Amino acid dipepetide frequency for Trypanosoma rangeli SC58

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.675AlaAla: 11.675 ± 0.102	1.716AlaCys: 1.716 ± 0.026	3.785AlaAsp: 3.785 ± 0.03	6.331AlaGlu: 6.331 ± 0.056	3.266AlaPhe: 3.266 ± 0.034	5.463AlaGly: 5.463 ± 0.049	2.048AlaHis: 2.048 ± 0.024	3.079AlaIle: 3.079 ± 0.034	3.703AlaLys: 3.703 ± 0.044	9.835AlaLeu: 9.835 ± 0.069	2.426AlaMet: 2.426 ± 0.023	2.462AlaAsn: 2.462 ± 0.027	4.331AlaPro: 4.331 ± 0.038	3.204AlaGln: 3.204 ± 0.038	5.531AlaArg: 5.531 ± 0.042	7.231AlaSer: 7.231 ± 0.049	5.675AlaThr: 5.675 ± 0.051	7.592AlaVal: 7.592 ± 0.052	1.025AlaTrp: 1.025 ± 0.018	1.994AlaTyr: 1.994 ± 0.023	0.0AlaXaa: 0.0 ± 0.0
Cys	1.792CysAla: 1.792 ± 0.024	0.669CysCys: 0.669 ± 0.018	1.034CysAsp: 1.034 ± 0.021	1.118CysGlu: 1.118 ± 0.019	1.003CysPhe: 1.003 ± 0.017	1.823CysGly: 1.823 ± 0.028	0.553CysHis: 0.553 ± 0.015	0.975CysIle: 0.975 ± 0.019	0.645CysLys: 0.645 ± 0.013	1.947CysLeu: 1.947 ± 0.025	0.502CysMet: 0.502 ± 0.013	0.606CysAsn: 0.606 ± 0.013	0.898CysPro: 0.898 ± 0.017	0.596CysGln: 0.596 ± 0.014	1.536CysArg: 1.536 ± 0.023	1.633CysSer: 1.633 ± 0.027	1.119CysThr: 1.119 ± 0.017	2.021CysVal: 2.021 ± 0.027	0.255CysTrp: 0.255 ± 0.008	0.53CysTyr: 0.53 ± 0.013	0.001CysXaa: 0.001 ± 0.0
Asp	5.71AspAla: 5.71 ± 0.044	0.826AspCys: 0.826 ± 0.014	3.309AspAsp: 3.309 ± 0.046	3.818AspGlu: 3.818 ± 0.039	1.707AspPhe: 1.707 ± 0.023	3.843AspGly: 3.843 ± 0.035	0.95AspHis: 0.95 ± 0.017	2.091AspIle: 2.091 ± 0.026	1.709AspLys: 1.709 ± 0.027	3.683AspLeu: 3.683 ± 0.037	1.163AspMet: 1.163 ± 0.02	1.512AspAsn: 1.512 ± 0.021	2.258AspPro: 2.258 ± 0.026	1.005AspGln: 1.005 ± 0.016	2.473AspArg: 2.473 ± 0.03	2.895AspSer: 2.895 ± 0.031	2.676AspThr: 2.676 ± 0.03	4.517AspVal: 4.517 ± 0.033	0.52AspTrp: 0.52 ± 0.014	1.185AspTyr: 1.185 ± 0.019	0.001AspXaa: 0.001 ± 0.0
Glu	6.931GluAla: 6.931 ± 0.059	1.1GluCys: 1.1 ± 0.019	3.626GluAsp: 3.626 ± 0.037	7.445GluGlu: 7.445 ± 0.088	1.972GluPhe: 1.972 ± 0.027	4.435GluGly: 4.435 ± 0.036	1.512GluHis: 1.512 ± 0.02	2.119GluIle: 2.119 ± 0.026	3.82GluLys: 3.82 ± 0.048	6.654GluLeu: 6.654 ± 0.062	1.846GluMet: 1.846 ± 0.026	2.213GluAsn: 2.213 ± 0.028	2.111GluPro: 2.111 ± 0.024	2.711GluGln: 2.711 ± 0.034	5.412GluArg: 5.412 ± 0.055	3.824GluSer: 3.824 ± 0.034	3.381GluThr: 3.381 ± 0.034	5.005GluVal: 5.005 ± 0.042	0.815GluTrp: 0.815 ± 0.017	1.554GluTyr: 1.554 ± 0.023	0.001GluXaa: 0.001 ± 0.001
Phe	3.182PheAla: 3.182 ± 0.03	1.031PheCys: 1.031 ± 0.019	1.927PheAsp: 1.927 ± 0.027	1.901PheGlu: 1.901 ± 0.026	2.521PhePhe: 2.521 ± 0.037	2.348PheGly: 2.348 ± 0.032	0.993PheHis: 0.993 ± 0.016	1.641PheIle: 1.641 ± 0.023	1.104PheLys: 1.104 ± 0.02	4.302PheLeu: 4.302 ± 0.042	0.92PheMet: 0.92 ± 0.018	1.13PheAsn: 1.13 ± 0.02	1.886PhePro: 1.886 ± 0.026	1.091PheGln: 1.091 ± 0.016	2.156PheArg: 2.156 ± 0.028	3.199PheSer: 3.199 ± 0.035	2.105PheThr: 2.105 ± 0.025	3.234PheVal: 3.234 ± 0.035	0.456PheTrp: 0.456 ± 0.013	1.127PheTyr: 1.127 ± 0.018	0.003PheXaa: 0.003 ± 0.001
Gly	5.835GlyAla: 5.835 ± 0.045	1.381GlyCys: 1.381 ± 0.022	3.65GlyAsp: 3.65 ± 0.034	4.423GlyGlu: 4.423 ± 0.037	2.186GlyPhe: 2.186 ± 0.028	6.448GlyGly: 6.448 ± 0.076	1.49GlyHis: 1.49 ± 0.023	2.578GlyIle: 2.578 ± 0.031	3.025GlyLys: 3.025 ± 0.031	4.843GlyLeu: 4.843 ± 0.041	1.598GlyMet: 1.598 ± 0.024	2.4GlyAsn: 2.4 ± 0.027	2.24GlyPro: 2.24 ± 0.028	1.767GlyGln: 1.767 ± 0.027	4.417GlyArg: 4.417 ± 0.041	4.903GlySer: 4.903 ± 0.038	3.717GlyThr: 3.717 ± 0.033	5.535GlyVal: 5.535 ± 0.053	0.735GlyTrp: 0.735 ± 0.014	1.52GlyTyr: 1.52 ± 0.022	0.005GlyXaa: 0.005 ± 0.001
His	2.392HisAla: 2.392 ± 0.025	0.647HisCys: 0.647 ± 0.015	1.262HisAsp: 1.262 ± 0.019	1.542HisGlu: 1.542 ± 0.027	1.042HisPhe: 1.042 ± 0.017	1.83HisGly: 1.83 ± 0.028	0.962HisHis: 0.962 ± 0.021	1.103HisIle: 1.103 ± 0.018	0.845HisLys: 0.845 ± 0.016	2.575HisLeu: 2.575 ± 0.029	0.616HisMet: 0.616 ± 0.015	0.863HisAsn: 0.863 ± 0.017	1.471HisPro: 1.471 ± 0.023	0.997HisGln: 0.997 ± 0.021	2.007HisArg: 2.007 ± 0.025	1.859HisSer: 1.859 ± 0.024	1.481HisThr: 1.481 ± 0.022	2.15HisVal: 2.15 ± 0.027	0.331HisTrp: 0.331 ± 0.011	0.775HisTyr: 0.775 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	3.364IleAla: 3.364 ± 0.033	0.803IleCys: 0.803 ± 0.018	1.9IleAsp: 1.9 ± 0.029	2.208IleGlu: 2.208 ± 0.029	1.566IlePhe: 1.566 ± 0.026	2.155IleGly: 2.155 ± 0.028	1.01IleHis: 1.01 ± 0.016	1.671IleIle: 1.671 ± 0.027	1.31IleLys: 1.31 ± 0.023	3.573IleLeu: 3.573 ± 0.037	0.889IleMet: 0.889 ± 0.018	1.192IleAsn: 1.192 ± 0.02	2.025IlePro: 2.025 ± 0.028	1.285IleGln: 1.285 ± 0.023	2.393IleArg: 2.393 ± 0.029	2.653IleSer: 2.653 ± 0.032	2.049IleThr: 2.049 ± 0.026	2.963IleVal: 2.963 ± 0.039	0.335IleTrp: 0.335 ± 0.011	0.989IleTyr: 0.989 ± 0.02	0.001IleXaa: 0.001 ± 0.0
Lys	3.396LysAla: 3.396 ± 0.037	0.671LysCys: 0.671 ± 0.013	2.058LysAsp: 2.058 ± 0.026	3.604LysGlu: 3.604 ± 0.046	1.103LysPhe: 1.103 ± 0.02	2.613LysGly: 2.613 ± 0.031	1.067LysHis: 1.067 ± 0.014	1.353LysIle: 1.353 ± 0.023	2.906LysLys: 2.906 ± 0.043	3.857LysLeu: 3.857 ± 0.04	1.122LysMet: 1.122 ± 0.018	1.515LysAsn: 1.515 ± 0.026	1.629LysPro: 1.629 ± 0.027	1.841LysGln: 1.841 ± 0.027	3.483LysArg: 3.483 ± 0.038	2.461LysSer: 2.461 ± 0.032	2.253LysThr: 2.253 ± 0.024	2.601LysVal: 2.601 ± 0.028	0.474LysTrp: 0.474 ± 0.013	1.093LysTyr: 1.093 ± 0.021	0.004LysXaa: 0.004 ± 0.001
Leu	7.982LeuAla: 7.982 ± 0.048	2.454LeuCys: 2.454 ± 0.03	4.298LeuAsp: 4.298 ± 0.039	6.227LeuGlu: 6.227 ± 0.058	4.239LeuPhe: 4.239 ± 0.048	5.154LeuGly: 5.154 ± 0.039	3.239LeuHis: 3.239 ± 0.036	3.036LeuIle: 3.036 ± 0.033	3.769LeuLys: 3.769 ± 0.037	12.327LeuLeu: 12.327 ± 0.088	2.382LeuMet: 2.382 ± 0.028	2.809LeuAsn: 2.809 ± 0.029	5.627LeuPro: 5.627 ± 0.047	5.504LeuGln: 5.504 ± 0.055	8.817LeuArg: 8.817 ± 0.062	7.696LeuSer: 7.696 ± 0.051	5.132LeuThr: 5.132 ± 0.041	6.535LeuVal: 6.535 ± 0.05	1.301LeuTrp: 1.301 ± 0.02	2.558LeuTyr: 2.558 ± 0.03	0.003LeuXaa: 0.003 ± 0.001
Met	1.95MetAla: 1.95 ± 0.02	0.511MetCys: 0.511 ± 0.013	1.244MetAsp: 1.244 ± 0.021	1.93MetGlu: 1.93 ± 0.026	0.833MetPhe: 0.833 ± 0.016	1.442MetGly: 1.442 ± 0.021	0.712MetHis: 0.712 ± 0.014	0.802MetIle: 0.802 ± 0.016	1.123MetLys: 1.123 ± 0.017	2.516MetLeu: 2.516 ± 0.028	0.76MetMet: 0.76 ± 0.017	0.854MetAsn: 0.854 ± 0.016	1.246MetPro: 1.246 ± 0.019	1.28MetGln: 1.28 ± 0.022	2.086MetArg: 2.086 ± 0.022	1.785MetSer: 1.785 ± 0.021	1.416MetThr: 1.416 ± 0.02	1.454MetVal: 1.454 ± 0.021	0.351MetTrp: 0.351 ± 0.01	0.692MetTyr: 0.692 ± 0.013	0.001MetXaa: 0.001 ± 0.001
Asn	3.176AsnAla: 3.176 ± 0.032	0.622AsnCys: 0.622 ± 0.013	1.769AsnAsp: 1.769 ± 0.023	2.109AsnGlu: 2.109 ± 0.026	1.127AsnPhe: 1.127 ± 0.019	2.357AsnGly: 2.357 ± 0.027	0.702AsnHis: 0.702 ± 0.015	1.416AsnIle: 1.416 ± 0.026	1.332AsnLys: 1.332 ± 0.024	2.414AsnLeu: 2.414 ± 0.035	0.813AsnMet: 0.813 ± 0.017	1.344AsnAsn: 1.344 ± 0.021	1.503AsnPro: 1.503 ± 0.023	0.808AsnGln: 0.808 ± 0.017	1.783AsnArg: 1.783 ± 0.024	2.249AsnSer: 2.249 ± 0.026	1.97AsnThr: 1.97 ± 0.025	2.521AsnVal: 2.521 ± 0.027	0.33AsnTrp: 0.33 ± 0.011	0.874AsnTyr: 0.874 ± 0.017	0.002AsnXaa: 0.002 ± 0.001
Pro	4.068ProAla: 4.068 ± 0.041	0.907ProCys: 0.907 ± 0.017	1.867ProAsp: 1.867 ± 0.024	2.685ProGlu: 2.685 ± 0.028	2.116ProPhe: 2.116 ± 0.024	2.424ProGly: 2.424 ± 0.032	1.498ProHis: 1.498 ± 0.025	1.601ProIle: 1.601 ± 0.022	1.722ProLys: 1.722 ± 0.024	5.484ProLeu: 5.484 ± 0.048	1.044ProMet: 1.044 ± 0.017	1.449ProAsn: 1.449 ± 0.021	4.227ProPro: 4.227 ± 0.055	2.165ProGln: 2.165 ± 0.033	3.221ProArg: 3.221 ± 0.039	4.39ProSer: 4.39 ± 0.041	3.06ProThr: 3.06 ± 0.033	3.449ProVal: 3.449 ± 0.033	0.576ProTrp: 0.576 ± 0.014	1.202ProTyr: 1.202 ± 0.021	0.004ProXaa: 0.004 ± 0.001
Gln	2.853GlnAla: 2.853 ± 0.036	0.741GlnCys: 0.741 ± 0.016	1.392GlnAsp: 1.392 ± 0.019	2.877GlnGlu: 2.877 ± 0.038	1.173GlnPhe: 1.173 ± 0.017	1.949GlnGly: 1.949 ± 0.027	1.364GlnHis: 1.364 ± 0.025	1.135GlnIle: 1.135 ± 0.02	1.93GlnLys: 1.93 ± 0.026	4.736GlnLeu: 4.736 ± 0.043	0.973GlnMet: 0.973 ± 0.017	1.106GlnAsn: 1.106 ± 0.017	1.815GlnPro: 1.815 ± 0.028	3.365GlnGln: 3.365 ± 0.063	4.212GlnArg: 4.212 ± 0.048	2.338GlnSer: 2.338 ± 0.027	1.841GlnThr: 1.841 ± 0.024	2.193GlnVal: 2.193 ± 0.03	0.557GlnTrp: 0.557 ± 0.012	0.979GlnTyr: 0.979 ± 0.018	0.001GlnXaa: 0.001 ± 0.001
Arg	5.587ArgAla: 5.587 ± 0.046	1.81ArgCys: 1.81 ± 0.024	3.396ArgAsp: 3.396 ± 0.033	5.325ArgGlu: 5.325 ± 0.052	2.543ArgPhe: 2.543 ± 0.029	4.78ArgGly: 4.78 ± 0.041	2.404ArgHis: 2.404 ± 0.029	2.672ArgIle: 2.672 ± 0.029	3.084ArgLys: 3.084 ± 0.034	7.473ArgLeu: 7.473 ± 0.048	1.794ArgMet: 1.794 ± 0.022	2.224ArgAsn: 2.224 ± 0.025	2.962ArgPro: 2.962 ± 0.035	3.564ArgGln: 3.564 ± 0.042	7.613ArgArg: 7.613 ± 0.073	4.849ArgSer: 4.849 ± 0.041	3.342ArgThr: 3.342 ± 0.034	5.175ArgVal: 5.175 ± 0.044	1.058ArgTrp: 1.058 ± 0.019	1.943ArgTyr: 1.943 ± 0.023	0.001ArgXaa: 0.001 ± 0.001
Ser	6.53SerAla: 6.53 ± 0.058	1.641SerCys: 1.641 ± 0.027	3.184SerAsp: 3.184 ± 0.03	3.882SerGlu: 3.882 ± 0.033	3.101SerPhe: 3.101 ± 0.034	5.004SerGly: 5.004 ± 0.049	1.937SerHis: 1.937 ± 0.023	2.745SerIle: 2.745 ± 0.037	2.585SerLys: 2.585 ± 0.032	7.866SerLeu: 7.866 ± 0.046	1.769SerMet: 1.769 ± 0.022	2.245SerAsn: 2.245 ± 0.03	4.198SerPro: 4.198 ± 0.044	2.421SerGln: 2.421 ± 0.025	4.82SerArg: 4.82 ± 0.039	7.23SerSer: 7.23 ± 0.061	4.462SerThr: 4.462 ± 0.037	5.672SerVal: 5.672 ± 0.05	0.846SerTrp: 0.846 ± 0.017	1.677SerTyr: 1.677 ± 0.024	0.002SerXaa: 0.002 ± 0.001
Thr	5.748ThrAla: 5.748 ± 0.049	1.019ThrCys: 1.019 ± 0.017	2.374ThrAsp: 2.374 ± 0.029	3.356ThrGlu: 3.356 ± 0.028	2.038ThrPhe: 2.038 ± 0.025	3.471ThrGly: 3.471 ± 0.033	1.447ThrHis: 1.447 ± 0.025	2.078ThrIle: 2.078 ± 0.028	2.047ThrLys: 2.047 ± 0.026	5.689ThrLeu: 5.689 ± 0.045	1.352ThrMet: 1.352 ± 0.019	1.691ThrAsn: 1.691 ± 0.021	3.466ThrPro: 3.466 ± 0.039	1.979ThrGln: 1.979 ± 0.02	3.501ThrArg: 3.501 ± 0.031	4.459ThrSer: 4.459 ± 0.043	3.944ThrThr: 3.944 ± 0.037	4.354ThrVal: 4.354 ± 0.037	0.569ThrTrp: 0.569 ± 0.014	1.249ThrTyr: 1.249 ± 0.021	0.001ThrXaa: 0.001 ± 0.0
Val	7.201ValAla: 7.201 ± 0.048	1.765ValCys: 1.765 ± 0.026	3.784ValAsp: 3.784 ± 0.036	5.367ValGlu: 5.367 ± 0.042	3.111ValPhe: 3.111 ± 0.037	4.719ValGly: 4.719 ± 0.046	1.815ValHis: 1.815 ± 0.023	2.724ValIle: 2.724 ± 0.033	2.954ValLys: 2.954 ± 0.031	7.767ValLeu: 7.767 ± 0.062	1.956ValMet: 1.956 ± 0.023	2.219ValAsn: 2.219 ± 0.026	3.849ValPro: 3.849 ± 0.038	2.72ValGln: 2.72 ± 0.029	5.169ValArg: 5.169 ± 0.042	5.643ValSer: 5.643 ± 0.04	4.206ValThr: 4.206 ± 0.043	6.753ValVal: 6.753 ± 0.052	0.926ValTrp: 0.926 ± 0.017	1.908ValTyr: 1.908 ± 0.025	0.002ValXaa: 0.002 ± 0.001
Trp	0.793TrpAla: 0.793 ± 0.016	0.344TrpCys: 0.344 ± 0.01	0.614TrpAsp: 0.614 ± 0.015	0.808TrpGlu: 0.808 ± 0.016	0.416TrpPhe: 0.416 ± 0.013	0.748TrpGly: 0.748 ± 0.016	0.326TrpHis: 0.326 ± 0.01	0.432TrpIle: 0.432 ± 0.013	0.599TrpLys: 0.599 ± 0.013	1.167TrpLeu: 1.167 ± 0.02	0.395TrpMet: 0.395 ± 0.011	0.468TrpAsn: 0.468 ± 0.013	0.404TrpPro: 0.404 ± 0.012	0.456TrpGln: 0.456 ± 0.012	1.193TrpArg: 1.193 ± 0.021	0.895TrpSer: 0.895 ± 0.017	0.565TrpThr: 0.565 ± 0.013	0.806TrpVal: 0.806 ± 0.016	0.235TrpTrp: 0.235 ± 0.009	0.346TrpTyr: 0.346 ± 0.011	0.001TrpXaa: 0.001 ± 0.0
Tyr	2.208TyrAla: 2.208 ± 0.023	0.597TyrCys: 0.597 ± 0.014	1.377TyrAsp: 1.377 ± 0.021	1.53TyrGlu: 1.53 ± 0.023	1.193TyrPhe: 1.193 ± 0.018	1.688TyrGly: 1.688 ± 0.026	0.719TyrHis: 0.719 ± 0.014	1.081TyrIle: 1.081 ± 0.019	0.891TyrLys: 0.891 ± 0.017	2.379TyrLeu: 2.379 ± 0.032	0.666TyrMet: 0.666 ± 0.015	0.917TyrAsn: 0.917 ± 0.017	1.014TyrPro: 1.014 ± 0.018	0.773TyrGln: 0.773 ± 0.015	1.769TyrArg: 1.769 ± 0.024	1.619TyrSer: 1.619 ± 0.024	1.434TyrThr: 1.434 ± 0.023	2.025TyrVal: 2.025 ± 0.024	0.315TyrTrp: 0.315 ± 0.011	0.871TyrTyr: 0.871 ± 0.018	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.001XaaAla: 0.001 ± 0.0	0.001XaaCys: 0.001 ± 0.0	0.002XaaAsp: 0.002 ± 0.001	0.002XaaGlu: 0.002 ± 0.001	0.001XaaPhe: 0.001 ± 0.001	0.003XaaGly: 0.003 ± 0.001	0.001XaaHis: 0.001 ± 0.001	0.001XaaIle: 0.001 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.002XaaLeu: 0.002 ± 0.001	0.002XaaMet: 0.002 ± 0.001	0.001XaaAsn: 0.001 ± 0.001	0.001XaaPro: 0.001 ± 0.001	0.001XaaGln: 0.001 ± 0.001	0.004XaaArg: 0.004 ± 0.001	0.003XaaSer: 0.003 ± 0.001	0.002XaaThr: 0.002 ± 0.001	0.003XaaVal: 0.003 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 7365 proteins (3404951 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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