Amino acid dipepetide frequency for Acetobacter peroxydans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.175AlaAla: 16.175 ± 0.189	1.67AlaCys: 1.67 ± 0.052	6.343AlaAsp: 6.343 ± 0.096	6.918AlaGlu: 6.918 ± 0.113	3.984AlaPhe: 3.984 ± 0.077	10.977AlaGly: 10.977 ± 0.137	2.834AlaHis: 2.834 ± 0.069	5.056AlaIle: 5.056 ± 0.081	2.547AlaLys: 2.547 ± 0.074	14.707AlaLeu: 14.707 ± 0.209	3.529AlaMet: 3.529 ± 0.065	2.552AlaAsn: 2.552 ± 0.051	6.409AlaPro: 6.409 ± 0.102	5.177AlaGln: 5.177 ± 0.095	9.906AlaArg: 9.906 ± 0.152	6.695AlaSer: 6.695 ± 0.112	6.545AlaThr: 6.545 ± 0.088	8.419AlaVal: 8.419 ± 0.107	1.629AlaTrp: 1.629 ± 0.05	2.43AlaTyr: 2.43 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	1.399CysAla: 1.399 ± 0.046	0.163CysCys: 0.163 ± 0.015	0.575CysAsp: 0.575 ± 0.028	0.455CysGlu: 0.455 ± 0.026	0.361CysPhe: 0.361 ± 0.018	1.221CysGly: 1.221 ± 0.04	0.282CysHis: 0.282 ± 0.022	0.49CysIle: 0.49 ± 0.028	0.22CysLys: 0.22 ± 0.017	1.155CysLeu: 1.155 ± 0.038	0.241CysMet: 0.241 ± 0.018	0.262CysAsn: 0.262 ± 0.019	0.62CysPro: 0.62 ± 0.033	0.312CysGln: 0.312 ± 0.021	0.715CysArg: 0.715 ± 0.031	0.532CysSer: 0.532 ± 0.023	0.656CysThr: 0.656 ± 0.034	0.936CysVal: 0.936 ± 0.035	0.133CysTrp: 0.133 ± 0.013	0.234CysTyr: 0.234 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	6.255AspAla: 6.255 ± 0.104	0.519AspCys: 0.519 ± 0.027	2.531AspAsp: 2.531 ± 0.064	3.034AspGlu: 3.034 ± 0.065	1.862AspPhe: 1.862 ± 0.049	4.543AspGly: 4.543 ± 0.088	1.211AspHis: 1.211 ± 0.043	3.017AspIle: 3.017 ± 0.069	1.362AspLys: 1.362 ± 0.047	5.398AspLeu: 5.398 ± 0.087	1.744AspMet: 1.744 ± 0.043	1.313AspAsn: 1.313 ± 0.04	3.073AspPro: 3.073 ± 0.064	1.59AspGln: 1.59 ± 0.043	3.515AspArg: 3.515 ± 0.078	2.506AspSer: 2.506 ± 0.059	3.151AspThr: 3.151 ± 0.072	4.034AspVal: 4.034 ± 0.074	0.882AspTrp: 0.882 ± 0.035	1.292AspTyr: 1.292 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	7.098GluAla: 7.098 ± 0.117	0.385GluCys: 0.385 ± 0.025	2.65GluAsp: 2.65 ± 0.061	3.118GluGlu: 3.118 ± 0.074	1.392GluPhe: 1.392 ± 0.045	4.307GluGly: 4.307 ± 0.084	1.315GluHis: 1.315 ± 0.044	2.752GluIle: 2.752 ± 0.062	2.194GluLys: 2.194 ± 0.061	4.649GluLeu: 4.649 ± 0.09	1.235GluMet: 1.235 ± 0.04	1.699GluAsn: 1.699 ± 0.054	2.33GluPro: 2.33 ± 0.056	2.82GluGln: 2.82 ± 0.071	4.665GluArg: 4.665 ± 0.084	2.533GluSer: 2.533 ± 0.055	3.571GluThr: 3.571 ± 0.075	3.191GluVal: 3.191 ± 0.069	0.623GluTrp: 0.623 ± 0.03	0.963GluTyr: 0.963 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	3.7PheAla: 3.7 ± 0.07	0.475PheCys: 0.475 ± 0.024	2.027PheAsp: 2.027 ± 0.064	1.751PheGlu: 1.751 ± 0.049	1.274PhePhe: 1.274 ± 0.042	3.187PheGly: 3.187 ± 0.066	0.782PheHis: 0.782 ± 0.034	1.556PheIle: 1.556 ± 0.045	0.682PheLys: 0.682 ± 0.035	3.436PheLeu: 3.436 ± 0.065	0.952PheMet: 0.952 ± 0.032	0.982PheAsn: 0.982 ± 0.044	1.559PhePro: 1.559 ± 0.047	0.985PheGln: 0.985 ± 0.035	2.259PheArg: 2.259 ± 0.052	2.428PheSer: 2.428 ± 0.058	1.969PheThr: 1.969 ± 0.051	2.577PheVal: 2.577 ± 0.058	0.487PheTrp: 0.487 ± 0.028	0.872PheTyr: 0.872 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	9.149GlyAla: 9.149 ± 0.113	1.1GlyCys: 1.1 ± 0.038	3.566GlyAsp: 3.566 ± 0.061	4.158GlyGlu: 4.158 ± 0.08	3.217GlyPhe: 3.217 ± 0.062	7.293GlyGly: 7.293 ± 0.124	2.081GlyHis: 2.081 ± 0.061	3.931GlyIle: 3.931 ± 0.068	2.586GlyLys: 2.586 ± 0.078	9.466GlyLeu: 9.466 ± 0.131	2.492GlyMet: 2.492 ± 0.052	1.997GlyAsn: 1.997 ± 0.055	3.508GlyPro: 3.508 ± 0.073	3.616GlyGln: 3.616 ± 0.071	6.257GlyArg: 6.257 ± 0.092	4.466GlySer: 4.466 ± 0.072	4.678GlyThr: 4.678 ± 0.082	6.579GlyVal: 6.579 ± 0.105	1.48GlyTrp: 1.48 ± 0.048	2.082GlyTyr: 2.082 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	2.944HisAla: 2.944 ± 0.073	0.264HisCys: 0.264 ± 0.019	1.505HisAsp: 1.505 ± 0.046	1.293HisGlu: 1.293 ± 0.041	0.881HisPhe: 0.881 ± 0.035	2.162HisGly: 2.162 ± 0.051	0.684HisHis: 0.684 ± 0.034	1.0HisIle: 1.0 ± 0.038	0.561HisLys: 0.561 ± 0.028	2.175HisLeu: 2.175 ± 0.057	0.636HisMet: 0.636 ± 0.03	0.621HisAsn: 0.621 ± 0.029	1.485HisPro: 1.485 ± 0.044	0.638HisGln: 0.638 ± 0.029	1.427HisArg: 1.427 ± 0.044	1.044HisSer: 1.044 ± 0.035	1.285HisThr: 1.285 ± 0.048	1.917HisVal: 1.917 ± 0.051	0.418HisTrp: 0.418 ± 0.025	0.594HisTyr: 0.594 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.801IleAla: 5.801 ± 0.082	0.5IleCys: 0.5 ± 0.026	2.502IleAsp: 2.502 ± 0.051	2.617IleGlu: 2.617 ± 0.061	1.374IlePhe: 1.374 ± 0.049	4.062IleGly: 4.062 ± 0.07	0.962IleHis: 0.962 ± 0.037	2.058IleIle: 2.058 ± 0.064	1.205IleLys: 1.205 ± 0.047	4.372IleLeu: 4.372 ± 0.082	1.14IleMet: 1.14 ± 0.041	1.357IleAsn: 1.357 ± 0.041	2.338IlePro: 2.338 ± 0.045	1.238IleGln: 1.238 ± 0.043	3.207IleArg: 3.207 ± 0.069	2.879IleSer: 2.879 ± 0.071	2.858IleThr: 2.858 ± 0.063	3.517IleVal: 3.517 ± 0.067	0.486IleTrp: 0.486 ± 0.023	0.917IleTyr: 0.917 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	3.544LysAla: 3.544 ± 0.078	0.14LysCys: 0.14 ± 0.014	1.503LysAsp: 1.503 ± 0.043	1.341LysGlu: 1.341 ± 0.046	0.584LysPhe: 0.584 ± 0.028	2.192LysGly: 2.192 ± 0.061	0.499LysHis: 0.499 ± 0.026	1.257LysIle: 1.257 ± 0.043	1.151LysLys: 1.151 ± 0.046	2.672LysLeu: 2.672 ± 0.065	0.6LysMet: 0.6 ± 0.031	0.842LysAsn: 0.842 ± 0.035	1.636LysPro: 1.636 ± 0.045	0.953LysGln: 0.953 ± 0.035	1.716LysArg: 1.716 ± 0.048	1.367LysSer: 1.367 ± 0.046	1.814LysThr: 1.814 ± 0.05	1.933LysVal: 1.933 ± 0.055	0.291LysTrp: 0.291 ± 0.018	0.492LysTyr: 0.492 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	14.0LeuAla: 14.0 ± 0.18	1.401LeuCys: 1.401 ± 0.042	5.991LeuAsp: 5.991 ± 0.088	5.571LeuGlu: 5.571 ± 0.097	3.751LeuPhe: 3.751 ± 0.072	7.98LeuGly: 7.98 ± 0.107	2.618LeuHis: 2.618 ± 0.066	4.204LeuIle: 4.204 ± 0.077	2.834LeuLys: 2.834 ± 0.067	10.61LeuLeu: 10.61 ± 0.181	2.492LeuMet: 2.492 ± 0.06	2.786LeuAsn: 2.786 ± 0.06	6.913LeuPro: 6.913 ± 0.106	3.063LeuGln: 3.063 ± 0.058	7.998LeuArg: 7.998 ± 0.118	7.279LeuSer: 7.279 ± 0.108	5.665LeuThr: 5.665 ± 0.093	7.642LeuVal: 7.642 ± 0.131	1.335LeuTrp: 1.335 ± 0.053	2.211LeuTyr: 2.211 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	3.492MetAla: 3.492 ± 0.069	0.158MetCys: 0.158 ± 0.014	1.32MetAsp: 1.32 ± 0.038	1.31MetGlu: 1.31 ± 0.038	0.579MetPhe: 0.579 ± 0.026	2.134MetGly: 2.134 ± 0.05	0.485MetHis: 0.485 ± 0.026	1.209MetIle: 1.209 ± 0.043	0.861MetLys: 0.861 ± 0.031	2.803MetLeu: 2.803 ± 0.062	0.603MetMet: 0.603 ± 0.03	0.743MetAsn: 0.743 ± 0.027	1.607MetPro: 1.607 ± 0.042	1.072MetGln: 1.072 ± 0.037	1.785MetArg: 1.785 ± 0.045	1.579MetSer: 1.579 ± 0.043	1.974MetThr: 1.974 ± 0.049	1.779MetVal: 1.779 ± 0.05	0.197MetTrp: 0.197 ± 0.016	0.269MetTyr: 0.269 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.296AsnAla: 3.296 ± 0.064	0.264AsnCys: 0.264 ± 0.018	1.283AsnAsp: 1.283 ± 0.041	1.138AsnGlu: 1.138 ± 0.036	0.803AsnPhe: 0.803 ± 0.036	2.353AsnGly: 2.353 ± 0.055	0.517AsnHis: 0.517 ± 0.027	1.322AsnIle: 1.322 ± 0.042	0.605AsnLys: 0.605 ± 0.029	2.367AsnLeu: 2.367 ± 0.055	0.644AsnMet: 0.644 ± 0.03	0.707AsnAsn: 0.707 ± 0.038	1.827AsnPro: 1.827 ± 0.052	0.828AsnGln: 0.828 ± 0.03	1.749AsnArg: 1.749 ± 0.047	1.248AsnSer: 1.248 ± 0.045	1.6AsnThr: 1.6 ± 0.045	1.748AsnVal: 1.748 ± 0.055	0.403AsnTrp: 0.403 ± 0.022	0.644AsnTyr: 0.644 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	7.335ProAla: 7.335 ± 0.112	0.467ProCys: 0.467 ± 0.023	4.045ProAsp: 4.045 ± 0.072	3.87ProGlu: 3.87 ± 0.071	2.022ProPhe: 2.022 ± 0.054	4.635ProGly: 4.635 ± 0.085	1.347ProHis: 1.347 ± 0.044	1.764ProIle: 1.764 ± 0.045	1.149ProLys: 1.149 ± 0.041	5.365ProLeu: 5.365 ± 0.083	1.298ProMet: 1.298 ± 0.042	1.092ProAsn: 1.092 ± 0.035	3.274ProPro: 3.274 ± 0.087	2.147ProGln: 2.147 ± 0.051	3.114ProArg: 3.114 ± 0.067	2.947ProSer: 2.947 ± 0.059	2.829ProThr: 2.829 ± 0.058	4.984ProVal: 4.984 ± 0.077	0.794ProTrp: 0.794 ± 0.028	1.255ProTyr: 1.255 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	5.859GlnAla: 5.859 ± 0.112	0.288GlnCys: 0.288 ± 0.019	2.062GlnAsp: 2.062 ± 0.051	1.934GlnGlu: 1.934 ± 0.051	1.04GlnPhe: 1.04 ± 0.036	2.805GlnGly: 2.805 ± 0.056	0.823GlnHis: 0.823 ± 0.031	1.974GlnIle: 1.974 ± 0.05	1.269GlnLys: 1.269 ± 0.047	2.696GlnLeu: 2.696 ± 0.057	0.961GlnMet: 0.961 ± 0.034	1.076GlnAsn: 1.076 ± 0.035	2.19GlnPro: 2.19 ± 0.051	1.542GlnGln: 1.542 ± 0.053	2.248GlnArg: 2.248 ± 0.057	2.026GlnSer: 2.026 ± 0.054	2.481GlnThr: 2.481 ± 0.068	2.457GlnVal: 2.457 ± 0.063	0.452GlnTrp: 0.452 ± 0.024	0.737GlnTyr: 0.737 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	8.676ArgAla: 8.676 ± 0.147	0.635ArgCys: 0.635 ± 0.029	3.638ArgAsp: 3.638 ± 0.066	3.968ArgGlu: 3.968 ± 0.079	2.705ArgPhe: 2.705 ± 0.056	4.602ArgGly: 4.602 ± 0.08	1.982ArgHis: 1.982 ± 0.053	3.727ArgIle: 3.727 ± 0.065	2.225ArgLys: 2.225 ± 0.057	8.755ArgLeu: 8.755 ± 0.147	1.921ArgMet: 1.921 ± 0.051	1.959ArgAsn: 1.959 ± 0.048	3.733ArgPro: 3.733 ± 0.077	3.123ArgGln: 3.123 ± 0.076	5.78ArgArg: 5.78 ± 0.104	3.492ArgSer: 3.492 ± 0.072	3.579ArgThr: 3.579 ± 0.061	5.002ArgVal: 5.002 ± 0.088	0.977ArgTrp: 0.977 ± 0.039	1.783ArgTyr: 1.783 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	6.636SerAla: 6.636 ± 0.105	0.568SerCys: 0.568 ± 0.029	2.705SerAsp: 2.705 ± 0.051	2.527SerGlu: 2.527 ± 0.054	2.324SerPhe: 2.324 ± 0.058	5.574SerGly: 5.574 ± 0.094	1.257SerHis: 1.257 ± 0.035	2.611SerIle: 2.611 ± 0.057	1.106SerLys: 1.106 ± 0.044	6.255SerLeu: 6.255 ± 0.099	1.422SerMet: 1.422 ± 0.042	1.284SerAsn: 1.284 ± 0.053	3.117SerPro: 3.117 ± 0.067	1.694SerGln: 1.694 ± 0.054	3.826SerArg: 3.826 ± 0.079	3.459SerSer: 3.459 ± 0.096	3.132SerThr: 3.132 ± 0.074	4.449SerVal: 4.449 ± 0.085	0.767SerTrp: 0.767 ± 0.031	1.254SerTyr: 1.254 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	6.741ThrAla: 6.741 ± 0.099	0.579ThrCys: 0.579 ± 0.027	2.99ThrAsp: 2.99 ± 0.058	2.709ThrGlu: 2.709 ± 0.066	1.86ThrPhe: 1.86 ± 0.046	5.385ThrGly: 5.385 ± 0.096	1.376ThrHis: 1.376 ± 0.042	2.486ThrIle: 2.486 ± 0.057	1.149ThrLys: 1.149 ± 0.041	7.162ThrLeu: 7.162 ± 0.112	1.191ThrMet: 1.191 ± 0.038	1.184ThrAsn: 1.184 ± 0.044	4.085ThrPro: 4.085 ± 0.086	2.204ThrGln: 2.204 ± 0.058	3.847ThrArg: 3.847 ± 0.072	2.884ThrSer: 2.884 ± 0.074	3.27ThrThr: 3.27 ± 0.084	4.41ThrVal: 4.41 ± 0.072	0.739ThrTrp: 0.739 ± 0.036	1.189ThrTyr: 1.189 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	8.707ValAla: 8.707 ± 0.121	0.905ValCys: 0.905 ± 0.036	3.611ValAsp: 3.611 ± 0.072	4.005ValGlu: 4.005 ± 0.075	2.658ValPhe: 2.658 ± 0.054	5.329ValGly: 5.329 ± 0.092	1.55ValHis: 1.55 ± 0.042	3.553ValIle: 3.553 ± 0.07	1.764ValLys: 1.764 ± 0.051	8.385ValLeu: 8.385 ± 0.119	2.065ValMet: 2.065 ± 0.051	1.817ValAsn: 1.817 ± 0.053	4.25ValPro: 4.25 ± 0.072	2.482ValGln: 2.482 ± 0.064	5.38ValArg: 5.38 ± 0.086	4.741ValSer: 4.741 ± 0.082	4.426ValThr: 4.426 ± 0.073	6.021ValVal: 6.021 ± 0.104	0.996ValTrp: 0.996 ± 0.037	1.397ValTyr: 1.397 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	1.169TrpAla: 1.169 ± 0.04	0.202TrpCys: 0.202 ± 0.017	0.589TrpAsp: 0.589 ± 0.032	0.625TrpGlu: 0.625 ± 0.029	0.499TrpPhe: 0.499 ± 0.029	0.932TrpGly: 0.932 ± 0.036	0.417TrpHis: 0.417 ± 0.025	0.565TrpIle: 0.565 ± 0.025	0.471TrpLys: 0.471 ± 0.026	1.847TrpLeu: 1.847 ± 0.052	0.348TrpMet: 0.348 ± 0.019	0.438TrpAsn: 0.438 ± 0.025	0.745TrpPro: 0.745 ± 0.035	0.683TrpGln: 0.683 ± 0.03	1.255TrpArg: 1.255 ± 0.041	0.763TrpSer: 0.763 ± 0.032	0.675TrpThr: 0.675 ± 0.033	0.867TrpVal: 0.867 ± 0.037	0.203TrpTrp: 0.203 ± 0.017	0.291TrpTyr: 0.291 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.524TyrAla: 2.524 ± 0.057	0.282TyrCys: 0.282 ± 0.019	1.396TyrAsp: 1.396 ± 0.043	1.149TyrGlu: 1.149 ± 0.042	0.77TyrPhe: 0.77 ± 0.028	2.027TyrGly: 2.027 ± 0.061	0.512TyrHis: 0.512 ± 0.024	0.857TyrIle: 0.857 ± 0.036	0.588TyrLys: 0.588 ± 0.028	2.071TyrLeu: 2.071 ± 0.056	0.443TyrMet: 0.443 ± 0.023	0.633TyrAsn: 0.633 ± 0.031	1.035TyrPro: 1.035 ± 0.039	0.755TyrGln: 0.755 ± 0.028	1.611TyrArg: 1.611 ± 0.048	1.1TyrSer: 1.1 ± 0.041	1.282TyrThr: 1.282 ± 0.042	1.58TyrVal: 1.58 ± 0.047	0.292TyrTrp: 0.292 ± 0.02	0.616TyrTyr: 0.616 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2457 proteins (798204 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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