Amino acid dipepetide frequency for Synchytrium microbalum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.63AlaAla: 8.63 ± 0.073	0.955AlaCys: 0.955 ± 0.019	4.307AlaAsp: 4.307 ± 0.038	4.679AlaGlu: 4.679 ± 0.047	2.977AlaPhe: 2.977 ± 0.034	5.067AlaGly: 5.067 ± 0.051	1.567AlaHis: 1.567 ± 0.021	4.514AlaIle: 4.514 ± 0.034	4.478AlaLys: 4.478 ± 0.044	7.724AlaLeu: 7.724 ± 0.059	2.056AlaMet: 2.056 ± 0.024	3.104AlaAsn: 3.104 ± 0.037	4.355AlaPro: 4.355 ± 0.047	3.081AlaGln: 3.081 ± 0.037	4.361AlaArg: 4.361 ± 0.042	7.721AlaSer: 7.721 ± 0.061	5.484AlaThr: 5.484 ± 0.044	5.529AlaVal: 5.529 ± 0.049	0.874AlaTrp: 0.874 ± 0.017	2.042AlaTyr: 2.042 ± 0.026	0.0AlaXaa: 0.0 ± 0.0
Cys	0.797CysAla: 0.797 ± 0.016	0.231CysCys: 0.231 ± 0.008	0.598CysAsp: 0.598 ± 0.014	0.568CysGlu: 0.568 ± 0.014	0.534CysPhe: 0.534 ± 0.011	0.891CysGly: 0.891 ± 0.019	0.308CysHis: 0.308 ± 0.01	0.812CysIle: 0.812 ± 0.015	0.603CysLys: 0.603 ± 0.013	1.226CysLeu: 1.226 ± 0.021	0.269CysMet: 0.269 ± 0.007	0.448CysAsn: 0.448 ± 0.012	0.555CysPro: 0.555 ± 0.016	0.4CysGln: 0.4 ± 0.012	0.653CysArg: 0.653 ± 0.014	0.773CysSer: 0.773 ± 0.019	0.683CysThr: 0.683 ± 0.014	0.787CysVal: 0.787 ± 0.016	0.154CysTrp: 0.154 ± 0.007	0.338CysTyr: 0.338 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	4.906AspAla: 4.906 ± 0.037	0.585AspCys: 0.585 ± 0.013	4.836AspAsp: 4.836 ± 0.07	4.633AspGlu: 4.633 ± 0.051	2.132AspPhe: 2.132 ± 0.027	3.883AspGly: 3.883 ± 0.035	1.131AspHis: 1.131 ± 0.02	3.213AspIle: 3.213 ± 0.031	2.675AspLys: 2.675 ± 0.033	5.316AspLeu: 5.316 ± 0.044	1.404AspMet: 1.404 ± 0.021	1.9AspAsn: 1.9 ± 0.023	2.71AspPro: 2.71 ± 0.033	1.824AspGln: 1.824 ± 0.023	2.638AspArg: 2.638 ± 0.033	4.077AspSer: 4.077 ± 0.034	3.073AspThr: 3.073 ± 0.029	4.335AspVal: 4.335 ± 0.035	0.715AspTrp: 0.715 ± 0.015	1.654AspTyr: 1.654 ± 0.025	0.0AspXaa: 0.0 ± 0.0
Glu	5.081GluAla: 5.081 ± 0.054	0.646GluCys: 0.646 ± 0.015	3.873GluAsp: 3.873 ± 0.046	4.865GluGlu: 4.865 ± 0.071	2.103GluPhe: 2.103 ± 0.027	3.152GluGly: 3.152 ± 0.032	1.236GluHis: 1.236 ± 0.02	3.149GluIle: 3.149 ± 0.032	3.453GluLys: 3.453 ± 0.038	5.639GluLeu: 5.639 ± 0.066	1.518GluMet: 1.518 ± 0.021	2.193GluAsn: 2.193 ± 0.023	2.231GluPro: 2.231 ± 0.025	2.24GluGln: 2.24 ± 0.032	3.684GluArg: 3.684 ± 0.05	4.44GluSer: 4.44 ± 0.055	3.304GluThr: 3.304 ± 0.03	3.65GluVal: 3.65 ± 0.032	0.794GluTrp: 0.794 ± 0.016	1.814GluTyr: 1.814 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	3.059PheAla: 3.059 ± 0.031	0.54PheCys: 0.54 ± 0.011	2.343PheAsp: 2.343 ± 0.029	2.235PheGlu: 2.235 ± 0.027	1.511PhePhe: 1.511 ± 0.026	2.861PheGly: 2.861 ± 0.04	0.788PheHis: 0.788 ± 0.016	1.915PheIle: 1.915 ± 0.024	1.868PheLys: 1.868 ± 0.023	3.311PheLeu: 3.311 ± 0.033	0.907PheMet: 0.907 ± 0.016	1.433PheAsn: 1.433 ± 0.021	1.595PhePro: 1.595 ± 0.024	1.318PheGln: 1.318 ± 0.02	1.715PheArg: 1.715 ± 0.026	2.648PheSer: 2.648 ± 0.033	2.062PheThr: 2.062 ± 0.025	2.693PheVal: 2.693 ± 0.031	0.492PheTrp: 0.492 ± 0.012	1.142PheTyr: 1.142 ± 0.021	0.0PheXaa: 0.0 ± 0.0
Gly	4.728GlyAla: 4.728 ± 0.05	0.775GlyCys: 0.775 ± 0.015	3.353GlyAsp: 3.353 ± 0.036	2.942GlyGlu: 2.942 ± 0.034	2.566GlyPhe: 2.566 ± 0.037	5.33GlyGly: 5.33 ± 0.066	1.413GlyHis: 1.413 ± 0.022	3.566GlyIle: 3.566 ± 0.036	3.3GlyLys: 3.3 ± 0.034	5.567GlyLeu: 5.567 ± 0.046	1.566GlyMet: 1.566 ± 0.025	2.428GlyAsn: 2.428 ± 0.03	2.46GlyPro: 2.46 ± 0.031	2.133GlyGln: 2.133 ± 0.028	3.514GlyArg: 3.514 ± 0.04	5.345GlySer: 5.345 ± 0.043	3.559GlyThr: 3.559 ± 0.037	4.263GlyVal: 4.263 ± 0.044	0.863GlyTrp: 0.863 ± 0.017	1.826GlyTyr: 1.826 ± 0.027	0.0GlyXaa: 0.0 ± 0.0
His	1.603HisAla: 1.603 ± 0.019	0.292HisCys: 0.292 ± 0.008	1.22HisAsp: 1.22 ± 0.018	1.195HisGlu: 1.195 ± 0.019	0.854HisPhe: 0.854 ± 0.017	1.364HisGly: 1.364 ± 0.022	0.876HisHis: 0.876 ± 0.019	1.285HisIle: 1.285 ± 0.02	0.966HisLys: 0.966 ± 0.014	2.147HisLeu: 2.147 ± 0.029	0.487HisMet: 0.487 ± 0.01	0.834HisAsn: 0.834 ± 0.015	1.487HisPro: 1.487 ± 0.021	1.019HisGln: 1.019 ± 0.017	1.262HisArg: 1.262 ± 0.019	1.662HisSer: 1.662 ± 0.023	1.202HisThr: 1.202 ± 0.018	1.575HisVal: 1.575 ± 0.022	0.256HisTrp: 0.256 ± 0.008	0.677HisTyr: 0.677 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	4.492IleAla: 4.492 ± 0.04	0.766IleCys: 0.766 ± 0.014	3.064IleAsp: 3.064 ± 0.03	3.169IleGlu: 3.169 ± 0.034	1.954IlePhe: 1.954 ± 0.028	3.106IleGly: 3.106 ± 0.032	1.317IleHis: 1.317 ± 0.018	2.906IleIle: 2.906 ± 0.034	2.915IleLys: 2.915 ± 0.025	4.959IleLeu: 4.959 ± 0.042	1.242IleMet: 1.242 ± 0.019	2.105IleAsn: 2.105 ± 0.025	3.527IlePro: 3.527 ± 0.036	2.256IleGln: 2.256 ± 0.027	3.066IleArg: 3.066 ± 0.028	4.169IleSer: 4.169 ± 0.041	3.189IleThr: 3.189 ± 0.035	3.936IleVal: 3.936 ± 0.033	0.652IleTrp: 0.652 ± 0.014	1.432IleTyr: 1.432 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	4.474LysAla: 4.474 ± 0.046	0.555LysCys: 0.555 ± 0.013	3.006LysAsp: 3.006 ± 0.034	3.485LysGlu: 3.485 ± 0.043	1.704LysPhe: 1.704 ± 0.021	2.784LysGly: 2.784 ± 0.031	1.232LysHis: 1.232 ± 0.02	2.755LysIle: 2.755 ± 0.027	3.922LysLys: 3.922 ± 0.053	4.924LysLeu: 4.924 ± 0.044	1.292LysMet: 1.292 ± 0.018	2.047LysAsn: 2.047 ± 0.027	2.919LysPro: 2.919 ± 0.035	2.222LysGln: 2.222 ± 0.028	3.564LysArg: 3.564 ± 0.037	4.331LysSer: 4.331 ± 0.046	3.387LysThr: 3.387 ± 0.035	3.255LysVal: 3.255 ± 0.031	0.646LysTrp: 0.646 ± 0.014	1.675LysTyr: 1.675 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	7.757LeuAla: 7.757 ± 0.051	1.164LeuCys: 1.164 ± 0.02	5.394LeuAsp: 5.394 ± 0.044	5.61LeuGlu: 5.61 ± 0.073	3.315LeuPhe: 3.315 ± 0.037	5.284LeuGly: 5.284 ± 0.042	2.115LeuHis: 2.115 ± 0.026	4.443LeuIle: 4.443 ± 0.043	5.261LeuLys: 5.261 ± 0.05	8.674LeuLeu: 8.674 ± 0.065	2.139LeuMet: 2.139 ± 0.025	3.707LeuAsn: 3.707 ± 0.032	5.196LeuPro: 5.196 ± 0.042	3.912LeuGln: 3.912 ± 0.045	5.069LeuArg: 5.069 ± 0.046	7.382LeuSer: 7.382 ± 0.053	5.064LeuThr: 5.064 ± 0.041	6.223LeuVal: 6.223 ± 0.051	0.973LeuTrp: 0.973 ± 0.018	2.623LeuTyr: 2.623 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	2.259MetAla: 2.259 ± 0.028	0.25MetCys: 0.25 ± 0.009	1.513MetAsp: 1.513 ± 0.022	1.513MetGlu: 1.513 ± 0.024	0.8MetPhe: 0.8 ± 0.015	1.456MetGly: 1.456 ± 0.023	0.454MetHis: 0.454 ± 0.012	1.17MetIle: 1.17 ± 0.019	1.299MetLys: 1.299 ± 0.018	2.028MetLeu: 2.028 ± 0.025	0.774MetMet: 0.774 ± 0.015	1.083MetAsn: 1.083 ± 0.016	1.27MetPro: 1.27 ± 0.023	0.931MetGln: 0.931 ± 0.017	1.115MetArg: 1.115 ± 0.019	2.141MetSer: 2.141 ± 0.025	1.509MetThr: 1.509 ± 0.021	1.529MetVal: 1.529 ± 0.018	0.256MetTrp: 0.256 ± 0.009	0.678MetTyr: 0.678 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.302AsnAla: 3.302 ± 0.031	0.418AsnCys: 0.418 ± 0.011	2.242AsnAsp: 2.242 ± 0.025	2.217AsnGlu: 2.217 ± 0.026	1.329AsnPhe: 1.329 ± 0.019	3.036AsnGly: 3.036 ± 0.043	0.915AsnHis: 0.915 ± 0.017	2.275AsnIle: 2.275 ± 0.025	1.914AsnLys: 1.914 ± 0.025	3.548AsnLeu: 3.548 ± 0.031	1.057AsnMet: 1.057 ± 0.018	2.138AsnAsn: 2.138 ± 0.039	2.446AsnPro: 2.446 ± 0.029	1.553AsnGln: 1.553 ± 0.02	1.989AsnArg: 1.989 ± 0.027	3.227AsnSer: 3.227 ± 0.035	2.478AsnThr: 2.478 ± 0.027	2.903AsnVal: 2.903 ± 0.032	0.471AsnTrp: 0.471 ± 0.012	1.096AsnTyr: 1.096 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	