Amino acid dipepetide frequency for Halobacterium hubeiense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.52AlaAla: 15.52 ± 0.254	0.767AlaCys: 0.767 ± 0.035	10.762AlaAsp: 10.762 ± 0.169	8.658AlaGlu: 8.658 ± 0.127	4.341AlaPhe: 4.341 ± 0.075	10.267AlaGly: 10.267 ± 0.138	1.945AlaHis: 1.945 ± 0.048	4.285AlaIle: 4.285 ± 0.082	1.939AlaLys: 1.939 ± 0.05	11.125AlaLeu: 11.125 ± 0.15	2.112AlaMet: 2.112 ± 0.054	2.598AlaAsn: 2.598 ± 0.056	3.978AlaPro: 3.978 ± 0.071	2.302AlaGln: 2.302 ± 0.049	6.312AlaArg: 6.312 ± 0.098	5.993AlaSer: 5.993 ± 0.099	7.116AlaThr: 7.116 ± 0.124	11.677AlaVal: 11.677 ± 0.15	1.272AlaTrp: 1.272 ± 0.046	2.988AlaTyr: 2.988 ± 0.066	0.0AlaXaa: 0.0 ± 0.0
Cys	0.602CysAla: 0.602 ± 0.03	0.063CysCys: 0.063 ± 0.009	0.473CysAsp: 0.473 ± 0.025	0.644CysGlu: 0.644 ± 0.029	0.177CysPhe: 0.177 ± 0.015	0.871CysGly: 0.871 ± 0.038	0.172CysHis: 0.172 ± 0.017	0.223CysIle: 0.223 ± 0.018	0.107CysLys: 0.107 ± 0.011	0.435CysLeu: 0.435 ± 0.022	0.1CysMet: 0.1 ± 0.011	0.171CysAsn: 0.171 ± 0.013	0.585CysPro: 0.585 ± 0.026	0.176CysGln: 0.176 ± 0.015	0.41CysArg: 0.41 ± 0.022	0.44CysSer: 0.44 ± 0.022	0.377CysThr: 0.377 ± 0.019	0.49CysVal: 0.49 ± 0.023	0.072CysTrp: 0.072 ± 0.01	0.179CysTyr: 0.179 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	12.055AspAla: 12.055 ± 0.165	0.656AspCys: 0.656 ± 0.029	8.331AspAsp: 8.331 ± 0.128	7.811AspGlu: 7.811 ± 0.141	2.224AspPhe: 2.224 ± 0.049	7.703AspGly: 7.703 ± 0.119	1.884AspHis: 1.884 ± 0.045	2.79AspIle: 2.79 ± 0.071	0.968AspLys: 0.968 ± 0.036	7.446AspLeu: 7.446 ± 0.107	1.154AspMet: 1.154 ± 0.039	1.315AspAsn: 1.315 ± 0.047	4.316AspPro: 4.316 ± 0.069	1.718AspGln: 1.718 ± 0.046	5.6AspArg: 5.6 ± 0.094	3.784AspSer: 3.784 ± 0.073	4.019AspThr: 4.019 ± 0.069	9.011AspVal: 9.011 ± 0.126	1.085AspTrp: 1.085 ± 0.039	2.175AspTyr: 2.175 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	8.701GluAla: 8.701 ± 0.131	0.555GluCys: 0.555 ± 0.029	6.641GluAsp: 6.641 ± 0.115	6.88GluGlu: 6.88 ± 0.143	3.168GluPhe: 3.168 ± 0.063	5.259GluGly: 5.259 ± 0.082	2.174GluHis: 2.174 ± 0.049	3.141GluIle: 3.141 ± 0.076	1.945GluLys: 1.945 ± 0.058	7.442GluLeu: 7.442 ± 0.098	1.896GluMet: 1.896 ± 0.05	2.331GluAsn: 2.331 ± 0.059	3.86GluPro: 3.86 ± 0.079	3.103GluGln: 3.103 ± 0.07	7.52GluArg: 7.52 ± 0.118	4.717GluSer: 4.717 ± 0.078	6.025GluThr: 6.025 ± 0.087	6.133GluVal: 6.133 ± 0.087	1.159GluTrp: 1.159 ± 0.036	2.759GluTyr: 2.759 ± 0.055	0.0GluXaa: 0.0 ± 0.0
Phe	4.088PheAla: 4.088 ± 0.078	0.27PheCys: 0.27 ± 0.019	3.368PheAsp: 3.368 ± 0.071	3.153PheGlu: 3.153 ± 0.061	1.013PhePhe: 1.013 ± 0.039	3.193PheGly: 3.193 ± 0.071	0.633PheHis: 0.633 ± 0.027	0.933PheIle: 0.933 ± 0.04	0.495PheLys: 0.495 ± 0.028	2.898PheLeu: 2.898 ± 0.065	0.499PheMet: 0.499 ± 0.024	0.685PheAsn: 0.685 ± 0.027	1.389PhePro: 1.389 ± 0.041	0.852PheGln: 0.852 ± 0.033	1.793PheArg: 1.793 ± 0.045	1.756PheSer: 1.756 ± 0.044	1.947PheThr: 1.947 ± 0.048	3.517PheVal: 3.517 ± 0.07	0.403PheTrp: 0.403 ± 0.022	0.926PheTyr: 0.926 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	8.253GlyAla: 8.253 ± 0.131	0.682GlyCys: 0.682 ± 0.03	7.39GlyAsp: 7.39 ± 0.113	7.052GlyGlu: 7.052 ± 0.109	3.372GlyPhe: 3.372 ± 0.066	7.219GlyGly: 7.219 ± 0.135	1.621GlyHis: 1.621 ± 0.047	3.507GlyIle: 3.507 ± 0.068	1.883GlyLys: 1.883 ± 0.051	6.986GlyLeu: 6.986 ± 0.119	1.578GlyMet: 1.578 ± 0.041	2.032GlyAsn: 2.032 ± 0.057	3.066GlyPro: 3.066 ± 0.066	2.021GlyGln: 2.021 ± 0.05	4.553GlyArg: 4.553 ± 0.072	4.626GlySer: 4.626 ± 0.074	5.117GlyThr: 5.117 ± 0.075	8.573GlyVal: 8.573 ± 0.104	1.076GlyTrp: 1.076 ± 0.038	2.637GlyTyr: 2.637 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	2.28HisAla: 2.28 ± 0.056	0.167HisCys: 0.167 ± 0.014	1.913HisAsp: 1.913 ± 0.048	1.835HisGlu: 1.835 ± 0.049	0.559HisPhe: 0.559 ± 0.026	1.898HisGly: 1.898 ± 0.039	0.545HisHis: 0.545 ± 0.027	0.639HisIle: 0.639 ± 0.028	0.299HisLys: 0.299 ± 0.018	1.646HisLeu: 1.646 ± 0.044	0.274HisMet: 0.274 ± 0.018	0.412HisAsn: 0.412 ± 0.022	1.17HisPro: 1.17 ± 0.036	0.501HisGln: 0.501 ± 0.022	1.243HisArg: 1.243 ± 0.038	0.885HisSer: 0.885 ± 0.032	1.012HisThr: 1.012 ± 0.037	2.061HisVal: 2.061 ± 0.041	0.219HisTrp: 0.219 ± 0.016	0.627HisTyr: 0.627 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	3.877IleAla: 3.877 ± 0.068	0.211IleCys: 0.211 ± 0.015	3.215IleAsp: 3.215 ± 0.07	3.552IleGlu: 3.552 ± 0.075	0.905IlePhe: 0.905 ± 0.04	2.984IleGly: 2.984 ± 0.063	0.752IleHis: 0.752 ± 0.031	1.145IleIle: 1.145 ± 0.044	0.591IleLys: 0.591 ± 0.029	2.658IleLeu: 2.658 ± 0.073	0.403IleMet: 0.403 ± 0.02	0.858IleAsn: 0.858 ± 0.033	1.887IlePro: 1.887 ± 0.05	1.079IleGln: 1.079 ± 0.039	2.189IleArg: 2.189 ± 0.053	1.921IleSer: 1.921 ± 0.054	2.031IleThr: 2.031 ± 0.051	3.029IleVal: 3.029 ± 0.061	0.289IleTrp: 0.289 ± 0.02	0.741IleTyr: 0.741 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	1.737LysAla: 1.737 ± 0.043	0.121LysCys: 0.121 ± 0.013	1.18LysAsp: 1.18 ± 0.041	1.363LysGlu: 1.363 ± 0.047	0.571LysPhe: 0.571 ± 0.029	1.309LysGly: 1.309 ± 0.04	0.512LysHis: 0.512 ± 0.027	0.714LysIle: 0.714 ± 0.033	0.49LysLys: 0.49 ± 0.029	1.74LysLeu: 1.74 ± 0.047	0.355LysMet: 0.355 ± 0.02	0.521LysAsn: 0.521 ± 0.027	0.916LysPro: 0.916 ± 0.036	0.849LysGln: 0.849 ± 0.034	1.604LysArg: 1.604 ± 0.044	1.153LysSer: 1.153 ± 0.037	1.291LysThr: 1.291 ± 0.038	1.257LysVal: 1.257 ± 0.037	0.249LysTrp: 0.249 ± 0.018	0.629LysTyr: 0.629 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	12.249LeuAla: 12.249 ± 0.165	0.49LeuCys: 0.49 ± 0.024	8.114LeuAsp: 8.114 ± 0.114	6.206LeuGlu: 6.206 ± 0.097	3.04LeuPhe: 3.04 ± 0.077	7.558LeuGly: 7.558 ± 0.102	1.523LeuHis: 1.523 ± 0.047	2.2LeuIle: 2.2 ± 0.062	1.556LeuLys: 1.556 ± 0.039	8.292LeuLeu: 8.292 ± 0.127	1.308LeuMet: 1.308 ± 0.047	1.871LeuAsn: 1.871 ± 0.048	4.153LeuPro: 4.153 ± 0.072	2.12LeuGln: 2.12 ± 0.053	5.512LeuArg: 5.512 ± 0.079	5.213LeuSer: 5.213 ± 0.08	5.086LeuThr: 5.086 ± 0.083	8.913LeuVal: 8.913 ± 0.146	0.861LeuTrp: 0.861 ± 0.036	2.222LeuTyr: 2.222 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	1.793MetAla: 1.793 ± 0.046	0.097MetCys: 0.097 ± 0.01	1.27MetAsp: 1.27 ± 0.042	1.081MetGlu: 1.081 ± 0.041	0.498MetPhe: 0.498 ± 0.025	1.355MetGly: 1.355 ± 0.045	0.323MetHis: 0.323 ± 0.019	0.491MetIle: 0.491 ± 0.023	0.423MetLys: 0.423 ± 0.022	1.427MetLeu: 1.427 ± 0.044	0.292MetMet: 0.292 ± 0.018	0.589MetAsn: 0.589 ± 0.026	0.836MetPro: 0.836 ± 0.03	0.54MetGln: 0.54 ± 0.025	1.115MetArg: 1.115 ± 0.033	1.499MetSer: 1.499 ± 0.043	1.432MetThr: 1.432 ± 0.039	1.274MetVal: 1.274 ± 0.041	0.149MetTrp: 0.149 ± 0.013	0.367MetTyr: 0.367 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	2.719AsnAla: 2.719 ± 0.056	0.221AsnCys: 0.221 ± 0.016	1.824AsnAsp: 1.824 ± 0.046	1.727AsnGlu: 1.727 ± 0.045	0.689AsnPhe: 0.689 ± 0.028	1.921AsnGly: 1.921 ± 0.05	0.505AsnHis: 0.505 ± 0.025	0.894AsnIle: 0.894 ± 0.036	0.413AsnLys: 0.413 ± 0.024	2.028AsnLeu: 2.028 ± 0.045	0.389AsnMet: 0.389 ± 0.02	0.612AsnAsn: 0.612 ± 0.028	1.64AsnPro: 1.64 ± 0.041	0.702AsnGln: 0.702 ± 0.03	1.487AsnArg: 1.487 ± 0.041	1.119AsnSer: 1.119 ± 0.037	1.339AsnThr: 1.339 ± 0.044	2.437AsnVal: 2.437 ± 0.053	0.32AsnTrp: 0.32 ± 0.017	0.691AsnTyr: 0.691 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	4.809ProAla: 4.809 ± 0.08	0.22ProCys: 0.22 ± 0.015	4.653ProAsp: 4.653 ± 0.074	4.963ProGlu: 4.963 ± 0.081	1.559ProPhe: 1.559 ± 0.044	3.651ProGly: 3.651 ± 0.063	0.897ProHis: 0.897 ± 0.031	1.623ProIle: 1.623 ± 0.041	0.867ProLys: 0.867 ± 0.032	3.646ProLeu: 3.646 ± 0.075	0.77ProMet: 0.77 ± 0.029	1.151ProAsn: 1.151 ± 0.037	2.066ProPro: 2.066 ± 0.054	0.987ProGln: 0.987 ± 0.035	2.174ProArg: 2.174 ± 0.056	2.646ProSer: 2.646 ± 0.056	2.972ProThr: 2.972 ± 0.062	4.277ProVal: 4.277 ± 0.076	0.498ProTrp: 0.498 ± 0.025	1.089ProTyr: 1.089 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	2.519GlnAla: 2.519 ± 0.052	0.168GlnCys: 0.168 ± 0.014	1.531GlnAsp: 1.531 ± 0.048	1.708GlnGlu: 1.708 ± 0.045	1.164GlnPhe: 1.164 ± 0.035	1.515GlnGly: 1.515 ± 0.043	0.585GlnHis: 0.585 ± 0.025	0.937GlnIle: 0.937 ± 0.038	0.622GlnLys: 0.622 ± 0.031	2.373GlnLeu: 2.373 ± 0.051	0.594GlnMet: 0.594 ± 0.024	0.901GlnAsn: 0.901 ± 0.029	1.321GlnPro: 1.321 ± 0.039	1.233GlnGln: 1.233 ± 0.049	2.21GlnArg: 2.21 ± 0.051	1.904GlnSer: 1.904 ± 0.049	1.894GlnThr: 1.894 ± 0.049	1.797GlnVal: 1.797 ± 0.046	0.372GlnTrp: 0.372 ± 0.021	0.947GlnTyr: 0.947 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	6.511ArgAla: 6.511 ± 0.1	0.412ArgCys: 0.412 ± 0.025	5.346ArgAsp: 5.346 ± 0.083	7.0ArgGlu: 7.0 ± 0.109	2.105ArgPhe: 2.105 ± 0.043	4.484ArgGly: 4.484 ± 0.076	1.233ArgHis: 1.233 ± 0.035	2.478ArgIle: 2.478 ± 0.052	1.414ArgLys: 1.414 ± 0.041	5.473ArgLeu: 5.473 ± 0.088	1.146ArgMet: 1.146 ± 0.031	1.612ArgAsn: 1.612 ± 0.043	2.338ArgPro: 2.338 ± 0.053	1.821ArgGln: 1.821 ± 0.048	4.529ArgArg: 4.529 ± 0.077	3.172ArgSer: 3.172 ± 0.063	3.573ArgThr: 3.573 ± 0.066	5.959ArgVal: 5.959 ± 0.09	0.686ArgTrp: 0.686 ± 0.028	1.823ArgTyr: 1.823 ± 0.054	0.0ArgXaa: 0.0 ± 0.0
Ser	5.438SerAla: 5.438 ± 0.081	0.344SerCys: 0.344 ± 0.02	4.059SerAsp: 4.059 ± 0.069	4.555SerGlu: 4.555 ± 0.078	1.927SerPhe: 1.927 ± 0.051	5.126SerGly: 5.126 ± 0.082	1.006SerHis: 1.006 ± 0.036	2.123SerIle: 2.123 ± 0.052	1.216SerLys: 1.216 ± 0.037	4.888SerLeu: 4.888 ± 0.081	1.093SerMet: 1.093 ± 0.035	1.346SerAsn: 1.346 ± 0.04	2.544SerPro: 2.544 ± 0.056	1.44SerGln: 1.44 ± 0.05	3.144SerArg: 3.144 ± 0.059	2.99SerSer: 2.99 ± 0.078	3.413SerThr: 3.413 ± 0.064	5.165SerVal: 5.165 ± 0.079	0.645SerTrp: 0.645 ± 0.029	1.411SerTyr: 1.411 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	6.775ThrAla: 6.775 ± 0.097	0.351ThrCys: 0.351 ± 0.021	5.183ThrAsp: 5.183 ± 0.083	4.703ThrGlu: 4.703 ± 0.075	2.038ThrPhe: 2.038 ± 0.047	5.463ThrGly: 5.463 ± 0.078	1.199ThrHis: 1.199 ± 0.035	2.5ThrIle: 2.5 ± 0.056	1.071ThrLys: 1.071 ± 0.036	5.549ThrLeu: 5.549 ± 0.082	0.993ThrMet: 0.993 ± 0.036	1.511ThrAsn: 1.511 ± 0.04	3.224ThrPro: 3.224 ± 0.064	1.452ThrGln: 1.452 ± 0.04	3.182ThrArg: 3.182 ± 0.053	3.005ThrSer: 3.005 ± 0.072	4.459ThrThr: 4.459 ± 0.084	6.906ThrVal: 6.906 ± 0.12	0.6ThrTrp: 0.6 ± 0.027	1.754ThrTyr: 1.754 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	12.004ValAla: 12.004 ± 0.179	0.654ValCys: 0.654 ± 0.028	7.299ValAsp: 7.299 ± 0.105	9.078ValGlu: 9.078 ± 0.125	3.147ValPhe: 3.147 ± 0.069	8.21ValGly: 8.21 ± 0.127	1.827ValHis: 1.827 ± 0.047	2.599ValIle: 2.599 ± 0.057	1.551ValLys: 1.551 ± 0.041	8.729ValLeu: 8.729 ± 0.134	1.281ValMet: 1.281 ± 0.042	2.161ValAsn: 2.161 ± 0.053	4.501ValPro: 4.501 ± 0.07	2.22ValGln: 2.22 ± 0.051	5.73ValArg: 5.73 ± 0.09	5.154ValSer: 5.154 ± 0.078	6.468ValThr: 6.468 ± 0.094	10.829ValVal: 10.829 ± 0.151	0.905ValTrp: 0.905 ± 0.035	2.426ValTyr: 2.426 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	1.007TrpAla: 1.007 ± 0.04	0.088TrpCys: 0.088 ± 0.011	0.743TrpAsp: 0.743 ± 0.033	0.852TrpGlu: 0.852 ± 0.031	0.454TrpPhe: 0.454 ± 0.024	0.828TrpGly: 0.828 ± 0.032	0.247TrpHis: 0.247 ± 0.016	0.384TrpIle: 0.384 ± 0.021	0.287TrpLys: 0.287 ± 0.015	1.271TrpLeu: 1.271 ± 0.043	0.226TrpMet: 0.226 ± 0.016	0.356TrpAsn: 0.356 ± 0.02	0.473TrpPro: 0.473 ± 0.022	0.392TrpGln: 0.392 ± 0.022	0.858TrpArg: 0.858 ± 0.032	0.617TrpSer: 0.617 ± 0.029	0.827TrpThr: 0.827 ± 0.033	0.941TrpVal: 0.941 ± 0.037	0.237TrpTrp: 0.237 ± 0.018	0.382TrpTyr: 0.382 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.018TyrAla: 3.018 ± 0.063	0.233TyrCys: 0.233 ± 0.016	2.749TyrAsp: 2.749 ± 0.057	2.587TyrGlu: 2.587 ± 0.059	0.863TyrPhe: 0.863 ± 0.03	2.43TyrGly: 2.43 ± 0.052	0.6TyrHis: 0.6 ± 0.029	0.712TyrIle: 0.712 ± 0.031	0.425TyrLys: 0.425 ± 0.023	2.44TyrLeu: 2.44 ± 0.054	0.387TyrMet: 0.387 ± 0.02	0.645TyrAsn: 0.645 ± 0.027	1.252TyrPro: 1.252 ± 0.036	0.785TyrGln: 0.785 ± 0.03	1.953TyrArg: 1.953 ± 0.048	1.275TyrSer: 1.275 ± 0.036	1.521TyrThr: 1.521 ± 0.039	2.526TyrVal: 2.526 ± 0.048	0.373TyrTrp: 0.373 ± 0.022	0.955TyrTyr: 0.955 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3340 proteins (910421 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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