Amino acid dipepetide frequency for Cronobacter phage ENT47670

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.446AlaAla: 12.446 ± 2.48
1.177AlaCys: 1.177 ± 0.343
4.878AlaAsp: 4.878 ± 0.783
5.887AlaGlu: 5.887 ± 0.822
3.196AlaPhe: 3.196 ± 0.535
6.812AlaGly: 6.812 ± 1.276
1.177AlaHis: 1.177 ± 0.301
5.635AlaIle: 5.635 ± 0.632
4.457AlaLys: 4.457 ± 0.62
9.167AlaLeu: 9.167 ± 1.047
3.532AlaMet: 3.532 ± 0.576
3.784AlaAsn: 3.784 ± 0.511
2.355AlaPro: 2.355 ± 0.415
4.541AlaGln: 4.541 ± 0.94
4.373AlaArg: 4.373 ± 0.644
5.887AlaSer: 5.887 ± 0.958
6.223AlaThr: 6.223 ± 1.078
6.728AlaVal: 6.728 ± 0.871
1.682AlaTrp: 1.682 ± 0.455
2.187AlaTyr: 2.187 ± 0.41
0.0AlaXaa: 0.0 ± 0.0
Cys
0.757CysAla: 0.757 ± 0.193
0.084CysCys: 0.084 ± 0.088
0.589CysAsp: 0.589 ± 0.212
0.589CysGlu: 0.589 ± 0.224
0.252CysPhe: 0.252 ± 0.16
0.757CysGly: 0.757 ± 0.262
0.336CysHis: 0.336 ± 0.152
0.42CysIle: 0.42 ± 0.16
0.168CysLys: 0.168 ± 0.114
1.009CysLeu: 1.009 ± 0.36
0.673CysMet: 0.673 ± 0.305
0.336CysAsn: 0.336 ± 0.149
0.841CysPro: 0.841 ± 0.319
0.252CysGln: 0.252 ± 0.127
0.925CysArg: 0.925 ± 0.248
0.925CysSer: 0.925 ± 0.306
0.757CysThr: 0.757 ± 0.217
0.841CysVal: 0.841 ± 0.277
0.252CysTrp: 0.252 ± 0.139
0.673CysTyr: 0.673 ± 0.269
0.0CysXaa: 0.0 ± 0.0
Asp
5.803AspAla: 5.803 ± 0.745
0.505AspCys: 0.505 ± 0.186
4.541AspAsp: 4.541 ± 0.918
3.532AspGlu: 3.532 ± 0.518
1.85AspPhe: 1.85 ± 0.341
5.298AspGly: 5.298 ± 0.683
0.925AspHis: 0.925 ± 0.286
2.775AspIle: 2.775 ± 0.537
3.027AspLys: 3.027 ± 0.551
4.541AspLeu: 4.541 ± 0.585
1.934AspMet: 1.934 ± 0.429
2.691AspAsn: 2.691 ± 0.569
1.85AspPro: 1.85 ± 0.518
1.261AspGln: 1.261 ± 0.261
2.018AspArg: 2.018 ± 0.42
3.953AspSer: 3.953 ± 0.471
3.28AspThr: 3.28 ± 0.501
4.205AspVal: 4.205 ± 0.732
0.757AspTrp: 0.757 ± 0.22
2.607AspTyr: 2.607 ± 0.653
0.0AspXaa: 0.0 ± 0.0
Glu
5.466GluAla: 5.466 ± 0.74
0.673GluCys: 0.673 ± 0.259
2.102GluAsp: 2.102 ± 0.445
3.616GluGlu: 3.616 ± 0.567
2.355GluPhe: 2.355 ± 0.489
3.364GluGly: 3.364 ± 0.615
0.925GluHis: 0.925 ± 0.354
2.691GluIle: 2.691 ± 0.41
3.616GluLys: 3.616 ± 0.891
4.794GluLeu: 4.794 ± 0.611
2.102GluMet: 2.102 ± 0.431
3.027GluAsn: 3.027 ± 0.488
2.018GluPro: 2.018 ± 0.478
4.457GluGln: 4.457 ± 0.725
5.046GluArg: 5.046 ± 0.863
4.541GluSer: 4.541 ± 0.484
1.934GluThr: 1.934 ± 0.361
3.532GluVal: 3.532 ± 0.486
1.766GluTrp: 1.766 ± 0.372
2.271GluTyr: 2.271 ± 0.475
0.0GluXaa: 0.0 ± 0.0
Phe
2.775PheAla: 2.775 ± 0.446
0.168PheCys: 0.168 ± 0.104
2.439PheAsp: 2.439 ± 0.507
2.018PheGlu: 2.018 ± 0.36
1.093PhePhe: 1.093 ± 0.314
2.523PheGly: 2.523 ± 0.389
0.589PheHis: 0.589 ± 0.194
1.85PheIle: 1.85 ± 0.29
2.018PheLys: 2.018 ± 0.532
2.102PheLeu: 2.102 ± 0.566
0.841PheMet: 0.841 ± 0.281
1.598PheAsn: 1.598 ± 0.331
1.177PhePro: 1.177 ± 0.436
1.093PheGln: 1.093 ± 0.287
2.859PheArg: 2.859 ± 0.391
2.523PheSer: 2.523 ± 0.471
3.364PheThr: 3.364 ± 0.736
2.607PheVal: 2.607 ± 0.453
0.589PheTrp: 0.589 ± 0.227
1.346PheTyr: 1.346 ± 0.379
0.0PheXaa: 0.0 ± 0.0
Gly
5.55GlyAla: 5.55 ± 0.758
1.093GlyCys: 1.093 ± 0.354
3.112GlyAsp: 3.112 ± 0.583
3.868GlyGlu: 3.868 ± 0.607
3.448GlyPhe: 3.448 ± 0.659
5.298GlyGly: 5.298 ± 0.844
1.009GlyHis: 1.009 ± 0.308
4.625GlyIle: 4.625 ± 0.541
4.121GlyLys: 4.121 ± 0.696
5.046GlyLeu: 5.046 ± 0.77
2.102GlyMet: 2.102 ± 0.435
3.448GlyAsn: 3.448 ± 0.511
1.43GlyPro: 1.43 ± 0.342
2.439GlyGln: 2.439 ± 0.503
4.709GlyArg: 4.709 ± 0.675
3.784GlySer: 3.784 ± 0.569
4.037GlyThr: 4.037 ± 0.85
4.794GlyVal: 4.794 ± 0.804
1.43GlyTrp: 1.43 ± 0.461
2.439GlyTyr: 2.439 ± 0.443
0.0GlyXaa: 0.0 ± 0.0
His
1.177HisAla: 1.177 ± 0.288
0.42HisCys: 0.42 ± 0.186
0.589HisAsp: 0.589 ± 0.209
1.093HisGlu: 1.093 ± 0.335
0.757HisPhe: 0.757 ± 0.289
0.841HisGly: 0.841 ± 0.285
0.252HisHis: 0.252 ± 0.146
1.093HisIle: 1.093 ± 0.358
0.589HisLys: 0.589 ± 0.219
1.682HisLeu: 1.682 ± 0.429
0.168HisMet: 0.168 ± 0.116
0.673HisAsn: 0.673 ± 0.277
1.093HisPro: 1.093 ± 0.282
0.168HisGln: 0.168 ± 0.113
1.177HisArg: 1.177 ± 0.299
0.925HisSer: 0.925 ± 0.333
1.598HisThr: 1.598 ± 0.417
0.925HisVal: 0.925 ± 0.505
0.336HisTrp: 0.336 ± 0.16
0.673HisTyr: 0.673 ± 0.222
0.0HisXaa: 0.0 ± 0.0
Ile
5.466IleAla: 5.466 ± 0.653
0.42IleCys: 0.42 ± 0.153
3.532IleAsp: 3.532 ± 0.484
4.037IleGlu: 4.037 ± 0.572
1.934IlePhe: 1.934 ± 0.334
4.205IleGly: 4.205 ± 0.602
1.682IleHis: 1.682 ± 0.395
2.859IleIle: 2.859 ± 0.425
2.775IleLys: 2.775 ± 0.388
2.943IleLeu: 2.943 ± 0.805
0.757IleMet: 0.757 ± 0.234
3.364IleAsn: 3.364 ± 0.551
2.355IlePro: 2.355 ± 0.433
2.271IleGln: 2.271 ± 0.46
2.523IleArg: 2.523 ± 0.541
5.466IleSer: 5.466 ± 0.891
3.196IleThr: 3.196 ± 0.52
4.205IleVal: 4.205 ± 0.526
0.505IleTrp: 0.505 ± 0.218
1.934IleTyr: 1.934 ± 0.428
0.0IleXaa: 0.0 ± 0.0
Lys
6.223LysAla: 6.223 ± 1.287
0.42LysCys: 0.42 ± 0.185
3.196LysAsp: 3.196 ± 0.561
2.271LysGlu: 2.271 ± 0.372
1.346LysPhe: 1.346 ± 0.318
2.691LysGly: 2.691 ± 0.545
0.589LysHis: 0.589 ± 0.228
2.018LysIle: 2.018 ± 0.444
2.018LysLys: 2.018 ± 0.385
4.962LysLeu: 4.962 ± 0.557
1.85LysMet: 1.85 ± 0.347
1.766LysAsn: 1.766 ± 0.37
3.027LysPro: 3.027 ± 0.526
2.187LysGln: 2.187 ± 0.387
3.784LysArg: 3.784 ± 0.736
3.448LysSer: 3.448 ± 0.587
3.532LysThr: 3.532 ± 0.539
3.448LysVal: 3.448 ± 0.622
0.925LysTrp: 0.925 ± 0.263
1.85LysTyr: 1.85 ± 0.468
0.0LysXaa: 0.0 ± 0.0
Leu
7.485LeuAla: 7.485 ± 0.99
1.093LeuCys: 1.093 ± 0.316
4.794LeuAsp: 4.794 ± 0.656
4.205LeuGlu: 4.205 ± 0.87
1.934LeuPhe: 1.934 ± 0.457
4.289LeuGly: 4.289 ± 0.576
1.093LeuHis: 1.093 ± 0.312
6.055LeuIle: 6.055 ± 0.853
4.541LeuLys: 4.541 ± 0.668
5.971LeuLeu: 5.971 ± 1.01
2.102LeuMet: 2.102 ± 0.484
4.962LeuAsn: 4.962 ± 0.632
2.943LeuPro: 2.943 ± 0.674
3.196LeuGln: 3.196 ± 0.637
4.794LeuArg: 4.794 ± 0.609
6.055LeuSer: 6.055 ± 0.844
5.298LeuThr: 5.298 ± 0.617
5.214LeuVal: 5.214 ± 0.768
0.925LeuTrp: 0.925 ± 0.259
3.28LeuTyr: 3.28 ± 0.556
0.0LeuXaa: 0.0 ± 0.0
Met
2.943MetAla: 2.943 ± 0.501
0.252MetCys: 0.252 ± 0.152
0.505MetAsp: 0.505 ± 0.192
0.757MetGlu: 0.757 ± 0.202
0.757MetPhe: 0.757 ± 0.263
1.766MetGly: 1.766 ± 0.341
0.42MetHis: 0.42 ± 0.18
1.009MetIle: 1.009 ± 0.284
2.187MetLys: 2.187 ± 0.367
2.607MetLeu: 2.607 ± 0.534
0.252MetMet: 0.252 ± 0.131
1.85MetAsn: 1.85 ± 0.388
1.43MetPro: 1.43 ± 0.299
1.43MetGln: 1.43 ± 0.319
2.102MetArg: 2.102 ± 0.486
1.682MetSer: 1.682 ± 0.35
2.018MetThr: 2.018 ± 0.401
1.177MetVal: 1.177 ± 0.361
0.42MetTrp: 0.42 ± 0.163
0.42MetTyr: 0.42 ± 0.137
0.0MetXaa: 0.0 ± 0.0
Asn
5.298AsnAla: 5.298 ± 1.02
0.757AsnCys: 0.757 ± 0.235
2.607AsnAsp: 2.607 ± 0.436
2.607AsnGlu: 2.607 ± 0.4
1.598AsnPhe: 1.598 ± 0.382
4.457AsnGly: 4.457 ± 0.598
1.009AsnHis: 1.009 ± 0.291
2.523AsnIle: 2.523 ± 0.528
2.271AsnLys: 2.271 ± 0.367
2.523AsnLeu: 2.523 ± 0.387
0.757AsnMet: 0.757 ± 0.215
1.598AsnAsn: 1.598 ± 0.444
2.102AsnPro: 2.102 ± 0.356
1.85AsnGln: 1.85 ± 0.35
2.271AsnArg: 2.271 ± 0.441
3.364AsnSer: 3.364 ± 0.678
3.112AsnThr: 3.112 ± 0.696
3.196AsnVal: 3.196 ± 0.583
0.757AsnTrp: 0.757 ± 0.251
1.346AsnTyr: 1.346 ± 0.316
0.0AsnXaa: 0.0 ± 0.0
Pro
3.28ProAla: 3.28 ± 0.477
0.42ProCys: 0.42 ± 0.169
3.28ProAsp: 3.28 ± 0.542
2.775ProGlu: 2.775 ± 0.634
1.177ProPhe: 1.177 ± 0.386
1.85ProGly: 1.85 ± 0.471
0.589ProHis: 0.589 ± 0.243
2.691ProIle: 2.691 ± 0.529
1.934ProLys: 1.934 ± 0.373
2.691ProLeu: 2.691 ± 0.616
0.589ProMet: 0.589 ± 0.285
1.682ProAsn: 1.682 ± 0.497
1.514ProPro: 1.514 ± 0.349
1.514ProGln: 1.514 ± 0.337
2.102ProArg: 2.102 ± 0.297
2.775ProSer: 2.775 ± 0.536
2.439ProThr: 2.439 ± 0.469
3.532ProVal: 3.532 ± 0.443
0.589ProTrp: 0.589 ± 0.197
0.673ProTyr: 0.673 ± 0.267
0.0ProXaa: 0.0 ± 0.0
Gln
5.803GlnAla: 5.803 ± 1.04
0.505GlnCys: 0.505 ± 0.178
1.346GlnAsp: 1.346 ± 0.381
2.607GlnGlu: 2.607 ± 0.384
1.766GlnPhe: 1.766 ± 0.468
1.934GlnGly: 1.934 ± 0.524
0.841GlnHis: 0.841 ± 0.316
2.691GlnIle: 2.691 ± 0.35
2.859GlnLys: 2.859 ± 0.561
3.616GlnLeu: 3.616 ± 0.62
1.177GlnMet: 1.177 ± 0.318
1.682GlnAsn: 1.682 ± 0.398
1.514GlnPro: 1.514 ± 0.327
3.868GlnGln: 3.868 ± 1.084
2.607GlnArg: 2.607 ± 0.424
3.28GlnSer: 3.28 ± 0.504
1.682GlnThr: 1.682 ± 0.37
3.196GlnVal: 3.196 ± 0.46
0.757GlnTrp: 0.757 ± 0.219
1.766GlnTyr: 1.766 ± 0.4
0.0GlnXaa: 0.0 ± 0.0
Arg
5.214ArgAla: 5.214 ± 0.612
0.841ArgCys: 0.841 ± 0.273
3.196ArgAsp: 3.196 ± 0.548
5.046ArgGlu: 5.046 ± 0.711
1.682ArgPhe: 1.682 ± 0.331
3.784ArgGly: 3.784 ± 0.589
1.261ArgHis: 1.261 ± 0.276
2.943ArgIle: 2.943 ± 0.554
3.112ArgLys: 3.112 ± 0.552
5.971ArgLeu: 5.971 ± 0.699
1.682ArgMet: 1.682 ± 0.355
2.355ArgAsn: 2.355 ± 0.459
2.271ArgPro: 2.271 ± 0.535
3.448ArgGln: 3.448 ± 0.657
4.289ArgArg: 4.289 ± 0.78
3.027ArgSer: 3.027 ± 0.464
3.112ArgThr: 3.112 ± 0.529
4.541ArgVal: 4.541 ± 0.687
1.177ArgTrp: 1.177 ± 0.343
1.934ArgTyr: 1.934 ± 0.46
0.0ArgXaa: 0.0 ± 0.0
Ser
6.139SerAla: 6.139 ± 0.959
0.505SerCys: 0.505 ± 0.192
5.046SerAsp: 5.046 ± 0.66
4.289SerGlu: 4.289 ± 0.666
3.532SerPhe: 3.532 ± 0.632
4.794SerGly: 4.794 ± 0.665
0.673SerHis: 0.673 ± 0.202
4.457SerIle: 4.457 ± 0.822
2.607SerLys: 2.607 ± 0.543
6.391SerLeu: 6.391 ± 0.601
1.598SerMet: 1.598 ± 0.359
3.784SerAsn: 3.784 ± 0.826
2.943SerPro: 2.943 ± 0.542
3.364SerGln: 3.364 ± 0.808
4.541SerArg: 4.541 ± 0.687
5.298SerSer: 5.298 ± 1.032
3.364SerThr: 3.364 ± 0.614
4.625SerVal: 4.625 ± 0.59
0.757SerTrp: 0.757 ± 0.233
1.009SerTyr: 1.009 ± 0.284
0.0SerXaa: 0.0 ± 0.0
Thr
4.709ThrAla: 4.709 ± 0.707
0.42ThrCys: 0.42 ± 0.192
4.289ThrAsp: 4.289 ± 0.75
3.868ThrGlu: 3.868 ± 0.589
3.027ThrPhe: 3.027 ± 0.601
4.962ThrGly: 4.962 ± 0.635
0.673ThrHis: 0.673 ± 0.239
3.027ThrIle: 3.027 ± 0.772
2.523ThrLys: 2.523 ± 0.451
4.878ThrLeu: 4.878 ± 0.577
1.177ThrMet: 1.177 ± 0.295
3.027ThrAsn: 3.027 ± 0.758
2.691ThrPro: 2.691 ± 0.424
2.607ThrGln: 2.607 ± 0.652
2.859ThrArg: 2.859 ± 0.492
3.868ThrSer: 3.868 ± 0.623
4.541ThrThr: 4.541 ± 0.826
4.373ThrVal: 4.373 ± 0.732
1.177ThrTrp: 1.177 ± 0.464
1.85ThrTyr: 1.85 ± 0.547
0.0ThrXaa: 0.0 ± 0.0
Val
5.382ValAla: 5.382 ± 0.513
0.673ValCys: 0.673 ± 0.196
4.962ValAsp: 4.962 ± 0.618
4.794ValGlu: 4.794 ± 0.629
2.607ValPhe: 2.607 ± 0.7
5.214ValGly: 5.214 ± 0.599
1.346ValHis: 1.346 ± 0.337
4.373ValIle: 4.373 ± 0.649
4.457ValLys: 4.457 ± 0.508
5.382ValLeu: 5.382 ± 0.713
1.682ValMet: 1.682 ± 0.38
2.775ValAsn: 2.775 ± 0.605
2.439ValPro: 2.439 ± 0.594
2.775ValGln: 2.775 ± 0.468
3.7ValArg: 3.7 ± 0.514
4.205ValSer: 4.205 ± 0.711
4.709ValThr: 4.709 ± 0.888
6.896ValVal: 6.896 ± 0.653
0.589ValTrp: 0.589 ± 0.321
2.775ValTyr: 2.775 ± 0.511
0.0ValXaa: 0.0 ± 0.0
Trp
1.43TrpAla: 1.43 ± 0.319
0.336TrpCys: 0.336 ± 0.14
0.673TrpAsp: 0.673 ± 0.176
0.589TrpGlu: 0.589 ± 0.219
0.336TrpPhe: 0.336 ± 0.149
0.757TrpGly: 0.757 ± 0.27
0.336TrpHis: 0.336 ± 0.156
0.589TrpIle: 0.589 ± 0.194
1.093TrpLys: 1.093 ± 0.311
1.766TrpLeu: 1.766 ± 0.494
0.252TrpMet: 0.252 ± 0.149
0.336TrpAsn: 0.336 ± 0.15
0.589TrpPro: 0.589 ± 0.251
0.925TrpGln: 0.925 ± 0.261
1.346TrpArg: 1.346 ± 0.349
1.514TrpSer: 1.514 ± 0.367
0.757TrpThr: 0.757 ± 0.221
1.43TrpVal: 1.43 ± 0.261
0.168TrpTrp: 0.168 ± 0.11
0.673TrpTyr: 0.673 ± 0.236
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.775TyrAla: 2.775 ± 0.39
0.673TyrCys: 0.673 ± 0.239
1.766TyrAsp: 1.766 ± 0.41
1.85TyrGlu: 1.85 ± 0.318
0.925TyrPhe: 0.925 ± 0.257
2.187TyrGly: 2.187 ± 0.483
0.505TyrHis: 0.505 ± 0.173
2.102TyrIle: 2.102 ± 0.375
1.177TyrLys: 1.177 ± 0.294
2.187TyrLeu: 2.187 ± 0.475
0.673TyrMet: 0.673 ± 0.249
1.261TyrAsn: 1.261 ± 0.308
1.514TyrPro: 1.514 ± 0.274
1.85TyrGln: 1.85 ± 0.522
2.859TyrArg: 2.859 ± 0.464
3.196TyrSer: 3.196 ± 0.604
1.598TyrThr: 1.598 ± 0.408
2.271TyrVal: 2.271 ± 0.495
0.336TyrTrp: 0.336 ± 0.16
0.925TyrTyr: 0.925 ± 0.228
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 46 proteins (11892 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski