Amino acid dipepetide frequency for Streptomyces gancidicus BKS 13-15

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.381AlaAla: 21.381 ± 0.155	1.061AlaCys: 1.061 ± 0.025	8.574AlaAsp: 8.574 ± 0.079	9.092AlaGlu: 9.092 ± 0.081	3.483AlaPhe: 3.483 ± 0.041	13.495AlaGly: 13.495 ± 0.088	2.983AlaHis: 2.983 ± 0.042	2.885AlaIle: 2.885 ± 0.046	2.604AlaLys: 2.604 ± 0.045	14.903AlaLeu: 14.903 ± 0.13	2.386AlaMet: 2.386 ± 0.032	1.734AlaAsn: 1.734 ± 0.03	7.361AlaPro: 7.361 ± 0.076	3.617AlaGln: 3.617 ± 0.048	10.969AlaArg: 10.969 ± 0.087	5.905AlaSer: 5.905 ± 0.055	6.801AlaThr: 6.801 ± 0.071	12.821AlaVal: 12.821 ± 0.102	1.908AlaTrp: 1.908 ± 0.028	2.778AlaTyr: 2.778 ± 0.033	0.003AlaXaa: 0.003 ± 0.001
Cys	1.073CysAla: 1.073 ± 0.023	0.091CysCys: 0.091 ± 0.008	0.478CysAsp: 0.478 ± 0.018	0.395CysGlu: 0.395 ± 0.013	0.207CysPhe: 0.207 ± 0.009	0.935CysGly: 0.935 ± 0.024	0.192CysHis: 0.192 ± 0.009	0.144CysIle: 0.144 ± 0.008	0.109CysLys: 0.109 ± 0.008	0.731CysLeu: 0.731 ± 0.019	0.109CysMet: 0.109 ± 0.006	0.138CysAsn: 0.138 ± 0.008	0.486CysPro: 0.486 ± 0.017	0.141CysGln: 0.141 ± 0.009	0.592CysArg: 0.592 ± 0.018	0.411CysSer: 0.411 ± 0.015	0.491CysThr: 0.491 ± 0.016	0.657CysVal: 0.657 ± 0.021	0.128CysTrp: 0.128 ± 0.008	0.136CysTyr: 0.136 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	8.431AspAla: 8.431 ± 0.085	0.43AspCys: 0.43 ± 0.016	4.002AspAsp: 4.002 ± 0.052	4.1AspGlu: 4.1 ± 0.056	1.614AspPhe: 1.614 ± 0.029	6.919AspGly: 6.919 ± 0.073	1.46AspHis: 1.46 ± 0.027	1.776AspIle: 1.776 ± 0.031	1.12AspLys: 1.12 ± 0.027	6.349AspLeu: 6.349 ± 0.058	0.834AspMet: 0.834 ± 0.021	0.926AspAsn: 0.926 ± 0.024	4.792AspPro: 4.792 ± 0.053	1.464AspGln: 1.464 ± 0.03	5.204AspArg: 5.204 ± 0.068	2.364AspSer: 2.364 ± 0.033	3.493AspThr: 3.493 ± 0.039	5.077AspVal: 5.077 ± 0.049	1.075AspTrp: 1.075 ± 0.024	1.055AspTyr: 1.055 ± 0.022	0.0AspXaa: 0.0 ± 0.0
Glu	7.678GluAla: 7.678 ± 0.077	0.36GluCys: 0.36 ± 0.015	3.245GluAsp: 3.245 ± 0.041	3.966GluGlu: 3.966 ± 0.058	1.45GluPhe: 1.45 ± 0.027	4.614GluGly: 4.614 ± 0.049	1.545GluHis: 1.545 ± 0.031	2.192GluIle: 2.192 ± 0.034	1.484GluLys: 1.484 ± 0.035	6.671GluLeu: 6.671 ± 0.066	0.922GluMet: 0.922 ± 0.019	1.049GluAsn: 1.049 ± 0.023	3.561GluPro: 3.561 ± 0.047	2.286GluGln: 2.286 ± 0.042	5.814GluArg: 5.814 ± 0.058	2.452GluSer: 2.452 ± 0.036	3.068GluThr: 3.068 ± 0.038	4.582GluVal: 4.582 ± 0.053	0.775GluTrp: 0.775 ± 0.02	1.117GluTyr: 1.117 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	