Amino acid dipepetide frequency for Desulfovibrio bizertensis DSM 18034

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.911AlaAla: 8.911 ± 0.14
1.466AlaCys: 1.466 ± 0.045
4.501AlaAsp: 4.501 ± 0.082
6.256AlaGlu: 6.256 ± 0.098
3.898AlaPhe: 3.898 ± 0.065
7.156AlaGly: 7.156 ± 0.113
1.997AlaHis: 1.997 ± 0.051
4.693AlaIle: 4.693 ± 0.084
4.444AlaLys: 4.444 ± 0.081
10.644AlaLeu: 10.644 ± 0.117
2.677AlaMet: 2.677 ± 0.055
2.283AlaAsn: 2.283 ± 0.049
3.925AlaPro: 3.925 ± 0.071
3.995AlaGln: 3.995 ± 0.073
5.021AlaArg: 5.021 ± 0.074
5.197AlaSer: 5.197 ± 0.075
4.001AlaThr: 4.001 ± 0.109
6.519AlaVal: 6.519 ± 0.095
1.03AlaTrp: 1.03 ± 0.035
2.336AlaTyr: 2.336 ± 0.06
0.0AlaXaa: 0.0 ± 0.0
Cys
1.451CysAla: 1.451 ± 0.042
0.273CysCys: 0.273 ± 0.018
0.68CysAsp: 0.68 ± 0.031
0.832CysGlu: 0.832 ± 0.034
0.6CysPhe: 0.6 ± 0.027
1.456CysGly: 1.456 ± 0.044
0.403CysHis: 0.403 ± 0.031
0.846CysIle: 0.846 ± 0.029
0.544CysLys: 0.544 ± 0.028
1.414CysLeu: 1.414 ± 0.039
0.372CysMet: 0.372 ± 0.021
0.367CysAsn: 0.367 ± 0.021
1.002CysPro: 1.002 ± 0.034
0.353CysGln: 0.353 ± 0.02
0.826CysArg: 0.826 ± 0.031
1.005CysSer: 1.005 ± 0.038
0.805CysThr: 0.805 ± 0.028
1.125CysVal: 1.125 ± 0.038
0.169CysTrp: 0.169 ± 0.015
0.343CysTyr: 0.343 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
5.025AspAla: 5.025 ± 0.086
0.728AspCys: 0.728 ± 0.031
2.58AspAsp: 2.58 ± 0.065
3.863AspGlu: 3.863 ± 0.08
2.583AspPhe: 2.583 ± 0.056
3.883AspGly: 3.883 ± 0.084
0.9AspHis: 0.9 ± 0.03
3.578AspIle: 3.578 ± 0.067
2.386AspLys: 2.386 ± 0.06
5.222AspLeu: 5.222 ± 0.085
1.677AspMet: 1.677 ± 0.041
1.448AspAsn: 1.448 ± 0.042
2.495AspPro: 2.495 ± 0.056
1.423AspGln: 1.423 ± 0.041
2.784AspArg: 2.784 ± 0.057
3.051AspSer: 3.051 ± 0.058
2.393AspThr: 2.393 ± 0.082
3.984AspVal: 3.984 ± 0.067
0.775AspTrp: 0.775 ± 0.03
1.606AspTyr: 1.606 ± 0.052
0.0AspXaa: 0.0 ± 0.0
Glu
5.99GluAla: 5.99 ± 0.088
0.775GluCys: 0.775 ± 0.031
3.573GluAsp: 3.573 ± 0.076
4.991GluGlu: 4.991 ± 0.081
2.526GluPhe: 2.526 ± 0.055
4.0GluGly: 4.0 ± 0.068
1.778GluHis: 1.778 ± 0.054
4.011GluIle: 4.011 ± 0.072
4.501GluLys: 4.501 ± 0.082
7.749GluLeu: 7.749 ± 0.108
1.919GluMet: 1.919 ± 0.045
2.72GluAsn: 2.72 ± 0.054
2.202GluPro: 2.202 ± 0.051
3.085GluGln: 3.085 ± 0.069
4.401GluArg: 4.401 ± 0.093
3.531GluSer: 3.531 ± 0.08
3.252GluThr: 3.252 ± 0.06
3.87GluVal: 3.87 ± 0.082
0.665GluTrp: 0.665 ± 0.033
1.762GluTyr: 1.762 ± 0.049
0.0GluXaa: 0.0 ± 0.0
Phe
3.815PheAla: 3.815 ± 0.074
0.811PheCys: 0.811 ± 0.027
2.426PheAsp: 2.426 ± 0.053
2.543PheGlu: 2.543 ± 0.063
2.333PhePhe: 2.333 ± 0.067
3.409PheGly: 3.409 ± 0.069
0.964PheHis: 0.964 ± 0.034
2.251PheIle: 2.251 ± 0.055
1.642PheLys: 1.642 ± 0.04
4.559PheLeu: 4.559 ± 0.101
1.229PheMet: 1.229 ± 0.04
1.246PheAsn: 1.246 ± 0.035
1.968PhePro: 1.968 ± 0.045
1.331PheGln: 1.331 ± 0.037
2.427PheArg: 2.427 ± 0.052
3.221PheSer: 3.221 ± 0.061
2.202PheThr: 2.202 ± 0.053
2.998PheVal: 2.998 ± 0.065
0.694PheTrp: 0.694 ± 0.03
1.313PheTyr: 1.313 ± 0.042
0.0PheXaa: 0.0 ± 0.0
Gly
6.475GlyAla: 6.475 ± 0.1
1.242GlyCys: 1.242 ± 0.038
3.488GlyAsp: 3.488 ± 0.077
4.707GlyGlu: 4.707 ± 0.08
3.34GlyPhe: 3.34 ± 0.072
5.694GlyGly: 5.694 ± 0.123
1.721GlyHis: 1.721 ± 0.049
4.88GlyIle: 4.88 ± 0.08
4.432GlyLys: 4.432 ± 0.069
8.035GlyLeu: 8.035 ± 0.101
2.452GlyMet: 2.452 ± 0.059
2.121GlyAsn: 2.121 ± 0.051
2.649GlyPro: 2.649 ± 0.053
2.68GlyGln: 2.68 ± 0.052
4.226GlyArg: 4.226 ± 0.086
4.175GlySer: 4.175 ± 0.079
4.197GlyThr: 4.197 ± 0.087
5.683GlyVal: 5.683 ± 0.095
1.0GlyTrp: 1.0 ± 0.034
2.257GlyTyr: 2.257 ± 0.048
0.0GlyXaa: 0.0 ± 0.0
His
1.926HisAla: 1.926 ± 0.052
0.437HisCys: 0.437 ± 0.023
1.203HisAsp: 1.203 ± 0.041
1.379HisGlu: 1.379 ± 0.046
1.117HisPhe: 1.117 ± 0.036
1.727HisGly: 1.727 ± 0.049
0.62HisHis: 0.62 ± 0.028
1.377HisIle: 1.377 ± 0.035
1.147HisLys: 1.147 ± 0.032
2.075HisLeu: 2.075 ± 0.049
0.612HisMet: 0.612 ± 0.028
0.721HisAsn: 0.721 ± 0.03
1.353HisPro: 1.353 ± 0.04
0.691HisGln: 0.691 ± 0.031
1.203HisArg: 1.203 ± 0.04
1.536HisSer: 1.536 ± 0.043
1.101HisThr: 1.101 ± 0.033
1.586HisVal: 1.586 ± 0.044
0.304HisTrp: 0.304 ± 0.017
0.651HisTyr: 0.651 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
5.158IleAla: 5.158 ± 0.091
0.82IleCys: 0.82 ± 0.027
2.878IleAsp: 2.878 ± 0.06
3.469IleGlu: 3.469 ± 0.071
2.459IlePhe: 2.459 ± 0.058
4.147IleGly: 4.147 ± 0.085
1.306IleHis: 1.306 ± 0.039
3.091IleIle: 3.091 ± 0.069
2.338IleLys: 2.338 ± 0.054
5.867IleLeu: 5.867 ± 0.093
1.426IleMet: 1.426 ± 0.042
1.676IleAsn: 1.676 ± 0.048
3.143IlePro: 3.143 ± 0.066
1.986IleGln: 1.986 ± 0.047
3.18IleArg: 3.18 ± 0.063
3.871IleSer: 3.871 ± 0.065
2.847IleThr: 2.847 ± 0.071
3.795IleVal: 3.795 ± 0.07
0.586IleTrp: 0.586 ± 0.024
1.369IleTyr: 1.369 ± 0.04
0.0IleXaa: 0.0 ± 0.0
Lys
4.81LysAla: 4.81 ± 0.087
0.489LysCys: 0.489 ± 0.025
3.069LysAsp: 3.069 ± 0.062
3.757LysGlu: 3.757 ± 0.077
1.624LysPhe: 1.624 ± 0.046
3.6LysGly: 3.6 ± 0.071
1.104LysHis: 1.104 ± 0.036
2.921LysIle: 2.921 ± 0.068
4.098LysLys: 4.098 ± 0.095
4.736LysLeu: 4.736 ± 0.078
1.467LysMet: 1.467 ± 0.038
2.27LysAsn: 2.27 ± 0.052
2.057LysPro: 2.057 ± 0.056
1.518LysGln: 1.518 ± 0.043
2.895LysArg: 2.895 ± 0.063
2.68LysSer: 2.68 ± 0.056
2.885LysThr: 2.885 ± 0.067
3.082LysVal: 3.082 ± 0.068
0.465LysTrp: 0.465 ± 0.02
1.361LysTyr: 1.361 ± 0.038
0.0LysXaa: 0.0 ± 0.0
Leu
10.187LeuAla: 10.187 ± 0.129
1.752LeuCys: 1.752 ± 0.042
5.854LeuAsp: 5.854 ± 0.096
6.958LeuGlu: 6.958 ± 0.1
4.632LeuPhe: 4.632 ± 0.083
8.524LeuGly: 8.524 ± 0.121
2.431LeuHis: 2.431 ± 0.061
4.802LeuIle: 4.802 ± 0.094
5.08LeuLys: 5.08 ± 0.085
10.4LeuLeu: 10.4 ± 0.149
2.552LeuMet: 2.552 ± 0.06
3.472LeuAsn: 3.472 ± 0.068
5.323LeuPro: 5.323 ± 0.086
3.34LeuGln: 3.34 ± 0.057
6.652LeuArg: 6.652 ± 0.093
7.85LeuSer: 7.85 ± 0.11
5.547LeuThr: 5.547 ± 0.103
7.154LeuVal: 7.154 ± 0.112
1.147LeuTrp: 1.147 ± 0.034
2.523LeuTyr: 2.523 ± 0.06
0.0LeuXaa: 0.0 ± 0.0
Met
2.531MetAla: 2.531 ± 0.061
0.339MetCys: 0.339 ± 0.022
1.566MetAsp: 1.566 ± 0.043
1.607MetGlu: 1.607 ± 0.044
0.909MetPhe: 0.909 ± 0.035
2.073MetGly: 2.073 ± 0.056
0.636MetHis: 0.636 ± 0.026
1.294MetIle: 1.294 ± 0.039
1.515MetLys: 1.515 ± 0.038
2.856MetLeu: 2.856 ± 0.058
0.676MetMet: 0.676 ± 0.028
1.14MetAsn: 1.14 ± 0.034
1.313MetPro: 1.313 ± 0.043
1.165MetGln: 1.165 ± 0.03
1.652MetArg: 1.652 ± 0.045
1.974MetSer: 1.974 ± 0.047
1.587MetThr: 1.587 ± 0.041
1.619MetVal: 1.619 ± 0.045
0.25MetTrp: 0.25 ± 0.015
0.6MetTyr: 0.6 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
3.052AsnAla: 3.052 ± 0.065
0.494AsnCys: 0.494 ± 0.024
1.431AsnAsp: 1.431 ± 0.041
1.761AsnGlu: 1.761 ± 0.049
1.465AsnPhe: 1.465 ± 0.045
2.378AsnGly: 2.378 ± 0.054
0.554AsnHis: 0.554 ± 0.023
2.138AsnIle: 2.138 ± 0.051
1.374AsnLys: 1.374 ± 0.043
3.079AsnLeu: 3.079 ± 0.062
0.951AsnMet: 0.951 ± 0.029
0.855AsnAsn: 0.855 ± 0.031
1.967AsnPro: 1.967 ± 0.054
0.915AsnGln: 0.915 ± 0.032
1.712AsnArg: 1.712 ± 0.042
1.975AsnSer: 1.975 ± 0.048
1.696AsnThr: 1.696 ± 0.045
2.321AsnVal: 2.321 ± 0.056
0.418AsnTrp: 0.418 ± 0.02
0.876AsnTyr: 0.876 ± 0.037
0.0AsnXaa: 0.0 ± 0.0
Pro
4.06ProAla: 4.06 ± 0.091
0.648ProCys: 0.648 ± 0.029
2.751ProAsp: 2.751 ± 0.061
4.475ProGlu: 4.475 ± 0.073
2.067ProPhe: 2.067 ± 0.049
3.514ProGly: 3.514 ± 0.073
1.119ProHis: 1.119 ± 0.036
2.003ProIle: 2.003 ± 0.047
2.292ProLys: 2.292 ± 0.059
4.681ProLeu: 4.681 ± 0.087
1.009ProMet: 1.009 ± 0.033
1.34ProAsn: 1.34 ± 0.044
1.604ProPro: 1.604 ± 0.06
2.001ProGln: 2.001 ± 0.057
2.328ProArg: 2.328 ± 0.057
2.733ProSer: 2.733 ± 0.065
1.929ProThr: 1.929 ± 0.053
3.734ProVal: 3.734 ± 0.068
0.597ProTrp: 0.597 ± 0.025
1.262ProTyr: 1.262 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
3.536GlnAla: 3.536 ± 0.063
0.457GlnCys: 0.457 ± 0.023
2.069GlnAsp: 2.069 ± 0.052
2.595GlnGlu: 2.595 ± 0.054
1.218GlnPhe: 1.218 ± 0.035
2.644GlnGly: 2.644 ± 0.058
0.96GlnHis: 0.96 ± 0.036
1.971GlnIle: 1.971 ± 0.048
2.38GlnLys: 2.38 ± 0.054
3.7GlnLeu: 3.7 ± 0.066
0.811GlnMet: 0.811 ± 0.028
1.399GlnAsn: 1.399 ± 0.041
1.393GlnPro: 1.393 ± 0.042
1.552GlnGln: 1.552 ± 0.049
2.237GlnArg: 2.237 ± 0.052
2.115GlnSer: 2.115 ± 0.059
1.804GlnThr: 1.804 ± 0.045
2.266GlnVal: 2.266 ± 0.054
0.405GlnTrp: 0.405 ± 0.02
1.006GlnTyr: 1.006 ± 0.032
0.0GlnXaa: 0.0 ± 0.0
Arg
4.632ArgAla: 4.632 ± 0.074
0.729ArgCys: 0.729 ± 0.029
3.086ArgAsp: 3.086 ± 0.055
4.405ArgGlu: 4.405 ± 0.074
2.663ArgPhe: 2.663 ± 0.055
3.6ArgGly: 3.6 ± 0.071
1.351ArgHis: 1.351 ± 0.038
3.673ArgIle: 3.673 ± 0.066
3.335ArgLys: 3.335 ± 0.072
6.149ArgLeu: 6.149 ± 0.085
1.684ArgMet: 1.684 ± 0.045
1.889ArgAsn: 1.889 ± 0.049
2.402ArgPro: 2.402 ± 0.062
2.296ArgGln: 2.296 ± 0.052
3.767ArgArg: 3.767 ± 0.087
3.341ArgSer: 3.341 ± 0.065
2.715ArgThr: 2.715 ± 0.057
4.046ArgVal: 4.046 ± 0.061
0.671ArgTrp: 0.671 ± 0.029
1.661ArgTyr: 1.661 ± 0.044
0.0ArgXaa: 0.0 ± 0.0
Ser
5.367SerAla: 5.367 ± 0.096
0.991SerCys: 0.991 ± 0.038
2.722SerAsp: 2.722 ± 0.057
3.749SerGlu: 3.749 ± 0.073
3.074SerPhe: 3.074 ± 0.06
5.316SerGly: 5.316 ± 0.093
1.404SerHis: 1.404 ± 0.04
3.604SerIle: 3.604 ± 0.059
2.643SerLys: 2.643 ± 0.061
6.871SerLeu: 6.871 ± 0.109
1.755SerMet: 1.755 ± 0.048
1.537SerAsn: 1.537 ± 0.051
3.05SerPro: 3.05 ± 0.062
2.25SerGln: 2.25 ± 0.052
3.744SerArg: 3.744 ± 0.077
4.309SerSer: 4.309 ± 0.089
3.213SerThr: 3.213 ± 0.064
4.316SerVal: 4.316 ± 0.07
0.828SerTrp: 0.828 ± 0.035
1.648SerTyr: 1.648 ± 0.045
0.0SerXaa: 0.0 ± 0.0
Thr
4.639ThrAla: 4.639 ± 0.108
0.672ThrCys: 0.672 ± 0.028
2.538ThrAsp: 2.538 ± 0.079
3.117ThrGlu: 3.117 ± 0.064
1.965ThrPhe: 1.965 ± 0.043
4.58ThrGly: 4.58 ± 0.071
1.168ThrHis: 1.168 ± 0.041
2.596ThrIle: 2.596 ± 0.064
1.936ThrLys: 1.936 ± 0.05
6.027ThrLeu: 6.027 ± 0.085
1.192ThrMet: 1.192 ± 0.033
1.369ThrAsn: 1.369 ± 0.04
3.157ThrPro: 3.157 ± 0.077
1.879ThrGln: 1.879 ± 0.053
2.663ThrArg: 2.663 ± 0.055
2.766ThrSer: 2.766 ± 0.058
2.423ThrThr: 2.423 ± 0.056
3.936ThrVal: 3.936 ± 0.072
0.521ThrTrp: 0.521 ± 0.024
1.269ThrTyr: 1.269 ± 0.04
0.0ThrXaa: 0.0 ± 0.0
Val
6.004ValAla: 6.004 ± 0.093
1.151ValCys: 1.151 ± 0.04
3.77ValAsp: 3.77 ± 0.08
4.505ValGlu: 4.505 ± 0.076
3.118ValPhe: 3.118 ± 0.063
4.644ValGly: 4.644 ± 0.082
1.546ValHis: 1.546 ± 0.042
3.689ValIle: 3.689 ± 0.07
2.961ValLys: 2.961 ± 0.059
8.103ValLeu: 8.103 ± 0.118
1.86ValMet: 1.86 ± 0.046
2.289ValAsn: 2.289 ± 0.055
3.355ValPro: 3.355 ± 0.068
2.727ValGln: 2.727 ± 0.051
4.058ValArg: 4.058 ± 0.073
4.492ValSer: 4.492 ± 0.069
3.699ValThr: 3.699 ± 0.072
4.966ValVal: 4.966 ± 0.095
0.803ValTrp: 0.803 ± 0.029
1.754ValTyr: 1.754 ± 0.044
0.0ValXaa: 0.0 ± 0.0
Trp
0.976TrpAla: 0.976 ± 0.036
0.155TrpCys: 0.155 ± 0.013
0.659TrpAsp: 0.659 ± 0.026
0.729TrpGlu: 0.729 ± 0.031
0.505TrpPhe: 0.505 ± 0.027
0.897TrpGly: 0.897 ± 0.033
0.258TrpHis: 0.258 ± 0.017
0.65TrpIle: 0.65 ± 0.027
0.741TrpLys: 0.741 ± 0.026
1.282TrpLeu: 1.282 ± 0.042
0.355TrpMet: 0.355 ± 0.02
0.496TrpAsn: 0.496 ± 0.024
0.568TrpPro: 0.568 ± 0.025
0.504TrpGln: 0.504 ± 0.025
0.702TrpArg: 0.702 ± 0.027
0.654TrpSer: 0.654 ± 0.029
0.605TrpThr: 0.605 ± 0.026
0.713TrpVal: 0.713 ± 0.029
0.207TrpTrp: 0.207 ± 0.015
0.283TrpTyr: 0.283 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.406TyrAla: 2.406 ± 0.059
0.437TyrCys: 0.437 ± 0.019
1.541TyrAsp: 1.541 ± 0.043
1.603TyrGlu: 1.603 ± 0.042
1.285TyrPhe: 1.285 ± 0.044
2.211TyrGly: 2.211 ± 0.052
0.544TyrHis: 0.544 ± 0.024
1.344TyrIle: 1.344 ± 0.042
1.103TyrLys: 1.103 ± 0.037
2.731TyrLeu: 2.731 ± 0.056
0.626TyrMet: 0.626 ± 0.029
0.774TyrAsn: 0.774 ± 0.031
1.222TyrPro: 1.222 ± 0.037
0.828TyrGln: 0.828 ± 0.03
1.616TyrArg: 1.616 ± 0.045
1.916TyrSer: 1.916 ± 0.045
1.509TyrThr: 1.509 ± 0.042
1.782TyrVal: 1.782 ± 0.042
0.405TyrTrp: 0.405 ± 0.022
0.818TyrTyr: 0.818 ± 0.034
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2903 proteins (952713 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski