Amino acid dipepetide frequency for Nonomuraea solani

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.193AlaAla: 20.193 ± 0.099	1.075AlaCys: 1.075 ± 0.016	7.609AlaAsp: 7.609 ± 0.049	8.216AlaGlu: 8.216 ± 0.062	3.702AlaPhe: 3.702 ± 0.033	13.574AlaGly: 13.574 ± 0.071	2.638AlaHis: 2.638 ± 0.026	4.554AlaIle: 4.554 ± 0.035	2.864AlaLys: 2.864 ± 0.033	14.221AlaLeu: 14.221 ± 0.085	2.728AlaMet: 2.728 ± 0.028	2.103AlaAsn: 2.103 ± 0.027	6.082AlaPro: 6.082 ± 0.047	3.53AlaGln: 3.53 ± 0.034	10.034AlaArg: 10.034 ± 0.07	5.44AlaSer: 5.44 ± 0.039	7.346AlaThr: 7.346 ± 0.057	11.092AlaVal: 11.092 ± 0.065	1.971AlaTrp: 1.971 ± 0.026	2.851AlaTyr: 2.851 ± 0.029	0.0AlaXaa: 0.0 ± 0.0
Cys	1.0CysAla: 1.0 ± 0.018	0.094CysCys: 0.094 ± 0.005	0.509CysAsp: 0.509 ± 0.011	0.398CysGlu: 0.398 ± 0.01	0.224CysPhe: 0.224 ± 0.006	0.917CysGly: 0.917 ± 0.016	0.204CysHis: 0.204 ± 0.007	0.126CysIle: 0.126 ± 0.005	0.113CysLys: 0.113 ± 0.006	0.767CysLeu: 0.767 ± 0.013	0.125CysMet: 0.125 ± 0.006	0.134CysAsn: 0.134 ± 0.006	0.477CysPro: 0.477 ± 0.011	0.173CysGln: 0.173 ± 0.006	0.591CysArg: 0.591 ± 0.013	0.418CysSer: 0.418 ± 0.011	0.426CysThr: 0.426 ± 0.013	0.654CysVal: 0.654 ± 0.012	0.13CysTrp: 0.13 ± 0.005	0.172CysTyr: 0.172 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	6.552AspAla: 6.552 ± 0.046	0.362AspCys: 0.362 ± 0.012	3.65AspAsp: 3.65 ± 0.039	3.638AspGlu: 3.638 ± 0.031	1.611AspPhe: 1.611 ± 0.019	6.087AspGly: 6.087 ± 0.044	1.454AspHis: 1.454 ± 0.022	1.777AspIle: 1.777 ± 0.021	1.066AspLys: 1.066 ± 0.019	6.822AspLeu: 6.822 ± 0.051	0.832AspMet: 0.832 ± 0.017	0.975AspAsn: 0.975 ± 0.018	4.486AspPro: 4.486 ± 0.034	1.692AspGln: 1.692 ± 0.021	4.79AspArg: 4.79 ± 0.04	2.175AspSer: 2.175 ± 0.023	2.744AspThr: 2.744 ± 0.027	4.837AspVal: 4.837 ± 0.039	0.99AspTrp: 0.99 ± 0.016	1.267AspTyr: 1.267 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	6.819GluAla: 6.819 ± 0.057	0.344GluCys: 0.344 ± 0.008	2.397GluAsp: 2.397 ± 0.025	3.382GluGlu: 3.382 ± 0.037	1.49GluPhe: 1.49 ± 0.02	3.959GluGly: 3.959 ± 0.034	1.579GluHis: 1.579 ± 0.021	2.424GluIle: 2.424 ± 0.028	1.114GluLys: 1.114 ± 0.019	7.071GluLeu: 7.071 ± 0.062	0.933GluMet: 0.933 ± 0.017	0.924GluAsn: 0.924 ± 0.016	3.478GluPro: 3.478 ± 0.034	2.108GluGln: 2.108 ± 0.026	5.756GluArg: 5.756 ± 0.049	2.632GluSer: 2.632 ± 0.027	2.79GluThr: 2.79 ± 0.027	4.581GluVal: 4.581 ± 0.037	0.838GluTrp: 0.838 ± 0.015	1.053GluTyr: 1.053 ± 0.016	0.0GluXaa: 0.0 ± 0.0
Phe	3.866PheAla: 3.866 ± 0.039	0.259PheCys: 0.259 ± 0.009	2.095PheAsp: 2.095 ± 0.025	1.525PheGlu: 1.525 ± 0.02	0.933PhePhe: 0.933 ± 0.019	3.142PheGly: 3.142 ± 0.031	0.646PheHis: 0.646 ± 0.012	0.821PheIle: 0.821 ± 0.016	0.541PheLys: 0.541 ± 0.014	2.699PheLeu: 2.699 ± 0.03	0.469PheMet: 0.469 ± 0.011	0.616PheAsn: 0.616 ± 0.014	1.433PhePro: 1.433 ± 0.018	0.774PheGln: 0.774 ± 0.014	1.813PheArg: 1.813 ± 0.022	1.536PheSer: 1.536 ± 0.021	2.118PheThr: 2.118 ± 0.024	2.356PheVal: 2.356 ± 0.022	0.478PheTrp: 0.478 ± 0.011	0.646PheTyr: 0.646 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	10.287GlyAla: 10.287 ± 0.062	0.831GlyCys: 0.831 ± 0.017	5.287GlyAsp: 5.287 ± 0.04	5.179GlyGlu: 5.179 ± 0.038	2.984GlyPhe: 2.984 ± 0.028	8.71GlyGly: 8.71 ± 0.077	2.341GlyHis: 2.341 ± 0.025	3.318GlyIle: 3.318 ± 0.034	2.438GlyLys: 2.438 ± 0.029	10.035GlyLeu: 10.035 ± 0.057	2.064GlyMet: 2.064 ± 0.024	1.814GlyAsn: 1.814 ± 0.03	5.001GlyPro: 5.001 ± 0.047	2.858GlyGln: 2.858 ± 0.036	7.926GlyArg: 7.926 ± 0.045	4.818GlySer: 4.818 ± 0.052	5.877GlyThr: 5.877 ± 0.055	7.723GlyVal: 7.723 ± 0.046	1.778GlyTrp: 1.778 ± 0.025	2.439GlyTyr: 2.439 ± 0.028	0.0GlyXaa: 0.0 ± 0.0
His	2.622HisAla: 2.622 ± 0.028	0.192HisCys: 0.192 ± 0.007	1.438HisAsp: 1.438 ± 0.022	1.225HisGlu: 1.225 ± 0.017	0.62HisPhe: 0.62 ± 0.013	2.206HisGly: 2.206 ± 0.027	0.696HisHis: 0.696 ± 0.014	0.685HisIle: 0.685 ± 0.012	0.32HisLys: 0.32 ± 0.008	2.582HisLeu: 2.582 ± 0.028	0.329HisMet: 0.329 ± 0.008	0.404HisAsn: 0.404 ± 0.012	1.696HisPro: 1.696 ± 0.023	0.645HisGln: 0.645 ± 0.012	1.949HisArg: 1.949 ± 0.024	0.892HisSer: 0.892 ± 0.018	1.2HisThr: 1.2 ± 0.019	1.813HisVal: 1.813 ± 0.021	0.372HisTrp: 0.372 ± 0.01	0.522HisTyr: 0.522 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	5.186IleAla: 5.186 ± 0.03	0.308IleCys: 0.308 ± 0.008	2.588IleAsp: 2.588 ± 0.024	2.304IleGlu: 2.304 ± 0.027	0.914IlePhe: 0.914 ± 0.016	3.823IleGly: 3.823 ± 0.034	0.667IleHis: 0.667 ± 0.012	1.132IleIle: 1.132 ± 0.021	0.846IleLys: 0.846 ± 0.019	2.783IleLeu: 2.783 ± 0.032	0.617IleMet: 0.617 ± 0.015	0.78IleAsn: 0.78 ± 0.016	1.938IlePro: 1.938 ± 0.024	0.804IleGln: 0.804 ± 0.016	2.516IleArg: 2.516 ± 0.024	2.0IleSer: 2.0 ± 0.023	2.568IleThr: 2.568 ± 0.031	3.243IleVal: 3.243 ± 0.031	0.485IleTrp: 0.485 ± 0.011	0.692IleTyr: 0.692 ± 0.012	0.0IleXaa: 0.0 ± 0.0
Lys	2.72LysAla: 2.72 ± 0.032	0.114LysCys: 0.114 ± 0.005	1.181LysAsp: 1.181 ± 0.019	1.161LysGlu: 1.161 ± 0.02	0.455LysPhe: 0.455 ± 0.011	1.797LysGly: 1.797 ± 0.023	0.404LysHis: 0.404 ± 0.011	1.014LysIle: 1.014 ± 0.017	0.675LysLys: 0.675 ± 0.017	2.039LysLeu: 2.039 ± 0.025	0.39LysMet: 0.39 ± 0.011	0.493LysAsn: 0.493 ± 0.012	1.368LysPro: 1.368 ± 0.019	0.626LysGln: 0.626 ± 0.013	1.455LysArg: 1.455 ± 0.02	1.115LysSer: 1.115 ± 0.019	1.298LysThr: 1.298 ± 0.024	1.958LysVal: 1.958 ± 0.027	0.299LysTrp: 0.299 ± 0.009	0.432LysTyr: 0.432 ± 0.012	0.0LysXaa: 0.0 ± 0.0
Leu	15.853LeuAla: 15.853 ± 0.084	0.778LeuCys: 0.778 ± 0.016	6.627LeuAsp: 6.627 ± 0.053	4.9LeuGlu: 4.9 ± 0.043	2.805LeuPhe: 2.805 ± 0.031	9.577LeuGly: 9.577 ± 0.052	2.11LeuHis: 2.11 ± 0.027	4.04LeuIle: 4.04 ± 0.033	2.029LeuLys: 2.029 ± 0.023	11.464LeuLeu: 11.464 ± 0.08	1.836LeuMet: 1.836 ± 0.02	1.947LeuAsn: 1.947 ± 0.019	6.567LeuPro: 6.567 ± 0.043	2.139LeuGln: 2.139 ± 0.023	9.04LeuArg: 9.04 ± 0.063	5.753LeuSer: 5.753 ± 0.037	7.125LeuThr: 7.125 ± 0.051	8.878LeuVal: 8.878 ± 0.055	1.388LeuTrp: 1.388 ± 0.02	1.99LeuTyr: 1.99 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	2.512MetAla: 2.512 ± 0.026	0.126MetCys: 0.126 ± 0.006	0.917MetAsp: 0.917 ± 0.017	0.828MetGlu: 0.828 ± 0.015	0.531MetPhe: 0.531 ± 0.011	1.409MetGly: 1.409 ± 0.021	0.35MetHis: 0.35 ± 0.01	0.895MetIle: 0.895 ± 0.016	0.461MetLys: 0.461 ± 0.011	1.939MetLeu: 1.939 ± 0.022	0.346MetMet: 0.346 ± 0.009	0.479MetAsn: 0.479 ± 0.011	1.153MetPro: 1.153 ± 0.018	0.396MetGln: 0.396 ± 0.01	1.703MetArg: 1.703 ± 0.021	1.358MetSer: 1.358 ± 0.018	1.59MetThr: 1.59 ± 0.02	1.414MetVal: 1.414 ± 0.022	0.238MetTrp: 0.238 ± 0.008	0.35MetTyr: 0.35 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	2.271AsnAla: 2.271 ± 0.025	0.164AsnCys: 0.164 ± 0.008	1.057AsnAsp: 1.057 ± 0.02	0.876AsnGlu: 0.876 ± 0.016	0.519AsnPhe: 0.519 ± 0.012	2.064AsnGly: 2.064 ± 0.03	0.396AsnHis: 0.396 ± 0.011	0.64AsnIle: 0.64 ± 0.013	0.397AsnLys: 0.397 ± 0.012	1.915AsnLeu: 1.915 ± 0.025	0.312AsnMet: 0.312 ± 0.009	0.46AsnAsn: 0.46 ± 0.013	1.442AsnPro: 1.442 ± 0.023	0.531AsnGln: 0.531 ± 0.013	1.385AsnArg: 1.385 ± 0.02	0.868AsnSer: 0.868 ± 0.016	1.102AsnThr: 1.102 ± 0.019	1.588AsnVal: 1.588 ± 0.025	0.32AsnTrp: 0.32 ± 0.009	0.438AsnTyr: 0.438 ± 0.011	0.0AsnXaa: 0.0 ± 0.0
Pro	8.407ProAla: 8.407 ± 0.063	0.344ProCys: 0.344 ± 0.009	4.231ProAsp: 4.231 ± 0.032	4.087ProGlu: 4.087 ± 0.034	1.647ProPhe: 1.647 ± 0.023	6.661ProGly: 6.661 ± 0.051	1.26ProHis: 1.26 ± 0.018	1.885ProIle: 1.885 ± 0.019	1.226ProLys: 1.226 ± 0.019	5.399ProLeu: 5.399 ± 0.045	1.157ProMet: 1.157 ± 0.017	0.984ProAsn: 0.984 ± 0.018	3.755ProPro: 3.755 ± 0.049	1.553ProGln: 1.553 ± 0.024	3.742ProArg: 3.742 ± 0.036	3.175ProSer: 3.175 ± 0.035	2.906ProThr: 2.906 ± 0.032	5.137ProVal: 5.137 ± 0.038	0.96ProTrp: 0.96 ± 0.017	1.494ProTyr: 1.494 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	4.046GlnAla: 4.046 ± 0.04	0.163GlnCys: 0.163 ± 0.006	1.338GlnAsp: 1.338 ± 0.019	1.448GlnGlu: 1.448 ± 0.02	0.675GlnPhe: 0.675 ± 0.012	2.216GlnGly: 2.216 ± 0.024	0.571GlnHis: 0.571 ± 0.012	1.197GlnIle: 1.197 ± 0.017	0.509GlnLys: 0.509 ± 0.012	2.663GlnLeu: 2.663 ± 0.029	0.465GlnMet: 0.465 ± 0.011	0.531GlnAsn: 0.531 ± 0.012	1.691GlnPro: 1.691 ± 0.026	1.023GlnGln: 1.023 ± 0.028	2.354GlnArg: 2.354 ± 0.027	1.242GlnSer: 1.242 ± 0.017	1.359GlnThr: 1.359 ± 0.02	2.63GlnVal: 2.63 ± 0.026	0.491GlnTrp: 0.491 ± 0.011	0.539GlnTyr: 0.539 ± 0.012	0.0GlnXaa: 0.0 ± 0.0
Arg	9.503ArgAla: 9.503 ± 0.068	0.581ArgCys: 0.581 ± 0.014	4.416ArgAsp: 4.416 ± 0.04	4.624ArgGlu: 4.624 ± 0.04	2.521ArgPhe: 2.521 ± 0.03	5.542ArgGly: 5.542 ± 0.04	2.278ArgHis: 2.278 ± 0.023	3.091ArgIle: 3.091 ± 0.029	1.616ArgLys: 1.616 ± 0.02	9.875ArgLeu: 9.875 ± 0.07	1.892ArgMet: 1.892 ± 0.022	1.407ArgAsn: 1.407 ± 0.02	5.07ArgPro: 5.07 ± 0.046	2.466ArgGln: 2.466 ± 0.027	7.815ArgArg: 7.815 ± 0.057	3.881ArgSer: 3.881 ± 0.032	4.692ArgThr: 4.692 ± 0.038	6.181ArgVal: 6.181 ± 0.049	1.46ArgTrp: 1.46 ± 0.021	1.921ArgTyr: 1.921 ± 0.022	0.0ArgXaa: 0.0 ± 0.0
Ser	6.313SerAla: 6.313 ± 0.043	0.41SerCys: 0.41 ± 0.012	2.54SerAsp: 2.54 ± 0.028	2.386SerGlu: 2.386 ± 0.026	1.564SerPhe: 1.564 ± 0.02	5.883SerGly: 5.883 ± 0.046	0.955SerHis: 0.955 ± 0.017	1.775SerIle: 1.775 ± 0.021	0.996SerLys: 0.996 ± 0.017	4.876SerLeu: 4.876 ± 0.037	1.195SerMet: 1.195 ± 0.017	0.865SerAsn: 0.865 ± 0.017	3.234SerPro: 3.234 ± 0.034	1.23SerGln: 1.23 ± 0.017	3.668SerArg: 3.668 ± 0.033	2.726SerSer: 2.726 ± 0.035	2.865SerThr: 2.865 ± 0.031	4.086SerVal: 4.086 ± 0.035	0.965SerTrp: 0.965 ± 0.016	1.232SerTyr: 1.232 ± 0.019	0.0SerXaa: 0.0 ± 0.0
Thr	7.923ThrAla: 7.923 ± 0.052	0.481ThrCys: 0.481 ± 0.011	3.104ThrAsp: 3.104 ± 0.031	2.93ThrGlu: 2.93 ± 0.025	1.872ThrPhe: 1.872 ± 0.025	6.539ThrGly: 6.539 ± 0.054	1.14ThrHis: 1.14 ± 0.016	2.272ThrIle: 2.272 ± 0.023	1.21ThrLys: 1.21 ± 0.019	6.062ThrLeu: 6.062 ± 0.042	1.179ThrMet: 1.179 ± 0.017	1.058ThrAsn: 1.058 ± 0.019	3.965ThrPro: 3.965 ± 0.036	1.342ThrGln: 1.342 ± 0.02	3.968ThrArg: 3.968 ± 0.035	3.207ThrSer: 3.207 ± 0.033	3.858ThrThr: 3.858 ± 0.042	5.549ThrVal: 5.549 ± 0.041	1.059ThrTrp: 1.059 ± 0.02	1.46ThrTyr: 1.46 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	11.22ValAla: 11.22 ± 0.056	0.679ValCys: 0.679 ± 0.012	4.389ValAsp: 4.389 ± 0.037	4.587ValGlu: 4.587 ± 0.038	2.502ValPhe: 2.502 ± 0.03	6.209ValGly: 6.209 ± 0.042	1.811ValHis: 1.811 ± 0.022	3.38ValIle: 3.38 ± 0.031	1.823ValLys: 1.823 ± 0.024	9.387ValLeu: 9.387 ± 0.064	1.512ValMet: 1.512 ± 0.021	1.803ValAsn: 1.803 ± 0.025	5.14ValPro: 5.14 ± 0.038	1.962ValGln: 1.962 ± 0.023	6.899ValArg: 6.899 ± 0.044	4.534ValSer: 4.534 ± 0.035	5.931ValThr: 5.931 ± 0.047	7.682ValVal: 7.682 ± 0.055	1.16ValTrp: 1.16 ± 0.021	1.649ValTyr: 1.649 ± 0.021	0.0ValXaa: 0.0 ± 0.0
Trp	1.722TrpAla: 1.722 ± 0.021	0.153TrpCys: 0.153 ± 0.006	0.88TrpAsp: 0.88 ± 0.016	0.763TrpGlu: 0.763 ± 0.013	0.516TrpPhe: 0.516 ± 0.011	1.09TrpGly: 1.09 ± 0.017	0.435TrpHis: 0.435 ± 0.011	0.616TrpIle: 0.616 ± 0.013	0.363TrpLys: 0.363 ± 0.01	1.916TrpLeu: 1.916 ± 0.03	0.323TrpMet: 0.323 ± 0.009	0.485TrpAsn: 0.485 ± 0.011	0.896TrpPro: 0.896 ± 0.016	0.617TrpGln: 0.617 ± 0.013	1.505TrpArg: 1.505 ± 0.023	1.012TrpSer: 1.012 ± 0.018	1.084TrpThr: 1.084 ± 0.017	1.018TrpVal: 1.018 ± 0.016	0.367TrpTrp: 0.367 ± 0.01	0.384TrpTyr: 0.384 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.808TyrAla: 2.808 ± 0.027	0.192TyrCys: 0.192 ± 0.007	1.554TyrAsp: 1.554 ± 0.032	1.214TyrGlu: 1.214 ± 0.017	0.681TyrPhe: 0.681 ± 0.013	2.302TyrGly: 2.302 ± 0.027	0.473TyrHis: 0.473 ± 0.01	0.554TyrIle: 0.554 ± 0.013	0.388TyrLys: 0.388 ± 0.012	2.332TyrLeu: 2.332 ± 0.026	0.292TyrMet: 0.292 ± 0.008	0.481TyrAsn: 0.481 ± 0.013	1.139TyrPro: 1.139 ± 0.015	0.685TyrGln: 0.685 ± 0.014	1.923TyrArg: 1.923 ± 0.024	0.982TyrSer: 0.982 ± 0.014	1.298TyrThr: 1.298 ± 0.021	1.843TyrVal: 1.843 ± 0.022	0.391TyrTrp: 0.391 ± 0.01	0.507TyrTyr: 0.507 ± 0.012	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.001

Statistics based on 12105 proteins (3978721 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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