3.597PheAla: 3.597 ± 0.041	0.246PheCys: 0.246 ± 0.01	1.945PheAsp: 1.945 ± 0.032	1.401PheGlu: 1.401 ± 0.028	0.841PhePhe: 0.841 ± 0.023	2.881PheGly: 2.881 ± 0.044	0.593PheHis: 0.593 ± 0.017	0.587PheIle: 0.587 ± 0.018	0.471PheLys: 0.471 ± 0.017	2.623PheLeu: 2.623 ± 0.043	0.396PheMet: 0.396 ± 0.015	0.521PheAsn: 0.521 ± 0.016	1.385PhePro: 1.385 ± 0.023	0.646PheGln: 0.646 ± 0.017	1.891PheArg: 1.891 ± 0.03	1.347PheSer: 1.347 ± 0.027	1.977PheThr: 1.977 ± 0.034	2.286PheVal: 2.286 ± 0.039	0.417PheTrp: 0.417 ± 0.014	0.546PheTyr: 0.546 ± 0.018	0.001PheXaa: 0.001 ± 0.001
Gly	11.324GlyAla: 11.324 ± 0.09	0.796GlyCys: 0.796 ± 0.022	5.591GlyAsp: 5.591 ± 0.056	5.312GlyGlu: 5.312 ± 0.052	2.774GlyPhe: 2.774 ± 0.041	9.022GlyGly: 9.022 ± 0.092	2.387GlyHis: 2.387 ± 0.034	3.115GlyIle: 3.115 ± 0.037	2.216GlyLys: 2.216 ± 0.04	9.434GlyLeu: 9.434 ± 0.078	1.954GlyMet: 1.954 ± 0.033	1.649GlyAsn: 1.649 ± 0.033	5.34GlyPro: 5.34 ± 0.054	2.534GlyGln: 2.534 ± 0.039	8.293GlyArg: 8.293 ± 0.067	5.006GlySer: 5.006 ± 0.06	6.433GlyThr: 6.433 ± 0.072	7.814GlyVal: 7.814 ± 0.072	1.69GlyTrp: 1.69 ± 0.03	2.163GlyTyr: 2.163 ± 0.035	0.0GlyXaa: 0.0 ± 0.0
His	2.793HisAla: 2.793 ± 0.034	0.196HisCys: 0.196 ± 0.01	1.407HisAsp: 1.407 ± 0.028	1.226HisGlu: 1.226 ± 0.025	0.643HisPhe: 0.643 ± 0.016	2.478HisGly: 2.478 ± 0.036	0.701HisHis: 0.701 ± 0.022	0.628HisIle: 0.628 ± 0.02	0.333HisLys: 0.333 ± 0.012	2.453HisLeu: 2.453 ± 0.038	0.339HisMet: 0.339 ± 0.013	0.341HisAsn: 0.341 ± 0.013	1.871HisPro: 1.871 ± 0.032	0.587HisGln: 0.587 ± 0.018	2.178HisArg: 2.178 ± 0.037	0.949HisSer: 0.949 ± 0.021	1.378HisThr: 1.378 ± 0.028	1.81HisVal: 1.81 ± 0.035	0.366HisTrp: 0.366 ± 0.013	0.462HisTyr: 0.462 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	4.221IleAla: 4.221 ± 0.05	0.247IleCys: 0.247 ± 0.012	2.029IleAsp: 2.029 ± 0.038	1.803IleGlu: 1.803 ± 0.035	0.641IlePhe: 0.641 ± 0.019	3.21IleGly: 3.21 ± 0.041	0.552IleHis: 0.552 ± 0.019	0.68IleIle: 0.68 ± 0.02	0.659IleLys: 0.659 ± 0.021	2.185IleLeu: 2.185 ± 0.032	0.414IleMet: 0.414 ± 0.016	0.594IleAsn: 0.594 ± 0.019	1.576IlePro: 1.576 ± 0.028	0.637IleGln: 0.637 ± 0.018	2.076IleArg: 2.076 ± 0.038	1.399IleSer: 1.399 ± 0.024	2.002IleThr: 2.002 ± 0.032	2.584IleVal: 2.584 ± 0.036	0.323IleTrp: 0.323 ± 0.013	0.455IleTyr: 0.455 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	2.824LysAla: 2.824 ± 0.048	0.102LysCys: 0.102 ± 0.007	1.324LysAsp: 1.324 ± 0.028	1.241LysGlu: 1.241 ± 0.029	0.391LysPhe: 0.391 ± 0.016	1.801LysGly: 1.801 ± 0.036	0.398LysHis: 0.398 ± 0.015	0.761LysIle: 0.761 ± 0.023	0.845LysLys: 0.845 ± 0.028	1.894LysLeu: 1.894 ± 0.034	0.343LysMet: 0.343 ± 0.014	0.493LysAsn: 0.493 ± 0.021	1.222LysPro: 1.222 ± 0.027	0.673LysGln: 0.673 ± 0.023	1.389LysArg: 1.389 ± 0.03	0.966LysSer: 0.966 ± 0.027	1.169LysThr: 1.169 ± 0.028	1.811LysVal: 1.811 ± 0.036	0.234LysTrp: 0.234 ± 0.01	0.414LysTyr: 0.414 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	14.95LeuAla: 14.95 ± 0.106	0.848LeuCys: 0.848 ± 0.021	6.871LeuAsp: 6.871 ± 0.069	4.971LeuGlu: 4.971 ± 0.059	2.572LeuPhe: 2.572 ± 0.044	9.083LeuGly: 9.083 ± 0.08	2.373LeuHis: 2.373 ± 0.032	3.014LeuIle: 3.014 ± 0.049	2.01LeuLys: 2.01 ± 0.036	11.494LeuLeu: 11.494 ± 0.123	1.638LeuMet: 1.638 ± 0.03	1.625LeuAsn: 1.625 ± 0.03	6.564LeuPro: 6.564 ± 0.065	2.065LeuGln: 2.065 ± 0.03	9.011LeuArg: 9.011 ± 0.076	5.081LeuSer: 5.081 ± 0.047	7.182LeuThr: 7.182 ± 0.072	8.958LeuVal: 8.958 ± 0.081	1.3LeuTrp: 1.3 ± 0.024	1.837LeuTyr: 1.837 ± 0.028	0.001LeuXaa: 0.001 ± 0.001
Met	2.153MetAla: 2.153 ± 0.035	0.121MetCys: 0.121 ± 0.006	0.917MetAsp: 0.917 ± 0.021	0.755MetGlu: 0.755 ± 0.017	0.468MetPhe: 0.468 ± 0.015	1.273MetGly: 1.273 ± 0.025	0.335MetHis: 0.335 ± 0.013	0.652MetIle: 0.652 ± 0.016	0.398MetLys: 0.398 ± 0.015	1.637MetLeu: 1.637 ± 0.031	0.273MetMet: 0.273 ± 0.013	0.398MetAsn: 0.398 ± 0.014	1.085MetPro: 1.085 ± 0.019	0.423MetGln: 0.423 ± 0.015	1.444MetArg: 1.444 ± 0.029	1.26MetSer: 1.26 ± 0.025	1.573MetThr: 1.573 ± 0.028	1.245MetVal: 1.245 ± 0.025	0.22MetTrp: 0.22 ± 0.012	0.3MetTyr: 0.3 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.101AsnAla: 2.101 ± 0.036	0.154AsnCys: 0.154 ± 0.008	0.918AsnAsp: 0.918 ± 0.022	0.786AsnGlu: 0.786 ± 0.02	0.458AsnPhe: 0.458 ± 0.014	1.796AsnGly: 1.796 ± 0.033	0.363AsnHis: 0.363 ± 0.014	0.562AsnIle: 0.562 ± 0.018	0.375AsnLys: 0.375 ± 0.014	1.56AsnLeu: 1.56 ± 0.029	0.265AsnMet: 0.265 ± 0.011	0.397AsnAsn: 0.397 ± 0.016	1.28AsnPro: 1.28 ± 0.029	0.453AsnGln: 0.453 ± 0.017	1.235AsnArg: 1.235 ± 0.026	0.813AsnSer: 0.813 ± 0.021	1.037AsnThr: 1.037 ± 0.029	1.352AsnVal: 1.352 ± 0.027	0.278AsnTrp: 0.278 ± 0.012	0.376AsnTyr: 0.376 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	9.104ProAla: 9.104 ± 0.096	0.351ProCys: 0.351 ± 0.015	4.875ProAsp: 4.875 ± 0.05	4.64ProGlu: 4.64 ± 0.053	1.51ProPhe: 1.51 ± 0.03	6.816ProGly: 6.816 ± 0.06	1.408ProHis: 1.408 ± 0.026	1.035ProIle: 1.035 ± 0.021	1.077ProLys: 1.077 ± 0.026	5.435ProLeu: 5.435 ± 0.056	0.959ProMet: 0.959 ± 0.023	0.793ProAsn: 0.793 ± 0.02	3.65ProPro: 3.65 ± 0.064	1.647ProGln: 1.647 ± 0.034	4.267ProArg: 4.267 ± 0.047	3.194ProSer: 3.194 ± 0.051	2.994ProThr: 2.994 ± 0.04	5.793ProVal: 5.793 ± 0.054	0.901ProTrp: 0.901 ± 0.023	1.458ProTyr: 1.458 ± 0.03	0.001ProXaa: 0.001 ± 0.001
Gln	3.642GlnAla: 3.642 ± 0.048	0.153GlnCys: 0.153 ± 0.008	1.444GlnAsp: 1.444 ± 0.026	1.446GlnGlu: 1.446 ± 0.028	0.633GlnPhe: 0.633 ± 0.019	2.301GlnGly: 2.301 ± 0.036	0.616GlnHis: 0.616 ± 0.018	0.972GlnIle: 0.972 ± 0.027	0.582GlnLys: 0.582 ± 0.017	2.863GlnLeu: 2.863 ± 0.039	0.478GlnMet: 0.478 ± 0.016	0.466GlnAsn: 0.466 ± 0.016	1.575GlnPro: 1.575 ± 0.036	1.18GlnGln: 1.18 ± 0.032	2.258GlnArg: 2.258 ± 0.04	1.092GlnSer: 1.092 ± 0.026	1.233GlnThr: 1.233 ± 0.025	2.285GlnVal: 2.285 ± 0.037	0.421GlnTrp: 0.421 ± 0.015	0.582GlnTyr: 0.582 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	10.478ArgAla: 10.478 ± 0.083	0.607ArgCys: 0.607 ± 0.017	4.69ArgAsp: 4.69 ± 0.053	5.03ArgGlu: 5.03 ± 0.051	2.36ArgPhe: 2.36 ± 0.035	6.032ArgGly: 6.032 ± 0.056	2.265ArgHis: 2.265 ± 0.039	3.059ArgIle: 3.059 ± 0.039	1.625ArgLys: 1.625 ± 0.03	9.234ArgLeu: 9.234 ± 0.088	1.79ArgMet: 1.79 ± 0.028	1.326ArgAsn: 1.326 ± 0.026	5.445ArgPro: 5.445 ± 0.064	2.268ArgGln: 2.268 ± 0.031	8.504ArgArg: 8.504 ± 0.093	3.971ArgSer: 3.971 ± 0.043	5.784ArgThr: 5.784 ± 0.062	6.305ArgVal: 6.305 ± 0.065	1.429ArgTrp: 1.429 ± 0.028	1.82ArgTyr: 1.82 ± 0.034	0.001ArgXaa: 0.001 ± 0.001
Ser	6.399SerAla: 6.399 ± 0.06	0.379SerCys: 0.379 ± 0.014	2.635SerAsp: 2.635 ± 0.033	2.306SerGlu: 2.306 ± 0.035	1.442SerPhe: 1.442 ± 0.025	5.693SerGly: 5.693 ± 0.061	0.957SerHis: 0.957 ± 0.022	1.166SerIle: 1.166 ± 0.029	0.928SerLys: 0.928 ± 0.027	4.661SerLeu: 4.661 ± 0.052	0.976SerMet: 0.976 ± 0.022	0.766SerAsn: 0.766 ± 0.022	3.034SerPro: 3.034 ± 0.045	1.094SerGln: 1.094 ± 0.023	3.666SerArg: 3.666 ± 0.044	2.558SerSer: 2.558 ± 0.045	2.802SerThr: 2.802 ± 0.04	4.242SerVal: 4.242 ± 0.046	0.845SerTrp: 0.845 ± 0.017	1.168SerTyr: 1.168 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	9.137ThrAla: 9.137 ± 0.073	0.4ThrCys: 0.4 ± 0.015	3.778ThrAsp: 3.778 ± 0.048	3.404ThrGlu: 3.404 ± 0.039	1.538ThrPhe: 1.538 ± 0.029	6.743ThrGly: 6.743 ± 0.074	1.207ThrHis: 1.207 ± 0.025	1.447ThrIle: 1.447 ± 0.031	1.046ThrLys: 1.046 ± 0.027	5.864ThrLeu: 5.864 ± 0.051	0.897ThrMet: 0.897 ± 0.02	0.941ThrAsn: 0.941 ± 0.02	4.334ThrPro: 4.334 ± 0.056	1.291ThrGln: 1.291 ± 0.027	4.124ThrArg: 4.124 ± 0.051	2.974ThrSer: 2.974 ± 0.041	3.718ThrThr: 3.718 ± 0.056	6.464ThrVal: 6.464 ± 0.066	0.905ThrTrp: 0.905 ± 0.024	1.394ThrTyr: 1.394 ± 0.032	0.002ThrXaa: 0.002 ± 0.001
Val	10.911ValAla: 10.911 ± 0.082	0.777ValCys: 0.777 ± 0.017	5.3ValAsp: 5.3 ± 0.047	4.963ValGlu: 4.963 ± 0.056	2.476ValPhe: 2.476 ± 0.038	6.399ValGly: 6.399 ± 0.067	2.077ValHis: 2.077 ± 0.032	2.633ValIle: 2.633 ± 0.033	1.68ValLys: 1.68 ± 0.034	9.738ValLeu: 9.738 ± 0.094	1.433ValMet: 1.433 ± 0.029	1.63ValAsn: 1.63 ± 0.033	5.567ValPro: 5.567 ± 0.058	2.04ValGln: 2.04 ± 0.031	7.889ValArg: 7.889 ± 0.071	4.198ValSer: 4.198 ± 0.041	6.222ValThr: 6.222 ± 0.059	8.388ValVal: 8.388 ± 0.079	1.215ValTrp: 1.215 ± 0.024	1.605ValTyr: 1.605 ± 0.031	0.001ValXaa: 0.001 ± 0.001
Trp	1.714TrpAla: 1.714 ± 0.029	0.158TrpCys: 0.158 ± 0.008	0.844TrpAsp: 0.844 ± 0.021	0.764TrpGlu: 0.764 ± 0.02	0.481TrpPhe: 0.481 ± 0.016	1.084TrpGly: 1.084 ± 0.025	0.353TrpHis: 0.353 ± 0.015	0.536TrpIle: 0.536 ± 0.017	0.356TrpLys: 0.356 ± 0.013	1.747TrpLeu: 1.747 ± 0.032	0.288TrpMet: 0.288 ± 0.011	0.412TrpAsn: 0.412 ± 0.015	0.77TrpPro: 0.77 ± 0.019	0.608TrpGln: 0.608 ± 0.018	1.358TrpArg: 1.358 ± 0.032	0.877TrpSer: 0.877 ± 0.022	1.078TrpThr: 1.078 ± 0.021	0.981TrpVal: 0.981 ± 0.024	0.326TrpTrp: 0.326 ± 0.015	0.372TrpTyr: 0.372 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.83TyrAla: 2.83 ± 0.039	0.168TyrCys: 0.168 ± 0.009	1.618TyrAsp: 1.618 ± 0.04	1.231TyrGlu: 1.231 ± 0.026	0.616TyrPhe: 0.616 ± 0.019	2.27TyrGly: 2.27 ± 0.035	0.374TyrHis: 0.374 ± 0.015	0.442TyrIle: 0.442 ± 0.017	0.378TyrLys: 0.378 ± 0.015	1.969TyrLeu: 1.969 ± 0.032	0.239TyrMet: 0.239 ± 0.011	0.361TyrAsn: 0.361 ± 0.014	1.007TyrPro: 1.007 ± 0.023	0.568TyrGln: 0.568 ± 0.017	1.859TyrArg: 1.859 ± 0.032	0.9TyrSer: 0.9 ± 0.025	1.17TyrThr: 1.17 ± 0.022	1.686TyrVal: 1.686 ± 0.029	0.351TyrTrp: 0.351 ± 0.013	0.422TyrTyr: 0.422 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.001	0.001XaaGlu: 0.001 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.002XaaGly: 0.002 ± 0.001	0.001XaaHis: 0.001 ± 0.001	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.002XaaArg: 0.002 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.001	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6555 proteins (2106892 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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