Amino acid dipepetide frequency for Tolypothrix bouteillei VB521301

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.862AlaAla: 6.862 ± 0.077	0.841AlaCys: 0.841 ± 0.019	3.587AlaAsp: 3.587 ± 0.045	4.833AlaGlu: 4.833 ± 0.051	3.072AlaPhe: 3.072 ± 0.038	5.124AlaGly: 5.124 ± 0.061	1.296AlaHis: 1.296 ± 0.023	6.796AlaIle: 6.796 ± 0.066	4.103AlaLys: 4.103 ± 0.039	8.759AlaLeu: 8.759 ± 0.081	1.602AlaMet: 1.602 ± 0.029	3.381AlaAsn: 3.381 ± 0.049	2.765AlaPro: 2.765 ± 0.041	3.892AlaGln: 3.892 ± 0.051	3.96AlaArg: 3.96 ± 0.048	5.114AlaSer: 5.114 ± 0.058	4.726AlaThr: 4.726 ± 0.049	5.604AlaVal: 5.604 ± 0.053	1.015AlaTrp: 1.015 ± 0.023	2.362AlaTyr: 2.362 ± 0.034	0.003AlaXaa: 0.003 ± 0.002
Cys	0.659CysAla: 0.659 ± 0.019	0.166CysCys: 0.166 ± 0.008	0.578CysAsp: 0.578 ± 0.017	0.522CysGlu: 0.522 ± 0.015	0.431CysPhe: 0.431 ± 0.014	0.777CysGly: 0.777 ± 0.019	0.287CysHis: 0.287 ± 0.011	0.631CysIle: 0.631 ± 0.018	0.402CysLys: 0.402 ± 0.014	1.139CysLeu: 1.139 ± 0.024	0.173CysMet: 0.173 ± 0.01	0.377CysAsn: 0.377 ± 0.012	0.524CysPro: 0.524 ± 0.016	0.566CysGln: 0.566 ± 0.016	0.494CysArg: 0.494 ± 0.016	0.672CysSer: 0.672 ± 0.017	0.504CysThr: 0.504 ± 0.013	0.613CysVal: 0.613 ± 0.018	0.147CysTrp: 0.147 ± 0.007	0.376CysTyr: 0.376 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	3.589AspAla: 3.589 ± 0.042	0.543AspCys: 0.543 ± 0.016	2.154AspAsp: 2.154 ± 0.04	2.985AspGlu: 2.985 ± 0.044	2.233AspPhe: 2.233 ± 0.033	3.419AspGly: 3.419 ± 0.052	0.485AspHis: 0.485 ± 0.017	3.416AspIle: 3.416 ± 0.036	2.427AspLys: 2.427 ± 0.036	5.381AspLeu: 5.381 ± 0.056	0.745AspMet: 0.745 ± 0.017	2.017AspAsn: 2.017 ± 0.039	2.224AspPro: 2.224 ± 0.034	1.076AspGln: 1.076 ± 0.019	3.616AspArg: 3.616 ± 0.043	3.017AspSer: 3.017 ± 0.036	2.621AspThr: 2.621 ± 0.041	3.055AspVal: 3.055 ± 0.036	0.903AspTrp: 0.903 ± 0.02	1.721AspTyr: 1.721 ± 0.029	0.003AspXaa: 0.003 ± 0.002
Glu	5.32GluAla: 5.32 ± 0.048	0.51GluCys: 0.51 ± 0.015	2.759GluAsp: 2.759 ± 0.047	4.327GluGlu: 4.327 ± 0.057	2.494GluPhe: 2.494 ± 0.036	3.333GluGly: 3.333 ± 0.039	1.063GluHis: 1.063 ± 0.023	4.733GluIle: 4.733 ± 0.044	3.663GluLys: 3.663 ± 0.051	6.992GluLeu: 6.992 ± 0.064	1.296GluMet: 1.296 ± 0.024	2.799GluAsn: 2.799 ± 0.034	2.466GluPro: 2.466 ± 0.03	3.719GluGln: 3.719 ± 0.05	3.715GluArg: 3.715 ± 0.044	3.492GluSer: 3.492 ± 0.045	3.565GluThr: 3.565 ± 0.043	4.491GluVal: 4.491 ± 0.049	0.834GluTrp: 0.834 ± 0.019	1.909GluTyr: 1.909 ± 0.033	0.003GluXaa: 0.003 ± 0.001
Phe	3.171PheAla: 3.171 ± 0.042	0.54PheCys: 0.54 ± 0.015	2.185PheAsp: 2.185 ± 0.034	2.277PheGlu: 2.277 ± 0.036	1.767PhePhe: 1.767 ± 0.029	2.924PheGly: 2.924 ± 0.036	0.808PheHis: 0.808 ± 0.02	2.396PheIle: 2.396 ± 0.03	1.618PheLys: 1.618 ± 0.028	4.253PheLeu: 4.253 ± 0.049	0.685PheMet: 0.685 ± 0.016	1.776PheAsn: 1.776 ± 0.033	1.817PhePro: 1.817 ± 0.027	1.88PheGln: 1.88 ± 0.027	1.821PheArg: 1.821 ± 0.027	3.052PheSer: 3.052 ± 0.041	2.323PheThr: 2.323 ± 0.036	2.557PheVal: 2.557 ± 0.034	0.707PheTrp: 0.707 ± 0.018	1.389PheTyr: 1.389 ± 0.026	0.003PheXaa: 0.003 ± 0.001
Gly	4.703GlyAla: 4.703 ± 0.057	0.748GlyCys: 0.748 ± 0.02	3.235GlyAsp: 3.235 ± 0.044	4.084GlyGlu: 4.084 ± 0.04	2.961GlyPhe: 2.961 ± 0.033	4.719GlyGly: 4.719 ± 0.072	1.32GlyHis: 1.32 ± 0.028	4.94GlyIle: 4.94 ± 0.051	3.998GlyLys: 3.998 ± 0.045	6.733GlyLeu: 6.733 ± 0.066	1.471GlyMet: 1.471 ± 0.03	3.083GlyAsn: 3.083 ± 0.058	1.317GlyPro: 1.317 ± 0.026	2.927GlyGln: 2.927 ± 0.043	3.294GlyArg: 3.294 ± 0.041	4.204GlySer: 4.204 ± 0.05	3.986GlyThr: 3.986 ± 0.055	4.811GlyVal: 4.811 ± 0.045	1.071GlyTrp: 1.071 ± 0.022	2.383GlyTyr: 2.383 ± 0.031	0.003GlyXaa: 0.003 ± 0.002
His	1.111HisAla: 1.111 ± 0.023	0.266HisCys: 0.266 ± 0.01	0.759HisAsp: 0.759 ± 0.019	0.981HisGlu: 0.981 ± 0.019	0.801HisPhe: 0.801 ± 0.018	1.104HisGly: 1.104 ± 0.023	0.559HisHis: 0.559 ± 0.02	1.166HisIle: 1.166 ± 0.024	0.822HisLys: 0.822 ± 0.022	2.258HisLeu: 2.258 ± 0.031	0.277HisMet: 0.277 ± 0.011	0.738HisAsn: 0.738 ± 0.016	1.277HisPro: 1.277 ± 0.026	1.102HisGln: 1.102 ± 0.027	1.068HisArg: 1.068 ± 0.022	1.293HisSer: 1.293 ± 0.023	0.953HisThr: 0.953 ± 0.025	0.872HisVal: 0.872 ± 0.018	0.347HisTrp: 0.347 ± 0.011	0.688HisTyr: 0.688 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	7.027IleAla: 7.027 ± 0.058	0.751IleCys: 0.751 ± 0.018	3.513IleAsp: 3.513 ± 0.04	4.341IleGlu: 4.341 ± 0.051	2.541IlePhe: 2.541 ± 0.039	4.469IleGly: 4.469 ± 0.046	1.253IleHis: 1.253 ± 0.022	3.395IleIle: 3.395 ± 0.041	3.024IleLys: 3.024 ± 0.043	6.654IleLeu: 6.654 ± 0.057	0.814IleMet: 0.814 ± 0.02	2.813IleAsn: 2.813 ± 0.04	3.498IlePro: 3.498 ± 0.043	3.101IleGln: 3.101 ± 0.043	3.166IleArg: 3.166 ± 0.038	4.474IleSer: 4.474 ± 0.047	3.504IleThr: 3.504 ± 0.044	4.612IleVal: 4.612 ± 0.043	0.868IleTrp: 0.868 ± 0.02	1.963IleTyr: 1.963 ± 0.028	0.005IleXaa: 0.005 ± 0.001
Lys	4.003LysAla: 4.003 ± 0.048	0.334LysCys: 0.334 ± 0.013	2.359LysAsp: 2.359 ± 0.033	3.098LysGlu: 3.098 ± 0.044	1.841LysPhe: 1.841 ± 0.027	2.841LysGly: 2.841 ± 0.04	0.898LysHis: 0.898 ± 0.019	3.483LysIle: 3.483 ± 0.045	2.534LysLys: 2.534 ± 0.04	5.541LysLeu: 5.541 ± 0.052	0.935LysMet: 0.935 ± 0.021	2.297LysAsn: 2.297 ± 0.039	2.513LysPro: 2.513 ± 0.033	2.862LysGln: 2.862 ± 0.034	2.537LysArg: 2.537 ± 0.035	3.003LysSer: 3.003 ± 0.037	3.102LysThr: 3.102 ± 0.041	3.385LysVal: 3.385 ± 0.038	0.525LysTrp: 0.525 ± 0.015	1.545LysTyr: 1.545 ± 0.026	0.002LysXaa: 0.002 ± 0.001
Leu	9.371LeuAla: 9.371 ± 0.081	1.084LeuCys: 1.084 ± 0.022	5.216LeuAsp: 5.216 ± 0.053	7.427LeuGlu: 7.427 ± 0.07	3.878LeuPhe: 3.878 ± 0.047	7.339LeuGly: 7.339 ± 0.058	1.983LeuHis: 1.983 ± 0.031	6.477LeuIle: 6.477 ± 0.065	5.711LeuLys: 5.711 ± 0.061	11.653LeuLeu: 11.653 ± 0.106	2.02LeuMet: 2.02 ± 0.033	4.655LeuAsn: 4.655 ± 0.049	5.526LeuPro: 5.526 ± 0.057	5.865LeuGln: 5.865 ± 0.054	5.687LeuArg: 5.687 ± 0.058	7.721LeuSer: 7.721 ± 0.061	6.298LeuThr: 6.298 ± 0.053	7.276LeuVal: 7.276 ± 0.065	1.479LeuTrp: 1.479 ± 0.033	2.816LeuTyr: 2.816 ± 0.034	0.005LeuXaa: 0.005 ± 0.003
Met	1.604MetAla: 1.604 ± 0.028	0.133MetCys: 0.133 ± 0.007	0.714MetAsp: 0.714 ± 0.018	1.035MetGlu: 1.035 ± 0.022	0.568MetPhe: 0.568 ± 0.017	1.271MetGly: 1.271 ± 0.024	0.326MetHis: 0.326 ± 0.012	0.943MetIle: 0.943 ± 0.021	1.001MetLys: 1.001 ± 0.022	1.88MetLeu: 1.88 ± 0.026	0.404MetMet: 0.404 ± 0.014	0.865MetAsn: 0.865 ± 0.018	0.889MetPro: 0.889 ± 0.02	0.904MetGln: 0.904 ± 0.021	0.975MetArg: 0.975 ± 0.02	1.331MetSer: 1.331 ± 0.023	1.351MetThr: 1.351 ± 0.026	1.246MetVal: 1.246 ± 0.023	0.169MetTrp: 0.169 ± 0.008	0.376MetTyr: 0.376 ± 0.012	0.001MetXaa: 0.001 ± 0.001
Asn	3.156AsnAla: 3.156 ± 0.038	0.481AsnCys: 0.481 ± 0.015	1.721AsnAsp: 1.721 ± 0.036	2.0AsnGlu: 2.0 ± 0.028	1.998AsnPhe: 1.998 ± 0.035	2.846AsnGly: 2.846 ± 0.049	0.807AsnHis: 0.807 ± 0.019	2.825AsnIle: 2.825 ± 0.042	1.823AsnLys: 1.823 ± 0.031	5.379AsnLeu: 5.379 ± 0.061	0.59AsnMet: 0.59 ± 0.016	2.078AsnAsn: 2.078 ± 0.041	2.836AsnPro: 2.836 ± 0.033	2.457AsnGln: 2.457 ± 0.035	2.467AsnArg: 2.467 ± 0.036	3.176AsnSer: 3.176 ± 0.045	2.433AsnThr: 2.433 ± 0.043	2.39AsnVal: 2.39 ± 0.036	0.744AsnTrp: 0.744 ± 0.017	1.5AsnTyr: 1.5 ± 0.027	0.001AsnXaa: 0.001 ± 0.001
Pro	2.849ProAla: 2.849 ± 0.038	0.335ProCys: 0.335 ± 0.012	2.726ProAsp: 2.726 ± 0.035	3.728ProGlu: 3.728 ± 0.042	1.759ProPhe: 1.759 ± 0.025	2.928ProGly: 2.928 ± 0.041	0.911ProHis: 0.911 ± 0.019	3.019ProIle: 3.019 ± 0.037	2.338ProLys: 2.338 ± 0.033	4.623ProLeu: 4.623 ± 0.057	0.727ProMet: 0.727 ± 0.017	2.337ProAsn: 2.337 ± 0.032	2.284ProPro: 2.284 ± 0.037	2.479ProGln: 2.479 ± 0.039	1.725ProArg: 1.725 ± 0.028	3.177ProSer: 3.177 ± 0.046	2.924ProThr: 2.924 ± 0.043	3.398ProVal: 3.398 ± 0.043	0.592ProTrp: 0.592 ± 0.017	1.372ProTyr: 1.372 ± 0.026	0.002ProXaa: 0.002 ± 0.001
Gln	4.522GlnAla: 4.522 ± 0.058	0.364GlnCys: 0.364 ± 0.014	2.052GlnAsp: 2.052 ± 0.031	3.633GlnGlu: 3.633 ± 0.051	1.769GlnPhe: 1.769 ± 0.028	3.038GlnGly: 3.038 ± 0.04	0.879GlnHis: 0.879 ± 0.02	3.529GlnIle: 3.529 ± 0.036	2.876GlnLys: 2.876 ± 0.038	5.943GlnLeu: 5.943 ± 0.071	1.06GlnMet: 1.06 ± 0.022	2.136GlnAsn: 2.136 ± 0.032	2.489GlnPro: 2.489 ± 0.037	3.81GlnGln: 3.81 ± 0.056	2.898GlnArg: 2.898 ± 0.036	2.991GlnSer: 2.991 ± 0.038	2.871GlnThr: 2.871 ± 0.033	3.632GlnVal: 3.632 ± 0.046	0.67GlnTrp: 0.67 ± 0.018	1.319GlnTyr: 1.319 ± 0.021	0.003GlnXaa: 0.003 ± 0.002
Arg	3.535ArgAla: 3.535 ± 0.038	0.518ArgCys: 0.518 ± 0.016	2.649ArgAsp: 2.649 ± 0.033	3.515ArgGlu: 3.515 ± 0.04	2.232ArgPhe: 2.232 ± 0.034	3.078ArgGly: 3.078 ± 0.036	1.017ArgHis: 1.017 ± 0.022	3.453ArgIle: 3.453 ± 0.041	2.402ArgLys: 2.402 ± 0.036	6.043ArgLeu: 6.043 ± 0.06	1.057ArgMet: 1.057 ± 0.021	2.287ArgAsn: 2.287 ± 0.029	2.035ArgPro: 2.035 ± 0.035	3.207ArgGln: 3.207 ± 0.041	3.08ArgArg: 3.08 ± 0.046	3.446ArgSer: 3.446 ± 0.038	2.684ArgThr: 2.684 ± 0.032	3.669ArgVal: 3.669 ± 0.042	0.817ArgTrp: 0.817 ± 0.019	1.971ArgTyr: 1.971 ± 0.032	0.001ArgXaa: 0.001 ± 0.001
Ser	4.513SerAla: 4.513 ± 0.05	0.648SerCys: 0.648 ± 0.017	3.348SerAsp: 3.348 ± 0.038	3.926SerGlu: 3.926 ± 0.047	2.762SerPhe: 2.762 ± 0.033	4.768SerGly: 4.768 ± 0.059	1.372SerHis: 1.372 ± 0.025	4.028SerIle: 4.028 ± 0.038	2.868SerLys: 2.868 ± 0.041	7.458SerLeu: 7.458 ± 0.063	1.175SerMet: 1.175 ± 0.022	2.854SerAsn: 2.854 ± 0.042	3.518SerPro: 3.518 ± 0.046	3.715SerGln: 3.715 ± 0.046	3.286SerArg: 3.286 ± 0.039	4.836SerSer: 4.836 ± 0.054	3.818SerThr: 3.818 ± 0.037	4.52SerVal: 4.52 ± 0.048	0.938SerTrp: 0.938 ± 0.018	1.904SerTyr: 1.904 ± 0.033	0.003SerXaa: 0.003 ± 0.002
Thr	4.783ThrAla: 4.783 ± 0.057	0.478ThrCys: 0.478 ± 0.016	2.618ThrAsp: 2.618 ± 0.038	3.331ThrGlu: 3.331 ± 0.043	2.213ThrPhe: 2.213 ± 0.035	4.315ThrGly: 4.315 ± 0.057	1.127ThrHis: 1.127 ± 0.022	3.788ThrIle: 3.788 ± 0.042	2.444ThrLys: 2.444 ± 0.039	6.398ThrLeu: 6.398 ± 0.055	0.787ThrMet: 0.787 ± 0.018	2.349ThrAsn: 2.349 ± 0.037	3.419ThrPro: 3.419 ± 0.041	2.931ThrGln: 2.931 ± 0.041	2.482ThrArg: 2.482 ± 0.032	3.784ThrSer: 3.784 ± 0.042	3.423ThrThr: 3.423 ± 0.05	4.338ThrVal: 4.338 ± 0.045	0.716ThrTrp: 0.716 ± 0.016	1.624ThrTyr: 1.624 ± 0.027	0.005ThrXaa: 0.005 ± 0.002
Val	5.938ValAla: 5.938 ± 0.056	0.728ValCys: 0.728 ± 0.017	3.364ValAsp: 3.364 ± 0.037	4.674ValGlu: 4.674 ± 0.047	2.663ValPhe: 2.663 ± 0.035	4.676ValGly: 4.676 ± 0.054	1.062ValHis: 1.062 ± 0.022	4.155ValIle: 4.155 ± 0.04	3.483ValLys: 3.483 ± 0.045	7.11ValLeu: 7.11 ± 0.065	1.41ValMet: 1.41 ± 0.028	2.898ValAsn: 2.898 ± 0.037	3.036ValPro: 3.036 ± 0.038	2.983ValGln: 2.983 ± 0.037	3.525ValArg: 3.525 ± 0.038	4.602ValSer: 4.602 ± 0.049	4.042ValThr: 4.042 ± 0.045	4.989ValVal: 4.989 ± 0.06	0.882ValTrp: 0.882 ± 0.021	1.913ValTyr: 1.913 ± 0.027	0.004ValXaa: 0.004 ± 0.001
Trp	0.875TrpAla: 0.875 ± 0.019	0.148TrpCys: 0.148 ± 0.008	0.672TrpAsp: 0.672 ± 0.018	0.936TrpGlu: 0.936 ± 0.02	0.612TrpPhe: 0.612 ± 0.018	0.939TrpGly: 0.939 ± 0.022	0.341TrpHis: 0.341 ± 0.012	0.875TrpIle: 0.875 ± 0.02	0.674TrpLys: 0.674 ± 0.018	1.79TrpLeu: 1.79 ± 0.035	0.315TrpMet: 0.315 ± 0.011	0.694TrpAsn: 0.694 ± 0.018	0.214TrpPro: 0.214 ± 0.01	1.084TrpGln: 1.084 ± 0.025	0.864TrpArg: 0.864 ± 0.024	0.89TrpSer: 0.89 ± 0.022	0.644TrpThr: 0.644 ± 0.018	0.953TrpVal: 0.953 ± 0.022	0.24TrpTrp: 0.24 ± 0.012	0.466TrpTyr: 0.466 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.103TyrAla: 2.103 ± 0.028	0.421TyrCys: 0.421 ± 0.013	1.419TyrAsp: 1.419 ± 0.027	1.826TyrGlu: 1.826 ± 0.029	1.353TyrPhe: 1.353 ± 0.026	2.083TyrGly: 2.083 ± 0.032	0.648TyrHis: 0.648 ± 0.017	1.734TyrIle: 1.734 ± 0.026	1.427TyrLys: 1.427 ± 0.029	3.493TyrLeu: 3.493 ± 0.038	0.439TyrMet: 0.439 ± 0.014	1.273TyrAsn: 1.273 ± 0.026	1.582TyrPro: 1.582 ± 0.031	1.921TyrGln: 1.921 ± 0.029	2.032TyrArg: 2.032 ± 0.032	1.981TyrSer: 1.981 ± 0.029	1.577TyrThr: 1.577 ± 0.028	1.72TyrVal: 1.72 ± 0.027	0.563TyrTrp: 0.563 ± 0.016	1.097TyrTyr: 1.097 ± 0.025	0.003TyrXaa: 0.003 ± 0.001
Xaa	0.004XaaAla: 0.004 ± 0.002	0.001XaaCys: 0.001 ± 0.001	0.003XaaAsp: 0.003 ± 0.002	0.005XaaGlu: 0.005 ± 0.002	0.002XaaPhe: 0.002 ± 0.001	0.003XaaGly: 0.003 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.005XaaIle: 0.005 ± 0.002	0.001XaaLys: 0.001 ± 0.001	0.005XaaLeu: 0.005 ± 0.002	0.002XaaMet: 0.002 ± 0.001	0.003XaaAsn: 0.003 ± 0.002	0.002XaaPro: 0.002 ± 0.001	0.002XaaGln: 0.002 ± 0.002	0.003XaaArg: 0.003 ± 0.001	0.002XaaSer: 0.002 ± 0.001	0.003XaaThr: 0.003 ± 0.001	0.002XaaVal: 0.002 ± 0.002	0.002XaaTrp: 0.002 ± 0.001	0.001XaaTyr: 0.001 ± 0.001	0.027XaaXaa: 0.027 ± 0.009

Statistics based on 7755 proteins (2420647 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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