Amino acid dipepetide frequency for Sphingobacterium lactis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.838AlaAla: 5.838 ± 0.105
0.619AlaCys: 0.619 ± 0.024
4.196AlaAsp: 4.196 ± 0.055
4.779AlaGlu: 4.779 ± 0.077
3.467AlaPhe: 3.467 ± 0.057
5.209AlaGly: 5.209 ± 0.083
1.345AlaHis: 1.345 ± 0.034
5.555AlaIle: 5.555 ± 0.093
5.068AlaLys: 5.068 ± 0.079
6.97AlaLeu: 6.97 ± 0.092
1.933AlaMet: 1.933 ± 0.041
3.75AlaAsn: 3.75 ± 0.065
2.17AlaPro: 2.17 ± 0.048
2.95AlaGln: 2.95 ± 0.053
2.487AlaArg: 2.487 ± 0.049
4.406AlaSer: 4.406 ± 0.063
3.695AlaThr: 3.695 ± 0.056
4.838AlaVal: 4.838 ± 0.069
0.831AlaTrp: 0.831 ± 0.025
2.993AlaTyr: 2.993 ± 0.054
0.0AlaXaa: 0.0 ± 0.0
Cys
0.484CysAla: 0.484 ± 0.02
0.131CysCys: 0.131 ± 0.011
0.321CysAsp: 0.321 ± 0.018
0.346CysGlu: 0.346 ± 0.018
0.34CysPhe: 0.34 ± 0.019
0.58CysGly: 0.58 ± 0.025
0.173CysHis: 0.173 ± 0.013
0.558CysIle: 0.558 ± 0.023
0.396CysLys: 0.396 ± 0.018
0.672CysLeu: 0.672 ± 0.023
0.18CysMet: 0.18 ± 0.015
0.334CysAsn: 0.334 ± 0.018
0.306CysPro: 0.306 ± 0.019
0.245CysGln: 0.245 ± 0.017
0.259CysArg: 0.259 ± 0.015
0.522CysSer: 0.522 ± 0.021
0.39CysThr: 0.39 ± 0.018
0.381CysVal: 0.381 ± 0.017
0.06CysTrp: 0.06 ± 0.008
0.278CysTyr: 0.278 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
4.019AspAla: 4.019 ± 0.057
0.329AspCys: 0.329 ± 0.015
2.499AspAsp: 2.499 ± 0.049
3.534AspGlu: 3.534 ± 0.053
3.286AspPhe: 3.286 ± 0.054
3.859AspGly: 3.859 ± 0.067
1.145AspHis: 1.145 ± 0.038
3.987AspIle: 3.987 ± 0.057
3.844AspLys: 3.844 ± 0.068
5.452AspLeu: 5.452 ± 0.063
1.319AspMet: 1.319 ± 0.029
2.708AspAsn: 2.708 ± 0.053
2.225AspPro: 2.225 ± 0.042
2.208AspGln: 2.208 ± 0.047
2.661AspArg: 2.661 ± 0.048
3.065AspSer: 3.065 ± 0.063
2.411AspThr: 2.411 ± 0.058
3.483AspVal: 3.483 ± 0.065
0.806AspTrp: 0.806 ± 0.024
2.684AspTyr: 2.684 ± 0.054
0.0AspXaa: 0.0 ± 0.0
Glu
4.529GluAla: 4.529 ± 0.069
0.273GluCys: 0.273 ± 0.016
3.317GluAsp: 3.317 ± 0.054
4.87GluGlu: 4.87 ± 0.096
2.833GluPhe: 2.833 ± 0.046
3.825GluGly: 3.825 ± 0.061
1.279GluHis: 1.279 ± 0.033
4.858GluIle: 4.858 ± 0.074
4.981GluLys: 4.981 ± 0.082
6.124GluLeu: 6.124 ± 0.074
1.558GluMet: 1.558 ± 0.038
3.811GluAsn: 3.811 ± 0.059
1.698GluPro: 1.698 ± 0.04
2.841GluGln: 2.841 ± 0.056
2.893GluArg: 2.893 ± 0.06
3.108GluSer: 3.108 ± 0.052
3.103GluThr: 3.103 ± 0.056
4.34GluVal: 4.34 ± 0.069
0.688GluTrp: 0.688 ± 0.026
2.18GluTyr: 2.18 ± 0.045
0.0GluXaa: 0.0 ± 0.0
Phe
3.447PheAla: 3.447 ± 0.059
0.41PheCys: 0.41 ± 0.021
3.095PheAsp: 3.095 ± 0.052
2.903PheGlu: 2.903 ± 0.06
2.528PhePhe: 2.528 ± 0.053
3.698PheGly: 3.698 ± 0.065
0.964PheHis: 0.964 ± 0.031
3.373PheIle: 3.373 ± 0.062
3.12PheLys: 3.12 ± 0.047
4.565PheLeu: 4.565 ± 0.075
1.26PheMet: 1.26 ± 0.036
2.797PheAsn: 2.797 ± 0.047
1.85PhePro: 1.85 ± 0.035
1.855PheGln: 1.855 ± 0.038
2.048PheArg: 2.048 ± 0.038
3.546PheSer: 3.546 ± 0.057
2.855PheThr: 2.855 ± 0.051
3.093PheVal: 3.093 ± 0.057
0.571PheTrp: 0.571 ± 0.023
2.04PheTyr: 2.04 ± 0.046
0.0PheXaa: 0.0 ± 0.0
Gly
4.692GlyAla: 4.692 ± 0.081
0.541GlyCys: 0.541 ± 0.025
3.423GlyAsp: 3.423 ± 0.053
3.78GlyGlu: 3.78 ± 0.057
3.719GlyPhe: 3.719 ± 0.065
4.604GlyGly: 4.604 ± 0.088
1.225GlyHis: 1.225 ± 0.033
5.315GlyIle: 5.315 ± 0.059
5.378GlyLys: 5.378 ± 0.073
6.323GlyLeu: 6.323 ± 0.078
1.881GlyMet: 1.881 ± 0.041
3.623GlyAsn: 3.623 ± 0.062
1.602GlyPro: 1.602 ± 0.038
2.534GlyGln: 2.534 ± 0.053
2.762GlyArg: 2.762 ± 0.056
4.21GlySer: 4.21 ± 0.071
3.98GlyThr: 3.98 ± 0.077
4.49GlyVal: 4.49 ± 0.073
0.836GlyTrp: 0.836 ± 0.029
3.181GlyTyr: 3.181 ± 0.056
0.0GlyXaa: 0.0 ± 0.0
His
1.446HisAla: 1.446 ± 0.037
0.187HisCys: 0.187 ± 0.014
0.98HisAsp: 0.98 ± 0.037
1.058HisGlu: 1.058 ± 0.029
1.135HisPhe: 1.135 ± 0.041
1.258HisGly: 1.258 ± 0.037
0.484HisHis: 0.484 ± 0.025
1.588HisIle: 1.588 ± 0.039
0.978HisLys: 0.978 ± 0.027
1.916HisLeu: 1.916 ± 0.043
0.416HisMet: 0.416 ± 0.02
0.947HisAsn: 0.947 ± 0.03
0.994HisPro: 0.994 ± 0.028
0.789HisGln: 0.789 ± 0.028
0.849HisArg: 0.849 ± 0.028
1.059HisSer: 1.059 ± 0.028
0.978HisThr: 0.978 ± 0.033
1.158HisVal: 1.158 ± 0.033
0.244HisTrp: 0.244 ± 0.015
0.938HisTyr: 0.938 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
5.841IleAla: 5.841 ± 0.081
0.629IleCys: 0.629 ± 0.025
4.401IleAsp: 4.401 ± 0.06
4.266IleGlu: 4.266 ± 0.069
3.237IlePhe: 3.237 ± 0.068
5.048IleGly: 5.048 ± 0.066
1.495IleHis: 1.495 ± 0.039
4.87IleIle: 4.87 ± 0.079
4.621IleLys: 4.621 ± 0.063
6.71IleLeu: 6.71 ± 0.105
1.441IleMet: 1.441 ± 0.039
3.883IleAsn: 3.883 ± 0.068
3.245IlePro: 3.245 ± 0.053
2.977IleGln: 2.977 ± 0.051
3.055IleArg: 3.055 ± 0.041
4.894IleSer: 4.894 ± 0.058
3.869IleThr: 3.869 ± 0.059
4.421IleVal: 4.421 ± 0.081
0.713IleTrp: 0.713 ± 0.027
2.614IleTyr: 2.614 ± 0.058
0.0IleXaa: 0.0 ± 0.0
Lys
4.975LysAla: 4.975 ± 0.068
0.245LysCys: 0.245 ± 0.015
4.346LysAsp: 4.346 ± 0.06
5.122LysGlu: 5.122 ± 0.085
2.769LysPhe: 2.769 ± 0.05
4.44LysGly: 4.44 ± 0.063
1.343LysHis: 1.343 ± 0.038
4.867LysIle: 4.867 ± 0.068
5.154LysLys: 5.154 ± 0.079
6.018LysLeu: 6.018 ± 0.078
1.958LysMet: 1.958 ± 0.041
4.007LysAsn: 4.007 ± 0.061
2.618LysPro: 2.618 ± 0.047
2.675LysGln: 2.675 ± 0.051
2.901LysArg: 2.901 ± 0.055
3.968LysSer: 3.968 ± 0.06
3.693LysThr: 3.693 ± 0.066
4.375LysVal: 4.375 ± 0.058
0.718LysTrp: 0.718 ± 0.023
2.735LysTyr: 2.735 ± 0.05
0.0LysXaa: 0.0 ± 0.0
Leu
7.148LeuAla: 7.148 ± 0.098
0.779LeuCys: 0.779 ± 0.028
5.265LeuAsp: 5.265 ± 0.068
5.64LeuGlu: 5.64 ± 0.082
4.844LeuPhe: 4.844 ± 0.072
6.331LeuGly: 6.331 ± 0.075
1.804LeuHis: 1.804 ± 0.044
6.462LeuIle: 6.462 ± 0.097
6.667LeuLys: 6.667 ± 0.077
9.258LeuLeu: 9.258 ± 0.133
2.339LeuMet: 2.339 ± 0.05
5.233LeuAsn: 5.233 ± 0.073
4.051LeuPro: 4.051 ± 0.058
3.879LeuGln: 3.879 ± 0.06
3.774LeuArg: 3.774 ± 0.053
6.466LeuSer: 6.466 ± 0.075
5.144LeuThr: 5.144 ± 0.079
5.71LeuVal: 5.71 ± 0.081
0.846LeuTrp: 0.846 ± 0.029
3.303LeuTyr: 3.303 ± 0.055
0.0LeuXaa: 0.0 ± 0.0
Met
1.955MetAla: 1.955 ± 0.04
0.131MetCys: 0.131 ± 0.011
1.505MetAsp: 1.505 ± 0.039
1.701MetGlu: 1.701 ± 0.037
0.885MetPhe: 0.885 ± 0.029
1.703MetGly: 1.703 ± 0.041
0.46MetHis: 0.46 ± 0.022
1.466MetIle: 1.466 ± 0.041
2.018MetLys: 2.018 ± 0.041
2.274MetLeu: 2.274 ± 0.051
0.644MetMet: 0.644 ± 0.026
1.419MetAsn: 1.419 ± 0.033
1.01MetPro: 1.01 ± 0.03
0.994MetGln: 0.994 ± 0.027
1.098MetArg: 1.098 ± 0.032
1.406MetSer: 1.406 ± 0.039
1.277MetThr: 1.277 ± 0.03
1.577MetVal: 1.577 ± 0.036
0.228MetTrp: 0.228 ± 0.012
0.719MetTyr: 0.719 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
3.738AsnAla: 3.738 ± 0.053
0.302AsnCys: 0.302 ± 0.015
2.527AsnAsp: 2.527 ± 0.049
2.962AsnGlu: 2.962 ± 0.05
2.797AsnPhe: 2.797 ± 0.049
3.708AsnGly: 3.708 ± 0.056
1.021AsnHis: 1.021 ± 0.027
4.028AsnIle: 4.028 ± 0.065
3.654AsnLys: 3.654 ± 0.056
5.243AsnLeu: 5.243 ± 0.072
1.31AsnMet: 1.31 ± 0.033
3.027AsnAsn: 3.027 ± 0.063
2.82AsnPro: 2.82 ± 0.052
2.146AsnGln: 2.146 ± 0.046
2.463AsnArg: 2.463 ± 0.052
3.377AsnSer: 3.377 ± 0.053
2.959AsnThr: 2.959 ± 0.057
3.07AsnVal: 3.07 ± 0.055
0.729AsnTrp: 0.729 ± 0.024
2.433AsnTyr: 2.433 ± 0.052
0.0AsnXaa: 0.0 ± 0.0
Pro
2.674ProAla: 2.674 ± 0.055
0.199ProCys: 0.199 ± 0.013
2.17ProAsp: 2.17 ± 0.046
3.068ProGlu: 3.068 ± 0.053
1.909ProPhe: 1.909 ± 0.04
2.365ProGly: 2.365 ± 0.047
0.706ProHis: 0.706 ± 0.027
2.803ProIle: 2.803 ± 0.052
2.5ProLys: 2.5 ± 0.046
3.265ProLeu: 3.265 ± 0.053
0.826ProMet: 0.826 ± 0.025
2.213ProAsn: 2.213 ± 0.041
0.814ProPro: 0.814 ± 0.028
1.449ProGln: 1.449 ± 0.037
1.194ProArg: 1.194 ± 0.031
2.198ProSer: 2.198 ± 0.045
2.25ProThr: 2.25 ± 0.043
2.594ProVal: 2.594 ± 0.051
0.438ProTrp: 0.438 ± 0.021
1.551ProTyr: 1.551 ± 0.042
0.0ProXaa: 0.0 ± 0.0
Gln
2.914GlnAla: 2.914 ± 0.05
0.171GlnCys: 0.171 ± 0.01
2.252GlnAsp: 2.252 ± 0.04
2.978GlnGlu: 2.978 ± 0.05
1.83GlnPhe: 1.83 ± 0.043
2.348GlnGly: 2.348 ± 0.045
0.918GlnHis: 0.918 ± 0.031
2.775GlnIle: 2.775 ± 0.047
2.539GlnLys: 2.539 ± 0.049
3.797GlnLeu: 3.797 ± 0.07
0.947GlnMet: 0.947 ± 0.031
1.902GlnAsn: 1.902 ± 0.044
1.312GlnPro: 1.312 ± 0.035
2.228GlnGln: 2.228 ± 0.055
1.663GlnArg: 1.663 ± 0.037
2.075GlnSer: 2.075 ± 0.046
2.012GlnThr: 2.012 ± 0.044
2.839GlnVal: 2.839 ± 0.048
0.476GlnTrp: 0.476 ± 0.021
1.615GlnTyr: 1.615 ± 0.037
0.0GlnXaa: 0.0 ± 0.0
Arg
2.625ArgAla: 2.625 ± 0.049
0.216ArgCys: 0.216 ± 0.015
2.166ArgAsp: 2.166 ± 0.044
2.719ArgGlu: 2.719 ± 0.048
2.188ArgPhe: 2.188 ± 0.043
2.301ArgGly: 2.301 ± 0.049
0.722ArgHis: 0.722 ± 0.024
3.268ArgIle: 3.268 ± 0.058
3.073ArgLys: 3.073 ± 0.055
3.816ArgLeu: 3.816 ± 0.061
1.178ArgMet: 1.178 ± 0.034
2.421ArgAsn: 2.421 ± 0.047
1.409ArgPro: 1.409 ± 0.034
1.496ArgGln: 1.496 ± 0.035
1.655ArgArg: 1.655 ± 0.044
2.343ArgSer: 2.343 ± 0.044
2.27ArgThr: 2.27 ± 0.051
2.524ArgVal: 2.524 ± 0.047
0.537ArgTrp: 0.537 ± 0.022
1.952ArgTyr: 1.952 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
4.297SerAla: 4.297 ± 0.062
0.612SerCys: 0.612 ± 0.022
3.082SerAsp: 3.082 ± 0.051
3.296SerGlu: 3.296 ± 0.051
3.388SerPhe: 3.388 ± 0.055
4.624SerGly: 4.624 ± 0.073
1.068SerHis: 1.068 ± 0.031
4.787SerIle: 4.787 ± 0.065
3.995SerLys: 3.995 ± 0.066
6.067SerLeu: 6.067 ± 0.079
1.435SerMet: 1.435 ± 0.035
3.248SerAsn: 3.248 ± 0.061
2.237SerPro: 2.237 ± 0.042
1.968SerGln: 1.968 ± 0.044
2.465SerArg: 2.465 ± 0.049
3.991SerSer: 3.991 ± 0.068
3.615SerThr: 3.615 ± 0.06
3.735SerVal: 3.735 ± 0.056
0.754SerTrp: 0.754 ± 0.029
2.721SerTyr: 2.721 ± 0.056
0.0SerXaa: 0.0 ± 0.0
Thr
4.132ThrAla: 4.132 ± 0.074
0.321ThrCys: 0.321 ± 0.018
3.042ThrAsp: 3.042 ± 0.054
3.15ThrGlu: 3.15 ± 0.061
2.801ThrPhe: 2.801 ± 0.051
4.057ThrGly: 4.057 ± 0.071
0.973ThrHis: 0.973 ± 0.028
3.994ThrIle: 3.994 ± 0.056
3.276ThrLys: 3.276 ± 0.058
5.173ThrLeu: 5.173 ± 0.074
1.114ThrMet: 1.114 ± 0.034
2.589ThrAsn: 2.589 ± 0.044
2.369ThrPro: 2.369 ± 0.045
1.729ThrGln: 1.729 ± 0.036
1.718ThrArg: 1.718 ± 0.041
3.264ThrSer: 3.264 ± 0.055
2.956ThrThr: 2.956 ± 0.061
3.781ThrVal: 3.781 ± 0.057
0.654ThrTrp: 0.654 ± 0.025
2.397ThrTyr: 2.397 ± 0.044
0.0ThrXaa: 0.0 ± 0.0
Val
4.583ValAla: 4.583 ± 0.072
0.487ValCys: 0.487 ± 0.02
3.935ValAsp: 3.935 ± 0.051
4.093ValGlu: 4.093 ± 0.073
3.11ValPhe: 3.11 ± 0.056
4.308ValGly: 4.308 ± 0.071
1.153ValHis: 1.153 ± 0.036
4.343ValIle: 4.343 ± 0.07
4.256ValLys: 4.256 ± 0.069
6.252ValLeu: 6.252 ± 0.084
1.492ValMet: 1.492 ± 0.038
3.396ValAsn: 3.396 ± 0.05
2.476ValPro: 2.476 ± 0.052
2.479ValGln: 2.479 ± 0.042
2.595ValArg: 2.595 ± 0.049
4.252ValSer: 4.252 ± 0.063
3.168ValThr: 3.168 ± 0.054
4.366ValVal: 4.366 ± 0.07
0.68ValTrp: 0.68 ± 0.024
2.384ValTyr: 2.384 ± 0.047
0.0ValXaa: 0.0 ± 0.0
Trp
0.767TrpAla: 0.767 ± 0.024
0.087TrpCys: 0.087 ± 0.009
0.627TrpAsp: 0.627 ± 0.024
0.705TrpGlu: 0.705 ± 0.026
0.559TrpPhe: 0.559 ± 0.026
0.819TrpGly: 0.819 ± 0.03
0.237TrpHis: 0.237 ± 0.014
0.755TrpIle: 0.755 ± 0.024
0.871TrpLys: 0.871 ± 0.027
1.105TrpLeu: 1.105 ± 0.035
0.351TrpMet: 0.351 ± 0.021
0.702TrpAsn: 0.702 ± 0.025
0.3TrpPro: 0.3 ± 0.015
0.448TrpGln: 0.448 ± 0.018
0.507TrpArg: 0.507 ± 0.019
0.658TrpSer: 0.658 ± 0.024
0.621TrpThr: 0.621 ± 0.026
0.72TrpVal: 0.72 ± 0.024
0.149TrpTrp: 0.149 ± 0.011
0.49TrpTyr: 0.49 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.997TyrAla: 2.997 ± 0.056
0.288TyrCys: 0.288 ± 0.015
2.372TyrAsp: 2.372 ± 0.045
2.143TyrGlu: 2.143 ± 0.04
2.391TyrPhe: 2.391 ± 0.047
3.015TyrGly: 3.015 ± 0.058
0.888TyrHis: 0.888 ± 0.031
2.579TyrIle: 2.579 ± 0.044
2.537TyrLys: 2.537 ± 0.046
3.94TyrLeu: 3.94 ± 0.07
0.886TyrMet: 0.886 ± 0.024
2.309TyrAsn: 2.309 ± 0.046
1.679TyrPro: 1.679 ± 0.042
1.7TyrGln: 1.7 ± 0.041
1.832TyrArg: 1.832 ± 0.04
2.576TyrSer: 2.576 ± 0.048
2.241TyrThr: 2.241 ± 0.048
2.317TyrVal: 2.317 ± 0.046
0.52TyrTrp: 0.52 ± 0.021
1.888TyrTyr: 1.888 ± 0.043
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3523 proteins (1183612 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski