Amino acid dipepetide frequency for Mycobacterium phage Rabbs

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.01AlaAla: 19.01 ± 1.984
0.94AlaCys: 0.94 ± 0.25
7.951AlaAsp: 7.951 ± 1.046
8.818AlaGlu: 8.818 ± 1.059
4.265AlaPhe: 4.265 ± 0.761
14.167AlaGly: 14.167 ± 1.557
2.313AlaHis: 2.313 ± 0.546
6.216AlaIle: 6.216 ± 0.739
5.06AlaLys: 5.06 ± 0.822
9.83AlaLeu: 9.83 ± 0.912
3.542AlaMet: 3.542 ± 0.515
3.686AlaAsn: 3.686 ± 0.553
7.156AlaPro: 7.156 ± 0.91
4.626AlaGln: 4.626 ± 0.524
8.457AlaArg: 8.457 ± 0.856
5.349AlaSer: 5.349 ± 1.037
6.65AlaThr: 6.65 ± 0.681
8.746AlaVal: 8.746 ± 0.808
2.385AlaTrp: 2.385 ± 0.401
1.879AlaTyr: 1.879 ± 0.469
0.0AlaXaa: 0.0 ± 0.0
Cys
0.578CysAla: 0.578 ± 0.226
0.145CysCys: 0.145 ± 0.113
0.217CysAsp: 0.217 ± 0.112
0.651CysGlu: 0.651 ± 0.252
0.145CysPhe: 0.145 ± 0.115
1.952CysGly: 1.952 ± 0.553
0.217CysHis: 0.217 ± 0.126
0.361CysIle: 0.361 ± 0.159
0.145CysLys: 0.145 ± 0.118
0.217CysLeu: 0.217 ± 0.114
0.072CysMet: 0.072 ± 0.073
0.217CysAsn: 0.217 ± 0.114
0.651CysPro: 0.651 ± 0.292
0.578CysGln: 0.578 ± 0.211
1.012CysArg: 1.012 ± 0.298
0.361CysSer: 0.361 ± 0.222
0.361CysThr: 0.361 ± 0.185
0.578CysVal: 0.578 ± 0.189
0.289CysTrp: 0.289 ± 0.176
0.072CysTyr: 0.072 ± 0.088
0.0CysXaa: 0.0 ± 0.0
Asp
8.385AspAla: 8.385 ± 0.844
0.506AspCys: 0.506 ± 0.238
6.216AspAsp: 6.216 ± 0.809
4.987AspGlu: 4.987 ± 0.685
2.241AspPhe: 2.241 ± 0.447
8.168AspGly: 8.168 ± 0.899
0.795AspHis: 0.795 ± 0.221
1.807AspIle: 1.807 ± 0.459
1.879AspLys: 1.879 ± 0.424
5.06AspLeu: 5.06 ± 0.616
1.012AspMet: 1.012 ± 0.275
1.518AspAsn: 1.518 ± 0.327
4.626AspPro: 4.626 ± 0.764
2.819AspGln: 2.819 ± 0.54
4.626AspArg: 4.626 ± 0.629
2.458AspSer: 2.458 ± 0.379
3.686AspThr: 3.686 ± 0.437
4.626AspVal: 4.626 ± 0.579
1.735AspTrp: 1.735 ± 0.357
2.168AspTyr: 2.168 ± 0.47
0.0AspXaa: 0.0 ± 0.0
Glu
6.072GluAla: 6.072 ± 0.785
0.434GluCys: 0.434 ± 0.185
4.337GluAsp: 4.337 ± 0.606
3.325GluGlu: 3.325 ± 0.665
1.952GluPhe: 1.952 ± 0.45
4.192GluGly: 4.192 ± 0.504
2.747GluHis: 2.747 ± 0.448
2.313GluIle: 2.313 ± 0.379
1.373GluLys: 1.373 ± 0.26
5.999GluLeu: 5.999 ± 0.722
1.156GluMet: 1.156 ± 0.304
2.313GluAsn: 2.313 ± 0.525
3.903GluPro: 3.903 ± 0.719
2.313GluGln: 2.313 ± 0.437
3.975GluArg: 3.975 ± 0.762
2.313GluSer: 2.313 ± 0.409
3.325GluThr: 3.325 ± 0.59
4.048GluVal: 4.048 ± 0.558
1.229GluTrp: 1.229 ± 0.385
0.578GluTyr: 0.578 ± 0.247
0.0GluXaa: 0.0 ± 0.0
Phe
3.036PheAla: 3.036 ± 0.345
0.651PheCys: 0.651 ± 0.212
2.963PheAsp: 2.963 ± 0.42
2.674PheGlu: 2.674 ± 0.606
0.723PhePhe: 0.723 ± 0.24
3.542PheGly: 3.542 ± 0.638
0.506PheHis: 0.506 ± 0.217
0.723PheIle: 0.723 ± 0.256
0.867PheLys: 0.867 ± 0.235
2.53PheLeu: 2.53 ± 0.579
0.651PheMet: 0.651 ± 0.221
1.084PheAsn: 1.084 ± 0.305
1.59PhePro: 1.59 ± 0.329
0.578PheGln: 0.578 ± 0.226
1.735PheArg: 1.735 ± 0.398
2.024PheSer: 2.024 ± 0.419
1.301PheThr: 1.301 ± 0.275
2.096PheVal: 2.096 ± 0.395
0.361PheTrp: 0.361 ± 0.185
0.434PheTyr: 0.434 ± 0.164
0.0PheXaa: 0.0 ± 0.0
Gly
11.059GlyAla: 11.059 ± 0.975
0.94GlyCys: 0.94 ± 0.238
7.011GlyAsp: 7.011 ± 0.686
4.481GlyGlu: 4.481 ± 0.512
2.747GlyPhe: 2.747 ± 0.406
7.517GlyGly: 7.517 ± 1.454
2.385GlyHis: 2.385 ± 0.408
4.626GlyIle: 4.626 ± 0.695
4.554GlyLys: 4.554 ± 0.778
7.589GlyLeu: 7.589 ± 0.908
1.59GlyMet: 1.59 ± 0.302
3.108GlyAsn: 3.108 ± 0.645
4.409GlyPro: 4.409 ± 0.683
2.458GlyGln: 2.458 ± 0.472
5.276GlyArg: 5.276 ± 0.615
5.204GlySer: 5.204 ± 0.661
5.349GlyThr: 5.349 ± 0.746
5.566GlyVal: 5.566 ± 0.521
1.952GlyTrp: 1.952 ± 0.414
2.458GlyTyr: 2.458 ± 0.517
0.0GlyXaa: 0.0 ± 0.0
His
2.819HisAla: 2.819 ± 0.627
0.289HisCys: 0.289 ± 0.135
1.229HisAsp: 1.229 ± 0.282
0.867HisGlu: 0.867 ± 0.251
0.434HisPhe: 0.434 ± 0.205
1.735HisGly: 1.735 ± 0.314
0.578HisHis: 0.578 ± 0.188
1.229HisIle: 1.229 ± 0.277
0.723HisLys: 0.723 ± 0.221
1.156HisLeu: 1.156 ± 0.343
0.651HisMet: 0.651 ± 0.155
0.723HisAsn: 0.723 ± 0.233
2.096HisPro: 2.096 ± 0.518
0.867HisGln: 0.867 ± 0.248
2.096HisArg: 2.096 ± 0.416
0.578HisSer: 0.578 ± 0.176
0.867HisThr: 0.867 ± 0.284
1.59HisVal: 1.59 ± 0.298
0.723HisTrp: 0.723 ± 0.184
0.506HisTyr: 0.506 ± 0.223
0.0HisXaa: 0.0 ± 0.0
Ile
6.361IleAla: 6.361 ± 0.782
0.506IleCys: 0.506 ± 0.209
3.253IleAsp: 3.253 ± 0.565
3.614IleGlu: 3.614 ± 0.565
0.94IlePhe: 0.94 ± 0.196
3.542IleGly: 3.542 ± 0.623
1.084IleHis: 1.084 ± 0.23
1.229IleIle: 1.229 ± 0.433
1.518IleLys: 1.518 ± 0.436
2.963IleLeu: 2.963 ± 0.498
0.651IleMet: 0.651 ± 0.244
1.084IleAsn: 1.084 ± 0.287
4.048IlePro: 4.048 ± 0.674
1.156IleGln: 1.156 ± 0.267
4.048IleArg: 4.048 ± 0.618
1.735IleSer: 1.735 ± 0.419
2.674IleThr: 2.674 ± 0.565
3.18IleVal: 3.18 ± 0.577
1.012IleTrp: 1.012 ± 0.229
1.084IleTyr: 1.084 ± 0.276
0.0IleXaa: 0.0 ± 0.0
Lys
5.855LysAla: 5.855 ± 0.81
0.361LysCys: 0.361 ± 0.142
1.156LysAsp: 1.156 ± 0.35
0.94LysGlu: 0.94 ± 0.3
1.012LysPhe: 1.012 ± 0.275
1.952LysGly: 1.952 ± 0.418
0.723LysHis: 0.723 ± 0.276
2.241LysIle: 2.241 ± 0.491
1.518LysLys: 1.518 ± 0.401
2.53LysLeu: 2.53 ± 0.444
1.084LysMet: 1.084 ± 0.244
1.735LysAsn: 1.735 ± 0.339
2.819LysPro: 2.819 ± 0.484
1.012LysGln: 1.012 ± 0.277
2.674LysArg: 2.674 ± 0.537
2.096LysSer: 2.096 ± 0.404
2.241LysThr: 2.241 ± 0.358
1.735LysVal: 1.735 ± 0.285
0.217LysTrp: 0.217 ± 0.129
0.795LysTyr: 0.795 ± 0.251
0.0LysXaa: 0.0 ± 0.0
Leu
9.975LeuAla: 9.975 ± 0.982
0.578LeuCys: 0.578 ± 0.236
6.072LeuAsp: 6.072 ± 0.706
3.469LeuGlu: 3.469 ± 0.422
2.458LeuPhe: 2.458 ± 0.464
7.083LeuGly: 7.083 ± 0.918
1.373LeuHis: 1.373 ± 0.284
4.626LeuIle: 4.626 ± 0.524
2.747LeuLys: 2.747 ± 0.554
4.843LeuLeu: 4.843 ± 0.637
1.301LeuMet: 1.301 ± 0.391
2.313LeuAsn: 2.313 ± 0.389
4.915LeuPro: 4.915 ± 0.558
1.807LeuGln: 1.807 ± 0.418
5.276LeuArg: 5.276 ± 0.745
3.975LeuSer: 3.975 ± 0.57
4.915LeuThr: 4.915 ± 0.723
5.204LeuVal: 5.204 ± 0.726
1.373LeuTrp: 1.373 ± 0.465
1.662LeuTyr: 1.662 ± 0.357
0.0LeuXaa: 0.0 ± 0.0
Met
2.602MetAla: 2.602 ± 0.458
0.072MetCys: 0.072 ± 0.075
1.084MetAsp: 1.084 ± 0.296
0.651MetGlu: 0.651 ± 0.243
0.94MetPhe: 0.94 ± 0.289
1.879MetGly: 1.879 ± 0.371
0.506MetHis: 0.506 ± 0.281
1.084MetIle: 1.084 ± 0.29
0.651MetLys: 0.651 ± 0.193
2.241MetLeu: 2.241 ± 0.4
0.651MetMet: 0.651 ± 0.191
0.723MetAsn: 0.723 ± 0.22
0.434MetPro: 0.434 ± 0.213
0.506MetGln: 0.506 ± 0.194
1.446MetArg: 1.446 ± 0.399
2.024MetSer: 2.024 ± 0.364
2.024MetThr: 2.024 ± 0.382
1.229MetVal: 1.229 ± 0.313
0.289MetTrp: 0.289 ± 0.146
0.217MetTyr: 0.217 ± 0.125
0.0MetXaa: 0.0 ± 0.0
Asn
4.987AsnAla: 4.987 ± 0.712
0.434AsnCys: 0.434 ± 0.254
1.373AsnAsp: 1.373 ± 0.397
1.952AsnGlu: 1.952 ± 0.38
1.012AsnPhe: 1.012 ± 0.291
3.542AsnGly: 3.542 ± 0.511
0.578AsnHis: 0.578 ± 0.177
1.446AsnIle: 1.446 ± 0.345
0.506AsnLys: 0.506 ± 0.196
2.024AsnLeu: 2.024 ± 0.327
0.506AsnMet: 0.506 ± 0.19
0.578AsnAsn: 0.578 ± 0.235
3.253AsnPro: 3.253 ± 0.409
1.301AsnGln: 1.301 ± 0.305
2.168AsnArg: 2.168 ± 0.361
0.795AsnSer: 0.795 ± 0.227
1.662AsnThr: 1.662 ± 0.324
1.879AsnVal: 1.879 ± 0.589
0.361AsnTrp: 0.361 ± 0.116
0.723AsnTyr: 0.723 ± 0.19
0.0AsnXaa: 0.0 ± 0.0
Pro
10.842ProAla: 10.842 ± 1.226
0.289ProCys: 0.289 ± 0.179
5.493ProAsp: 5.493 ± 0.824
4.265ProGlu: 4.265 ± 0.576
1.662ProPhe: 1.662 ± 0.357
5.204ProGly: 5.204 ± 0.744
1.301ProHis: 1.301 ± 0.37
2.53ProIle: 2.53 ± 0.476
1.879ProLys: 1.879 ± 0.396
4.048ProLeu: 4.048 ± 0.553
0.94ProMet: 0.94 ± 0.31
1.735ProAsn: 1.735 ± 0.466
3.686ProPro: 3.686 ± 0.662
1.807ProGln: 1.807 ± 0.412
3.397ProArg: 3.397 ± 0.63
3.325ProSer: 3.325 ± 0.515
3.686ProThr: 3.686 ± 0.607
3.759ProVal: 3.759 ± 0.611
0.94ProTrp: 0.94 ± 0.317
0.94ProTyr: 0.94 ± 0.28
0.0ProXaa: 0.0 ± 0.0
Gln
3.759GlnAla: 3.759 ± 0.553
0.217GlnCys: 0.217 ± 0.134
2.024GlnAsp: 2.024 ± 0.354
1.373GlnGlu: 1.373 ± 0.304
1.229GlnPhe: 1.229 ± 0.28
2.313GlnGly: 2.313 ± 0.425
1.084GlnHis: 1.084 ± 0.386
1.807GlnIle: 1.807 ± 0.369
1.084GlnLys: 1.084 ± 0.322
3.397GlnLeu: 3.397 ± 0.578
0.867GlnMet: 0.867 ± 0.258
1.301GlnAsn: 1.301 ± 0.48
1.735GlnPro: 1.735 ± 0.331
1.807GlnGln: 1.807 ± 0.464
2.674GlnArg: 2.674 ± 0.424
2.168GlnSer: 2.168 ± 0.475
1.735GlnThr: 1.735 ± 0.239
2.024GlnVal: 2.024 ± 0.351
0.434GlnTrp: 0.434 ± 0.149
0.578GlnTyr: 0.578 ± 0.209
0.0GlnXaa: 0.0 ± 0.0
Arg
8.023ArgAla: 8.023 ± 0.955
0.94ArgCys: 0.94 ± 0.263
4.481ArgAsp: 4.481 ± 0.53
3.759ArgGlu: 3.759 ± 0.567
1.59ArgPhe: 1.59 ± 0.364
4.626ArgGly: 4.626 ± 0.574
1.373ArgHis: 1.373 ± 0.332
3.542ArgIle: 3.542 ± 0.579
2.819ArgLys: 2.819 ± 0.522
5.349ArgLeu: 5.349 ± 0.72
1.952ArgMet: 1.952 ± 0.34
2.313ArgAsn: 2.313 ± 0.458
4.192ArgPro: 4.192 ± 0.622
2.963ArgGln: 2.963 ± 0.448
7.3ArgArg: 7.3 ± 1.038
3.253ArgSer: 3.253 ± 0.497
4.843ArgThr: 4.843 ± 0.606
4.048ArgVal: 4.048 ± 0.562
1.59ArgTrp: 1.59 ± 0.461
1.446ArgTyr: 1.446 ± 0.383
0.0ArgXaa: 0.0 ± 0.0
Ser
6.65SerAla: 6.65 ± 1.197
0.361SerCys: 0.361 ± 0.175
3.903SerAsp: 3.903 ± 0.463
2.747SerGlu: 2.747 ± 0.656
1.373SerPhe: 1.373 ± 0.333
4.337SerGly: 4.337 ± 1.044
0.361SerHis: 0.361 ± 0.153
2.602SerIle: 2.602 ± 0.452
2.168SerLys: 2.168 ± 0.415
3.542SerLeu: 3.542 ± 0.552
1.446SerMet: 1.446 ± 0.299
1.59SerAsn: 1.59 ± 0.348
2.602SerPro: 2.602 ± 0.476
1.156SerGln: 1.156 ± 0.362
2.747SerArg: 2.747 ± 0.329
3.397SerSer: 3.397 ± 0.662
3.542SerThr: 3.542 ± 0.498
3.686SerVal: 3.686 ± 0.516
1.301SerTrp: 1.301 ± 0.417
1.084SerTyr: 1.084 ± 0.298
0.0SerXaa: 0.0 ± 0.0
Thr
8.746ThrAla: 8.746 ± 0.922
0.217ThrCys: 0.217 ± 0.114
3.975ThrAsp: 3.975 ± 0.476
2.819ThrGlu: 2.819 ± 0.439
2.168ThrPhe: 2.168 ± 0.406
5.493ThrGly: 5.493 ± 0.802
1.156ThrHis: 1.156 ± 0.251
2.819ThrIle: 2.819 ± 0.491
1.879ThrLys: 1.879 ± 0.342
3.686ThrLeu: 3.686 ± 0.534
1.662ThrMet: 1.662 ± 0.366
1.807ThrAsn: 1.807 ± 0.283
3.759ThrPro: 3.759 ± 0.592
1.735ThrGln: 1.735 ± 0.345
3.469ThrArg: 3.469 ± 0.671
4.048ThrSer: 4.048 ± 0.627
3.759ThrThr: 3.759 ± 0.592
4.554ThrVal: 4.554 ± 0.548
0.723ThrTrp: 0.723 ± 0.256
0.867ThrTyr: 0.867 ± 0.292
0.0ThrXaa: 0.0 ± 0.0
Val
7.517ValAla: 7.517 ± 0.795
0.867ValCys: 0.867 ± 0.257
4.915ValAsp: 4.915 ± 0.59
4.843ValGlu: 4.843 ± 0.597
2.385ValPhe: 2.385 ± 0.361
5.204ValGly: 5.204 ± 0.66
1.301ValHis: 1.301 ± 0.236
2.819ValIle: 2.819 ± 0.544
2.024ValLys: 2.024 ± 0.41
5.132ValLeu: 5.132 ± 0.561
0.723ValMet: 0.723 ± 0.247
2.313ValAsn: 2.313 ± 0.477
3.686ValPro: 3.686 ± 0.482
1.952ValGln: 1.952 ± 0.352
4.915ValArg: 4.915 ± 0.727
2.819ValSer: 2.819 ± 0.604
4.192ValThr: 4.192 ± 0.737
5.132ValVal: 5.132 ± 0.783
2.241ValTrp: 2.241 ± 0.512
1.807ValTyr: 1.807 ± 0.277
0.0ValXaa: 0.0 ± 0.0
Trp
2.241TrpAla: 2.241 ± 0.416
0.072TrpCys: 0.072 ± 0.076
1.012TrpAsp: 1.012 ± 0.279
0.651TrpGlu: 0.651 ± 0.263
0.506TrpPhe: 0.506 ± 0.18
1.59TrpGly: 1.59 ± 0.416
0.578TrpHis: 0.578 ± 0.19
0.94TrpIle: 0.94 ± 0.292
0.795TrpLys: 0.795 ± 0.274
2.241TrpLeu: 2.241 ± 0.525
0.506TrpMet: 0.506 ± 0.213
0.578TrpAsn: 0.578 ± 0.227
1.084TrpPro: 1.084 ± 0.25
0.94TrpGln: 0.94 ± 0.229
1.518TrpArg: 1.518 ± 0.378
1.59TrpSer: 1.59 ± 0.353
1.373TrpThr: 1.373 ± 0.314
0.94TrpVal: 0.94 ± 0.25
0.289TrpTrp: 0.289 ± 0.13
0.434TrpTyr: 0.434 ± 0.184
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.53TyrAla: 2.53 ± 0.63
0.0TyrCys: 0.0 ± 0.0
0.651TyrAsp: 0.651 ± 0.221
1.012TyrGlu: 1.012 ± 0.247
0.289TyrPhe: 0.289 ± 0.2
2.241TyrGly: 2.241 ± 0.364
0.795TyrHis: 0.795 ± 0.247
0.723TyrIle: 0.723 ± 0.207
0.506TyrLys: 0.506 ± 0.19
1.59TyrLeu: 1.59 ± 0.373
0.217TyrMet: 0.217 ± 0.167
0.361TyrAsn: 0.361 ± 0.16
1.084TyrPro: 1.084 ± 0.26
1.229TyrGln: 1.229 ± 0.278
1.59TyrArg: 1.59 ± 0.38
1.156TyrSer: 1.156 ± 0.33
1.156TyrThr: 1.156 ± 0.291
2.168TyrVal: 2.168 ± 0.407
0.434TyrTrp: 0.434 ± 0.142
0.072TyrTyr: 0.072 ± 0.08
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 65 proteins (13836 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski