Amino acid dipepetide frequency for Zetapapillomavirus 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.34AlaAla: 5.34 ± 1.119
1.335AlaCys: 1.335 ± 1.089
4.895AlaAsp: 4.895 ± 1.153
2.225AlaGlu: 2.225 ± 1.379
2.67AlaPhe: 2.67 ± 0.478
3.115AlaGly: 3.115 ± 0.503
0.0AlaHis: 0.0 ± 0.0
2.67AlaIle: 2.67 ± 0.62
2.225AlaLys: 2.225 ± 0.609
5.34AlaLeu: 5.34 ± 1.273
1.335AlaMet: 1.335 ± 0.622
1.335AlaAsn: 1.335 ± 0.388
6.676AlaPro: 6.676 ± 1.694
4.005AlaGln: 4.005 ± 1.371
3.115AlaArg: 3.115 ± 1.283
3.115AlaSer: 3.115 ± 0.503
5.34AlaThr: 5.34 ± 0.94
6.676AlaVal: 6.676 ± 1.199
0.89AlaTrp: 0.89 ± 0.388
2.225AlaTyr: 2.225 ± 0.979
0.0AlaXaa: 0.0 ± 0.0
Cys
0.89CysAla: 0.89 ± 1.163
0.89CysCys: 0.89 ± 0.611
1.335CysAsp: 1.335 ± 0.702
0.0CysGlu: 0.0 ± 0.0
0.89CysPhe: 0.89 ± 0.575
1.335CysGly: 1.335 ± 0.936
0.445CysHis: 0.445 ± 0.565
0.0CysIle: 0.0 ± 0.0
1.78CysLys: 1.78 ± 0.868
0.89CysLeu: 0.89 ± 0.513
0.89CysMet: 0.89 ± 0.575
0.445CysAsn: 0.445 ± 0.565
2.67CysPro: 2.67 ± 0.802
0.0CysGln: 0.0 ± 0.0
3.56CysArg: 3.56 ± 0.611
2.225CysSer: 2.225 ± 1.19
1.335CysThr: 1.335 ± 0.724
0.89CysVal: 0.89 ± 0.89
0.445CysTrp: 0.445 ± 0.565
1.335CysTyr: 1.335 ± 1.129
0.0CysXaa: 0.0 ± 0.0
Asp
6.676AspAla: 6.676 ± 1.415
2.225AspCys: 2.225 ± 0.438
2.67AspAsp: 2.67 ± 1.636
3.56AspGlu: 3.56 ± 1.449
0.89AspPhe: 0.89 ± 0.388
4.005AspGly: 4.005 ± 1.33
0.445AspHis: 0.445 ± 0.481
1.335AspIle: 1.335 ± 0.81
2.225AspLys: 2.225 ± 0.453
6.676AspLeu: 6.676 ± 1.409
1.78AspMet: 1.78 ± 0.599
1.335AspAsn: 1.335 ± 0.435
4.895AspPro: 4.895 ± 1.157
1.335AspGln: 1.335 ± 0.687
1.78AspArg: 1.78 ± 0.676
3.115AspSer: 3.115 ± 0.503
4.45AspThr: 4.45 ± 1.666
4.45AspVal: 4.45 ± 1.621
1.335AspTrp: 1.335 ± 0.936
1.78AspTyr: 1.78 ± 0.561
0.0AspXaa: 0.0 ± 0.0
Glu
5.34GluAla: 5.34 ± 1.756
0.445GluCys: 0.445 ± 0.565
4.005GluAsp: 4.005 ± 1.477
7.121GluGlu: 7.121 ± 2.139
0.89GluPhe: 0.89 ± 0.63
5.34GluGly: 5.34 ± 1.887
0.89GluHis: 0.89 ± 0.388
3.115GluIle: 3.115 ± 1.183
2.67GluLys: 2.67 ± 1.095
7.121GluLeu: 7.121 ± 1.802
0.445GluMet: 0.445 ± 0.338
2.67GluAsn: 2.67 ± 0.777
4.005GluPro: 4.005 ± 0.632
2.67GluGln: 2.67 ± 0.478
1.78GluArg: 1.78 ± 1.035
4.005GluSer: 4.005 ± 1.354
2.67GluThr: 2.67 ± 0.996
6.231GluVal: 6.231 ± 2.249
1.78GluTrp: 1.78 ± 1.071