4.529ProAla: 4.529 ± 0.048	0.438ProCys: 0.438 ± 0.012	2.835ProAsp: 2.835 ± 0.03	3.0ProGlu: 3.0 ± 0.031	1.909ProPhe: 1.909 ± 0.026	2.805ProGly: 2.805 ± 0.033	1.179ProHis: 1.179 ± 0.019	3.067ProIle: 3.067 ± 0.035	2.743ProLys: 2.743 ± 0.031	4.418ProLeu: 4.418 ± 0.039	1.093ProMet: 1.093 ± 0.019	2.29ProAsn: 2.29 ± 0.026	4.723ProPro: 4.723 ± 0.074	2.199ProGln: 2.199 ± 0.035	2.609ProArg: 2.609 ± 0.029	5.728ProSer: 5.728 ± 0.06	4.163ProThr: 4.163 ± 0.042	3.691ProVal: 3.691 ± 0.037	0.526ProTrp: 0.526 ± 0.011	1.468ProTyr: 1.468 ± 0.022	0.0ProXaa: 0.0 ± 0.0
Gln	3.102GlnAla: 3.102 ± 0.035	0.411GlnCys: 0.411 ± 0.011	1.954GlnAsp: 1.954 ± 0.025	2.198GlnGlu: 2.198 ± 0.034	1.308GlnPhe: 1.308 ± 0.019	1.863GlnGly: 1.863 ± 0.025	1.1GlnHis: 1.1 ± 0.02	2.075GlnIle: 2.075 ± 0.03	1.957GlnLys: 1.957 ± 0.025	3.626GlnLeu: 3.626 ± 0.044	0.978GlnMet: 0.978 ± 0.017	1.544GlnAsn: 1.544 ± 0.023	2.522GlnPro: 2.522 ± 0.041	3.408GlnGln: 3.408 ± 0.098	2.332GlnArg: 2.332 ± 0.027	2.993GlnSer: 2.993 ± 0.031	2.279GlnThr: 2.279 ± 0.024	2.498GlnVal: 2.498 ± 0.027	0.465GlnTrp: 0.465 ± 0.011	1.284GlnTyr: 1.284 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	4.219ArgAla: 4.219 ± 0.035	0.562ArgCys: 0.562 ± 0.012	3.206ArgAsp: 3.206 ± 0.037	3.294ArgGlu: 3.294 ± 0.042	2.012ArgPhe: 2.012 ± 0.026	3.126ArgGly: 3.126 ± 0.036	1.308ArgHis: 1.308 ± 0.019	3.158ArgIle: 3.158 ± 0.033	3.482ArgLys: 3.482 ± 0.038	5.076ArgLeu: 5.076 ± 0.042	1.364ArgMet: 1.364 ± 0.02	2.248ArgAsn: 2.248 ± 0.025	2.939ArgPro: 2.939 ± 0.036	2.31ArgGln: 2.31 ± 0.028	3.956ArgArg: 3.956 ± 0.045	3.829ArgSer: 3.829 ± 0.037	2.982ArgThr: 2.982 ± 0.033	3.59ArgVal: 3.59 ± 0.027	0.644ArgTrp: 0.644 ± 0.014	1.513ArgTyr: 1.513 ± 0.023	0.0ArgXaa: 0.0 ± 0.0
Ser	6.526SerAla: 6.526 ± 0.047	0.811SerCys: 0.811 ± 0.016	4.247SerAsp: 4.247 ± 0.035	3.939SerGlu: 3.939 ± 0.038	2.866SerPhe: 2.866 ± 0.03	5.057SerGly: 5.057 ± 0.048	1.775SerHis: 1.775 ± 0.021	4.55SerIle: 4.55 ± 0.032	4.477SerLys: 4.477 ± 0.038	7.392SerLeu: 7.392 ± 0.05	1.883SerMet: 1.883 ± 0.025	3.9SerAsn: 3.9 ± 0.039	5.202SerPro: 5.202 ± 0.07	3.171SerGln: 3.171 ± 0.035	4.635SerArg: 4.635 ± 0.048	9.746SerSer: 9.746 ± 0.096	6.032SerThr: 6.032 ± 0.052	5.125SerVal: 5.125 ± 0.039	0.94SerTrp: 0.94 ± 0.016	2.125SerTyr: 2.125 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	5.091ThrAla: 5.091 ± 0.041	0.732ThrCys: 0.732 ± 0.015	2.961ThrAsp: 2.961 ± 0.024	2.985ThrGlu: 2.985 ± 0.03	2.298ThrPhe: 2.298 ± 0.024	3.809ThrGly: 3.809 ± 0.038	1.247ThrHis: 1.247 ± 0.018	3.503ThrIle: 3.503 ± 0.034	2.9ThrLys: 2.9 ± 0.029	5.578ThrLeu: 5.578 ± 0.046	1.336ThrMet: 1.336 ± 0.018	2.469ThrAsn: 2.469 ± 0.031	4.225ThrPro: 4.225 ± 0.048	2.083ThrGln: 2.083 ± 0.026	3.277ThrArg: 3.277 ± 0.032	6.035ThrSer: 6.035 ± 0.056	4.774ThrThr: 4.774 ± 0.053	3.992ThrVal: 3.992 ± 0.035	0.689ThrTrp: 0.689 ± 0.017	1.662ThrTyr: 1.662 ± 0.023	0.0ThrXaa: 0.0 ± 0.0
Val	6.023ValAla: 6.023 ± 0.047	0.85ValCys: 0.85 ± 0.015	4.249ValAsp: 4.249 ± 0.034	4.26ValGlu: 4.26 ± 0.041	2.6ValPhe: 2.6 ± 0.033	3.976ValGly: 3.976 ± 0.036	1.325ValHis: 1.325 ± 0.016	3.61ValIle: 3.61 ± 0.029	3.868ValLys: 3.868 ± 0.037	6.288ValLeu: 6.288 ± 0.056	1.614ValMet: 1.614 ± 0.02	2.793ValAsn: 2.793 ± 0.029	3.336ValPro: 3.336 ± 0.037	2.254ValGln: 2.254 ± 0.028	3.164ValArg: 3.164 ± 0.031	5.187ValSer: 5.187 ± 0.041	3.928ValThr: 3.928 ± 0.035	5.232ValVal: 5.232 ± 0.05	0.804ValTrp: 0.804 ± 0.016	1.952ValTyr: 1.952 ± 0.025	0.0ValXaa: 0.0 ± 0.0
Trp	0.816TrpAla: 0.816 ± 0.018	0.185TrpCys: 0.185 ± 0.008	0.754TrpAsp: 0.754 ± 0.016	0.631TrpGlu: 0.631 ± 0.014	0.478TrpPhe: 0.478 ± 0.012	0.651TrpGly: 0.651 ± 0.014	0.263TrpHis: 0.263 ± 0.009	0.703TrpIle: 0.703 ± 0.013	0.747TrpLys: 0.747 ± 0.015	1.055TrpLeu: 1.055 ± 0.019	0.355TrpMet: 0.355 ± 0.01	0.629TrpAsn: 0.629 ± 0.015	0.404TrpPro: 0.404 ± 0.01	0.436TrpGln: 0.436 ± 0.01	0.668TrpArg: 0.668 ± 0.014	0.933TrpSer: 0.933 ± 0.018	0.826TrpThr: 0.826 ± 0.016	0.693TrpVal: 0.693 ± 0.014	0.207TrpTrp: 0.207 ± 0.008	0.372TrpTyr: 0.372 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.113TyrAla: 2.113 ± 0.025	0.461TyrCys: 0.461 ± 0.012	1.686TyrAsp: 1.686 ± 0.026	1.647TyrGlu: 1.647 ± 0.021	1.187TyrPhe: 1.187 ± 0.017	1.996TyrGly: 1.996 ± 0.029	0.715TyrHis: 0.715 ± 0.014	1.551TyrIle: 1.551 ± 0.019	1.349TyrLys: 1.349 ± 0.02	2.807TyrLeu: 2.807 ± 0.031	0.693TyrMet: 0.693 ± 0.015	1.26TyrAsn: 1.26 ± 0.021	1.31TyrPro: 1.31 ± 0.023	1.148TyrGln: 1.148 ± 0.017	1.547TyrArg: 1.547 ± 0.021	2.032TyrSer: 2.032 ± 0.026	1.668TyrThr: 1.668 ± 0.024	1.814TyrVal: 1.814 ± 0.024	0.386TyrTrp: 0.386 ± 0.01	1.014TyrTyr: 1.014 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6304 proteins (3623650 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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