Amino acid dipepetide frequency for Gordonia phage Fosterous

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.881AlaAla: 16.881 ± 1.136
0.849AlaCys: 0.849 ± 0.245
7.803AlaAsp: 7.803 ± 0.827
9.29AlaGlu: 9.29 ± 1.061
2.76AlaPhe: 2.76 ± 0.591
10.882AlaGly: 10.882 ± 1.004
1.911AlaHis: 1.911 ± 0.354
6.105AlaIle: 6.105 ± 1.045
3.769AlaLys: 3.769 ± 0.579
8.918AlaLeu: 8.918 ± 0.956
2.813AlaMet: 2.813 ± 0.368
2.654AlaAsn: 2.654 ± 0.405
6.689AlaPro: 6.689 ± 0.759
4.3AlaGln: 4.3 ± 0.376
8.653AlaArg: 8.653 ± 0.789
5.308AlaSer: 5.308 ± 0.598
7.432AlaThr: 7.432 ± 0.688
8.016AlaVal: 8.016 ± 0.658
2.813AlaTrp: 2.813 ± 0.428
2.176AlaTyr: 2.176 ± 0.357
0.0AlaXaa: 0.0 ± 0.0
Cys
1.115CysAla: 1.115 ± 0.274
0.053CysCys: 0.053 ± 0.043
0.849CysAsp: 0.849 ± 0.253
0.319CysGlu: 0.319 ± 0.116
0.159CysPhe: 0.159 ± 0.09
1.168CysGly: 1.168 ± 0.306
0.531CysHis: 0.531 ± 0.198
0.053CysIle: 0.053 ± 0.067
0.212CysLys: 0.212 ± 0.121
0.212CysLeu: 0.212 ± 0.096
0.159CysMet: 0.159 ± 0.082
0.159CysAsn: 0.159 ± 0.089
1.168CysPro: 1.168 ± 0.336
0.212CysGln: 0.212 ± 0.145
0.637CysArg: 0.637 ± 0.195
0.478CysSer: 0.478 ± 0.164
0.584CysThr: 0.584 ± 0.251
0.743CysVal: 0.743 ± 0.227
0.159CysTrp: 0.159 ± 0.099
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
8.387AspAla: 8.387 ± 0.733
0.425AspCys: 0.425 ± 0.167
7.856AspAsp: 7.856 ± 1.014
6.37AspGlu: 6.37 ± 0.698
1.168AspPhe: 1.168 ± 0.355
6.848AspGly: 6.848 ± 0.803
1.274AspHis: 1.274 ± 0.314
1.964AspIle: 1.964 ± 0.353
1.486AspLys: 1.486 ± 0.308
4.671AspLeu: 4.671 ± 0.521
1.486AspMet: 1.486 ± 0.284
1.911AspAsn: 1.911 ± 0.354
7.485AspPro: 7.485 ± 0.885
2.548AspGln: 2.548 ± 0.519
5.362AspArg: 5.362 ± 0.579
2.336AspSer: 2.336 ± 0.294
3.769AspThr: 3.769 ± 0.524
6.476AspVal: 6.476 ± 0.678
1.433AspTrp: 1.433 ± 0.29
1.699AspTyr: 1.699 ± 0.312
0.0AspXaa: 0.0 ± 0.0
Glu
5.733GluAla: 5.733 ± 0.58
0.584GluCys: 0.584 ± 0.173
3.185GluAsp: 3.185 ± 0.511
1.433GluGlu: 1.433 ± 0.261
1.911GluPhe: 1.911 ± 0.388
4.141GluGly: 4.141 ± 0.492
2.495GluHis: 2.495 ± 0.418
2.176GluIle: 2.176 ± 0.307
1.221GluLys: 1.221 ± 0.322
5.308GluLeu: 5.308 ± 0.734
1.009GluMet: 1.009 ± 0.251
1.752GluAsn: 1.752 ± 0.282
3.132GluPro: 3.132 ± 0.507
3.981GluGln: 3.981 ± 0.546
4.247GluArg: 4.247 ± 0.652
2.867GluSer: 2.867 ± 0.486
2.867GluThr: 2.867 ± 0.487
5.415GluVal: 5.415 ± 0.788
1.539GluTrp: 1.539 ± 0.33
1.646GluTyr: 1.646 ± 0.29
0.0GluXaa: 0.0 ± 0.0
Phe
3.132PheAla: 3.132 ± 0.409
0.319PheCys: 0.319 ± 0.135
2.601PheAsp: 2.601 ± 0.386
1.486PheGlu: 1.486 ± 0.345
0.584PhePhe: 0.584 ± 0.22
2.76PheGly: 2.76 ± 0.441
0.584PheHis: 0.584 ± 0.146
1.433PheIle: 1.433 ± 0.312
0.69PheLys: 0.69 ± 0.175
1.38PheLeu: 1.38 ± 0.285
0.743PheMet: 0.743 ± 0.182
0.796PheAsn: 0.796 ± 0.234
0.849PhePro: 0.849 ± 0.191
0.637PheGln: 0.637 ± 0.194
0.849PheArg: 0.849 ± 0.207
1.115PheSer: 1.115 ± 0.285
1.858PheThr: 1.858 ± 0.306
2.176PheVal: 2.176 ± 0.319
0.319PheTrp: 0.319 ± 0.14
0.265PheTyr: 0.265 ± 0.126
0.0PheXaa: 0.0 ± 0.0
Gly
8.547GlyAla: 8.547 ± 1.005
1.062GlyCys: 1.062 ± 0.298
6.582GlyAsp: 6.582 ± 0.709
4.512GlyGlu: 4.512 ± 0.531
1.964GlyPhe: 1.964 ± 0.393
8.016GlyGly: 8.016 ± 1.032
2.23GlyHis: 2.23 ± 0.315
4.034GlyIle: 4.034 ± 0.474
2.867GlyLys: 2.867 ± 0.428
5.945GlyLeu: 5.945 ± 0.869
2.176GlyMet: 2.176 ± 0.283
2.601GlyAsn: 2.601 ± 0.423
3.928GlyPro: 3.928 ± 0.505
3.185GlyGln: 3.185 ± 0.513
6.423GlyArg: 6.423 ± 0.579
4.884GlySer: 4.884 ± 0.537
5.786GlyThr: 5.786 ± 0.806
7.803GlyVal: 7.803 ± 0.562
1.486GlyTrp: 1.486 ± 0.323
2.23GlyTyr: 2.23 ± 0.428
0.0GlyXaa: 0.0 ± 0.0
His
2.389HisAla: 2.389 ± 0.401
0.265HisCys: 0.265 ± 0.121
2.283HisAsp: 2.283 ± 0.454
1.433HisGlu: 1.433 ± 0.305
0.425HisPhe: 0.425 ± 0.149
1.593HisGly: 1.593 ± 0.248
0.212HisHis: 0.212 ± 0.099
0.849HisIle: 0.849 ± 0.233
0.212HisLys: 0.212 ± 0.107
2.07HisLeu: 2.07 ± 0.373
0.584HisMet: 0.584 ± 0.206
0.372HisAsn: 0.372 ± 0.161
1.327HisPro: 1.327 ± 0.259
1.009HisGln: 1.009 ± 0.17
1.964HisArg: 1.964 ± 0.367
0.956HisSer: 0.956 ± 0.256
1.433HisThr: 1.433 ± 0.194
1.964HisVal: 1.964 ± 0.335
0.319HisTrp: 0.319 ± 0.133
0.372HisTyr: 0.372 ± 0.142
0.0HisXaa: 0.0 ± 0.0
Ile
5.945IleAla: 5.945 ± 0.513
0.212IleCys: 0.212 ± 0.126
4.353IleAsp: 4.353 ± 0.426
3.769IleGlu: 3.769 ± 0.365
0.584IlePhe: 0.584 ± 0.204
5.255IleGly: 5.255 ± 1.006
0.902IleHis: 0.902 ± 0.204
2.176IleIle: 2.176 ± 0.509
0.849IleLys: 0.849 ± 0.359
2.017IleLeu: 2.017 ± 0.337
0.637IleMet: 0.637 ± 0.175
0.849IleAsn: 0.849 ± 0.217
2.76IlePro: 2.76 ± 0.348
1.486IleGln: 1.486 ± 0.368
2.973IleArg: 2.973 ± 0.425
1.699IleSer: 1.699 ± 0.336
3.663IleThr: 3.663 ± 0.537
3.61IleVal: 3.61 ± 0.381
0.637IleTrp: 0.637 ± 0.203
0.849IleTyr: 0.849 ± 0.203
0.0IleXaa: 0.0 ± 0.0
Lys
2.92LysAla: 2.92 ± 0.481
0.319LysCys: 0.319 ± 0.141
0.956LysAsp: 0.956 ± 0.25
0.743LysGlu: 0.743 ± 0.161
1.062LysPhe: 1.062 ± 0.273
1.593LysGly: 1.593 ± 0.327
0.425LysHis: 0.425 ± 0.149
1.221LysIle: 1.221 ± 0.243
0.478LysLys: 0.478 ± 0.177
2.283LysLeu: 2.283 ± 0.355
0.319LysMet: 0.319 ± 0.125
0.637LysAsn: 0.637 ± 0.248
1.646LysPro: 1.646 ± 0.369
0.849LysGln: 0.849 ± 0.187
2.23LysArg: 2.23 ± 0.362
1.911LysSer: 1.911 ± 0.39
1.911LysThr: 1.911 ± 0.328
2.389LysVal: 2.389 ± 0.361
0.265LysTrp: 0.265 ± 0.101
0.902LysTyr: 0.902 ± 0.226
0.0LysXaa: 0.0 ± 0.0
Leu
8.918LeuAla: 8.918 ± 0.834
0.478LeuCys: 0.478 ± 0.146
5.362LeuAsp: 5.362 ± 0.577
2.389LeuGlu: 2.389 ± 0.352
1.911LeuPhe: 1.911 ± 0.384
6.848LeuGly: 6.848 ± 1.137
1.911LeuHis: 1.911 ± 0.344
2.867LeuIle: 2.867 ± 0.409
0.956LeuLys: 0.956 ± 0.24
5.468LeuLeu: 5.468 ± 0.621
1.539LeuMet: 1.539 ± 0.235
2.389LeuAsn: 2.389 ± 0.285
4.778LeuPro: 4.778 ± 0.399
3.079LeuGln: 3.079 ± 0.39
6.848LeuArg: 6.848 ± 0.595
3.504LeuSer: 3.504 ± 0.372
5.521LeuThr: 5.521 ± 0.485
5.68LeuVal: 5.68 ± 0.638
1.964LeuTrp: 1.964 ± 0.36
1.274LeuTyr: 1.274 ± 0.271
0.0LeuXaa: 0.0 ± 0.0
Met
2.017MetAla: 2.017 ± 0.327
0.212MetCys: 0.212 ± 0.1
1.062MetAsp: 1.062 ± 0.214
0.743MetGlu: 0.743 ± 0.239
0.637MetPhe: 0.637 ± 0.225
1.221MetGly: 1.221 ± 0.261
0.265MetHis: 0.265 ± 0.128
0.902MetIle: 0.902 ± 0.199
0.743MetLys: 0.743 ± 0.223
1.964MetLeu: 1.964 ± 0.375
0.212MetMet: 0.212 ± 0.101
0.531MetAsn: 0.531 ± 0.16
1.805MetPro: 1.805 ± 0.299
0.956MetGln: 0.956 ± 0.337
1.752MetArg: 1.752 ± 0.305
1.539MetSer: 1.539 ± 0.293
3.663MetThr: 3.663 ± 0.491
1.327MetVal: 1.327 ± 0.276
0.425MetTrp: 0.425 ± 0.128
0.212MetTyr: 0.212 ± 0.118
0.0MetXaa: 0.0 ± 0.0
Asn
3.504AsnAla: 3.504 ± 0.509
0.265AsnCys: 0.265 ± 0.13
2.123AsnAsp: 2.123 ± 0.334
1.593AsnGlu: 1.593 ± 0.313
0.584AsnPhe: 0.584 ± 0.155
2.654AsnGly: 2.654 ± 0.314
0.425AsnHis: 0.425 ± 0.137
0.69AsnIle: 0.69 ± 0.173
0.478AsnLys: 0.478 ± 0.2
1.964AsnLeu: 1.964 ± 0.413
0.69AsnMet: 0.69 ± 0.181
0.69AsnAsn: 0.69 ± 0.162
2.283AsnPro: 2.283 ± 0.367
0.902AsnGln: 0.902 ± 0.246
1.911AsnArg: 1.911 ± 0.324
0.849AsnSer: 0.849 ± 0.283
1.593AsnThr: 1.593 ± 0.311
1.539AsnVal: 1.539 ± 0.257
0.796AsnTrp: 0.796 ± 0.226
0.531AsnTyr: 0.531 ± 0.163
0.0AsnXaa: 0.0 ± 0.0
Pro
8.918ProAla: 8.918 ± 0.801
0.159ProCys: 0.159 ± 0.112
5.68ProAsp: 5.68 ± 0.669
3.397ProGlu: 3.397 ± 0.467
1.805ProPhe: 1.805 ± 0.335
4.459ProGly: 4.459 ± 0.427
1.221ProHis: 1.221 ± 0.24
3.504ProIle: 3.504 ± 0.415
1.433ProLys: 1.433 ± 0.302
4.194ProLeu: 4.194 ± 0.434
1.699ProMet: 1.699 ± 0.329
1.964ProAsn: 1.964 ± 0.354
4.247ProPro: 4.247 ± 0.738
2.336ProGln: 2.336 ± 0.387
3.45ProArg: 3.45 ± 0.474
3.026ProSer: 3.026 ± 0.36
4.141ProThr: 4.141 ± 0.597
4.99ProVal: 4.99 ± 0.61
1.062ProTrp: 1.062 ± 0.256
1.115ProTyr: 1.115 ± 0.197
0.0ProXaa: 0.0 ± 0.0
Gln
4.937GlnAla: 4.937 ± 0.526
0.265GlnCys: 0.265 ± 0.112
1.274GlnAsp: 1.274 ± 0.279
0.902GlnGlu: 0.902 ± 0.239
1.38GlnPhe: 1.38 ± 0.234
2.07GlnGly: 2.07 ± 0.331
0.902GlnHis: 0.902 ± 0.2
2.176GlnIle: 2.176 ± 0.429
1.009GlnLys: 1.009 ± 0.196
3.079GlnLeu: 3.079 ± 0.403
1.168GlnMet: 1.168 ± 0.276
0.637GlnAsn: 0.637 ± 0.176
2.654GlnPro: 2.654 ± 0.377
2.389GlnGln: 2.389 ± 0.39
4.512GlnArg: 4.512 ± 0.585
1.699GlnSer: 1.699 ± 0.256
2.176GlnThr: 2.176 ± 0.312
2.76GlnVal: 2.76 ± 0.397
0.956GlnTrp: 0.956 ± 0.227
0.902GlnTyr: 0.902 ± 0.209
0.0GlnXaa: 0.0 ± 0.0
Arg
9.024ArgAla: 9.024 ± 0.864
0.69ArgCys: 0.69 ± 0.23
4.512ArgAsp: 4.512 ± 0.505
3.981ArgGlu: 3.981 ± 0.53
1.858ArgPhe: 1.858 ± 0.383
5.043ArgGly: 5.043 ± 0.61
1.752ArgHis: 1.752 ± 0.405
4.034ArgIle: 4.034 ± 0.564
2.176ArgLys: 2.176 ± 0.362
5.255ArgLeu: 5.255 ± 0.613
2.176ArgMet: 2.176 ± 0.26
2.389ArgAsn: 2.389 ± 0.358
4.194ArgPro: 4.194 ± 0.561
2.548ArgGln: 2.548 ± 0.396
8.6ArgArg: 8.6 ± 1.003
3.663ArgSer: 3.663 ± 0.471
4.778ArgThr: 4.778 ± 0.585
5.839ArgVal: 5.839 ± 0.862
1.911ArgTrp: 1.911 ± 0.317
2.017ArgTyr: 2.017 ± 0.336
0.0ArgXaa: 0.0 ± 0.0
Ser
5.468SerAla: 5.468 ± 0.637
0.425SerCys: 0.425 ± 0.18
3.291SerAsp: 3.291 ± 0.407
2.601SerGlu: 2.601 ± 0.445
0.956SerPhe: 0.956 ± 0.254
5.574SerGly: 5.574 ± 0.763
0.956SerHis: 0.956 ± 0.211
2.283SerIle: 2.283 ± 0.471
1.168SerLys: 1.168 ± 0.219
3.291SerLeu: 3.291 ± 0.427
0.849SerMet: 0.849 ± 0.239
0.956SerAsn: 0.956 ± 0.248
2.495SerPro: 2.495 ± 0.369
1.221SerGln: 1.221 ± 0.303
3.291SerArg: 3.291 ± 0.516
2.601SerSer: 2.601 ± 0.418
4.406SerThr: 4.406 ± 0.592
3.61SerVal: 3.61 ± 0.368
1.062SerTrp: 1.062 ± 0.231
1.115SerTyr: 1.115 ± 0.258
0.0SerXaa: 0.0 ± 0.0
Thr
8.653ThrAla: 8.653 ± 0.796
1.168ThrCys: 1.168 ± 0.314
5.308ThrAsp: 5.308 ± 0.629
3.185ThrGlu: 3.185 ± 0.587
1.486ThrPhe: 1.486 ± 0.25
5.839ThrGly: 5.839 ± 0.759
1.539ThrHis: 1.539 ± 0.301
3.132ThrIle: 3.132 ± 0.503
2.07ThrLys: 2.07 ± 0.326
5.308ThrLeu: 5.308 ± 0.452
1.539ThrMet: 1.539 ± 0.264
1.805ThrAsn: 1.805 ± 0.254
5.096ThrPro: 5.096 ± 0.539
1.593ThrGln: 1.593 ± 0.275
4.247ThrArg: 4.247 ± 0.546
3.663ThrSer: 3.663 ± 0.421
4.884ThrThr: 4.884 ± 0.682
4.778ThrVal: 4.778 ± 0.599
1.221ThrTrp: 1.221 ± 0.269
1.486ThrTyr: 1.486 ± 0.274
0.0ThrXaa: 0.0 ± 0.0
Val
8.44ValAla: 8.44 ± 0.875
0.743ValCys: 0.743 ± 0.227
7.007ValAsp: 7.007 ± 0.725
5.415ValGlu: 5.415 ± 0.589
1.858ValPhe: 1.858 ± 0.279
6.795ValGly: 6.795 ± 0.655
1.646ValHis: 1.646 ± 0.257
3.769ValIle: 3.769 ± 0.383
1.964ValLys: 1.964 ± 0.336
6.264ValLeu: 6.264 ± 0.614
1.168ValMet: 1.168 ± 0.234
2.23ValAsn: 2.23 ± 0.345
3.981ValPro: 3.981 ± 0.497
2.92ValGln: 2.92 ± 0.331
5.043ValArg: 5.043 ± 0.626
3.557ValSer: 3.557 ± 0.459
5.362ValThr: 5.362 ± 0.595
5.574ValVal: 5.574 ± 0.563
2.283ValTrp: 2.283 ± 0.3
2.176ValTyr: 2.176 ± 0.417
0.0ValXaa: 0.0 ± 0.0
Trp
2.389TrpAla: 2.389 ± 0.401
0.265TrpCys: 0.265 ± 0.121
1.062TrpAsp: 1.062 ± 0.25
1.009TrpGlu: 1.009 ± 0.244
0.849TrpPhe: 0.849 ± 0.221
1.274TrpGly: 1.274 ± 0.289
0.372TrpHis: 0.372 ± 0.137
1.168TrpIle: 1.168 ± 0.361
0.69TrpLys: 0.69 ± 0.212
2.283TrpLeu: 2.283 ± 0.414
0.796TrpMet: 0.796 ± 0.22
0.531TrpAsn: 0.531 ± 0.209
1.274TrpPro: 1.274 ± 0.241
1.115TrpGln: 1.115 ± 0.236
1.699TrpArg: 1.699 ± 0.304
1.062TrpSer: 1.062 ± 0.23
0.849TrpThr: 0.849 ± 0.235
1.805TrpVal: 1.805 ± 0.267
0.372TrpTrp: 0.372 ± 0.175
0.584TrpTyr: 0.584 ± 0.185
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.707TyrAla: 2.707 ± 0.464
0.212TyrCys: 0.212 ± 0.112
1.805TyrAsp: 1.805 ± 0.352
2.07TyrGlu: 2.07 ± 0.386
0.637TyrPhe: 0.637 ± 0.169
2.23TyrGly: 2.23 ± 0.385
0.478TyrHis: 0.478 ± 0.162
0.69TyrIle: 0.69 ± 0.177
0.584TyrLys: 0.584 ± 0.205
1.805TyrLeu: 1.805 ± 0.362
0.372TyrMet: 0.372 ± 0.143
0.212TyrAsn: 0.212 ± 0.107
1.009TyrPro: 1.009 ± 0.253
0.637TyrGln: 0.637 ± 0.224
1.752TyrArg: 1.752 ± 0.401
0.902TyrSer: 0.902 ± 0.187
1.327TyrThr: 1.327 ± 0.305
1.699TyrVal: 1.699 ± 0.354
0.425TyrTrp: 0.425 ± 0.15
0.425TyrTyr: 0.425 ± 0.131
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 87 proteins (18839 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski