Amino acid dipepetide frequency for Silvanigrella aquatica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.614AlaAla: 4.614 ± 0.119	0.763AlaCys: 0.763 ± 0.032	2.59AlaAsp: 2.59 ± 0.059	3.577AlaGlu: 3.577 ± 0.075	2.9AlaPhe: 2.9 ± 0.057	3.697AlaGly: 3.697 ± 0.079	1.343AlaHis: 1.343 ± 0.04	4.933AlaIle: 4.933 ± 0.077	5.029AlaLys: 5.029 ± 0.092	6.401AlaLeu: 6.401 ± 0.099	1.449AlaMet: 1.449 ± 0.041	3.191AlaAsn: 3.191 ± 0.066	2.077AlaPro: 2.077 ± 0.057	2.556AlaGln: 2.556 ± 0.056	2.355AlaArg: 2.355 ± 0.06	4.394AlaSer: 4.394 ± 0.117	3.294AlaThr: 3.294 ± 0.107	3.554AlaVal: 3.554 ± 0.069	0.582AlaTrp: 0.582 ± 0.028	1.859AlaTyr: 1.859 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.782CysAla: 0.782 ± 0.03	0.134CysCys: 0.134 ± 0.013	0.628CysAsp: 0.628 ± 0.025	0.718CysGlu: 0.718 ± 0.028	0.701CysPhe: 0.701 ± 0.025	0.805CysGly: 0.805 ± 0.027	0.282CysHis: 0.282 ± 0.015	0.947CysIle: 0.947 ± 0.027	0.696CysLys: 0.696 ± 0.024	1.179CysLeu: 1.179 ± 0.033	0.214CysMet: 0.214 ± 0.014	0.601CysAsn: 0.601 ± 0.026	0.449CysPro: 0.449 ± 0.022	0.425CysGln: 0.425 ± 0.023	0.357CysArg: 0.357 ± 0.02	0.966CysSer: 0.966 ± 0.044	0.551CysThr: 0.551 ± 0.041	0.697CysVal: 0.697 ± 0.027	0.122CysTrp: 0.122 ± 0.017	0.475CysTyr: 0.475 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	2.72AspAla: 2.72 ± 0.065	0.528AspCys: 0.528 ± 0.024	2.284AspAsp: 2.284 ± 0.064	3.198AspGlu: 3.198 ± 0.071	2.961AspPhe: 2.961 ± 0.059	2.373AspGly: 2.373 ± 0.056	0.9AspHis: 0.9 ± 0.03	4.303AspIle: 4.303 ± 0.065	3.883AspLys: 3.883 ± 0.075	4.654AspLeu: 4.654 ± 0.077	0.869AspMet: 0.869 ± 0.033	2.615AspAsn: 2.615 ± 0.053	1.831AspPro: 1.831 ± 0.053	1.244AspGln: 1.244 ± 0.035	1.539AspArg: 1.539 ± 0.041	3.3AspSer: 3.3 ± 0.058	1.968AspThr: 1.968 ± 0.044	2.541AspVal: 2.541 ± 0.053	0.54AspTrp: 0.54 ± 0.025	1.912AspTyr: 1.912 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	3.604GluAla: 3.604 ± 0.073	0.627GluCys: 0.627 ± 0.023	2.653GluAsp: 2.653 ± 0.056	4.35GluGlu: 4.35 ± 0.093	3.233GluPhe: 3.233 ± 0.059	2.971GluGly: 2.971 ± 0.056	1.114GluHis: 1.114 ± 0.041	6.283GluIle: 6.283 ± 0.108	6.805GluLys: 6.805 ± 0.116	5.793GluLeu: 5.793 ± 0.102	1.569GluMet: 1.569 ± 0.043	5.717GluAsn: 5.717 ± 0.078	1.495GluPro: 1.495 ± 0.049	2.24GluGln: 2.24 ± 0.053	2.426GluArg: 2.426 ± 0.06	4.037GluSer: 4.037 ± 0.071	2.948GluThr: 2.948 ± 0.06	3.449GluVal: 3.449 ± 0.06	0.582GluTrp: 0.582 ± 0.023	2.208GluTyr: 2.208 ± 0.048	0.0GluXaa: 0.0 ± 0.0
Phe	3.259PheAla: 3.259 ± 0.066	0.721PheCys: 0.721 ± 0.025	2.696PheAsp: 2.696 ± 0.057	3.347PheGlu: 3.347 ± 0.073	3.109PhePhe: 3.109 ± 0.071	3.107PheGly: 3.107 ± 0.063	1.144PheHis: 1.144 ± 0.031	5.09PheIle: 5.09 ± 0.074	3.713PheLys: 3.713 ± 0.066	5.501PheLeu: 5.501 ± 0.083	0.997PheMet: 0.997 ± 0.031	2.965PheAsn: 2.965 ± 0.062	2.032PhePro: 2.032 ± 0.041	1.949PheGln: 1.949 ± 0.041	1.603PheArg: 1.603 ± 0.041	4.809PheSer: 4.809 ± 0.071	2.376PheThr: 2.376 ± 0.049	2.813PheVal: 2.813 ± 0.054	0.554PheTrp: 0.554 ± 0.022	2.205PheTyr: 2.205 ± 0.05	0.0PheXaa: 0.0 ± 0.0
Gly	3.807GlyAla: 3.807 ± 0.081	0.721GlyCys: 0.721 ± 0.031	2.464GlyAsp: 2.464 ± 0.062	2.982GlyGlu: 2.982 ± 0.057	3.19GlyPhe: 3.19 ± 0.061	3.766GlyGly: 3.766 ± 0.077	1.106GlyHis: 1.106 ± 0.038	5.183GlyIle: 5.183 ± 0.077	4.337GlyLys: 4.337 ± 0.067	4.967GlyLeu: 4.967 ± 0.085	1.419GlyMet: 1.419 ± 0.045	3.189GlyAsn: 3.189 ± 0.065	1.126GlyPro: 1.126 ± 0.034	1.642GlyGln: 1.642 ± 0.041	1.975GlyArg: 1.975 ± 0.048	3.886GlySer: 3.886 ± 0.086	3.132GlyThr: 3.132 ± 0.108	3.751GlyVal: 3.751 ± 0.074	0.615GlyTrp: 0.615 ± 0.027	2.136GlyTyr: 2.136 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	1.197HisAla: 1.197 ± 0.036	0.267HisCys: 0.267 ± 0.017	0.95HisAsp: 0.95 ± 0.033	1.272HisGlu: 1.272 ± 0.037	1.307HisPhe: 1.307 ± 0.037	1.131HisGly: 1.131 ± 0.038	0.528HisHis: 0.528 ± 0.03	1.612HisIle: 1.612 ± 0.041	1.391HisLys: 1.391 ± 0.044	1.922HisLeu: 1.922 ± 0.049	0.409HisMet: 0.409 ± 0.023	1.196HisAsn: 1.196 ± 0.036	0.899HisPro: 0.899 ± 0.034	0.564HisGln: 0.564 ± 0.025	0.622HisArg: 0.622 ± 0.029	1.525HisSer: 1.525 ± 0.04	0.78HisThr: 0.78 ± 0.027	1.024HisVal: 1.024 ± 0.033	0.232HisTrp: 0.232 ± 0.015	0.774HisTyr: 0.774 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.56IleAla: 5.56 ± 0.074	1.139IleCys: 1.139 ± 0.038	4.399IleAsp: 4.399 ± 0.073	5.795IleGlu: 5.795 ± 0.089	4.934IlePhe: 4.934 ± 0.094	4.587IleGly: 4.587 ± 0.077	1.789IleHis: 1.789 ± 0.048	7.461IleIle: 7.461 ± 0.125	6.387IleLys: 6.387 ± 0.102	8.947IleLeu: 8.947 ± 0.128	1.573IleMet: 1.573 ± 0.043	5.266IleAsn: 5.266 ± 0.094	3.805IlePro: 3.805 ± 0.068	3.294IleGln: 3.294 ± 0.072	2.751IleArg: 2.751 ± 0.062	7.385IleSer: 7.385 ± 0.115	4.024IleThr: 4.024 ± 0.084	4.463IleVal: 4.463 ± 0.082	0.766IleTrp: 0.766 ± 0.031	3.224IleTyr: 3.224 ± 0.069	0.0IleXaa: 0.0 ± 0.0
Lys	3.89LysAla: 3.89 ± 0.073	0.716LysCys: 0.716 ± 0.028	3.707LysAsp: 3.707 ± 0.073	6.108LysGlu: 6.108 ± 0.104	3.509LysPhe: 3.509 ± 0.065	3.454LysGly: 3.454 ± 0.071	1.193LysHis: 1.193 ± 0.038	8.577LysIle: 8.577 ± 0.128	7.944LysLys: 7.944 ± 0.137	7.217LysLeu: 7.217 ± 0.113	2.067LysMet: 2.067 ± 0.058	7.656LysAsn: 7.656 ± 0.134	2.181LysPro: 2.181 ± 0.048	2.451LysGln: 2.451 ± 0.058	2.623LysArg: 2.623 ± 0.058	5.813LysSer: 5.813 ± 0.081	3.901LysThr: 3.901 ± 0.082	4.155LysVal: 4.155 ± 0.069	0.785LysTrp: 0.785 ± 0.031	3.293LysTyr: 3.293 ± 0.058	0.0LysXaa: 0.0 ± 0.0
Leu	6.093LeuAla: 6.093 ± 0.086	1.171LeuCys: 1.171 ± 0.034	4.5LeuAsp: 4.5 ± 0.081	6.049LeuGlu: 6.049 ± 0.089	5.316LeuPhe: 5.316 ± 0.093	5.622LeuGly: 5.622 ± 0.079	1.663LeuHis: 1.663 ± 0.045	7.608LeuIle: 7.608 ± 0.119	8.517LeuLys: 8.517 ± 0.129	8.809LeuLeu: 8.809 ± 0.125	1.972LeuMet: 1.972 ± 0.048	7.334LeuAsn: 7.334 ± 0.111	3.992LeuPro: 3.992 ± 0.07	3.305LeuGln: 3.305 ± 0.066	3.472LeuArg: 3.472 ± 0.071	8.531LeuSer: 8.531 ± 0.104	4.81LeuThr: 4.81 ± 0.086	4.745LeuVal: 4.745 ± 0.073	0.795LeuTrp: 0.795 ± 0.03	2.988LeuTyr: 2.988 ± 0.063	0.0LeuXaa: 0.0 ± 0.0
Met	1.459MetAla: 1.459 ± 0.038	0.215MetCys: 0.215 ± 0.015	0.919MetAsp: 0.919 ± 0.034	1.27MetGlu: 1.27 ± 0.04	0.782MetPhe: 0.782 ± 0.027	1.447MetGly: 1.447 ± 0.042	0.395MetHis: 0.395 ± 0.02	1.61MetIle: 1.61 ± 0.045	1.811MetLys: 1.811 ± 0.047	1.877MetLeu: 1.877 ± 0.043	0.506MetMet: 0.506 ± 0.023	1.461MetAsn: 1.461 ± 0.039	0.924MetPro: 0.924 ± 0.031	0.928MetGln: 0.928 ± 0.033	0.99MetArg: 0.99 ± 0.037	1.759MetSer: 1.759 ± 0.047	1.202MetThr: 1.202 ± 0.036	1.102MetVal: 1.102 ± 0.033	0.129MetTrp: 0.129 ± 0.011	0.509MetTyr: 0.509 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.661AsnAla: 3.661 ± 0.072	0.695AsnCys: 0.695 ± 0.026	2.887AsnAsp: 2.887 ± 0.063	4.278AsnGlu: 4.278 ± 0.082	3.469AsnPhe: 3.469 ± 0.065	3.152AsnGly: 3.152 ± 0.087	1.299AsnHis: 1.299 ± 0.039	6.259AsnIle: 6.259 ± 0.12	5.822AsnLys: 5.822 ± 0.093	6.715AsnLeu: 6.715 ± 0.099	1.362AsnMet: 1.362 ± 0.04	4.656AsnAsn: 4.656 ± 0.109	2.674AsnPro: 2.674 ± 0.05	2.453AsnGln: 2.453 ± 0.057	1.96AsnArg: 1.96 ± 0.046	5.605AsnSer: 5.605 ± 0.102	3.006AsnThr: 3.006 ± 0.087	3.069AsnVal: 3.069 ± 0.062	0.749AsnTrp: 0.749 ± 0.027	2.883AsnTyr: 2.883 ± 0.065	0.0AsnXaa: 0.0 ± 0.0
Pro	2.062ProAla: 2.062 ± 0.073	0.355ProCys: 0.355 ± 0.018	1.729ProAsp: 1.729 ± 0.042	2.706ProGlu: 2.706 ± 0.054	2.059ProPhe: 2.059 ± 0.047	1.878ProGly: 1.878 ± 0.056	0.885ProHis: 0.885 ± 0.031	2.788ProIle: 2.788 ± 0.058	2.76ProLys: 2.76 ± 0.059	3.53ProLeu: 3.53 ± 0.061	0.677ProMet: 0.677 ± 0.024	2.079ProAsn: 2.079 ± 0.054	1.258ProPro: 1.258 ± 0.046	1.473ProGln: 1.473 ± 0.045	1.05ProArg: 1.05 ± 0.036	2.718ProSer: 2.718 ± 0.073	1.889ProThr: 1.889 ± 0.056	2.156ProVal: 2.156 ± 0.06	0.403ProTrp: 0.403 ± 0.02	1.365ProTyr: 1.365 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	2.046GlnAla: 2.046 ± 0.054	0.349GlnCys: 0.349 ± 0.018	1.595GlnAsp: 1.595 ± 0.041	2.41GlnGlu: 2.41 ± 0.064	1.794GlnPhe: 1.794 ± 0.047	1.773GlnGly: 1.773 ± 0.052	0.566GlnHis: 0.566 ± 0.021	3.374GlnIle: 3.374 ± 0.065	3.426GlnLys: 3.426 ± 0.069	3.073GlnLeu: 3.073 ± 0.06	0.877GlnMet: 0.877 ± 0.029	3.1GlnAsn: 3.1 ± 0.06	0.932GlnPro: 0.932 ± 0.028	1.246GlnGln: 1.246 ± 0.046	1.225GlnArg: 1.225 ± 0.038	2.651GlnSer: 2.651 ± 0.052	1.729GlnThr: 1.729 ± 0.046	1.713GlnVal: 1.713 ± 0.043	0.359GlnTrp: 0.359 ± 0.017	1.161GlnTyr: 1.161 ± 0.04	0.0GlnXaa: 0.0 ± 0.0
Arg	2.272ArgAla: 2.272 ± 0.052	0.362ArgCys: 0.362 ± 0.02	1.646ArgAsp: 1.646 ± 0.041	2.332ArgGlu: 2.332 ± 0.055	1.755ArgPhe: 1.755 ± 0.052	1.812ArgGly: 1.812 ± 0.044	0.662ArgHis: 0.662 ± 0.026	3.108ArgIle: 3.108 ± 0.066	2.771ArgLys: 2.771 ± 0.06	3.178ArgLeu: 3.178 ± 0.064	0.88ArgMet: 0.88 ± 0.031	2.231ArgAsn: 2.231 ± 0.042	1.158ArgPro: 1.158 ± 0.04	1.092ArgGln: 1.092 ± 0.03	1.454ArgArg: 1.454 ± 0.044	2.44ArgSer: 2.44 ± 0.053	1.559ArgThr: 1.559 ± 0.04	2.112ArgVal: 2.112 ± 0.047	0.319ArgTrp: 0.319 ± 0.019	1.238ArgTyr: 1.238 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	4.512SerAla: 4.512 ± 0.113	1.004SerCys: 1.004 ± 0.039	3.628SerAsp: 3.628 ± 0.062	4.831SerGlu: 4.831 ± 0.08	4.61SerPhe: 4.61 ± 0.062	4.688SerGly: 4.688 ± 0.118	1.691SerHis: 1.691 ± 0.043	6.507SerIle: 6.507 ± 0.098	5.504SerLys: 5.504 ± 0.09	8.593SerLeu: 8.593 ± 0.11	1.555SerMet: 1.555 ± 0.041	4.714SerAsn: 4.714 ± 0.108	2.86SerPro: 2.86 ± 0.083	3.029SerGln: 3.029 ± 0.061	2.555SerArg: 2.555 ± 0.058	6.621SerSer: 6.621 ± 0.162	3.576SerThr: 3.576 ± 0.125	4.251SerVal: 4.251 ± 0.089	0.81SerTrp: 0.81 ± 0.036	2.822SerTyr: 2.822 ± 0.062	0.0SerXaa: 0.0 ± 0.0
Thr	3.359ThrAla: 3.359 ± 0.157	0.596ThrCys: 0.596 ± 0.046	2.058ThrAsp: 2.058 ± 0.052	2.814ThrGlu: 2.814 ± 0.052	2.399ThrPhe: 2.399 ± 0.055	3.25ThrGly: 3.25 ± 0.086	1.051ThrHis: 1.051 ± 0.036	3.786ThrIle: 3.786 ± 0.075	3.446ThrLys: 3.446 ± 0.066	5.062ThrLeu: 5.062 ± 0.083	0.889ThrMet: 0.889 ± 0.032	2.876ThrAsn: 2.876 ± 0.086	2.268ThrPro: 2.268 ± 0.068	1.89ThrGln: 1.89 ± 0.054	1.692ThrArg: 1.692 ± 0.043	3.857ThrSer: 3.857 ± 0.12	2.725ThrThr: 2.725 ± 0.158	2.762ThrVal: 2.762 ± 0.072	0.535ThrTrp: 0.535 ± 0.03	1.773ThrTyr: 1.773 ± 0.074	0.0ThrXaa: 0.0 ± 0.0
Val	3.679ValAla: 3.679 ± 0.064	0.679ValCys: 0.679 ± 0.026	2.544ValAsp: 2.544 ± 0.051	3.283ValGlu: 3.283 ± 0.065	2.912ValPhe: 2.912 ± 0.055	3.34ValGly: 3.34 ± 0.067	1.004ValHis: 1.004 ± 0.033	4.416ValIle: 4.416 ± 0.07	3.745ValLys: 3.745 ± 0.062	5.014ValLeu: 5.014 ± 0.086	1.109ValMet: 1.109 ± 0.036	2.948ValAsn: 2.948 ± 0.058	2.138ValPro: 2.138 ± 0.05	1.836ValGln: 1.836 ± 0.045	2.039ValArg: 2.039 ± 0.056	4.309ValSer: 4.309 ± 0.086	3.468ValThr: 3.468 ± 0.116	3.396ValVal: 3.396 ± 0.07	0.482ValTrp: 0.482 ± 0.022	1.827ValTyr: 1.827 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	0.51TrpAla: 0.51 ± 0.023	0.12TrpCys: 0.12 ± 0.009	0.522TrpAsp: 0.522 ± 0.027	0.622TrpGlu: 0.622 ± 0.025	0.474TrpPhe: 0.474 ± 0.022	0.573TrpGly: 0.573 ± 0.031	0.231TrpHis: 0.231 ± 0.016	0.835TrpIle: 0.835 ± 0.029	0.749TrpLys: 0.749 ± 0.027	1.06TrpLeu: 1.06 ± 0.035	0.244TrpMet: 0.244 ± 0.013	0.72TrpAsn: 0.72 ± 0.035	0.331TrpPro: 0.331 ± 0.02	0.446TrpGln: 0.446 ± 0.022	0.39TrpArg: 0.39 ± 0.018	0.664TrpSer: 0.664 ± 0.027	0.478TrpThr: 0.478 ± 0.03	0.515TrpVal: 0.515 ± 0.023	0.124TrpTrp: 0.124 ± 0.009	0.303TrpTyr: 0.303 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.069TyrAla: 2.069 ± 0.048	0.567TyrCys: 0.567 ± 0.024	1.764TyrAsp: 1.764 ± 0.046	2.164TyrGlu: 2.164 ± 0.048	2.576TyrPhe: 2.576 ± 0.051	1.97TyrGly: 1.97 ± 0.051	0.755TyrHis: 0.755 ± 0.027	2.871TyrIle: 2.871 ± 0.055	2.505TyrLys: 2.505 ± 0.051	3.801TyrLeu: 3.801 ± 0.069	0.656TyrMet: 0.656 ± 0.028	2.135TyrAsn: 2.135 ± 0.052	1.389TyrPro: 1.389 ± 0.043	1.338TyrGln: 1.338 ± 0.04	1.303TyrArg: 1.303 ± 0.042	3.088TyrSer: 3.088 ± 0.06	1.676TyrThr: 1.676 ± 0.055	1.901TyrVal: 1.901 ± 0.053	0.429TyrTrp: 0.429 ± 0.026	1.733TyrTyr: 1.733 ± 0.096	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2865 proteins (1001728 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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