0.445GluTyr: 0.445 ± 0.338
0.0GluXaa: 0.0 ± 0.0
Phe
2.225PheAla: 2.225 ± 0.999
0.89PheCys: 0.89 ± 0.611
4.005PheAsp: 4.005 ± 1.704
3.56PheGlu: 3.56 ± 0.531
0.89PhePhe: 0.89 ± 0.388
2.225PheGly: 2.225 ± 0.87
1.335PheHis: 1.335 ± 0.435
1.335PheIle: 1.335 ± 0.432
0.89PheLys: 0.89 ± 0.676
3.115PheLeu: 3.115 ± 1.382
0.0PheMet: 0.0 ± 0.0
3.115PheAsn: 3.115 ± 1.354
2.225PhePro: 2.225 ± 0.764
1.78PheGln: 1.78 ± 0.606
1.78PheArg: 1.78 ± 0.775
2.67PheSer: 2.67 ± 0.802
1.78PheThr: 1.78 ± 0.231
2.225PheVal: 2.225 ± 0.453
1.78PheTrp: 1.78 ± 0.569
0.445PheTyr: 0.445 ± 0.378
0.0PheXaa: 0.0 ± 0.0
Gly
5.34GlyAla: 5.34 ± 1.383
0.89GlyCys: 0.89 ± 0.388
7.121GlyAsp: 7.121 ± 1.24
2.67GlyGlu: 2.67 ± 0.792
0.89GlyPhe: 0.89 ± 0.499
9.346GlyGly: 9.346 ± 3.392
2.67GlyHis: 2.67 ± 1.086
4.005GlyIle: 4.005 ± 2.115
2.225GlyLys: 2.225 ± 1.08
7.121GlyLeu: 7.121 ± 1.796
0.445GlyMet: 0.445 ± 0.338
4.005GlyAsn: 4.005 ± 0.98
4.895GlyPro: 4.895 ± 2.111
3.115GlyGln: 3.115 ± 1.231
7.121GlyArg: 7.121 ± 2.621
6.231GlySer: 6.231 ± 0.714
4.895GlyThr: 4.895 ± 0.801
4.45GlyVal: 4.45 ± 0.912
0.445GlyTrp: 0.445 ± 0.378
0.445GlyTyr: 0.445 ± 0.355
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
0.445HisCys: 0.445 ± 0.338
0.445HisAsp: 0.445 ± 0.565
1.335HisGlu: 1.335 ± 0.755
1.78HisPhe: 1.78 ± 1.006
2.67HisGly: 2.67 ± 1.477
0.0HisHis: 0.0 ± 0.0
0.89HisIle: 0.89 ± 0.47
1.78HisLys: 1.78 ± 1.058
0.89HisLeu: 0.89 ± 0.417
0.89HisMet: 0.89 ± 0.475
0.445HisAsn: 0.445 ± 0.338
1.335HisPro: 1.335 ± 0.81
0.89HisGln: 0.89 ± 0.388
0.89HisArg: 0.89 ± 0.47
1.78HisSer: 1.78 ± 0.582
0.89HisThr: 0.89 ± 0.499
1.78HisVal: 1.78 ± 0.923
0.445HisTrp: 0.445 ± 0.378
0.445HisTyr: 0.445 ± 0.355
0.0HisXaa: 0.0 ± 0.0
Ile
1.78IleAla: 1.78 ± 0.599
1.78IleCys: 1.78 ± 1.035
2.225IleAsp: 2.225 ± 0.88
3.115IleGlu: 3.115 ± 1.549
1.335IlePhe: 1.335 ± 0.441
3.115IleGly: 3.115 ± 1.586
1.335IleHis: 1.335 ± 0.724
0.89IleIle: 0.89 ± 0.711
1.335IleLys: 1.335 ± 0.622
3.56IleLeu: 3.56 ± 0.751
0.0IleMet: 0.0 ± 0.523
2.225IleAsn: 2.225 ± 0.609
1.78IlePro: 1.78 ± 0.645
0.89IleGln: 0.89 ± 0.756
1.335IleArg: 1.335 ± 1.014
2.225IleSer: 2.225 ± 1.065
2.67IleThr: 2.67 ± 0.802
2.67IleVal: 2.67 ± 0.754
0.445IleTrp: 0.445 ± 0.338
1.78IleTyr: 1.78 ± 0.778
0.0IleXaa: 0.0 ± 0.0
Lys
3.56LysAla: 3.56 ± 0.992
1.78LysCys: 1.78 ± 0.552
1.78LysAsp: 1.78 ± 0.552
1.78LysGlu: 1.78 ± 0.582
0.89LysPhe: 0.89 ± 0.388
2.67LysGly: 2.67 ± 0.974
0.445LysHis: 0.445 ± 0.338
0.445LysIle: 0.445 ± 0.338
3.115LysLys: 3.115 ± 1.71
3.56LysLeu: 3.56 ± 0.58
0.445LysMet: 0.445 ± 0.378
0.89LysAsn: 0.89 ± 0.575
2.225LysPro: 2.225 ± 1.039
2.225LysGln: 2.225 ± 0.685
3.56LysArg: 3.56 ± 0.918
2.225LysSer: 2.225 ± 0.979
2.225LysThr: 2.225 ± 0.609
4.005LysVal: 4.005 ± 1.083
0.0LysTrp: 0.0 ± 0.0
1.335LysTyr: 1.335 ± 0.622
0.0LysXaa: 0.0 ± 0.0
Leu
3.115LeuAla: 3.115 ± 1.335
2.225LeuCys: 2.225 ± 1.902
6.676LeuAsp: 6.676 ± 1.094
3.115LeuGlu: 3.115 ± 1.474
5.785LeuPhe: 5.785 ± 1.801
9.791LeuGly: 9.791 ± 2.457
1.78LeuHis: 1.78 ± 0.561
3.115LeuIle: 3.115 ± 1.72
3.115LeuLys: 3.115 ± 0.893
8.011LeuLeu: 8.011 ± 1.997
2.67LeuMet: 2.67 ± 1.425
2.225LeuAsn: 2.225 ± 0.793
4.45LeuPro: 4.45 ± 1.368
6.231LeuGln: 6.231 ± 1.514
3.56LeuArg: 3.56 ± 0.611
8.011LeuSer: 8.011 ± 1.341
7.121LeuThr: 7.121 ± 1.807
3.115LeuVal: 3.115 ± 1.151
0.89LeuTrp: 0.89 ± 0.513
2.67LeuTyr: 2.67 ± 0.631
0.0LeuXaa: 0.0 ± 0.0
Met
1.78MetAla: 1.78 ± 1.215
0.445MetCys: 0.445 ± 0.481
1.335MetAsp: 1.335 ± 0.671
1.335MetGlu: 1.335 ± 0.879
0.445MetPhe: 0.445 ± 0.378
0.0MetGly: 0.0 ± 0.0
0.445MetHis: 0.445 ± 0.338
0.445MetIle: 0.445 ± 0.582
0.445MetLys: 0.445 ± 0.338
1.78MetLeu: 1.78 ± 1.019
0.89MetMet: 0.89 ± 0.475
0.89MetAsn: 0.89 ± 0.513
0.445MetPro: 0.445 ± 0.338
0.0MetGln: 0.0 ± 0.0
0.89MetArg: 0.89 ± 0.388
2.225MetSer: 2.225 ± 1.065
0.89MetThr: 0.89 ± 0.499
3.115MetVal: 3.115 ± 0.812
0.89MetTrp: 0.89 ± 0.63
0.89MetTyr: 0.89 ± 0.417
0.0MetXaa: 0.0 ± 0.0
Asn
3.115AsnAla: 3.115 ± 1.231
1.335AsnCys: 1.335 ± 0.702
0.89AsnAsp: 0.89 ± 0.513
1.78AsnGlu: 1.78 ± 1.019
1.335AsnPhe: 1.335 ± 0.569
1.78AsnGly: 1.78 ± 1.116
0.445AsnHis: 0.445 ± 0.338
1.335AsnIle: 1.335 ± 0.671
1.78AsnLys: 1.78 ± 0.7
3.56AsnLeu: 3.56 ± 0.9
0.89AsnMet: 0.89 ± 0.505
1.78AsnAsn: 1.78 ± 1.039
3.115AsnPro: 3.115 ± 1.103
3.56AsnGln: 3.56 ± 1.164
2.67AsnArg: 2.67 ± 0.919
3.56AsnSer: 3.56 ± 0.912
1.335AsnThr: 1.335 ± 0.687
1.78AsnVal: 1.78 ± 0.569
1.335AsnTrp: 1.335 ± 0.724
0.445AsnTyr: 0.445 ± 0.338
0.0AsnXaa: 0.0 ± 0.0
Pro
4.895ProAla: 4.895 ± 0.817
0.0ProCys: 0.0 ± 0.0
3.56ProAsp: 3.56 ± 1.516
4.45ProGlu: 4.45 ± 0.733
2.225ProPhe: 2.225 ± 0.744
4.45ProGly: 4.45 ± 1.167
0.89ProHis: 0.89 ± 0.47
3.115ProIle: 3.115 ± 1.036
2.67ProLys: 2.67 ± 0.675
5.34ProLeu: 5.34 ± 1.53
0.89ProMet: 0.89 ± 0.575
3.115ProAsn: 3.115 ± 0.719
8.011ProPro: 8.011 ± 1.301
3.115ProGln: 3.115 ± 1.333
4.45ProArg: 4.45 ± 1.501
7.121ProSer: 7.121 ± 2.678
2.225ProThr: 2.225 ± 0.456
7.566ProVal: 7.566 ± 1.778
0.89ProTrp: 0.89 ± 0.475
1.78ProTyr: 1.78 ± 0.821
0.0ProXaa: 0.0 ± 0.0
Gln
4.005GlnAla: 4.005 ± 1.618
1.78GlnCys: 1.78 ± 1.324
2.225GlnAsp: 2.225 ± 1.012
4.895GlnGlu: 4.895 ± 1.454
2.67GlnPhe: 2.67 ± 1.163
2.67GlnGly: 2.67 ± 0.621
0.89GlnHis: 0.89 ± 0.676
2.67GlnIle: 2.67 ± 0.62
1.335GlnLys: 1.335 ± 0.435
2.225GlnLeu: 2.225 ± 0.864
0.89GlnMet: 0.89 ± 0.475
1.78GlnAsn: 1.78 ± 1.039
1.335GlnPro: 1.335 ± 0.622
1.78GlnGln: 1.78 ± 0.923
2.225GlnArg: 2.225 ± 1.805
3.115GlnSer: 3.115 ± 1.285
1.78GlnThr: 1.78 ± 0.552
1.78GlnVal: 1.78 ± 0.599
1.335GlnTrp: 1.335 ± 0.671
0.445GlnTyr: 0.445 ± 0.355
0.0GlnXaa: 0.0 ± 0.0
Arg
3.115ArgAla: 3.115 ± 0.829
2.225ArgCys: 2.225 ± 1.232
1.335ArgAsp: 1.335 ± 0.622
4.895ArgGlu: 4.895 ± 1.114
2.225ArgPhe: 2.225 ± 1.526
4.895ArgGly: 4.895 ± 1.366
3.115ArgHis: 3.115 ± 1.323
0.0ArgIle: 0.0 ± 0.0
4.005ArgLys: 4.005 ± 0.874
5.785ArgLeu: 5.785 ± 2.35
0.89ArgMet: 0.89 ± 0.54
1.78ArgAsn: 1.78 ± 0.606
6.231ArgPro: 6.231 ± 2.27
2.67ArgGln: 2.67 ± 0.675
6.231ArgArg: 6.231 ± 1.927
4.005ArgSer: 4.005 ± 0.632
4.005ArgThr: 4.005 ± 0.629
4.895ArgVal: 4.895 ± 1.507
1.335ArgTrp: 1.335 ± 0.936
3.56ArgTyr: 3.56 ± 1.115
0.0ArgXaa: 0.0 ± 0.0
Ser
4.005SerAla: 4.005 ± 1.565
0.445SerCys: 0.445 ± 0.565
4.895SerAsp: 4.895 ± 0.989
6.676SerGlu: 6.676 ± 1.101
4.005SerPhe: 4.005 ± 1.13
8.011SerGly: 8.011 ± 3.306
1.78SerHis: 1.78 ± 0.616
4.005SerIle: 4.005 ± 0.685
1.78SerLys: 1.78 ± 0.582
7.566SerLeu: 7.566 ± 1.219
1.335SerMet: 1.335 ± 0.655
3.115SerAsn: 3.115 ± 1.168
4.895SerPro: 4.895 ± 2.263
2.225SerGln: 2.225 ± 1.242
2.67SerArg: 2.67 ± 0.996
5.785SerSer: 5.785 ± 2.132
2.67SerThr: 2.67 ± 1.013
5.34SerVal: 5.34 ± 1.273
1.335SerTrp: 1.335 ± 0.724
2.225SerTyr: 2.225 ± 0.999
0.0SerXaa: 0.0 ± 0.0
Thr
1.335ThrAla: 1.335 ± 0.441
0.445ThrCys: 0.445 ± 0.355
2.225ThrAsp: 2.225 ± 0.81
2.225ThrGlu: 2.225 ± 0.764
3.115ThrPhe: 3.115 ± 1.009
6.676ThrGly: 6.676 ± 0.837
0.89ThrHis: 0.89 ± 0.417
1.78ThrIle: 1.78 ± 1.162
1.78ThrLys: 1.78 ± 1.296
4.005ThrLeu: 4.005 ± 1.363
2.225ThrMet: 2.225 ± 0.744
2.67ThrAsn: 2.67 ± 0.642
5.34ThrPro: 5.34 ± 0.432
0.0ThrGln: 0.0 ± 0.0
5.785ThrArg: 5.785 ± 1.162
4.45ThrSer: 4.45 ± 1.169
3.56ThrThr: 3.56 ± 0.942
4.895ThrVal: 4.895 ± 0.804
1.335ThrTrp: 1.335 ± 0.883
2.67ThrTyr: 2.67 ± 0.802
0.0ThrXaa: 0.0 ± 0.0
Val
4.895ValAla: 4.895 ± 1.404
0.89ValCys: 0.89 ± 1.163
3.56ValAsp: 3.56 ± 0.751
4.895ValGlu: 4.895 ± 1.497
3.115ValPhe: 3.115 ± 1.353
3.56ValGly: 3.56 ± 1.214
1.335ValHis: 1.335 ± 0.432
4.005ValIle: 4.005 ± 1.094
2.67ValLys: 2.67 ± 1.243
4.45ValLeu: 4.45 ± 1.125
0.445ValMet: 0.445 ± 0.355
1.78ValAsn: 1.78 ± 0.977
4.895ValPro: 4.895 ± 1.799
2.67ValGln: 2.67 ± 0.431
8.011ValArg: 8.011 ± 2.184
7.121ValSer: 7.121 ± 1.983
5.34ValThr: 5.34 ± 0.844
4.895ValVal: 4.895 ± 1.18
1.335ValTrp: 1.335 ± 0.569
2.67ValTyr: 2.67 ± 0.549
0.0ValXaa: 0.0 ± 0.0
Trp
0.89TrpAla: 0.89 ± 0.388
0.89TrpCys: 0.89 ± 0.752
0.445TrpAsp: 0.445 ± 0.338
1.78TrpGlu: 1.78 ± 0.778
0.89TrpPhe: 0.89 ± 0.676
1.78TrpGly: 1.78 ± 0.569
0.0TrpHis: 0.0 ± 0.0
0.89TrpIle: 0.89 ± 0.676
0.0TrpLys: 0.0 ± 0.0
3.56TrpLeu: 3.56 ± 0.6
0.445TrpMet: 0.445 ± 0.481
1.335TrpAsn: 1.335 ± 0.435
0.0TrpPro: 0.0 ± 0.0
0.89TrpGln: 0.89 ± 0.513
2.225TrpArg: 2.225 ± 1.079
0.89TrpSer: 0.89 ± 0.648
0.89TrpThr: 0.89 ± 0.963
0.89TrpVal: 0.89 ± 0.513
0.0TrpTrp: 0.0 ± 0.0
0.89TrpTyr: 0.89 ± 0.513
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.225TyrAla: 2.225 ± 0.708
0.89TyrCys: 0.89 ± 0.388
1.335TyrAsp: 1.335 ± 0.388
2.225TyrGlu: 2.225 ± 0.846
1.335TyrPhe: 1.335 ± 0.432
0.89TyrGly: 0.89 ± 0.575
0.89TyrHis: 0.89 ± 0.499
0.89TyrIle: 0.89 ± 0.756
1.335TyrLys: 1.335 ± 0.687
3.115TyrLeu: 3.115 ± 0.835
1.335TyrMet: 1.335 ± 0.697
0.89TyrAsn: 0.89 ± 0.575
1.335TyrPro: 1.335 ± 0.779
1.78TyrGln: 1.78 ± 1.006
3.56TyrArg: 3.56 ± 0.58
0.89TyrSer: 0.89 ± 0.47
1.335TyrThr: 1.335 ± 0.432
0.89TyrVal: 0.89 ± 0.475
1.335TyrTrp: 1.335 ± 0.388
2.67TyrTyr: 2.67 ± 1.713
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (2248 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski