 ± 0.023	0.522HisMet: 0.522 ± 0.01	0.844HisAsn: 0.844 ± 0.013	1.877HisPro: 1.877 ± 0.019	0.851HisGln: 0.851 ± 0.013	1.55HisArg: 1.55 ± 0.021	1.943HisSer: 1.943 ± 0.022	1.504HisThr: 1.504 ± 0.018	1.748HisVal: 1.748 ± 0.02	0.34HisTrp: 0.34 ± 0.01	0.704HisTyr: 0.704 ± 0.013	0.017HisXaa: 0.017 ± 0.002
Ile	4.238IleAla: 4.238 ± 0.035	0.632IleCys: 0.632 ± 0.013	2.786IleAsp: 2.786 ± 0.024	2.558IleGlu: 2.558 ± 0.026	1.897IlePhe: 1.897 ± 0.027	2.867IleGly: 2.867 ± 0.033	1.267IleHis: 1.267 ± 0.017	2.35IleIle: 2.35 ± 0.026	2.045IleLys: 2.045 ± 0.024	4.589IleLeu: 4.589 ± 0.038	0.99IleMet: 0.99 ± 0.013	1.59IleAsn: 1.59 ± 0.017	3.343IlePro: 3.343 ± 0.026	1.778IleGln: 1.778 ± 0.021	2.859IleArg: 2.859 ± 0.024	3.694IleSer: 3.694 ± 0.031	2.78IleThr: 2.78 ± 0.026	3.404IleVal: 3.404 ± 0.031	0.645IleTrp: 0.645 ± 0.012	1.274IleTyr: 1.274 ± 0.016	0.027IleXaa: 0.027 ± 0.003
Lys	4.388LysAla: 4.388 ± 0.042	0.442LysCys: 0.442 ± 0.011	2.762LysAsp: 2.762 ± 0.029	3.251LysGlu: 3.251 ± 0.033	1.467LysPhe: 1.467 ± 0.019	2.845LysGly: 2.845 ± 0.026	1.139LysHis: 1.139 ± 0.017	2.066LysIle: 2.066 ± 0.022	3.292LysLys: 3.292 ± 0.048	4.125LysLeu: 4.125 ± 0.035	0.964LysMet: 0.964 ± 0.017	1.518LysAsn: 1.518 ± 0.02	2.642LysPro: 2.642 ± 0.026	1.699LysGln: 1.699 ± 0.022	3.478LysArg: 3.478 ± 0.035	3.235LysSer: 3.235 ± 0.03	2.809LysThr: 2.809 ± 0.031	2.91LysVal: 2.91 ± 0.027	0.674LysTrp: 0.674 ± 0.014	1.294LysTyr: 1.294 ± 0.018	0.028LysXaa: 0.028 ± 0.004
Leu	7.925LeuAla: 7.925 ± 0.042	1.13LeuCys: 1.13 ± 0.017	5.319LeuAsp: 5.319 ± 0.037	5.383LeuGlu: 5.383 ± 0.044	3.293LeuPhe: 3.293 ± 0.03	5.404LeuGly: 5.404 ± 0.038	2.418LeuHis: 2.418 ± 0.027	3.89LeuIle: 3.89 ± 0.031	4.332LeuLys: 4.332 ± 0.032	8.335LeuLeu: 8.335 ± 0.069	1.786LeuMet: 1.786 ± 0.02	3.16LeuAsn: 3.16 ± 0.026	5.906LeuPro: 5.906 ± 0.042	3.727LeuGln: 3.727 ± 0.033	5.889LeuArg: 5.889 ± 0.038	7.642LeuSer: 7.642 ± 0.045	5.347LeuThr: 5.347 ± 0.033	5.789LeuVal: 5.789 ± 0.042	1.138LeuTrp: 1.138 ± 0.018	2.403LeuTyr: 2.403 ± 0.023	0.042LeuXaa: 0.042 ± 0.004
Met	1.866MetAla: 1.866 ± 0.021	0.235MetCys: 0.235 ± 0.007	1.354MetAsp: 1.354 ± 0.017	1.252MetGlu: 1.252 ± 0.018	0.822MetPhe: 0.822 ± 0.012	1.283MetGly: 1.283 ± 0.018	0.552MetHis: 0.552 ± 0.011	0.947MetIle: 0.947 ± 0.012	1.028MetLys: 1.028 ± 0.019	1.893MetLeu: 1.893 ± 0.021	0.556MetMet: 0.556 ± 0.012	0.783MetAsn: 0.783 ± 0.016	1.26MetPro: 1.26 ± 0.017	0.903MetGln: 0.903 ± 0.016	1.292MetArg: 1.292 ± 0.019	2.113MetSer: 2.113 ± 0.021	1.284MetThr: 1.284 ± 0.017	1.269MetVal: 1.269 ± 0.017	0.277MetTrp: 0.277 ± 0.008	0.57MetTyr: 0.57 ± 0.012	0.009MetXaa: 0.009 ± 0.002
Asn	3.254AsnAla: 3.254 ± 0.029	0.332AsnCys: 0.332 ± 0.01	1.907AsnAsp: 1.907 ± 0.021	1.821AsnGlu: 1.821 ± 0.022	1.284AsnPhe: 1.284 ± 0.018	2.6AsnGly: 2.6 ± 0.029	0.817AsnHis: 0.817 ± 0.012	1.886AsnIle: 1.886 ± 0.021	1.364AsnLys: 1.364 ± 0.017	3.025AsnLeu: 3.025 ± 0.027	0.777AsnMet: 0.777 ± 0.014	1.283AsnAsn: 1.283 ± 0.022	2.265AsnPro: 2.265 ± 0.025	1.084AsnGln: 1.084 ± 0.018	1.624AsnArg: 1.624 ± 0.02	2.389AsnSer: 2.389 ± 0.026	2.123AsnThr: 2.123 ± 0.019	2.564AsnVal: 2.564 ± 0.024	0.468AsnTrp: 0.468 ± 0.01	0.891AsnTyr: 0.891 ± 0.013	0.021AsnXaa: 0.021 ± 0.002
Pro	5.725ProAla: 5.725 ± 0.05	0.441ProCys: 0.441 ± 0.01	3.455ProAsp: 3.455 ± 0.032	3.746ProGlu: 3.746 ± 0.034	2.185ProPhe: 2.185 ± 0.024	3.622ProGly: 3.622 ± 0.035	1.517ProHis: 1.517 ± 0.021	2.744ProIle: 2.744 ± 0.028	2.547ProLys: 2.547 ± 0.028	5.113ProLeu: 5.113 ± 0.037	1.08ProMet: 1.08 ± 0.018	2.168ProAsn: 2.168 ± 0.024	6.293ProPro: 6.293 ± 0.081	2.376ProGln: 2.376 ± 0.03	3.23ProArg: 3.23 ± 0.031	6.896ProSer: 6.896 ± 0.054	4.587ProThr: 4.587 ± 0.038	4.148ProVal: 4.148 ± 0.032	0.65ProTrp: 0.65 ± 0.013	1.566ProTyr: 1.566 ± 0.024	0.039ProXaa: 0.039 ± 0.004
Gln	3.433GlnAla: 3.433 ± 0.03	0.437GlnCys: 0.437 ± 0.01	2.087GlnAsp: 2.087 ± 0.024	2.248GlnGlu: 2.248 ± 0.022	1.317GlnPhe: 1.317 ± 0.018	2.075GlnGly: 2.075 ± 0.026	1.075GlnHis: 1.075 ± 0.015	1.758GlnIle: 1.758 ± 0.019	1.69GlnLys: 1.69 ± 0.023	3.365GlnLeu: 3.365 ± 0.03	0.843GlnMet: 0.843 ± 0.016	1.259GlnAsn: 1.259 ± 0.018	2.324GlnPro: 2.324 ± 0.031	2.077GlnGln: 2.077 ± 0.055	2.389GlnArg: 2.389 ± 0.029	2.915GlnSer: 2.915 ± 0.031	2.239GlnThr: 2.239 ± 0.021	2.262GlnVal: 2.262 ± 0.025	0.545GlnTrp: 0.545 ± 0.012	1.145GlnTyr: 1.145 ± 0.016	0.021GlnXaa: 0.021 ± 0.002
Arg	5.007ArgAla: 5.007 ± 0.04	0.652ArgCys: 0.652 ± 0.013	3.37ArgAsp: 3.37 ± 0.031	3.7ArgGlu: 3.7 ± 0.034	2.064ArgPhe: 2.064 ± 0.023	3.347ArgGly: 3.347 ± 0.034	1.525ArgHis: 1.525 ± 0.018	2.923ArgIle: 2.923 ± 0.028	3.46ArgLys: 3.46 ± 0.031	5.344ArgLeu: 5.344 ± 0.034	1.391ArgMet: 1.391 ± 0.017	2.036ArgAsn: 2.036 ± 0.021	3.399ArgPro: 3.399 ± 0.034	2.265ArgGln: 2.265 ± 0.021	4.789ArgArg: 4.789 ± 0.041	4.662ArgSer: 4.662 ± 0.036	3.575ArgThr: 3.575 ± 0.029	3.687ArgVal: 3.687 ± 0.032	0.882ArgTrp: 0.882 ± 0.014	1.617ArgTyr: 1.617 ± 0.021	0.03ArgXaa: 0.03 ± 0.003
Ser	7.085SerAla: 7.085 ± 0.046	0.786SerCys: 0.786 ± 0.013	4.763SerAsp: 4.763 ± 0.039	4.279SerGlu: 4.279 ± 0.034	3.016SerPhe: 3.016 ± 0.026	5.418SerGly: 5.418 ± 0.036	2.064SerHis: 2.064 ± 0.024	3.647SerIle: 3.647 ± 0.028	3.492SerLys: 3.492 ± 0.027	7.299SerLeu: 7.299 ± 0.048	1.715SerMet: 1.715 ± 0.019	2.709SerAsn: 2.709 ± 0.029	5.933SerPro: 5.933 ± 0.06	3.138SerGln: 3.138 ± 0.029	4.757SerArg: 4.757 ± 0.04	9.348SerSer: 9.348 ± 0.071	5.751SerThr: 5.751 ± 0.039	5.195SerVal: 5.195 ± 0.036	0.995SerTrp: 0.995 ± 0.014	1.98SerTyr: 1.98 ± 0.024	0.036SerXaa: 0.036 ± 0.003
Thr	5.325ThrAla: 5.325 ± 0.042	0.668ThrCys: 0.668 ± 0.012	3.029ThrAsp: 3.029 ± 0.025	3.015ThrGlu: 3.015 ± 0.03	2.415ThrPhe: 2.415 ± 0.024	3.833ThrGly: 3.833 ± 0.029	1.511ThrHis: 1.511 ± 0.018	3.053ThrIle: 3.053 ± 0.033	2.541ThrLys: 2.541 ± 0.025	5.854ThrLeu: 5.854 ± 0.037	1.183ThrMet: 1.183 ± 0.015	2.014ThrAsn: 2.014 ± 0.025	4.817ThrPro: 4.817 ± 0.045	2.179ThrGln: 2.179 ± 0.022	3.348ThrArg: 3.348 ± 0.029	5.609ThrSer: 5.609 ± 0.041	4.258ThrThr: 4.258 ± 0.038	4.062ThrVal: 4.062 ± 0.033	0.809ThrTrp: 0.809 ± 0.013	1.623ThrTyr: 1.623 ± 0.018	0.033ThrXaa: 0.033 ± 0.003
Val	5.811ValAla: 5.811 ± 0.04	0.771ValCys: 0.771 ± 0.014	4.239ValAsp: 4.239 ± 0.034	4.181ValGlu: 4.181 ± 0.031	2.564ValPhe: 2.564 ± 0.025	3.918ValGly: 3.918 ± 0.033	1.699ValHis: 1.699 ± 0.019	3.091ValIle: 3.091 ± 0.03	3.197ValLys: 3.197 ± 0.026	6.211ValLeu: 6.211 ± 0.045	1.409ValMet: 1.409 ± 0.014	2.277ValAsn: 2.277 ± 0.026	4.248ValPro: 4.248 ± 0.032	2.616ValGln: 2.616 ± 0.026	3.753ValArg: 3.753 ± 0.028	5.054ValSer: 5.054 ± 0.039	3.804ValThr: 3.804 ± 0.035	5.021ValVal: 5.021 ± 0.041	0.935ValTrp: 0.935 ± 0.017	1.878ValTyr: 1.878 ± 0.021	0.036ValXaa: 0.036 ± 0.004
Trp	0.995TrpAla: 0.995 ± 0.014	0.174TrpCys: 0.174 ± 0.005	0.897TrpAsp: 0.897 ± 0.017	0.861TrpGlu: 0.861 ± 0.015	0.545TrpPhe: 0.545 ± 0.012	0.813TrpGly: 0.813 ± 0.016	0.355TrpHis: 0.355 ± 0.01	0.709TrpIle: 0.709 ± 0.012	0.787TrpLys: 0.787 ± 0.013	1.268TrpLeu: 1.268 ± 0.017	0.332TrpMet: 0.332 ± 0.007	0.566TrpAsn: 0.566 ± 0.011	0.575TrpPro: 0.575 ± 0.012	0.507TrpGln: 0.507 ± 0.011	0.889TrpArg: 0.889 ± 0.016	1.011TrpSer: 1.011 ± 0.014	0.897TrpThr: 0.897 ± 0.014	0.846TrpVal: 0.846 ± 0.014	0.28TrpTrp: 0.28 ± 0.008	0.409TrpTyr: 0.409 ± 0.008	0.01TrpXaa: 0.01 ± 0.002
Tyr	2.267TyrAla: 2.267 ± 0.022	0.341TyrCys: 0.341 ± 0.009	1.779TyrAsp: 1.779 ± 0.022	1.473TyrGlu: 1.473 ± 0.02	1.092TyrPhe: 1.092 ± 0.016	1.841TyrGly: 1.841 ± 0.022	0.747TyrHis: 0.747 ± 0.014	1.323TyrIle: 1.323 ± 0.019	1.087TyrLys: 1.087 ± 0.015	2.555TyrLeu: 2.555 ± 0.025	0.588TyrMet: 0.588 ± 0.011	1.027TyrAsn: 1.027 ± 0.017	1.533TyrPro: 1.533 ± 0.02	0.961TyrGln: 0.961 ± 0.015	1.582TyrArg: 1.582 ± 0.02	1.922TyrSer: 1.922 ± 0.024	1.601TyrThr: 1.601 ± 0.019	1.788TyrVal: 1.788 ± 0.019	0.405TyrTrp: 0.405 ± 0.009	0.854TyrTyr: 0.854 ± 0.014	0.015TyrXaa: 0.015 ± 0.002
Xaa	0.045XaaAla: 0.045 ± 0.004	0.008XaaCys: 0.008 ± 0.001	0.032XaaAsp: 0.032 ± 0.004	0.034XaaGlu: 0.034 ± 0.003	0.022XaaPhe: 0.022 ± 0.003	0.032XaaGly: 0.032 ± 0.003	0.017XaaHis: 0.017 ± 0.002	0.023XaaIle: 0.023 ± 0.002	0.022XaaLys: 0.022 ± 0.003	0.043XaaLeu: 0.043 ± 0.004	0.014XaaMet: 0.014 ± 0.002	0.02XaaAsn: 0.02 ± 0.002	0.041XaaPro: 0.041 ± 0.004	0.018XaaGln: 0.018 ± 0.002	0.032XaaArg: 0.032 ± 0.003	0.044XaaSer: 0.044 ± 0.004	0.032XaaThr: 0.032 ± 0.003	0.044XaaVal: 0.044 ± 0.004	0.01XaaTrp: 0.01 ± 0.002	0.014XaaTyr: 0.014 ± 0.002	0.061XaaXaa: 0.061 ± 0.011

Statistics based on 9798 proteins (4715391 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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