Amino acid dipepetide frequency for Aureimonas fodinaquatilis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.516AlaAla: 15.516 ± 0.165
0.925AlaCys: 0.925 ± 0.032
6.604AlaAsp: 6.604 ± 0.089
7.338AlaGlu: 7.338 ± 0.094
4.545AlaPhe: 4.545 ± 0.067
10.742AlaGly: 10.742 ± 0.102
1.973AlaHis: 1.973 ± 0.048
6.795AlaIle: 6.795 ± 0.087
3.407AlaLys: 3.407 ± 0.057
12.83AlaLeu: 12.83 ± 0.136
3.642AlaMet: 3.642 ± 0.058
3.256AlaAsn: 3.256 ± 0.063
4.943AlaPro: 4.943 ± 0.08
4.343AlaGln: 4.343 ± 0.071
7.845AlaArg: 7.845 ± 0.095
6.714AlaSer: 6.714 ± 0.084
5.955AlaThr: 5.955 ± 0.075
8.579AlaVal: 8.579 ± 0.089
1.168AlaTrp: 1.168 ± 0.038
2.597AlaTyr: 2.597 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
0.817CysAla: 0.817 ± 0.031
0.1CysCys: 0.1 ± 0.009
0.457CysAsp: 0.457 ± 0.021
0.418CysGlu: 0.418 ± 0.019
0.317CysPhe: 0.317 ± 0.016
0.867CysGly: 0.867 ± 0.028
0.203CysHis: 0.203 ± 0.012
0.434CysIle: 0.434 ± 0.019
0.176CysLys: 0.176 ± 0.012
0.792CysLeu: 0.792 ± 0.026
0.148CysMet: 0.148 ± 0.01
0.233CysAsn: 0.233 ± 0.014
0.381CysPro: 0.381 ± 0.018
0.247CysGln: 0.247 ± 0.016
0.553CysArg: 0.553 ± 0.026
0.436CysSer: 0.436 ± 0.023
0.395CysThr: 0.395 ± 0.02
0.578CysVal: 0.578 ± 0.025
0.112CysTrp: 0.112 ± 0.012
0.189CysTyr: 0.189 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
6.346AspAla: 6.346 ± 0.088
0.447AspCys: 0.447 ± 0.022
2.891AspAsp: 2.891 ± 0.06
3.564AspGlu: 3.564 ± 0.056
2.152AspPhe: 2.152 ± 0.043
4.879AspGly: 4.879 ± 0.082
1.109AspHis: 1.109 ± 0.032
3.361AspIle: 3.361 ± 0.055
1.636AspLys: 1.636 ± 0.041
5.64AspLeu: 5.64 ± 0.079
1.463AspMet: 1.463 ± 0.029
1.452AspAsn: 1.452 ± 0.038
2.87AspPro: 2.87 ± 0.052
1.652AspGln: 1.652 ± 0.037
3.83AspArg: 3.83 ± 0.074
2.428AspSer: 2.428 ± 0.049
2.536AspThr: 2.536 ± 0.05
4.191AspVal: 4.191 ± 0.05
0.882AspTrp: 0.882 ± 0.03
1.562AspTyr: 1.562 ± 0.04
0.0AspXaa: 0.0 ± 0.0
Glu
7.3GluAla: 7.3 ± 0.098
0.346GluCys: 0.346 ± 0.019
2.705GluAsp: 2.705 ± 0.053
3.217GluGlu: 3.217 ± 0.065
2.055GluPhe: 2.055 ± 0.041
4.01GluGly: 4.01 ± 0.067
1.202GluHis: 1.202 ± 0.035
3.56GluIle: 3.56 ± 0.066
2.402GluLys: 2.402 ± 0.045
5.746GluLeu: 5.746 ± 0.064
1.567GluMet: 1.567 ± 0.04
1.941GluAsn: 1.941 ± 0.046
2.637GluPro: 2.637 ± 0.053
2.249GluGln: 2.249 ± 0.044
4.604GluArg: 4.604 ± 0.072
2.534GluSer: 2.534 ± 0.05
3.58GluThr: 3.58 ± 0.056
3.856GluVal: 3.856 ± 0.054
0.748GluTrp: 0.748 ± 0.025
1.03GluTyr: 1.03 ± 0.031
0.0GluXaa: 0.0 ± 0.0
Phe
4.747PheAla: 4.747 ± 0.064
0.414PheCys: 0.414 ± 0.017
2.665PheAsp: 2.665 ± 0.053
2.182PheGlu: 2.182 ± 0.042
1.522PhePhe: 1.522 ± 0.042
3.74PheGly: 3.74 ± 0.064
0.781PheHis: 0.781 ± 0.026
1.973PheIle: 1.973 ± 0.041
0.964PheLys: 0.964 ± 0.031
3.741PheLeu: 3.741 ± 0.069
0.88PheMet: 0.88 ± 0.026
1.168PheAsn: 1.168 ± 0.034
1.693PhePro: 1.693 ± 0.039
1.256PheGln: 1.256 ± 0.031
2.253PheArg: 2.253 ± 0.046
2.706PheSer: 2.706 ± 0.043
2.117PheThr: 2.117 ± 0.042
2.988PheVal: 2.988 ± 0.048
0.592PheTrp: 0.592 ± 0.02
1.002PheTyr: 1.002 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
8.498GlyAla: 8.498 ± 0.1
0.825GlyCys: 0.825 ± 0.029
4.204GlyAsp: 4.204 ± 0.076
4.669GlyGlu: 4.669 ± 0.069
3.895GlyPhe: 3.895 ± 0.062
7.132GlyGly: 7.132 ± 0.107
1.808GlyHis: 1.808 ± 0.038
4.873GlyIle: 4.873 ± 0.059
3.167GlyLys: 3.167 ± 0.052
8.919GlyLeu: 8.919 ± 0.102
2.297GlyMet: 2.297 ± 0.047
2.47GlyAsn: 2.47 ± 0.057
3.333GlyPro: 3.333 ± 0.054
3.325GlyGln: 3.325 ± 0.059
5.671GlyArg: 5.671 ± 0.067
4.949GlySer: 4.949 ± 0.078
4.572GlyThr: 4.572 ± 0.068
6.228GlyVal: 6.228 ± 0.066
1.258GlyTrp: 1.258 ± 0.036
2.269GlyTyr: 2.269 ± 0.047
0.0GlyXaa: 0.0 ± 0.0
His
2.141HisAla: 2.141 ± 0.051
0.221HisCys: 0.221 ± 0.016
1.131HisAsp: 1.131 ± 0.034
1.085HisGlu: 1.085 ± 0.029
0.881HisPhe: 0.881 ± 0.026
1.766HisGly: 1.766 ± 0.043
0.554HisHis: 0.554 ± 0.026
1.052HisIle: 1.052 ± 0.029
0.506HisLys: 0.506 ± 0.02
2.016HisLeu: 2.016 ± 0.04
0.549HisMet: 0.549 ± 0.022
0.492HisAsn: 0.492 ± 0.02
1.209HisPro: 1.209 ± 0.033
0.633HisGln: 0.633 ± 0.022
1.35HisArg: 1.35 ± 0.038
1.119HisSer: 1.119 ± 0.031
0.835HisThr: 0.835 ± 0.027
1.381HisVal: 1.381 ± 0.034
0.308HisTrp: 0.308 ± 0.016
0.567HisTyr: 0.567 ± 0.019
0.0HisXaa: 0.0 ± 0.0
Ile
7.579IleAla: 7.579 ± 0.08
0.567IleCys: 0.567 ± 0.026
3.49IleAsp: 3.49 ± 0.054
3.425IleGlu: 3.425 ± 0.054
2.069IlePhe: 2.069 ± 0.043
5.35IleGly: 5.35 ± 0.069
0.952IleHis: 0.952 ± 0.033
2.789IleIle: 2.789 ± 0.053
1.335IleLys: 1.335 ± 0.036
5.095IleLeu: 5.095 ± 0.083
1.138IleMet: 1.138 ± 0.03
1.618IleAsn: 1.618 ± 0.041
2.415IlePro: 2.415 ± 0.045
1.381IleGln: 1.381 ± 0.036
3.315IleArg: 3.315 ± 0.049
3.661IleSer: 3.661 ± 0.065
2.739IleThr: 2.739 ± 0.051
4.658IleVal: 4.658 ± 0.071
0.619IleTrp: 0.619 ± 0.023
1.258IleTyr: 1.258 ± 0.03
0.0IleXaa: 0.0 ± 0.0
Lys
3.86LysAla: 3.86 ± 0.062
0.133LysCys: 0.133 ± 0.011
1.564LysAsp: 1.564 ± 0.039
1.431LysGlu: 1.431 ± 0.036
0.915LysPhe: 0.915 ± 0.027
2.33LysGly: 2.33 ± 0.045
0.566LysHis: 0.566 ± 0.022
1.67LysIle: 1.67 ± 0.034
0.96LysLys: 0.96 ± 0.034
3.138LysLeu: 3.138 ± 0.056
0.739LysMet: 0.739 ± 0.025
0.865LysAsn: 0.865 ± 0.025
1.874LysPro: 1.874 ± 0.042
0.979LysGln: 0.979 ± 0.029
2.159LysArg: 2.159 ± 0.046
1.829LysSer: 1.829 ± 0.038
1.725LysThr: 1.725 ± 0.038
2.25LysVal: 2.25 ± 0.049
0.318LysTrp: 0.318 ± 0.018
0.574LysTyr: 0.574 ± 0.023
0.0LysXaa: 0.0 ± 0.0
Leu
13.721LeuAla: 13.721 ± 0.124
0.871LeuCys: 0.871 ± 0.027
5.652LeuAsp: 5.652 ± 0.079
5.56LeuGlu: 5.56 ± 0.078
3.818LeuPhe: 3.818 ± 0.069
8.004LeuGly: 8.004 ± 0.084
1.847LeuHis: 1.847 ± 0.041
5.334LeuIle: 5.334 ± 0.081
3.352LeuLys: 3.352 ± 0.057
9.789LeuLeu: 9.789 ± 0.122
2.552LeuMet: 2.552 ± 0.053
3.023LeuAsn: 3.023 ± 0.049
5.66LeuPro: 5.66 ± 0.078
3.483LeuGln: 3.483 ± 0.056
6.417LeuArg: 6.417 ± 0.071
6.825LeuSer: 6.825 ± 0.08
5.869LeuThr: 5.869 ± 0.079
7.694LeuVal: 7.694 ± 0.102
1.095LeuTrp: 1.095 ± 0.036
2.201LeuTyr: 2.201 ± 0.047
0.0LeuXaa: 0.0 ± 0.0
Met
3.289MetAla: 3.289 ± 0.052
0.155MetCys: 0.155 ± 0.012
1.189MetAsp: 1.189 ± 0.027
1.23MetGlu: 1.23 ± 0.032
0.762MetPhe: 0.762 ± 0.023
1.809MetGly: 1.809 ± 0.04
0.484MetHis: 0.484 ± 0.022
1.393MetIle: 1.393 ± 0.042
0.878MetLys: 0.878 ± 0.031
2.733MetLeu: 2.733 ± 0.052
0.639MetMet: 0.639 ± 0.025
0.808MetAsn: 0.808 ± 0.023
1.552MetPro: 1.552 ± 0.032
1.069MetGln: 1.069 ± 0.03
1.953MetArg: 1.953 ± 0.041
1.731MetSer: 1.731 ± 0.036
1.785MetThr: 1.785 ± 0.037
1.875MetVal: 1.875 ± 0.036
0.194MetTrp: 0.194 ± 0.014
0.295MetTyr: 0.295 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
3.459AsnAla: 3.459 ± 0.06
0.239AsnCys: 0.239 ± 0.017
1.499AsnAsp: 1.499 ± 0.043
1.466AsnGlu: 1.466 ± 0.036
1.166AsnPhe: 1.166 ± 0.032
2.76AsnGly: 2.76 ± 0.056
0.524AsnHis: 0.524 ± 0.02
1.719AsnIle: 1.719 ± 0.047
0.706AsnLys: 0.706 ± 0.024
2.882AsnLeu: 2.882 ± 0.055
0.722AsnMet: 0.722 ± 0.026
0.858AsnAsn: 0.858 ± 0.03
1.906AsnPro: 1.906 ± 0.041
0.886AsnGln: 0.886 ± 0.03
2.081AsnArg: 2.081 ± 0.043
1.672AsnSer: 1.672 ± 0.043
1.364AsnThr: 1.364 ± 0.037
2.125AsnVal: 2.125 ± 0.042
0.493AsnTrp: 0.493 ± 0.023
0.77AsnTyr: 0.77 ± 0.027
0.0AsnXaa: 0.0 ± 0.0
Pro
6.033ProAla: 6.033 ± 0.089
0.256ProCys: 0.256 ± 0.014
3.553ProAsp: 3.553 ± 0.065
3.671ProGlu: 3.671 ± 0.057
2.064ProPhe: 2.064 ± 0.047
4.244ProGly: 4.244 ± 0.056
1.036ProHis: 1.036 ± 0.027
2.333ProIle: 2.333 ± 0.043
1.297ProLys: 1.297 ± 0.032
4.719ProLeu: 4.719 ± 0.067
1.144ProMet: 1.144 ± 0.031
1.395ProAsn: 1.395 ± 0.029
2.127ProPro: 2.127 ± 0.059
1.868ProGln: 1.868 ± 0.047
2.605ProArg: 2.605 ± 0.053
2.586ProSer: 2.586 ± 0.052
2.359ProThr: 2.359 ± 0.053
4.416ProVal: 4.416 ± 0.068
0.552ProTrp: 0.552 ± 0.021
1.217ProTyr: 1.217 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
4.385GlnAla: 4.385 ± 0.069
0.207GlnCys: 0.207 ± 0.013
1.608GlnAsp: 1.608 ± 0.04
1.894GlnGlu: 1.894 ± 0.038
1.267GlnPhe: 1.267 ± 0.036
2.439GlnGly: 2.439 ± 0.047
0.733GlnHis: 0.733 ± 0.024
2.159GlnIle: 2.159 ± 0.041
1.212GlnLys: 1.212 ± 0.03
3.364GlnLeu: 3.364 ± 0.051
0.999GlnMet: 0.999 ± 0.031
1.166GlnAsn: 1.166 ± 0.035
2.001GlnPro: 2.001 ± 0.046
1.493GlnGln: 1.493 ± 0.045
2.662GlnArg: 2.662 ± 0.055
2.246GlnSer: 2.246 ± 0.045
2.115GlnThr: 2.115 ± 0.046
2.377GlnVal: 2.377 ± 0.05
0.43GlnTrp: 0.43 ± 0.019
0.673GlnTyr: 0.673 ± 0.022
0.0GlnXaa: 0.0 ± 0.0
Arg
6.816ArgAla: 6.816 ± 0.082
0.432ArgCys: 0.432 ± 0.024
3.56ArgAsp: 3.56 ± 0.056
3.876ArgGlu: 3.876 ± 0.061
2.883ArgPhe: 2.883 ± 0.045
4.331ArgGly: 4.331 ± 0.059
1.627ArgHis: 1.627 ± 0.04
4.075ArgIle: 4.075 ± 0.064
2.276ArgLys: 2.276 ± 0.049
7.863ArgLeu: 7.863 ± 0.103
1.843ArgMet: 1.843 ± 0.041
2.151ArgAsn: 2.151 ± 0.041
3.258ArgPro: 3.258 ± 0.05
3.011ArgGln: 3.011 ± 0.052
4.981ArgArg: 4.981 ± 0.076
3.751ArgSer: 3.751 ± 0.061
3.141ArgThr: 3.141 ± 0.055
4.49ArgVal: 4.49 ± 0.061
0.852ArgTrp: 0.852 ± 0.028
1.655ArgTyr: 1.655 ± 0.039
0.0ArgXaa: 0.0 ± 0.0
Ser
6.556SerAla: 6.556 ± 0.081
0.387SerCys: 0.387 ± 0.018
3.132SerAsp: 3.132 ± 0.055
3.12SerGlu: 3.12 ± 0.054
2.649SerPhe: 2.649 ± 0.05
6.249SerGly: 6.249 ± 0.085
1.192SerHis: 1.192 ± 0.033
3.217SerIle: 3.217 ± 0.057
1.456SerLys: 1.456 ± 0.034
5.986SerLeu: 5.986 ± 0.08
1.494SerMet: 1.494 ± 0.034
1.616SerAsn: 1.616 ± 0.034
2.959SerPro: 2.959 ± 0.046
2.029SerGln: 2.029 ± 0.038
3.893SerArg: 3.893 ± 0.054
3.462SerSer: 3.462 ± 0.057
2.981SerThr: 2.981 ± 0.054
4.325SerVal: 4.325 ± 0.066
0.7SerTrp: 0.7 ± 0.024
1.426SerTyr: 1.426 ± 0.035
0.0SerXaa: 0.0 ± 0.0
Thr
6.011ThrAla: 6.011 ± 0.072
0.383ThrCys: 0.383 ± 0.018
2.728ThrAsp: 2.728 ± 0.049
2.45ThrGlu: 2.45 ± 0.05
1.955ThrPhe: 1.955 ± 0.043
5.241ThrGly: 5.241 ± 0.076
1.003ThrHis: 1.003 ± 0.03
3.173ThrIle: 3.173 ± 0.052
1.164ThrLys: 1.164 ± 0.033
5.859ThrLeu: 5.859 ± 0.078
1.312ThrMet: 1.312 ± 0.034
1.421ThrAsn: 1.421 ± 0.035
3.143ThrPro: 3.143 ± 0.053
1.607ThrGln: 1.607 ± 0.034
3.288ThrArg: 3.288 ± 0.059
3.16ThrSer: 3.16 ± 0.046
2.723ThrThr: 2.723 ± 0.048
4.484ThrVal: 4.484 ± 0.066
0.519ThrTrp: 0.519 ± 0.02
1.238ThrTyr: 1.238 ± 0.038
0.0ThrXaa: 0.0 ± 0.0
Val
9.043ValAla: 9.043 ± 0.101
0.611ValCys: 0.611 ± 0.023
4.278ValAsp: 4.278 ± 0.063
4.857ValGlu: 4.857 ± 0.078
2.963ValPhe: 2.963 ± 0.053
5.452ValGly: 5.452 ± 0.074
1.402ValHis: 1.402 ± 0.039
3.92ValIle: 3.92 ± 0.07
2.002ValLys: 2.002 ± 0.047
7.739ValLeu: 7.739 ± 0.076
1.871ValMet: 1.871 ± 0.042
2.198ValAsn: 2.198 ± 0.05
3.754ValPro: 3.754 ± 0.057
2.413ValGln: 2.413 ± 0.047
4.785ValArg: 4.785 ± 0.066
4.871ValSer: 4.871 ± 0.069
4.293ValThr: 4.293 ± 0.064
6.051ValVal: 6.051 ± 0.078
0.846ValTrp: 0.846 ± 0.028
1.534ValTyr: 1.534 ± 0.033
0.0ValXaa: 0.0 ± 0.0
Trp
1.115TrpAla: 1.115 ± 0.029
0.115TrpCys: 0.115 ± 0.011
0.54TrpAsp: 0.54 ± 0.022
0.548TrpGlu: 0.548 ± 0.022
0.488TrpPhe: 0.488 ± 0.019
0.796TrpGly: 0.796 ± 0.029
0.303TrpHis: 0.303 ± 0.017
0.576TrpIle: 0.576 ± 0.02
0.414TrpLys: 0.414 ± 0.019
1.555TrpLeu: 1.555 ± 0.039
0.33TrpMet: 0.33 ± 0.016
0.476TrpAsn: 0.476 ± 0.022
0.639TrpPro: 0.639 ± 0.027
0.703TrpGln: 0.703 ± 0.022
0.993TrpArg: 0.993 ± 0.032
0.74TrpSer: 0.74 ± 0.026
0.658TrpThr: 0.658 ± 0.026
0.75TrpVal: 0.75 ± 0.026
0.204TrpTrp: 0.204 ± 0.015
0.267TrpTyr: 0.267 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.485TyrAla: 2.485 ± 0.046
0.216TyrCys: 0.216 ± 0.013
1.442TyrAsp: 1.442 ± 0.037
1.286TyrGlu: 1.286 ± 0.032
1.017TyrPhe: 1.017 ± 0.032
2.224TyrGly: 2.224 ± 0.049
0.498TyrHis: 0.498 ± 0.023
1.046TyrIle: 1.046 ± 0.03
0.569TyrLys: 0.569 ± 0.023
2.361TyrLeu: 2.361 ± 0.038
0.494TyrMet: 0.494 ± 0.019
0.693TyrAsn: 0.693 ± 0.025
1.119TyrPro: 1.119 ± 0.035
0.802TyrGln: 0.802 ± 0.025
1.634TyrArg: 1.634 ± 0.034
1.408TyrSer: 1.408 ± 0.039
1.119TyrThr: 1.119 ± 0.031
1.588TyrVal: 1.588 ± 0.041
0.32TyrTrp: 0.32 ± 0.017
0.612TyrTyr: 0.612 ± 0.022
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3594 proteins (1177670 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski