Amino acid dipepetide frequency for Podoviridae sp. ctrTa16

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.621AlaAla: 4.621 ± 0.818
0.699AlaCys: 0.699 ± 0.234
4.46AlaAsp: 4.46 ± 0.396
7.577AlaGlu: 7.577 ± 0.813
2.472AlaPhe: 2.472 ± 0.419
3.869AlaGly: 3.869 ± 0.654
0.645AlaHis: 0.645 ± 0.204
5.857AlaIle: 5.857 ± 0.66
4.621AlaLys: 4.621 ± 0.762
4.46AlaLeu: 4.46 ± 0.493
2.042AlaMet: 2.042 ± 0.338
3.332AlaAsn: 3.332 ± 0.409
2.257AlaPro: 2.257 ± 0.368
2.526AlaGln: 2.526 ± 0.481
2.741AlaArg: 2.741 ± 0.365
4.675AlaSer: 4.675 ± 0.762
4.783AlaThr: 4.783 ± 0.817
3.923AlaVal: 3.923 ± 0.581
0.537AlaTrp: 0.537 ± 0.158
2.042AlaTyr: 2.042 ± 0.421
0.0AlaXaa: 0.0 ± 0.0
Cys
0.86CysAla: 0.86 ± 0.235
0.054CysCys: 0.054 ± 0.045
0.591CysAsp: 0.591 ± 0.247
0.537CysGlu: 0.537 ± 0.194
0.537CysPhe: 0.537 ± 0.186
1.182CysGly: 1.182 ± 0.407
0.215CysHis: 0.215 ± 0.105
0.645CysIle: 0.645 ± 0.236
0.537CysLys: 0.537 ± 0.202
0.484CysLeu: 0.484 ± 0.175
0.215CysMet: 0.215 ± 0.115
0.484CysAsn: 0.484 ± 0.172
0.43CysPro: 0.43 ± 0.204
0.107CysGln: 0.107 ± 0.071
0.322CysArg: 0.322 ± 0.176
0.43CysSer: 0.43 ± 0.17
0.537CysThr: 0.537 ± 0.26
0.645CysVal: 0.645 ± 0.189
0.107CysTrp: 0.107 ± 0.068
0.591CysTyr: 0.591 ± 0.182
0.0CysXaa: 0.0 ± 0.0
Asp
5.213AspAla: 5.213 ± 0.586
0.43AspCys: 0.43 ± 0.15
3.224AspAsp: 3.224 ± 0.516
4.836AspGlu: 4.836 ± 0.689
2.794AspPhe: 2.794 ± 0.303
4.998AspGly: 4.998 ± 0.5
0.484AspHis: 0.484 ± 0.2
4.729AspIle: 4.729 ± 0.558
4.568AspLys: 4.568 ± 0.839
3.171AspLeu: 3.171 ± 0.581
1.72AspMet: 1.72 ± 0.373
3.278AspAsn: 3.278 ± 0.464
2.096AspPro: 2.096 ± 0.412
0.86AspGln: 0.86 ± 0.213
2.096AspArg: 2.096 ± 0.31
4.783AspSer: 4.783 ± 0.514
3.117AspThr: 3.117 ± 0.472
4.353AspVal: 4.353 ± 0.534
0.86AspTrp: 0.86 ± 0.203
2.257AspTyr: 2.257 ± 0.386
0.0AspXaa: 0.0 ± 0.0
Glu
5.804GluAla: 5.804 ± 0.695
0.537GluCys: 0.537 ± 0.192
3.977GluAsp: 3.977 ± 0.658
5.965GluGlu: 5.965 ± 0.773
3.063GluPhe: 3.063 ± 0.333
5.427GluGly: 5.427 ± 1.202
1.236GluHis: 1.236 ± 0.281
4.89GluIle: 4.89 ± 0.604
6.287GluLys: 6.287 ± 0.737
6.502GluLeu: 6.502 ± 0.488
1.72GluMet: 1.72 ± 0.507
3.869GluAsn: 3.869 ± 0.457
1.666GluPro: 1.666 ± 0.375
3.009GluGln: 3.009 ± 0.453
4.406GluArg: 4.406 ± 0.602
5.213GluSer: 5.213 ± 0.683
3.493GluThr: 3.493 ± 0.439
3.815GluVal: 3.815 ± 0.468
0.537GluTrp: 0.537 ± 0.191
3.278GluTyr: 3.278 ± 0.464
0.0GluXaa: 0.0 ± 0.0
Phe
2.203PheAla: 2.203 ± 0.274
0.376PheCys: 0.376 ± 0.174
3.009PheAsp: 3.009 ± 0.413
3.117PheGlu: 3.117 ± 0.386
2.418PhePhe: 2.418 ± 0.391
3.6PheGly: 3.6 ± 0.606
0.43PheHis: 0.43 ± 0.108
3.493PheIle: 3.493 ± 0.605
3.332PheLys: 3.332 ± 0.435
2.848PheLeu: 2.848 ± 0.416
1.128PheMet: 1.128 ± 0.2
3.332PheAsn: 3.332 ± 0.422
1.343PhePro: 1.343 ± 0.203
1.128PheGln: 1.128 ± 0.287
2.364PheArg: 2.364 ± 0.436
3.493PheSer: 3.493 ± 0.414
2.364PheThr: 2.364 ± 0.471
2.794PheVal: 2.794 ± 0.459
0.269PheTrp: 0.269 ± 0.126
2.418PheTyr: 2.418 ± 0.512
0.0PheXaa: 0.0 ± 0.0
Gly
4.998GlyAla: 4.998 ± 0.799
0.967GlyCys: 0.967 ± 0.273
3.278GlyAsp: 3.278 ± 0.397
5.051GlyGlu: 5.051 ± 1.537
2.526GlyPhe: 2.526 ± 0.315
4.783GlyGly: 4.783 ± 0.446
0.752GlyHis: 0.752 ± 0.242
4.514GlyIle: 4.514 ± 0.512
4.568GlyLys: 4.568 ± 0.504
4.46GlyLeu: 4.46 ± 0.412
1.451GlyMet: 1.451 ± 0.248
3.493GlyAsn: 3.493 ± 0.488
0.0GlyPro: 0.0 ± 0.0
1.343GlyGln: 1.343 ± 0.198
3.171GlyArg: 3.171 ± 0.366
4.621GlySer: 4.621 ± 0.614
3.815GlyThr: 3.815 ± 0.557
5.374GlyVal: 5.374 ± 0.606
0.914GlyTrp: 0.914 ± 0.232
3.654GlyTyr: 3.654 ± 0.395
0.0GlyXaa: 0.0 ± 0.0
His
0.752HisAla: 0.752 ± 0.199
0.107HisCys: 0.107 ± 0.12
0.591HisAsp: 0.591 ± 0.171
0.86HisGlu: 0.86 ± 0.212
0.537HisPhe: 0.537 ± 0.205
0.43HisGly: 0.43 ± 0.158
0.43HisHis: 0.43 ± 0.138
0.86HisIle: 0.86 ± 0.247
1.021HisLys: 1.021 ± 0.249
0.914HisLeu: 0.914 ± 0.268
0.322HisMet: 0.322 ± 0.129
0.806HisAsn: 0.806 ± 0.259
0.43HisPro: 0.43 ± 0.136
0.484HisGln: 0.484 ± 0.175
0.699HisArg: 0.699 ± 0.195
0.86HisSer: 0.86 ± 0.205
0.967HisThr: 0.967 ± 0.181
1.075HisVal: 1.075 ± 0.289
0.107HisTrp: 0.107 ± 0.069
0.752HisTyr: 0.752 ± 0.241
0.0HisXaa: 0.0 ± 0.0
Ile
4.89IleAla: 4.89 ± 0.551
0.484IleCys: 0.484 ± 0.21
5.159IleAsp: 5.159 ± 0.427
5.642IleGlu: 5.642 ± 0.565
3.063IlePhe: 3.063 ± 0.38
4.245IleGly: 4.245 ± 0.466
0.752IleHis: 0.752 ± 0.159
4.138IleIle: 4.138 ± 0.507
6.663IleLys: 6.663 ± 0.631
4.944IleLeu: 4.944 ± 0.858
1.236IleMet: 1.236 ± 0.306
3.977IleAsn: 3.977 ± 0.441
3.6IlePro: 3.6 ± 0.4
2.579IleGln: 2.579 ± 0.407
2.902IleArg: 2.902 ± 0.438
5.911IleSer: 5.911 ± 0.611
3.869IleThr: 3.869 ± 0.489
4.46IleVal: 4.46 ± 0.672
0.43IleTrp: 0.43 ± 0.121
1.988IleTyr: 1.988 ± 0.302
0.0IleXaa: 0.0 ± 0.0
Lys
5.642LysAla: 5.642 ± 0.979
0.699LysCys: 0.699 ± 0.238
5.213LysAsp: 5.213 ± 0.75
5.857LysGlu: 5.857 ± 0.733
2.956LysPhe: 2.956 ± 0.554
3.332LysGly: 3.332 ± 0.392
1.505LysHis: 1.505 ± 0.274
5.213LysIle: 5.213 ± 0.527
7.577LysLys: 7.577 ± 0.801
5.589LysLeu: 5.589 ± 0.474
2.741LysMet: 2.741 ± 0.477
5.159LysAsn: 5.159 ± 0.615
2.257LysPro: 2.257 ± 0.339
3.171LysGln: 3.171 ± 0.502
4.03LysArg: 4.03 ± 0.485
4.514LysSer: 4.514 ± 0.519
5.427LysThr: 5.427 ± 0.758
4.245LysVal: 4.245 ± 0.508
0.914LysTrp: 0.914 ± 0.21
3.385LysTyr: 3.385 ± 0.425
0.0LysXaa: 0.0 ± 0.0
Leu
4.568LeuAla: 4.568 ± 0.48
0.752LeuCys: 0.752 ± 0.251
4.245LeuAsp: 4.245 ± 0.385
5.105LeuGlu: 5.105 ± 0.52
3.224LeuPhe: 3.224 ± 0.462
3.762LeuGly: 3.762 ± 0.343
1.343LeuHis: 1.343 ± 0.282
4.46LeuIle: 4.46 ± 0.578
5.911LeuLys: 5.911 ± 0.763
5.213LeuLeu: 5.213 ± 0.551
2.149LeuMet: 2.149 ± 0.306
4.675LeuAsn: 4.675 ± 0.49
3.654LeuPro: 3.654 ± 0.576
2.794LeuGln: 2.794 ± 0.354
3.278LeuArg: 3.278 ± 0.385
6.502LeuSer: 6.502 ± 0.517
4.192LeuThr: 4.192 ± 0.475
3.923LeuVal: 3.923 ± 0.51
0.484LeuTrp: 0.484 ± 0.158
3.869LeuTyr: 3.869 ± 0.431
0.0LeuXaa: 0.0 ± 0.0
Met
1.72MetAla: 1.72 ± 0.275
0.322MetCys: 0.322 ± 0.142
1.397MetAsp: 1.397 ± 0.245
1.451MetGlu: 1.451 ± 0.228
1.236MetPhe: 1.236 ± 0.311
0.914MetGly: 0.914 ± 0.212
0.161MetHis: 0.161 ± 0.075
1.988MetIle: 1.988 ± 0.275
2.579MetLys: 2.579 ± 0.339
2.633MetLeu: 2.633 ± 0.383
0.806MetMet: 0.806 ± 0.243
2.149MetAsn: 2.149 ± 0.297
0.699MetPro: 0.699 ± 0.236
0.591MetGln: 0.591 ± 0.208
1.397MetArg: 1.397 ± 0.28
2.364MetSer: 2.364 ± 0.389
1.505MetThr: 1.505 ± 0.349
1.075MetVal: 1.075 ± 0.282
0.215MetTrp: 0.215 ± 0.116
1.558MetTyr: 1.558 ± 0.326
0.0MetXaa: 0.0 ± 0.0
Asn
4.406AsnAla: 4.406 ± 0.42
0.752AsnCys: 0.752 ± 0.28
2.794AsnAsp: 2.794 ± 0.299
4.299AsnGlu: 4.299 ± 0.526
2.472AsnPhe: 2.472 ± 0.518
4.621AsnGly: 4.621 ± 0.575
0.484AsnHis: 0.484 ± 0.185
3.708AsnIle: 3.708 ± 0.465
4.621AsnLys: 4.621 ± 0.553
4.406AsnLeu: 4.406 ± 0.507
1.558AsnMet: 1.558 ± 0.378
3.6AsnAsn: 3.6 ± 0.383
2.741AsnPro: 2.741 ± 0.298
1.935AsnGln: 1.935 ± 0.346
2.741AsnArg: 2.741 ± 0.41
4.192AsnSer: 4.192 ± 0.479
3.224AsnThr: 3.224 ± 0.404
3.547AsnVal: 3.547 ± 0.464
0.967AsnTrp: 0.967 ± 0.239
2.633AsnTyr: 2.633 ± 0.513
0.0AsnXaa: 0.0 ± 0.0
Pro
2.418ProAla: 2.418 ± 0.446
0.484ProCys: 0.484 ± 0.185
2.526ProAsp: 2.526 ± 0.43
2.741ProGlu: 2.741 ± 0.388
1.827ProPhe: 1.827 ± 0.243
2.096ProGly: 2.096 ± 0.292
0.322ProHis: 0.322 ± 0.141
2.633ProIle: 2.633 ± 0.357
2.096ProLys: 2.096 ± 0.317
2.848ProLeu: 2.848 ± 0.51
0.645ProMet: 0.645 ± 0.163
1.29ProAsn: 1.29 ± 0.232
1.182ProPro: 1.182 ± 0.254
1.505ProGln: 1.505 ± 0.263
0.914ProArg: 0.914 ± 0.267
3.117ProSer: 3.117 ± 0.458
2.096ProThr: 2.096 ± 0.365
1.988ProVal: 1.988 ± 0.359
0.0ProTrp: 0.0 ± 0.0
1.128ProTyr: 1.128 ± 0.249
0.0ProXaa: 0.0 ± 0.0
Gln
2.149GlnAla: 2.149 ± 0.367
0.215GlnCys: 0.215 ± 0.093
1.505GlnAsp: 1.505 ± 0.31
1.988GlnGlu: 1.988 ± 0.469
1.128GlnPhe: 1.128 ± 0.261
1.29GlnGly: 1.29 ± 0.326
0.322GlnHis: 0.322 ± 0.138
2.149GlnIle: 2.149 ± 0.35
3.063GlnLys: 3.063 ± 0.425
2.902GlnLeu: 2.902 ± 0.421
1.128GlnMet: 1.128 ± 0.245
2.311GlnAsn: 2.311 ± 0.421
1.343GlnPro: 1.343 ± 0.343
1.988GlnGln: 1.988 ± 0.5
1.343GlnArg: 1.343 ± 0.29
2.257GlnSer: 2.257 ± 0.366
1.988GlnThr: 1.988 ± 0.393
1.72GlnVal: 1.72 ± 0.294
0.376GlnTrp: 0.376 ± 0.198
2.042GlnTyr: 2.042 ± 0.295
0.0GlnXaa: 0.0 ± 0.0
Arg
2.364ArgAla: 2.364 ± 0.31
0.484ArgCys: 0.484 ± 0.16
2.902ArgAsp: 2.902 ± 0.381
3.278ArgGlu: 3.278 ± 0.469
2.526ArgPhe: 2.526 ± 0.314
2.687ArgGly: 2.687 ± 0.369
0.699ArgHis: 0.699 ± 0.233
3.117ArgIle: 3.117 ± 0.394
3.332ArgLys: 3.332 ± 0.515
4.299ArgLeu: 4.299 ± 0.43
1.128ArgMet: 1.128 ± 0.238
3.117ArgAsn: 3.117 ± 0.547
1.29ArgPro: 1.29 ± 0.256
1.29ArgGln: 1.29 ± 0.292
2.257ArgArg: 2.257 ± 0.396
2.364ArgSer: 2.364 ± 0.292
1.558ArgThr: 1.558 ± 0.268
2.956ArgVal: 2.956 ± 0.521
0.269ArgTrp: 0.269 ± 0.1
1.988ArgTyr: 1.988 ± 0.347
0.0ArgXaa: 0.0 ± 0.0
Ser
5.481SerAla: 5.481 ± 0.623
0.645SerCys: 0.645 ± 0.183
4.998SerAsp: 4.998 ± 0.43
4.729SerGlu: 4.729 ± 0.61
4.46SerPhe: 4.46 ± 0.63
5.804SerGly: 5.804 ± 0.729
0.752SerHis: 0.752 ± 0.186
5.75SerIle: 5.75 ± 0.746
4.89SerLys: 4.89 ± 0.603
5.105SerLeu: 5.105 ± 0.578
1.558SerMet: 1.558 ± 0.297
4.138SerAsn: 4.138 ± 0.572
2.579SerPro: 2.579 ± 0.308
2.579SerGln: 2.579 ± 0.356
2.633SerArg: 2.633 ± 0.469
4.192SerSer: 4.192 ± 0.666
3.869SerThr: 3.869 ± 0.831
4.836SerVal: 4.836 ± 0.545
0.43SerTrp: 0.43 ± 0.148
2.848SerTyr: 2.848 ± 0.288
0.0SerXaa: 0.0 ± 0.0
Thr
4.03ThrAla: 4.03 ± 0.529
0.269ThrCys: 0.269 ± 0.114
2.579ThrAsp: 2.579 ± 0.535
3.654ThrGlu: 3.654 ± 0.376
2.096ThrPhe: 2.096 ± 0.347
3.654ThrGly: 3.654 ± 0.565
0.806ThrHis: 0.806 ± 0.252
4.944ThrIle: 4.944 ± 0.628
4.084ThrLys: 4.084 ± 0.505
4.568ThrLeu: 4.568 ± 0.504
1.343ThrMet: 1.343 ± 0.272
3.224ThrAsn: 3.224 ± 0.445
2.741ThrPro: 2.741 ± 0.456
2.149ThrGln: 2.149 ± 0.281
1.881ThrArg: 1.881 ± 0.326
4.783ThrSer: 4.783 ± 0.723
3.117ThrThr: 3.117 ± 0.683
3.493ThrVal: 3.493 ± 0.536
0.699ThrTrp: 0.699 ± 0.14
1.988ThrTyr: 1.988 ± 0.458
0.0ThrXaa: 0.0 ± 0.0
Val
2.902ValAla: 2.902 ± 0.48
0.43ValCys: 0.43 ± 0.172
3.762ValAsp: 3.762 ± 0.381
4.084ValGlu: 4.084 ± 0.617
3.009ValPhe: 3.009 ± 0.406
4.03ValGly: 4.03 ± 0.432
0.752ValHis: 0.752 ± 0.196
4.353ValIle: 4.353 ± 0.473
5.32ValLys: 5.32 ± 0.641
5.051ValLeu: 5.051 ± 0.517
2.096ValMet: 2.096 ± 0.311
4.084ValAsn: 4.084 ± 0.467
2.257ValPro: 2.257 ± 0.415
1.827ValGln: 1.827 ± 0.327
2.042ValArg: 2.042 ± 0.326
4.568ValSer: 4.568 ± 0.485
3.493ValThr: 3.493 ± 0.392
4.514ValVal: 4.514 ± 0.534
0.699ValTrp: 0.699 ± 0.207
2.526ValTyr: 2.526 ± 0.318
0.0ValXaa: 0.0 ± 0.0
Trp
0.86TrpAla: 0.86 ± 0.272
0.161TrpCys: 0.161 ± 0.124
0.591TrpAsp: 0.591 ± 0.155
0.645TrpGlu: 0.645 ± 0.198
0.699TrpPhe: 0.699 ± 0.204
0.806TrpGly: 0.806 ± 0.274
0.054TrpHis: 0.054 ± 0.058
1.021TrpIle: 1.021 ± 0.218
0.645TrpLys: 0.645 ± 0.145
0.484TrpLeu: 0.484 ± 0.134
0.376TrpMet: 0.376 ± 0.124
0.537TrpAsn: 0.537 ± 0.14
0.054TrpPro: 0.054 ± 0.06
0.215TrpGln: 0.215 ± 0.112
0.484TrpArg: 0.484 ± 0.216
0.484TrpSer: 0.484 ± 0.144
0.484TrpThr: 0.484 ± 0.138
0.322TrpVal: 0.322 ± 0.137
0.376TrpTrp: 0.376 ± 0.121
0.43TrpTyr: 0.43 ± 0.145
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.257TyrAla: 2.257 ± 0.363
0.645TyrCys: 0.645 ± 0.188
3.063TyrAsp: 3.063 ± 0.416
3.332TyrGlu: 3.332 ± 0.413
2.418TyrPhe: 2.418 ± 0.38
2.203TyrGly: 2.203 ± 0.396
0.86TyrHis: 0.86 ± 0.206
2.472TyrIle: 2.472 ± 0.495
3.708TyrLys: 3.708 ± 0.393
3.224TyrLeu: 3.224 ± 0.391
1.343TyrMet: 1.343 ± 0.232
2.848TyrAsn: 2.848 ± 0.389
1.236TyrPro: 1.236 ± 0.315
1.128TyrGln: 1.128 ± 0.251
2.203TyrArg: 2.203 ± 0.316
2.956TyrSer: 2.956 ± 0.468
2.203TyrThr: 2.203 ± 0.329
2.741TyrVal: 2.741 ± 0.402
0.537TyrTrp: 0.537 ± 0.151
2.418TyrTyr: 2.418 ± 0.35
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 70 proteins (18610 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski