Amino acid dipepetide frequency for Helicobacter macacae MIT 99-5501

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.901AlaAla: 2.901 ± 0.104
1.085AlaCys: 1.085 ± 0.053
3.173AlaAsp: 3.173 ± 0.069
3.047AlaGlu: 3.047 ± 0.075
3.951AlaPhe: 3.951 ± 0.09
4.37AlaGly: 4.37 ± 0.106
1.699AlaHis: 1.699 ± 0.052
5.764AlaIle: 5.764 ± 0.105
8.434AlaLys: 8.434 ± 0.132
9.679AlaLeu: 9.679 ± 0.14
1.856AlaMet: 1.856 ± 0.061
4.743AlaAsn: 4.743 ± 0.093
2.305AlaPro: 2.305 ± 0.068
4.55AlaGln: 4.55 ± 0.094
3.516AlaArg: 3.516 ± 0.072
5.957AlaSer: 5.957 ± 0.121
4.06AlaThr: 4.06 ± 0.083
3.164AlaVal: 3.164 ± 0.078
0.489AlaTrp: 0.489 ± 0.026
2.703AlaTyr: 2.703 ± 0.075
0.0AlaXaa: 0.0 ± 0.0
Cys
1.441CysAla: 1.441 ± 0.046
0.135CysCys: 0.135 ± 0.016
0.825CysAsp: 0.825 ± 0.039
1.084CysGlu: 1.084 ± 0.048
0.657CysPhe: 0.657 ± 0.034
1.131CysGly: 1.131 ± 0.045
0.25CysHis: 0.25 ± 0.021
0.781CysIle: 0.781 ± 0.032
0.964CysLys: 0.964 ± 0.048
1.072CysLeu: 1.072 ± 0.046
0.22CysMet: 0.22 ± 0.019
0.442CysAsn: 0.442 ± 0.03
0.376CysPro: 0.376 ± 0.024
0.358CysGln: 0.358 ± 0.022
0.281CysArg: 0.281 ± 0.02
0.629CysSer: 0.629 ± 0.033
0.456CysThr: 0.456 ± 0.025
1.078CysVal: 1.078 ± 0.044
0.073CysTrp: 0.073 ± 0.011
0.458CysTyr: 0.458 ± 0.029
0.0CysXaa: 0.0 ± 0.0
Asp
2.582AspAla: 2.582 ± 0.064
0.723AspCys: 0.723 ± 0.031
2.395AspAsp: 2.395 ± 0.078
4.34AspGlu: 4.34 ± 0.082
5.059AspPhe: 5.059 ± 0.096
2.348AspGly: 2.348 ± 0.068
0.29AspHis: 0.29 ± 0.021
4.494AspIle: 4.494 ± 0.1
4.798AspLys: 4.798 ± 0.093
4.565AspLeu: 4.565 ± 0.102
1.322AspMet: 1.322 ± 0.05
2.22AspAsn: 2.22 ± 0.065
0.855AspPro: 0.855 ± 0.037
0.358AspGln: 0.358 ± 0.024
1.603AspArg: 1.603 ± 0.054
5.87AspSer: 5.87 ± 0.104
2.924AspThr: 2.924 ± 0.068
1.648AspVal: 1.648 ± 0.06
0.376AspTrp: 0.376 ± 0.026
1.911AspTyr: 1.911 ± 0.055
0.0AspXaa: 0.0 ± 0.0
Glu
4.845GluAla: 4.845 ± 0.088
0.931GluCys: 0.931 ± 0.039
2.182GluAsp: 2.182 ± 0.066
3.528GluGlu: 3.528 ± 0.087
3.37GluPhe: 3.37 ± 0.087
3.227GluGly: 3.227 ± 0.07
1.016GluHis: 1.016 ± 0.039
5.852GluIle: 5.852 ± 0.121
4.557GluLys: 4.557 ± 0.1
5.892GluLeu: 5.892 ± 0.1
1.44GluMet: 1.44 ± 0.042
3.685GluAsn: 3.685 ± 0.082
1.477GluPro: 1.477 ± 0.051
2.475GluGln: 2.475 ± 0.069
2.998GluArg: 2.998 ± 0.081
5.479GluSer: 5.479 ± 0.101
1.667GluThr: 1.667 ± 0.053
4.468GluVal: 4.468 ± 0.081
0.608GluTrp: 0.608 ± 0.032
2.142GluTyr: 2.142 ± 0.072
0.0GluXaa: 0.0 ± 0.0
Phe
4.719PheAla: 4.719 ± 0.091
1.158PheCys: 1.158 ± 0.048
3.109PheAsp: 3.109 ± 0.073
2.884PheGlu: 2.884 ± 0.068
2.712PhePhe: 2.712 ± 0.086
4.738PheGly: 4.738 ± 0.105
0.681PheHis: 0.681 ± 0.033
3.629PheIle: 3.629 ± 0.099
2.461PheLys: 2.461 ± 0.073
4.942PheLeu: 4.942 ± 0.092
1.2PheMet: 1.2 ± 0.045
1.763PheAsn: 1.763 ± 0.052
1.199PhePro: 1.199 ± 0.04
0.88PheGln: 0.88 ± 0.037
1.902PheArg: 1.902 ± 0.049
4.622PheSer: 4.622 ± 0.102
1.847PheThr: 1.847 ± 0.053
3.926PheVal: 3.926 ± 0.089
0.6PheTrp: 0.6 ± 0.034
2.059PheTyr: 2.059 ± 0.068
0.0PheXaa: 0.0 ± 0.0
Gly
5.211GlyAla: 5.211 ± 0.12
0.665GlyCys: 0.665 ± 0.039
3.008GlyAsp: 3.008 ± 0.074
4.456GlyGlu: 4.456 ± 0.087
3.987GlyPhe: 3.987 ± 0.089
5.499GlyGly: 5.499 ± 0.136
0.899GlyHis: 0.899 ± 0.036
5.367GlyIle: 5.367 ± 0.113
4.771GlyLys: 4.771 ± 0.093
5.708GlyLeu: 5.708 ± 0.104
1.149GlyMet: 1.149 ± 0.046
2.737GlyAsn: 2.737 ± 0.073
0.57GlyPro: 0.57 ± 0.033
1.703GlyGln: 1.703 ± 0.051
2.241GlyArg: 2.241 ± 0.062
4.004GlySer: 4.004 ± 0.084
2.495GlyThr: 2.495 ± 0.082
5.384GlyVal: 5.384 ± 0.106
0.45GlyTrp: 0.45 ± 0.028
2.636GlyTyr: 2.636 ± 0.067
0.0GlyXaa: 0.0 ± 0.0
His
1.019HisAla: 1.019 ± 0.043
0.335HisCys: 0.335 ± 0.024
0.588HisAsp: 0.588 ± 0.029
0.564HisGlu: 0.564 ± 0.029
1.366HisPhe: 1.366 ± 0.05
0.717HisGly: 0.717 ± 0.036
0.413HisHis: 0.413 ± 0.03
2.202HisIle: 2.202 ± 0.06
1.913HisLys: 1.913 ± 0.054
1.904HisLeu: 1.904 ± 0.064
0.132HisMet: 0.132 ± 0.014
1.124HisAsn: 1.124 ± 0.045
0.711HisPro: 0.711 ± 0.031
0.552HisGln: 0.552 ± 0.028
0.684HisArg: 0.684 ± 0.029
1.916HisSer: 1.916 ± 0.068
1.348HisThr: 1.348 ± 0.048
0.109HisVal: 0.109 ± 0.014
0.117HisTrp: 0.117 ± 0.012
0.847HisTyr: 0.847 ± 0.041
0.0HisXaa: 0.0 ± 0.0
Ile
7.355IleAla: 7.355 ± 0.115
1.167IleCys: 1.167 ± 0.051
4.848IleAsp: 4.848 ± 0.09
4.945IleGlu: 4.945 ± 0.092
3.745IlePhe: 3.745 ± 0.087
4.74IleGly: 4.74 ± 0.106
1.301IleHis: 1.301 ± 0.046
5.604IleIle: 5.604 ± 0.105
5.698IleLys: 5.698 ± 0.107
7.392IleLeu: 7.392 ± 0.117
1.322IleMet: 1.322 ± 0.047
3.65IleAsn: 3.65 ± 0.086
2.716IlePro: 2.716 ± 0.062
2.281IleGln: 2.281 ± 0.065
2.264IleArg: 2.264 ± 0.058
6.129IleSer: 6.129 ± 0.103
4.092IleThr: 4.092 ± 0.089
3.977IleVal: 3.977 ± 0.077
0.539IleTrp: 0.539 ± 0.031
2.959IleTyr: 2.959 ± 0.074
0.0IleXaa: 0.0 ± 0.0
Lys
5.942LysAla: 5.942 ± 0.098
0.735LysCys: 0.735 ± 0.041
5.047LysAsp: 5.047 ± 0.095
6.419LysGlu: 6.419 ± 0.122
2.314LysPhe: 2.314 ± 0.066
4.152LysGly: 4.152 ± 0.081
1.583LysHis: 1.583 ± 0.049
6.922LysIle: 6.922 ± 0.123
6.425LysLys: 6.425 ± 0.138
5.737LysLeu: 5.737 ± 0.095
1.877LysMet: 1.877 ± 0.057
5.61LysAsn: 5.61 ± 0.1
2.898LysPro: 2.898 ± 0.075
3.525LysGln: 3.525 ± 0.084
3.237LysArg: 3.237 ± 0.075
7.835LysSer: 7.835 ± 0.138
3.754LysThr: 3.754 ± 0.089
3.707LysVal: 3.707 ± 0.079
0.635LysTrp: 0.635 ± 0.031
2.547LysTyr: 2.547 ± 0.068
0.0LysXaa: 0.0 ± 0.0
Leu
8.257LeuAla: 8.257 ± 0.127
1.569LeuCys: 1.569 ± 0.059
5.9LeuAsp: 5.9 ± 0.096
7.407LeuGlu: 7.407 ± 0.104
4.333LeuPhe: 4.333 ± 0.092
7.346LeuGly: 7.346 ± 0.113
2.009LeuHis: 2.009 ± 0.054
5.838LeuIle: 5.838 ± 0.106
7.564LeuLys: 7.564 ± 0.112
8.984LeuLeu: 8.984 ± 0.155
1.618LeuMet: 1.618 ± 0.048
4.487LeuAsn: 4.487 ± 0.095
3.884LeuPro: 3.884 ± 0.085
4.536LeuGln: 4.536 ± 0.097
4.179LeuArg: 4.179 ± 0.081
8.45LeuSer: 8.45 ± 0.136
3.65LeuThr: 3.65 ± 0.087
4.598LeuVal: 4.598 ± 0.089
0.799LeuTrp: 0.799 ± 0.043
3.082LeuTyr: 3.082 ± 0.064
0.0LeuXaa: 0.0 ± 0.0
Met
1.383MetAla: 1.383 ± 0.055
0.259MetCys: 0.259 ± 0.018
0.807MetAsp: 0.807 ± 0.037
0.982MetGlu: 0.982 ± 0.039
0.765MetPhe: 0.765 ± 0.04
1.372MetGly: 1.372 ± 0.05
0.319MetHis: 0.319 ± 0.024
1.407MetIle: 1.407 ± 0.048
1.298MetLys: 1.298 ± 0.045
2.321MetLeu: 2.321 ± 0.065
0.397MetMet: 0.397 ± 0.026
0.789MetAsn: 0.789 ± 0.033
1.102MetPro: 1.102 ± 0.041
1.31MetGln: 1.31 ± 0.044
1.283MetArg: 1.283 ± 0.046
1.631MetSer: 1.631 ± 0.048
0.747MetThr: 0.747 ± 0.036
0.938MetVal: 0.938 ± 0.045
0.171MetTrp: 0.171 ± 0.018
0.406MetTyr: 0.406 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
5.422AsnAla: 5.422 ± 0.097
0.412AsnCys: 0.412 ± 0.026
2.58AsnAsp: 2.58 ± 0.068
3.118AsnGlu: 3.118 ± 0.06
2.3AsnPhe: 2.3 ± 0.063
3.412AsnGly: 3.412 ± 0.081
1.069AsnHis: 1.069 ± 0.038
4.129AsnIle: 4.129 ± 0.089
3.142AsnLys: 3.142 ± 0.072
6.201AsnLeu: 6.201 ± 0.129
0.885AsnMet: 0.885 ± 0.032
2.248AsnAsn: 2.248 ± 0.078
3.17AsnPro: 3.17 ± 0.075
1.977AsnGln: 1.977 ± 0.067
1.664AsnArg: 1.664 ± 0.05
3.487AsnSer: 3.487 ± 0.089
3.1AsnThr: 3.1 ± 0.123
2.606AsnVal: 2.606 ± 0.066
0.208AsnTrp: 0.208 ± 0.021
1.646AsnTyr: 1.646 ± 0.058
0.0AsnXaa: 0.0 ± 0.0
Pro
1.932ProAla: 1.932 ± 0.058
0.32ProCys: 0.32 ± 0.022
1.112ProAsp: 1.112 ± 0.04
1.112ProGlu: 1.112 ± 0.042
1.812ProPhe: 1.812 ± 0.054
0.675ProGly: 0.675 ± 0.04
1.004ProHis: 1.004 ± 0.039
2.365ProIle: 2.365 ± 0.068
3.863ProLys: 3.863 ± 0.088
3.616ProLeu: 3.616 ± 0.083
0.563ProMet: 0.563 ± 0.033
2.215ProAsn: 2.215 ± 0.064
1.446ProPro: 1.446 ± 0.051
2.218ProGln: 2.218 ± 0.066
1.209ProArg: 1.209 ± 0.048
2.917ProSer: 2.917 ± 0.08
2.157ProThr: 2.157 ± 0.065
1.205ProVal: 1.205 ± 0.044
0.145ProTrp: 0.145 ± 0.016
1.341ProTyr: 1.341 ± 0.047
0.0ProXaa: 0.0 ± 0.0
Gln
3.314GlnAla: 3.314 ± 0.088
0.346GlnCys: 0.346 ± 0.025
2.218GlnAsp: 2.218 ± 0.064
2.757GlnGlu: 2.757 ± 0.074
0.891GlnPhe: 0.891 ± 0.037
2.239GlnGly: 2.239 ± 0.059
0.479GlnHis: 0.479 ± 0.031
3.366GlnIle: 3.366 ± 0.079
4.755GlnLys: 4.755 ± 0.098
1.935GlnLeu: 1.935 ± 0.058
0.929GlnMet: 0.929 ± 0.036
4.514GlnAsn: 4.514 ± 0.113
0.817GlnPro: 0.817 ± 0.043
1.084GlnGln: 1.084 ± 0.041
1.381GlnArg: 1.381 ± 0.046
3.67GlnSer: 3.67 ± 0.085
2.121GlnThr: 2.121 ± 0.065
1.85GlnVal: 1.85 ± 0.06
0.281GlnTrp: 0.281 ± 0.018
1.145GlnTyr: 1.145 ± 0.039
0.0GlnXaa: 0.0 ± 0.0
Arg
3.106ArgAla: 3.106 ± 0.072
0.277ArgCys: 0.277 ± 0.02
2.291ArgAsp: 2.291 ± 0.062
3.326ArgGlu: 3.326 ± 0.077
2.704ArgPhe: 2.704 ± 0.067
2.508ArgGly: 2.508 ± 0.07
0.724ArgHis: 0.724 ± 0.033
2.974ArgIle: 2.974 ± 0.07
2.577ArgLys: 2.577 ± 0.066
4.038ArgLeu: 4.038 ± 0.078
0.688ArgMet: 0.688 ± 0.032
1.817ArgAsn: 1.817 ± 0.06
0.856ArgPro: 0.856 ± 0.034
1.383ArgGln: 1.383 ± 0.046
1.253ArgArg: 1.253 ± 0.051
2.068ArgSer: 2.068 ± 0.058
1.56ArgThr: 1.56 ± 0.044
2.597ArgVal: 2.597 ± 0.06
0.227ArgTrp: 0.227 ± 0.018
1.733ArgTyr: 1.733 ± 0.061
0.0ArgXaa: 0.0 ± 0.0
Ser
6.949SerAla: 6.949 ± 0.112
0.762SerCys: 0.762 ± 0.036
3.429SerAsp: 3.429 ± 0.073
4.15SerGlu: 4.15 ± 0.091
3.737SerPhe: 3.737 ± 0.079
5.137SerGly: 5.137 ± 0.1
1.738SerHis: 1.738 ± 0.058
5.686SerIle: 5.686 ± 0.109
6.859SerLys: 6.859 ± 0.113
8.482SerLeu: 8.482 ± 0.142
1.405SerMet: 1.405 ± 0.047
3.767SerAsn: 3.767 ± 0.107
2.886SerPro: 2.886 ± 0.072
3.968SerGln: 3.968 ± 0.094
2.829SerArg: 2.829 ± 0.072
6.952SerSer: 6.952 ± 0.136
4.905SerThr: 4.905 ± 0.118
4.638SerVal: 4.638 ± 0.085
0.501SerTrp: 0.501 ± 0.03
2.809SerTyr: 2.809 ± 0.072
0.0SerXaa: 0.0 ± 0.0
Thr
2.567ThrAla: 2.567 ± 0.066
0.383ThrCys: 0.383 ± 0.023
1.872ThrAsp: 1.872 ± 0.056
1.328ThrGlu: 1.328 ± 0.05
1.866ThrPhe: 1.866 ± 0.057
1.896ThrGly: 1.896 ± 0.065
1.395ThrHis: 1.395 ± 0.051
3.61ThrIle: 3.61 ± 0.089
4.728ThrLys: 4.728 ± 0.1
5.815ThrLeu: 5.815 ± 0.125
0.891ThrMet: 0.891 ± 0.039
2.91ThrAsn: 2.91 ± 0.082
3.026ThrPro: 3.026 ± 0.075
3.511ThrGln: 3.511 ± 0.091
1.841ThrArg: 1.841 ± 0.061
3.727ThrSer: 3.727 ± 0.08
3.139ThrThr: 3.139 ± 0.102
1.016ThrVal: 1.016 ± 0.047
0.198ThrTrp: 0.198 ± 0.018
1.564ThrTyr: 1.564 ± 0.049
0.0ThrXaa: 0.0 ± 0.0
Val
4.779ValAla: 4.779 ± 0.093
0.952ValCys: 0.952 ± 0.046
2.803ValAsp: 2.803 ± 0.068
3.221ValGlu: 3.221 ± 0.076
3.038ValPhe: 3.038 ± 0.072
4.328ValGly: 4.328 ± 0.096
0.714ValHis: 0.714 ± 0.031
3.915ValIle: 3.915 ± 0.082
3.007ValLys: 3.007 ± 0.068
6.067ValLeu: 6.067 ± 0.114
1.048ValMet: 1.048 ± 0.043
1.998ValAsn: 1.998 ± 0.066
1.63ValPro: 1.63 ± 0.052
1.694ValGln: 1.694 ± 0.053
2.607ValArg: 2.607 ± 0.061
3.659ValSer: 3.659 ± 0.087
1.245ValThr: 1.245 ± 0.046
3.623ValVal: 3.623 ± 0.093
0.518ValTrp: 0.518 ± 0.03
1.742ValTyr: 1.742 ± 0.05
0.0ValXaa: 0.0 ± 0.0
Trp
0.497TrpAla: 0.497 ± 0.03
0.108TrpCys: 0.108 ± 0.013
0.409TrpAsp: 0.409 ± 0.026
0.467TrpGlu: 0.467 ± 0.03
0.359TrpPhe: 0.359 ± 0.024
0.578TrpGly: 0.578 ± 0.03
0.227TrpHis: 0.227 ± 0.017
0.519TrpIle: 0.519 ± 0.03
0.379TrpLys: 0.379 ± 0.024
0.98TrpLeu: 0.98 ± 0.041
0.099TrpMet: 0.099 ± 0.012
0.343TrpAsn: 0.343 ± 0.027
0.046TrpPro: 0.046 ± 0.008
0.416TrpGln: 0.416 ± 0.025
0.391TrpArg: 0.391 ± 0.024
0.41TrpSer: 0.41 ± 0.026
0.204TrpThr: 0.204 ± 0.017
0.539TrpVal: 0.539 ± 0.03
0.121TrpTrp: 0.121 ± 0.015
0.244TrpTyr: 0.244 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.227TyrAla: 3.227 ± 0.081
0.389TyrCys: 0.389 ± 0.025
2.085TyrAsp: 2.085 ± 0.07
2.706TyrGlu: 2.706 ± 0.069
2.064TyrPhe: 2.064 ± 0.064
2.526TyrGly: 2.526 ± 0.064
0.751TyrHis: 0.751 ± 0.034
2.297TyrIle: 2.297 ± 0.064
2.707TyrLys: 2.707 ± 0.071
3.159TyrLeu: 3.159 ± 0.063
0.644TyrMet: 0.644 ± 0.029
1.715TyrAsn: 1.715 ± 0.061
1.259TyrPro: 1.259 ± 0.047
1.313TyrGln: 1.313 ± 0.05
1.346TyrArg: 1.346 ± 0.045
2.176TyrSer: 2.176 ± 0.05
1.811TyrThr: 1.811 ± 0.052
1.521TyrVal: 1.521 ± 0.044
0.278TyrTrp: 0.278 ± 0.024
1.426TyrTyr: 1.426 ± 0.055
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1946 proteins (668153 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski