Amino acid dipepetide frequency for Kuenenia stuttgartiensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.921AlaAla: 4.921 ± 0.089	0.986AlaCys: 0.986 ± 0.035	3.347AlaAsp: 3.347 ± 0.058	4.569AlaGlu: 4.569 ± 0.074	3.076AlaPhe: 3.076 ± 0.061	5.069AlaGly: 5.069 ± 0.086	1.354AlaHis: 1.354 ± 0.04	6.071AlaIle: 6.071 ± 0.087	4.69AlaLys: 4.69 ± 0.075	6.817AlaLeu: 6.817 ± 0.086	1.785AlaMet: 1.785 ± 0.047	2.7AlaAsn: 2.7 ± 0.054	1.938AlaPro: 1.938 ± 0.037	2.009AlaGln: 2.009 ± 0.046	3.001AlaArg: 3.001 ± 0.057	3.976AlaSer: 3.976 ± 0.068	3.291AlaThr: 3.291 ± 0.09	4.839AlaVal: 4.839 ± 0.077	0.704AlaTrp: 0.704 ± 0.031	2.425AlaTyr: 2.425 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.891CysAla: 0.891 ± 0.031	0.244CysCys: 0.244 ± 0.016	0.645CysAsp: 0.645 ± 0.027	0.791CysGlu: 0.791 ± 0.026	0.719CysPhe: 0.719 ± 0.029	1.158CysGly: 1.158 ± 0.04	0.555CysHis: 0.555 ± 0.034	1.08CysIle: 1.08 ± 0.035	0.865CysLys: 0.865 ± 0.028	1.293CysLeu: 1.293 ± 0.037	0.329CysMet: 0.329 ± 0.018	0.667CysAsn: 0.667 ± 0.026	0.692CysPro: 0.692 ± 0.032	0.355CysGln: 0.355 ± 0.018	0.686CysArg: 0.686 ± 0.025	0.823CysSer: 0.823 ± 0.028	0.65CysThr: 0.65 ± 0.028	0.806CysVal: 0.806 ± 0.026	0.143CysTrp: 0.143 ± 0.011	0.56CysTyr: 0.56 ± 0.025	0.0CysXaa: 0.0 ± 0.0
Asp	3.853AspAla: 3.853 ± 0.065	0.645AspCys: 0.645 ± 0.025	2.533AspAsp: 2.533 ± 0.055	3.73AspGlu: 3.73 ± 0.062	2.576AspPhe: 2.576 ± 0.053	3.38AspGly: 3.38 ± 0.08	0.833AspHis: 0.833 ± 0.026	4.957AspIle: 4.957 ± 0.075	3.551AspLys: 3.551 ± 0.061	4.313AspLeu: 4.313 ± 0.057	1.284AspMet: 1.284 ± 0.038	2.269AspAsn: 2.269 ± 0.046	1.87AspPro: 1.87 ± 0.041	1.101AspGln: 1.101 ± 0.03	2.287AspArg: 2.287 ± 0.044	2.737AspSer: 2.737 ± 0.058	2.913AspThr: 2.913 ± 0.07	3.544AspVal: 3.544 ± 0.06	0.696AspTrp: 0.696 ± 0.028	2.007AspTyr: 2.007 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	4.63GluAla: 4.63 ± 0.078	0.781GluCys: 0.781 ± 0.025	3.45GluAsp: 3.45 ± 0.064	5.601GluGlu: 5.601 ± 0.088	2.52GluPhe: 2.52 ± 0.054	4.361GluGly: 4.361 ± 0.069	1.375GluHis: 1.375 ± 0.032	6.36GluIle: 6.36 ± 0.088	6.889GluLys: 6.889 ± 0.1	5.917GluLeu: 5.917 ± 0.084	1.928GluMet: 1.928 ± 0.041	3.618GluAsn: 3.618 ± 0.057	1.794GluPro: 1.794 ± 0.042	2.136GluGln: 2.136 ± 0.048	3.683GluArg: 3.683 ± 0.063	3.595GluSer: 3.595 ± 0.071	3.682GluThr: 3.682 ± 0.065	4.295GluVal: 4.295 ± 0.078	0.758GluTrp: 0.758 ± 0.032	2.537GluTyr: 2.537 ± 0.056	0.0GluXaa: 0.0 ± 0.0
Phe	2.963PheAla: 2.963 ± 0.06	0.77PheCys: 0.77 ± 0.028	2.545PheAsp: 2.545 ± 0.048	2.701PheGlu: 2.701 ± 0.055	2.552PhePhe: 2.552 ± 0.064	3.022PheGly: 3.022 ± 0.059	0.978PheHis: 0.978 ± 0.028	3.544PheIle: 3.544 ± 0.071	2.65PheLys: 2.65 ± 0.055	4.64PheLeu: 4.64 ± 0.092	1.073PheMet: 1.073 ± 0.034	1.943PheAsn: 1.943 ± 0.049	1.826PhePro: 1.826 ± 0.046	1.296PheGln: 1.296 ± 0.033	2.131PheArg: 2.131 ± 0.048	3.313PheSer: 3.313 ± 0.061	2.41PheThr: 2.41 ± 0.064	2.971PheVal: 2.971 ± 0.065	0.494PheTrp: 0.494 ± 0.021	1.755PheTyr: 1.755 ± 0.048	0.0PheXaa: 0.0 ± 0.0
Gly	4.369GlyAla: 4.369 ± 0.086	1.065GlyCys: 1.065 ± 0.037	3.182GlyAsp: 3.182 ± 0.063	4.25GlyGlu: 4.25 ± 0.072	3.274GlyPhe: 3.274 ± 0.054	4.638GlyGly: 4.638 ± 0.106	1.375GlyHis: 1.375 ± 0.036	6.293GlyIle: 6.293 ± 0.086	5.674GlyLys: 5.674 ± 0.074	5.748GlyLeu: 5.748 ± 0.075	2.043GlyMet: 2.043 ± 0.049	3.308GlyAsn: 3.308 ± 0.088	1.43GlyPro: 1.43 ± 0.035	1.762GlyGln: 1.762 ± 0.045	3.246GlyArg: 3.246 ± 0.068	4.038GlySer: 4.038 ± 0.098	3.782GlyThr: 3.782 ± 0.118	4.389GlyVal: 4.389 ± 0.069	0.806GlyTrp: 0.806 ± 0.032	2.689GlyTyr: 2.689 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	1.494HisAla: 1.494 ± 0.036	0.314HisCys: 0.314 ± 0.019	0.982HisAsp: 0.982 ± 0.029	1.358HisGlu: 1.358 ± 0.036	1.077HisPhe: 1.077 ± 0.033	1.489HisGly: 1.489 ± 0.037	0.603HisHis: 0.603 ± 0.027	1.665HisIle: 1.665 ± 0.04	1.329HisLys: 1.329 ± 0.04	1.999HisLeu: 1.999 ± 0.045	0.45HisMet: 0.45 ± 0.019	0.882HisAsn: 0.882 ± 0.025	1.127HisPro: 1.127 ± 0.032	0.57HisGln: 0.57 ± 0.02	0.985HisArg: 0.985 ± 0.031	1.262HisSer: 1.262 ± 0.034	1.153HisThr: 1.153 ± 0.036	1.287HisVal: 1.287 ± 0.035	0.247HisTrp: 0.247 ± 0.014	0.914HisTyr: 0.914 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	6.191IleAla: 6.191 ± 0.105	1.198IleCys: 1.198 ± 0.041	4.532IleAsp: 4.532 ± 0.067	5.752IleGlu: 5.752 ± 0.081	3.403IlePhe: 3.403 ± 0.076	5.393IleGly: 5.393 ± 0.075	1.802IleHis: 1.802 ± 0.038	6.434IleIle: 6.434 ± 0.094	5.862IleLys: 5.862 ± 0.084	7.318IleLeu: 7.318 ± 0.098	1.767IleMet: 1.767 ± 0.042	3.844IleAsn: 3.844 ± 0.061	3.689IlePro: 3.689 ± 0.064	2.396IleGln: 2.396 ± 0.048	3.794IleArg: 3.794 ± 0.057	5.435IleSer: 5.435 ± 0.073	4.794IleThr: 4.794 ± 0.072	5.466IleVal: 5.466 ± 0.081	0.646IleTrp: 0.646 ± 0.024	2.547IleTyr: 2.547 ± 0.054	0.0IleXaa: 0.0 ± 0.0
Lys	4.626LysAla: 4.626 ± 0.07	0.833LysCys: 0.833 ± 0.029	4.098LysAsp: 4.098 ± 0.067	6.719LysGlu: 6.719 ± 0.107	2.216LysPhe: 2.216 ± 0.048	4.83LysGly: 4.83 ± 0.083	1.55LysHis: 1.55 ± 0.04	6.33LysIle: 6.33 ± 0.083	7.282LysLys: 7.282 ± 0.095	6.193LysLeu: 6.193 ± 0.082	2.011LysMet: 2.011 ± 0.046	4.339LysAsn: 4.339 ± 0.065	2.49LysPro: 2.49 ± 0.048	2.576LysGln: 2.576 ± 0.053	3.874LysArg: 3.874 ± 0.064	3.972LysSer: 3.972 ± 0.064	4.44LysThr: 4.44 ± 0.063	4.105LysVal: 4.105 ± 0.059	0.753LysTrp: 0.753 ± 0.03	2.859LysTyr: 2.859 ± 0.06	0.0LysXaa: 0.0 ± 0.0
Leu	6.454LeuAla: 6.454 ± 0.103	1.422LeuCys: 1.422 ± 0.039	4.411LeuAsp: 4.411 ± 0.08	6.202LeuGlu: 6.202 ± 0.08	4.605LeuPhe: 4.605 ± 0.092	5.893LeuGly: 5.893 ± 0.086	1.984LeuHis: 1.984 ± 0.041	6.594LeuIle: 6.594 ± 0.094	7.375LeuLys: 7.375 ± 0.112	9.303LeuLeu: 9.303 ± 0.128	2.104LeuMet: 2.104 ± 0.045	4.284LeuAsn: 4.284 ± 0.064	3.98LeuPro: 3.98 ± 0.062	3.152LeuGln: 3.152 ± 0.063	4.739LeuArg: 4.739 ± 0.076	6.934LeuSer: 6.934 ± 0.085	4.841LeuThr: 4.841 ± 0.08	5.197LeuVal: 5.197 ± 0.074	1.017LeuTrp: 1.017 ± 0.032	2.933LeuTyr: 2.933 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	1.864MetAla: 1.864 ± 0.043	0.288MetCys: 0.288 ± 0.016	1.311MetAsp: 1.311 ± 0.034	1.76MetGlu: 1.76 ± 0.043	0.942MetPhe: 0.942 ± 0.032	1.707MetGly: 1.707 ± 0.039	0.486MetHis: 0.486 ± 0.023	1.617MetIle: 1.617 ± 0.043	2.111MetLys: 2.111 ± 0.055	2.388MetLeu: 2.388 ± 0.05	0.553MetMet: 0.553 ± 0.021	1.253MetAsn: 1.253 ± 0.031	1.164MetPro: 1.164 ± 0.036	0.829MetGln: 0.829 ± 0.031	1.158MetArg: 1.158 ± 0.033	1.491MetSer: 1.491 ± 0.038	1.173MetThr: 1.173 ± 0.034	1.659MetVal: 1.659 ± 0.041	0.207MetTrp: 0.207 ± 0.014	0.626MetTyr: 0.626 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	3.422AsnAla: 3.422 ± 0.058	0.578AsnCys: 0.578 ± 0.026	2.366AsnAsp: 2.366 ± 0.05	2.955AsnGlu: 2.955 ± 0.051	1.785AsnPhe: 1.785 ± 0.042	2.954AsnGly: 2.954 ± 0.08	0.892AsnHis: 0.892 ± 0.03	4.403AsnIle: 4.403 ± 0.067	3.528AsnLys: 3.528 ± 0.052	4.124AsnLeu: 4.124 ± 0.064	1.084AsnMet: 1.084 ± 0.034	2.515AsnAsn: 2.515 ± 0.061	2.219AsnPro: 2.219 ± 0.049	1.169AsnGln: 1.169 ± 0.034	2.148AsnArg: 2.148 ± 0.048	2.535AsnSer: 2.535 ± 0.06	2.788AsnThr: 2.788 ± 0.059	2.949AsnVal: 2.949 ± 0.051	0.509AsnTrp: 0.509 ± 0.025	1.755AsnTyr: 1.755 ± 0.044	0.0AsnXaa: 0.0 ± 0.0
Pro	2.482ProAla: 2.482 ± 0.043	0.524ProCys: 0.524 ± 0.023	2.446ProAsp: 2.446 ± 0.05	3.217ProGlu: 3.217 ± 0.056	1.965ProPhe: 1.965 ± 0.049	2.572ProGly: 2.572 ± 0.052	0.839ProHis: 0.839 ± 0.024	2.409ProIle: 2.409 ± 0.051	2.196ProLys: 2.196 ± 0.047	3.556ProLeu: 3.556 ± 0.054	0.814ProMet: 0.814 ± 0.027	1.384ProAsn: 1.384 ± 0.036	1.47ProPro: 1.47 ± 0.044	1.172ProGln: 1.172 ± 0.037	1.448ProArg: 1.448 ± 0.039	2.207ProSer: 2.207 ± 0.049	1.661ProThr: 1.661 ± 0.056	3.112ProVal: 3.112 ± 0.058	0.39ProTrp: 0.39 ± 0.019	1.385ProTyr: 1.385 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	1.975GlnAla: 1.975 ± 0.043	0.362GlnCys: 0.362 ± 0.02	1.254GlnAsp: 1.254 ± 0.04	2.114GlnGlu: 2.114 ± 0.047	1.202GlnPhe: 1.202 ± 0.035	1.775GlnGly: 1.775 ± 0.044	0.624GlnHis: 0.624 ± 0.026	2.554GlnIle: 2.554 ± 0.052	2.856GlnLys: 2.856 ± 0.053	2.728GlnLeu: 2.728 ± 0.059	0.887GlnMet: 0.887 ± 0.03	1.401GlnAsn: 1.401 ± 0.036	0.986GlnPro: 0.986 ± 0.032	1.109GlnGln: 1.109 ± 0.037	1.549GlnArg: 1.549 ± 0.039	1.741GlnSer: 1.741 ± 0.041	1.66GlnThr: 1.66 ± 0.042	1.715GlnVal: 1.715 ± 0.04	0.351GlnTrp: 0.351 ± 0.02	1.07GlnTyr: 1.07 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	2.695ArgAla: 2.695 ± 0.057	0.644ArgCys: 0.644 ± 0.027	2.38ArgAsp: 2.38 ± 0.057	3.814ArgGlu: 3.814 ± 0.075	2.291ArgPhe: 2.291 ± 0.045	2.756ArgGly: 2.756 ± 0.053	1.094ArgHis: 1.094 ± 0.027	4.04ArgIle: 4.04 ± 0.065	3.934ArgLys: 3.934 ± 0.072	4.87ArgLeu: 4.87 ± 0.08	1.265ArgMet: 1.265 ± 0.038	2.385ArgAsn: 2.385 ± 0.048	1.521ArgPro: 1.521 ± 0.036	1.687ArgGln: 1.687 ± 0.039	2.528ArgArg: 2.528 ± 0.058	2.451ArgSer: 2.451 ± 0.048	2.191ArgThr: 2.191 ± 0.051	2.842ArgVal: 2.842 ± 0.05	0.532ArgTrp: 0.532 ± 0.023	1.893ArgTyr: 1.893 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	4.014SerAla: 4.014 ± 0.072	0.868SerCys: 0.868 ± 0.029	2.973SerAsp: 2.973 ± 0.067	3.802SerGlu: 3.802 ± 0.065	3.161SerPhe: 3.161 ± 0.053	5.051SerGly: 5.051 ± 0.124	1.284SerHis: 1.284 ± 0.039	4.913SerIle: 4.913 ± 0.062	3.913SerLys: 3.913 ± 0.07	6.275SerLeu: 6.275 ± 0.089	1.439SerMet: 1.439 ± 0.033	2.516SerAsn: 2.516 ± 0.055	2.5SerPro: 2.5 ± 0.057	1.888SerGln: 1.888 ± 0.045	2.814SerArg: 2.814 ± 0.06	3.862SerSer: 3.862 ± 0.108	3.001SerThr: 3.001 ± 0.092	3.985SerVal: 3.985 ± 0.06	0.639SerTrp: 0.639 ± 0.025	2.135SerTyr: 2.135 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	3.649ThrAla: 3.649 ± 0.085	0.684ThrCys: 0.684 ± 0.024	2.669ThrAsp: 2.669 ± 0.06	3.234ThrGlu: 3.234 ± 0.058	2.377ThrPhe: 2.377 ± 0.061	4.36ThrGly: 4.36 ± 0.098	1.144ThrHis: 1.144 ± 0.03	4.59ThrIle: 4.59 ± 0.082	3.372ThrLys: 3.372 ± 0.054	5.286ThrLeu: 5.286 ± 0.076	1.251ThrMet: 1.251 ± 0.032	2.247ThrAsn: 2.247 ± 0.058	2.548ThrPro: 2.548 ± 0.068	1.428ThrGln: 1.428 ± 0.042	2.197ThrArg: 2.197 ± 0.044	3.186ThrSer: 3.186 ± 0.094	3.246ThrThr: 3.246 ± 0.132	3.694ThrVal: 3.694 ± 0.083	0.486ThrTrp: 0.486 ± 0.026	1.799ThrTyr: 1.799 ± 0.052	0.0ThrXaa: 0.0 ± 0.0
Val	4.273ValAla: 4.273 ± 0.067	1.041ValCys: 1.041 ± 0.034	3.302ValAsp: 3.302 ± 0.053	4.214ValGlu: 4.214 ± 0.073	3.396ValPhe: 3.396 ± 0.058	3.839ValGly: 3.839 ± 0.063	1.286ValHis: 1.286 ± 0.037	5.157ValIle: 5.157 ± 0.072	4.62ValLys: 4.62 ± 0.065	5.987ValLeu: 5.987 ± 0.083	1.52ValMet: 1.52 ± 0.037	2.804ValAsn: 2.804 ± 0.058	2.26ValPro: 2.26 ± 0.054	1.726ValGln: 1.726 ± 0.042	3.035ValArg: 3.035 ± 0.057	4.616ValSer: 4.616 ± 0.084	3.473ValThr: 3.473 ± 0.076	4.65ValVal: 4.65 ± 0.066	0.654ValTrp: 0.654 ± 0.031	2.353ValTyr: 2.353 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.604TrpAla: 0.604 ± 0.025	0.128TrpCys: 0.128 ± 0.012	0.575TrpAsp: 0.575 ± 0.022	0.769TrpGlu: 0.769 ± 0.028	0.531TrpPhe: 0.531 ± 0.021	0.671TrpGly: 0.671 ± 0.031	0.253TrpHis: 0.253 ± 0.016	0.817TrpIle: 0.817 ± 0.026	0.854TrpLys: 0.854 ± 0.027	1.047TrpLeu: 1.047 ± 0.032	0.319TrpMet: 0.319 ± 0.018	0.551TrpAsn: 0.551 ± 0.026	0.305TrpPro: 0.305 ± 0.018	0.435TrpGln: 0.435 ± 0.022	0.572TrpArg: 0.572 ± 0.027	0.584TrpSer: 0.584 ± 0.027	0.472TrpThr: 0.472 ± 0.026	0.574TrpVal: 0.574 ± 0.025	0.13TrpTrp: 0.13 ± 0.01	0.387TrpTyr: 0.387 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.199TyrAla: 2.199 ± 0.05	0.578TyrCys: 0.578 ± 0.025	2.081TyrAsp: 2.081 ± 0.056	2.36TyrGlu: 2.36 ± 0.051	1.909TyrPhe: 1.909 ± 0.043	2.444TyrGly: 2.444 ± 0.048	0.873TyrHis: 0.873 ± 0.03	2.432TyrIle: 2.432 ± 0.044	2.546TyrLys: 2.546 ± 0.045	3.621TyrLeu: 3.621 ± 0.064	0.682TyrMet: 0.682 ± 0.023	1.768TyrAsn: 1.768 ± 0.042	1.439TyrPro: 1.439 ± 0.038	1.118TyrGln: 1.118 ± 0.03	1.938TyrArg: 1.938 ± 0.039	2.275TyrSer: 2.275 ± 0.052	1.825TyrThr: 1.825 ± 0.054	2.124TyrVal: 2.124 ± 0.047	0.418TyrTrp: 0.418 ± 0.022	1.462TyrTyr: 1.462 ± 0.041	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3801 proteins (1118467 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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