Amino acid dipepetide frequency for Thermovenabulum gondwanense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.474AlaAla: 5.474 ± 0.111	0.841AlaCys: 0.841 ± 0.043	2.976AlaAsp: 2.976 ± 0.074	4.64AlaGlu: 4.64 ± 0.087	3.154AlaPhe: 3.154 ± 0.072	5.521AlaGly: 5.521 ± 0.11	0.954AlaHis: 0.954 ± 0.041	5.707AlaIle: 5.707 ± 0.095	5.665AlaLys: 5.665 ± 0.097	7.466AlaLeu: 7.466 ± 0.108	1.751AlaMet: 1.751 ± 0.05	2.143AlaAsn: 2.143 ± 0.058	1.853AlaPro: 1.853 ± 0.059	1.875AlaGln: 1.875 ± 0.061	2.9AlaArg: 2.9 ± 0.06	3.203AlaSer: 3.203 ± 0.073	2.711AlaThr: 2.711 ± 0.06	5.891AlaVal: 5.891 ± 0.102	0.408AlaTrp: 0.408 ± 0.024	2.066AlaTyr: 2.066 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	0.761CysAla: 0.761 ± 0.034	0.133CysCys: 0.133 ± 0.013	0.568CysAsp: 0.568 ± 0.03	0.732CysGlu: 0.732 ± 0.039	0.458CysPhe: 0.458 ± 0.027	1.155CysGly: 1.155 ± 0.046	0.225CysHis: 0.225 ± 0.018	0.808CysIle: 0.808 ± 0.034	0.723CysLys: 0.723 ± 0.033	0.766CysLeu: 0.766 ± 0.04	0.212CysMet: 0.212 ± 0.018	0.459CysAsn: 0.459 ± 0.028	0.642CysPro: 0.642 ± 0.037	0.189CysGln: 0.189 ± 0.016	0.483CysArg: 0.483 ± 0.032	0.593CysSer: 0.593 ± 0.03	0.42CysThr: 0.42 ± 0.024	0.571CysVal: 0.571 ± 0.035	0.081CysTrp: 0.081 ± 0.011	0.361CysTyr: 0.361 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	2.954AspAla: 2.954 ± 0.074	0.492AspCys: 0.492 ± 0.029	1.942AspAsp: 1.942 ± 0.066	4.378AspGlu: 4.378 ± 0.089	2.775AspPhe: 2.775 ± 0.058	3.01AspGly: 3.01 ± 0.073	0.539AspHis: 0.539 ± 0.03	5.15AspIle: 5.15 ± 0.083	4.014AspLys: 4.014 ± 0.084	4.904AspLeu: 4.904 ± 0.081	1.149AspMet: 1.149 ± 0.039	1.776AspAsn: 1.776 ± 0.057	1.884AspPro: 1.884 ± 0.051	0.682AspGln: 0.682 ± 0.031	1.967AspArg: 1.967 ± 0.053	2.197AspSer: 2.197 ± 0.057	1.931AspThr: 1.931 ± 0.051	3.838AspVal: 3.838 ± 0.084	0.339AspTrp: 0.339 ± 0.021	2.311AspTyr: 2.311 ± 0.063	0.0AspXaa: 0.0 ± 0.0
Glu	5.023GluAla: 5.023 ± 0.087	0.549GluCys: 0.549 ± 0.035	4.14GluAsp: 4.14 ± 0.079	8.397GluGlu: 8.397 ± 0.14	2.951GluPhe: 2.951 ± 0.066	5.35GluGly: 5.35 ± 0.11	0.906GluHis: 0.906 ± 0.039	8.536GluIle: 8.536 ± 0.129	9.628GluLys: 9.628 ± 0.147	7.231GluLeu: 7.231 ± 0.121	2.128GluMet: 2.128 ± 0.053	4.743GluAsn: 4.743 ± 0.092	1.861GluPro: 1.861 ± 0.057	1.613GluGln: 1.613 ± 0.05	3.901GluArg: 3.901 ± 0.08	2.988GluSer: 2.988 ± 0.067	2.766GluThr: 2.766 ± 0.06	5.634GluVal: 5.634 ± 0.086	0.402GluTrp: 0.402 ± 0.029	2.719GluTyr: 2.719 ± 0.064	0.0GluXaa: 0.0 ± 0.0
Phe	3.068PheAla: 3.068 ± 0.085	0.579PheCys: 0.579 ± 0.026	2.409PheAsp: 2.409 ± 0.067	3.233PheGlu: 3.233 ± 0.065	2.414PhePhe: 2.414 ± 0.084	3.35PheGly: 3.35 ± 0.076	0.571PheHis: 0.571 ± 0.031	4.284PheIle: 4.284 ± 0.108	3.368PheLys: 3.368 ± 0.08	4.892PheLeu: 4.892 ± 0.114	1.026PheMet: 1.026 ± 0.039	2.199PheAsn: 2.199 ± 0.059	1.694PhePro: 1.694 ± 0.05	0.904PheGln: 0.904 ± 0.035	1.464PheArg: 1.464 ± 0.042	3.265PheSer: 3.265 ± 0.08	2.34PheThr: 2.34 ± 0.061	2.717PheVal: 2.717 ± 0.074	0.337PheTrp: 0.337 ± 0.024	1.892PheTyr: 1.892 ± 0.052	0.0PheXaa: 0.0 ± 0.0
Gly	5.094GlyAla: 5.094 ± 0.1	0.97GlyCys: 0.97 ± 0.039	3.103GlyAsp: 3.103 ± 0.066	5.087GlyGlu: 5.087 ± 0.091	3.617GlyPhe: 3.617 ± 0.087	5.197GlyGly: 5.197 ± 0.12	1.141GlyHis: 1.141 ± 0.045	7.804GlyIle: 7.804 ± 0.116	6.078GlyLys: 6.078 ± 0.093	6.704GlyLeu: 6.704 ± 0.108	2.023GlyMet: 2.023 ± 0.055	2.942GlyAsn: 2.942 ± 0.065	2.093GlyPro: 2.093 ± 0.06	1.645GlyGln: 1.645 ± 0.05	3.177GlyArg: 3.177 ± 0.077	3.529GlySer: 3.529 ± 0.066	3.589GlyThr: 3.589 ± 0.078	5.278GlyVal: 5.278 ± 0.095	0.502GlyTrp: 0.502 ± 0.029	2.889GlyTyr: 2.889 ± 0.066	0.0GlyXaa: 0.0 ± 0.0
His	0.839HisAla: 0.839 ± 0.035	0.177HisCys: 0.177 ± 0.017	0.576HisAsp: 0.576 ± 0.03	0.817HisGlu: 0.817 ± 0.033	0.645HisPhe: 0.645 ± 0.029	0.996HisGly: 0.996 ± 0.036	0.314HisHis: 0.314 ± 0.024	1.239HisIle: 1.239 ± 0.045	0.82HisLys: 0.82 ± 0.037	1.268HisLeu: 1.268 ± 0.041	0.302HisMet: 0.302 ± 0.019	0.558HisAsn: 0.558 ± 0.027	0.838HisPro: 0.838 ± 0.036	0.327HisGln: 0.327 ± 0.023	0.586HisArg: 0.586 ± 0.031	0.683HisSer: 0.683 ± 0.031	0.664HisThr: 0.664 ± 0.035	0.898HisVal: 0.898 ± 0.043	0.08HisTrp: 0.08 ± 0.009	0.49HisTyr: 0.49 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.793IleAla: 6.793 ± 0.1	0.913IleCys: 0.913 ± 0.044	4.679IleAsp: 4.679 ± 0.078	7.209IleGlu: 7.209 ± 0.118	4.53IlePhe: 4.53 ± 0.115	6.137IleGly: 6.137 ± 0.093	1.135IleHis: 1.135 ± 0.04	8.868IleIle: 8.868 ± 0.151	8.805IleLys: 8.805 ± 0.142	9.287IleLeu: 9.287 ± 0.133	2.097IleMet: 2.097 ± 0.059	4.786IleAsn: 4.786 ± 0.098	4.202IlePro: 4.202 ± 0.08	1.769IleGln: 1.769 ± 0.055	3.493IleArg: 3.493 ± 0.075	5.892IleSer: 5.892 ± 0.108	4.643IleThr: 4.643 ± 0.084	5.727IleVal: 5.727 ± 0.091	0.476IleTrp: 0.476 ± 0.032	3.154IleTyr: 3.154 ± 0.069	0.0IleXaa: 0.0 ± 0.0
Lys	5.821LysAla: 5.821 ± 0.108	0.664LysCys: 0.664 ± 0.04	5.092LysAsp: 5.092 ± 0.08	9.48LysGlu: 9.48 ± 0.142	2.794LysPhe: 2.794 ± 0.061	6.251LysGly: 6.251 ± 0.11	0.876LysHis: 0.876 ± 0.041	8.745LysIle: 8.745 ± 0.142	8.701LysLys: 8.701 ± 0.125	6.939LysLeu: 6.939 ± 0.109	2.367LysMet: 2.367 ± 0.054	5.673LysAsn: 5.673 ± 0.101	2.614LysPro: 2.614 ± 0.057	1.797LysGln: 1.797 ± 0.052	3.842LysArg: 3.842 ± 0.079	3.88LysSer: 3.88 ± 0.078	3.721LysThr: 3.721 ± 0.075	6.092LysVal: 6.092 ± 0.089	0.51LysTrp: 0.51 ± 0.03	2.966LysTyr: 2.966 ± 0.073	0.0LysXaa: 0.0 ± 0.0
Leu	6.182LeuAla: 6.182 ± 0.103	1.031LeuCys: 1.031 ± 0.042	4.408LeuAsp: 4.408 ± 0.088	7.257LeuGlu: 7.257 ± 0.107	4.308LeuPhe: 4.308 ± 0.104	6.816LeuGly: 6.816 ± 0.124	1.109LeuHis: 1.109 ± 0.048	8.524LeuIle: 8.524 ± 0.112	9.942LeuLys: 9.942 ± 0.139	9.347LeuLeu: 9.347 ± 0.139	2.539LeuMet: 2.539 ± 0.065	4.869LeuAsn: 4.869 ± 0.097	3.783LeuPro: 3.783 ± 0.066	2.221LeuGln: 2.221 ± 0.069	4.038LeuArg: 4.038 ± 0.085	6.705LeuSer: 6.705 ± 0.125	4.378LeuThr: 4.378 ± 0.081	5.601LeuVal: 5.601 ± 0.106	0.571LeuTrp: 0.571 ± 0.032	3.1LeuTyr: 3.1 ± 0.078	0.0LeuXaa: 0.0 ± 0.0
Met	1.975MetAla: 1.975 ± 0.056	0.191MetCys: 0.191 ± 0.018	1.402MetAsp: 1.402 ± 0.048	2.212MetGlu: 2.212 ± 0.06	0.781MetPhe: 0.781 ± 0.038	2.172MetGly: 2.172 ± 0.06	0.321MetHis: 0.321 ± 0.021	1.985MetIle: 1.985 ± 0.053	2.219MetLys: 2.219 ± 0.051	2.215MetLeu: 2.215 ± 0.065	0.655MetMet: 0.655 ± 0.029	1.115MetAsn: 1.115 ± 0.04	1.077MetPro: 1.077 ± 0.043	0.598MetGln: 0.598 ± 0.031	1.003MetArg: 1.003 ± 0.04	1.259MetSer: 1.259 ± 0.047	1.124MetThr: 1.124 ± 0.039	1.882MetVal: 1.882 ± 0.051	0.152MetTrp: 0.152 ± 0.016	0.604MetTyr: 0.604 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	2.752AsnAla: 2.752 ± 0.067	0.554AsnCys: 0.554 ± 0.029	1.823AsnAsp: 1.823 ± 0.048	3.126AsnGlu: 3.126 ± 0.072	2.545AsnPhe: 2.545 ± 0.068	2.742AsnGly: 2.742 ± 0.067	0.527AsnHis: 0.527 ± 0.029	5.118AsnIle: 5.118 ± 0.088	3.718AsnLys: 3.718 ± 0.083	5.215AsnLeu: 5.215 ± 0.087	1.184AsnMet: 1.184 ± 0.044	2.308AsnAsn: 2.308 ± 0.066	2.442AsnPro: 2.442 ± 0.062	1.019AsnGln: 1.019 ± 0.052	1.742AsnArg: 1.742 ± 0.049	2.496AsnSer: 2.496 ± 0.068	2.165AsnThr: 2.165 ± 0.055	3.037AsnVal: 3.037 ± 0.076	0.345AsnTrp: 0.345 ± 0.024	2.016AsnTyr: 2.016 ± 0.06	0.0AsnXaa: 0.0 ± 0.0
Pro	2.337ProAla: 2.337 ± 0.059	0.374ProCys: 0.374 ± 0.024	1.962ProAsp: 1.962 ± 0.054	3.589ProGlu: 3.589 ± 0.078	1.916ProPhe: 1.916 ± 0.057	3.118ProGly: 3.118 ± 0.077	0.633ProHis: 0.633 ± 0.034	2.604ProIle: 2.604 ± 0.059	2.365ProLys: 2.365 ± 0.052	3.642ProLeu: 3.642 ± 0.076	0.797ProMet: 0.797 ± 0.038	1.237ProAsn: 1.237 ± 0.046	1.281ProPro: 1.281 ± 0.04	0.97ProGln: 0.97 ± 0.038	1.287ProArg: 1.287 ± 0.039	1.835ProSer: 1.835 ± 0.058	1.537ProThr: 1.537 ± 0.046	3.567ProVal: 3.567 ± 0.068	0.324ProTrp: 0.324 ± 0.023	1.527ProTyr: 1.527 ± 0.049	0.0ProXaa: 0.0 ± 0.0
Gln	1.56GlnAla: 1.56 ± 0.052	0.194GlnCys: 0.194 ± 0.017	1.053GlnAsp: 1.053 ± 0.046	1.998GlnGlu: 1.998 ± 0.059	0.71GlnPhe: 0.71 ± 0.034	1.505GlnGly: 1.505 ± 0.048	0.311GlnHis: 0.311 ± 0.02	2.037GlnIle: 2.037 ± 0.064	2.433GlnLys: 2.433 ± 0.069	1.904GlnLeu: 1.904 ± 0.055	0.604GlnMet: 0.604 ± 0.031	1.255GlnAsn: 1.255 ± 0.042	0.689GlnPro: 0.689 ± 0.031	0.688GlnGln: 0.688 ± 0.059	1.009GlnArg: 1.009 ± 0.037	0.953GlnSer: 0.953 ± 0.038	0.881GlnThr: 0.881 ± 0.037	1.523GlnVal: 1.523 ± 0.05	0.158GlnTrp: 0.158 ± 0.016	0.652GlnTyr: 0.652 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	2.783ArgAla: 2.783 ± 0.058	0.399ArgCys: 0.399 ± 0.026	1.976ArgAsp: 1.976 ± 0.061	4.098ArgGlu: 4.098 ± 0.083	1.823ArgPhe: 1.823 ± 0.049	2.866ArgGly: 2.866 ± 0.071	0.558ArgHis: 0.558 ± 0.028	4.059ArgIle: 4.059 ± 0.086	3.396ArgLys: 3.396 ± 0.076	3.931ArgLeu: 3.931 ± 0.08	1.112ArgMet: 1.112 ± 0.043	1.779ArgAsn: 1.779 ± 0.051	1.308ArgPro: 1.308 ± 0.053	1.075ArgGln: 1.075 ± 0.044	1.87ArgArg: 1.87 ± 0.058	1.557ArgSer: 1.557 ± 0.048	1.708ArgThr: 1.708 ± 0.049	3.216ArgVal: 3.216 ± 0.072	0.303ArgTrp: 0.303 ± 0.019	1.428ArgTyr: 1.428 ± 0.053	0.0ArgXaa: 0.0 ± 0.0
Ser	3.311SerAla: 3.311 ± 0.079	0.62SerCys: 0.62 ± 0.028	2.18SerAsp: 2.18 ± 0.061	3.571SerGlu: 3.571 ± 0.08	2.891SerPhe: 2.891 ± 0.067	4.336SerGly: 4.336 ± 0.088	0.8SerHis: 0.8 ± 0.038	4.835SerIle: 4.835 ± 0.083	4.202SerLys: 4.202 ± 0.079	5.757SerLeu: 5.757 ± 0.107	1.327SerMet: 1.327 ± 0.05	2.019SerAsn: 2.019 ± 0.053	2.146SerPro: 2.146 ± 0.06	1.34SerGln: 1.34 ± 0.041	2.18SerArg: 2.18 ± 0.06	3.159SerSer: 3.159 ± 0.087	2.352SerThr: 2.352 ± 0.051	3.294SerVal: 3.294 ± 0.069	0.358SerTrp: 0.358 ± 0.027	1.929SerTyr: 1.929 ± 0.049	0.0SerXaa: 0.0 ± 0.0
Thr	3.434ThrAla: 3.434 ± 0.079	0.455ThrCys: 0.455 ± 0.026	1.898ThrAsp: 1.898 ± 0.05	2.68ThrGlu: 2.68 ± 0.061	2.003ThrPhe: 2.003 ± 0.054	4.347ThrGly: 4.347 ± 0.082	0.672ThrHis: 0.672 ± 0.034	3.64ThrIle: 3.64 ± 0.078	2.994ThrLys: 2.994 ± 0.072	4.559ThrLeu: 4.559 ± 0.088	0.954ThrMet: 0.954 ± 0.039	1.607ThrAsn: 1.607 ± 0.048	2.194ThrPro: 2.194 ± 0.067	1.01ThrGln: 1.01 ± 0.04	1.707ThrArg: 1.707 ± 0.042	2.384ThrSer: 2.384 ± 0.058	2.143ThrThr: 2.143 ± 0.059	3.685ThrVal: 3.685 ± 0.077	0.261ThrTrp: 0.261 ± 0.022	1.49ThrTyr: 1.49 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	4.601ValAla: 4.601 ± 0.087	0.716ValCys: 0.716 ± 0.038	3.724ValAsp: 3.724 ± 0.074	5.69ValGlu: 5.69 ± 0.091	3.383ValPhe: 3.383 ± 0.073	4.455ValGly: 4.455 ± 0.087	0.885ValHis: 0.885 ± 0.04	6.861ValIle: 6.861 ± 0.111	6.489ValLys: 6.489 ± 0.096	6.628ValLeu: 6.628 ± 0.102	1.766ValMet: 1.766 ± 0.054	3.294ValAsn: 3.294 ± 0.065	2.638ValPro: 2.638 ± 0.069	1.378ValGln: 1.378 ± 0.04	2.705ValArg: 2.705 ± 0.067	3.801ValSer: 3.801 ± 0.071	3.156ValThr: 3.156 ± 0.068	5.268ValVal: 5.268 ± 0.109	0.412ValTrp: 0.412 ± 0.027	2.336ValTyr: 2.336 ± 0.055	0.0ValXaa: 0.0 ± 0.0
Trp	0.44TrpAla: 0.44 ± 0.025	0.059TrpCys: 0.059 ± 0.01	0.368TrpAsp: 0.368 ± 0.027	0.54TrpGlu: 0.54 ± 0.027	0.28TrpPhe: 0.28 ± 0.022	0.527TrpGly: 0.527 ± 0.029	0.097TrpHis: 0.097 ± 0.011	0.507TrpIle: 0.507 ± 0.028	0.436TrpLys: 0.436 ± 0.022	0.558TrpLeu: 0.558 ± 0.031	0.199TrpMet: 0.199 ± 0.018	0.287TrpAsn: 0.287 ± 0.022	0.271TrpPro: 0.271 ± 0.019	0.222TrpGln: 0.222 ± 0.018	0.255TrpArg: 0.255 ± 0.019	0.286TrpSer: 0.286 ± 0.022	0.252TrpThr: 0.252 ± 0.02	0.439TrpVal: 0.439 ± 0.026	0.077TrpTrp: 0.077 ± 0.012	0.225TrpTyr: 0.225 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.997TyrAla: 1.997 ± 0.052	0.43TyrCys: 0.43 ± 0.028	1.951TyrAsp: 1.951 ± 0.057	2.73TyrGlu: 2.73 ± 0.063	2.031TyrPhe: 2.031 ± 0.062	2.611TyrGly: 2.611 ± 0.066	0.542TyrHis: 0.542 ± 0.029	3.287TyrIle: 3.287 ± 0.064	2.829TyrLys: 2.829 ± 0.063	3.515TyrLeu: 3.515 ± 0.069	0.748TyrMet: 0.748 ± 0.028	1.825TyrAsn: 1.825 ± 0.05	1.395TyrPro: 1.395 ± 0.049	0.794TyrGln: 0.794 ± 0.034	1.638TyrArg: 1.638 ± 0.047	1.938TyrSer: 1.938 ± 0.054	1.638TyrThr: 1.638 ± 0.05	2.028TyrVal: 2.028 ± 0.061	0.231TyrTrp: 0.231 ± 0.02	1.561TyrTyr: 1.561 ± 0.051	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2237 proteins (679041 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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